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Investigating the potential of a self-healing semiconducting supramolecular Mg(ii)-metallohydrogel in non-volatile memory design and its therapeutic properties towards bacteria infected wound healing†
IF 5.2
Materials Advances Pub Date : 2025-02-12 DOI: 10.1039/D4MA01238K
Subhendu Dhibar, Arpita Roy, Priyanka Das, Tuhin Sarkar, Mitrabrata Goswami, Sangita Some, Kripasindhu Karmakar, Pradip Ruidas, Subham Bhattacharjee, Timothy O. Ajiboye, Anindya Sundar Ray, Keka Sarkar, Soumya Jyoti Ray and Bidyut Saha
{"title":"Investigating the potential of a self-healing semiconducting supramolecular Mg(ii)-metallohydrogel in non-volatile memory design and its therapeutic properties towards bacteria infected wound healing†","authors":"Subhendu Dhibar, Arpita Roy, Priyanka Das, Tuhin Sarkar, Mitrabrata Goswami, Sangita Some, Kripasindhu Karmakar, Pradip Ruidas, Subham Bhattacharjee, Timothy O. Ajiboye, Anindya Sundar Ray, Keka Sarkar, Soumya Jyoti Ray and Bidyut Saha","doi":"10.1039/D4MA01238K","DOIUrl":"https://doi.org/10.1039/D4MA01238K","url":null,"abstract":"<p >A swift and effective technique was employed to fabricate a novel supramolecular metallohydrogel, named Mg@5AP, by incorporating Mg(<small>II</small>) ions. This groundbreaking gel utilized 5-amino-1-pentanol as a low molecular weight gelator, formulated in an aqueous solution at room temperature. Mechanical robustness was assessed through rheological analysis, affirming the resilience of Mg@5AP under various mechanical strains and angular frequencies. Notably, the metallohydrogel displayed thixotropic properties, indicating its ability to self-repair. Structural characterization revealed a distinct network of rectangular, mixed flake rod-like structures within Mg@5AP, as observed through scanning and transmission electron microscopy (FESEM and TEM). Elemental mapping using energy-dispersive X-ray (EDX) analysis confirmed the presence of key chemical components. Further insights into its formation were obtained <em>via</em> Fourier-transform infrared (FT-IR) spectroscopy. In this investigation, Schottky diode structures in a metal–semiconductor–metal arrangement were fabricated using the magnesium(<small>II</small>) metallohydrogel (Mg@5AP) to explore its charge transport behavior. Additionally, a resistive random access memory (RRAM) device was fabricated from Mg@5AP, showcasing bipolar resistive switching at room temperature. A detailed observation of the switching mechanism, involving the formation and disruption of conduction filaments, explained the resistive switching process. The RRAM device exhibited exceptional performance with a high ON/OFF ratio of approximately 120 and impressive endurance, surpassing 5000 switching cycles. This durability suggests the suitability of these devices without any electrical degradation. Furthermore, Mg@5AP demonstrated significant inhibitory activity against drug-resistant Klebsiella pneumonia strain and its biofilm formation. The minimum inhibitory concentration (MIC) was determined to be 3 mg mL<small><sup>−1</sup></small> when dissolved in 1% dimethyl sulfoxide (DMSO). An MTT assay revealed a 60% inhibition of biofilm formation at a concentration of 1 mg mL<small><sup>−1</sup></small> of Mg@5AP in 1% DMSO. Moreover, in a mouse excisional wound model, Mg@5AP played a pivotal role in preventing postoperative wound infections and promoting wound healing.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1899-1913"},"PeriodicalIF":5.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01238k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface modification of polylactic acid using a photo-activated chlorine dioxide process: surface properties and dissimilar adhesion†
IF 5.2
Materials Advances Pub Date : 2025-02-12 DOI: 10.1039/D4MA01275E
Haruyasu Asahara, Weiting Wu, Taka-Aki Asoh, Yu-I Hsu, Tsuyoshi Inoue and Hiroshi Uyama
{"title":"Surface modification of polylactic acid using a photo-activated chlorine dioxide process: surface properties and dissimilar adhesion†","authors":"Haruyasu Asahara, Weiting Wu, Taka-Aki Asoh, Yu-I Hsu, Tsuyoshi Inoue and Hiroshi Uyama","doi":"10.1039/D4MA01275E","DOIUrl":"https://doi.org/10.1039/D4MA01275E","url":null,"abstract":"<p >In this study, we examined the modification of polylactic acid (PLA) plates and powders using a photo-activated chlorine dioxide (ClO<small><sub>2</sub></small>˙) treatment. Changes in the degree of oxidation depending on the oxidation conditions, namely, temperature and time, were determined by surface elemental analysis using X-ray photoelectron spectroscopy and quantification of the number of carboxy groups using toluidine blue O staining. Oxidized PLA exhibited excellent adhesion to dissimilar materials, including aluminum and cellulose. In the adhesion to aluminum, the relationship between the adhesion strength and oxidation degree was investigated.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1608-1612"},"PeriodicalIF":5.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01275e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple size tuning of magnetic nanoparticles using a microwave solvothermal method and their application in facilitating the solid-phase synthesis of molecularly imprinted polymers†
IF 5.2
Materials Advances Pub Date : 2025-02-11 DOI: 10.1039/D4MA01115E
Andrei N. Stephen, Tim Mercer, William Stockburn, Sarah R. Dennison, Jennifer E. Readman and Subrayal M. Reddy
{"title":"Simple size tuning of magnetic nanoparticles using a microwave solvothermal method and their application in facilitating the solid-phase synthesis of molecularly imprinted polymers†","authors":"Andrei N. Stephen, Tim Mercer, William Stockburn, Sarah R. Dennison, Jennifer E. Readman and Subrayal M. Reddy","doi":"10.1039/D4MA01115E","DOIUrl":"https://doi.org/10.1039/D4MA01115E","url":null,"abstract":"<p >Herein, we have demonstrated a simple, economical, rapid and scalable microwave method to produce magnetite-based magnetic nanoparticles (MNPs) with desired sizes and their application in the facile synthesis of high-value polymer products. Solvothermal method is gaining traction in microwave synthesis as it offers a rapid and green method for MNP production. In this work, we report a novel, simple and reliable microwave synthesis method, where adjusting the temperature gradient from 20 °C to a dwell temperature of 200 °C enabled the size control of superparamagnetic aldehyde-functionalised nanoparticles (MNP@CHO). The size distribution of nanoparticles was measured using dynamic light scattering, which revealed values of 14 nm ± 8 nm at 90 °C min<small><sup>−1</sup></small> (a 2-minute ramp time to dwell temperature) and 122 nm ± 49 nm at 18 °C min<small><sup>−1</sup></small> (a 10-minute ramp time to dwell temperature), and these nanoparticles were produced within 20–30 minutes. Magnetic size analysis using the Chantrell method confirmed that the iron–oxide core size increased as a function of ramp time, with the median diameter in the range of 7.91 to 11.25 nm and lognormal <em>σ</em> values within 0.22 ≤ <em>σ</em> ≤ 0.33. The particle cluster size increased with an increase in the ramp time, which was measured using transmission electron microscopy, and it was found to be a function of particle agglomeration. Furthermore, we demonstrated that MNP@CHO functionalised with a protein of interest can be applied for the rational solid-phase synthesis of molecularly imprinted polymer nanoparticles (nanoMIPs) with high affinity for protein biomarkers. Thus, we demonstrated that an optimal MNP size is required for the highly efficient production of MNP-based nanoMIPs, which is the key to the mass production and commercialisation of low-cost and sustainable size-tuned MNPs and artificial antibodies.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 2016-2028"},"PeriodicalIF":5.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01115e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the magnetic properties of superparamagnetic iron oxide nanoparticles using hydrothermal treatment for magnetic hyperthermia application
IF 5.2
Materials Advances Pub Date : 2025-02-10 DOI: 10.1039/D4MA01120A
Carla Martins, Catarina Rolo, Vanessa R. G. Cacho, Laura C. J. Pereira, João Paulo Borges, Jorge Carvalho Silva, Tânia Vieira and Paula I. P. Soares
{"title":"Enhancing the magnetic properties of superparamagnetic iron oxide nanoparticles using hydrothermal treatment for magnetic hyperthermia application","authors":"Carla Martins, Catarina Rolo, Vanessa R. G. Cacho, Laura C. J. Pereira, João Paulo Borges, Jorge Carvalho Silva, Tânia Vieira and Paula I. P. Soares","doi":"10.1039/D4MA01120A","DOIUrl":"https://doi.org/10.1039/D4MA01120A","url":null,"abstract":"<p >Superparamagnetic iron oxide nanoparticles (SPIONs) are the most commonly used inorganic nanoparticles for magnetic hyperthermia in cancer treatment. In this technique, the temperature of the tumor is increased by applying an external alternating magnetic field, which induces heat release from magnetic nanoparticles located at the tumor site. In this study, SPIONs were produced using the chemical co-precipitation technique combined with hydrothermal treatment to reduce their size dispersibility and increase their crystallinity, which are directly related to their magnetic properties. The size of the SPIONs increased from 9 nm to 20 nm after hydrothermal treatment at 160 °C for 24 h. These NPs exhibit a cubic/rectangular shape with a structure composed of both magnetite and maghemite. Their superparamagnetic behavior was confirmed, and the magnetic saturation increased from 58 to 73 emu g<small><sup>−1</sup></small> at RT and from 67 to 81 emu g<small><sup>−1</sup></small> at 10 K. Magnetic hyperthermia measurements showed an increase in SAR values from 83 to about 160–200 W g<small><sup>−1</sup></small>, depending on the hydrothermal treatment conditions. Additionally, the exposure of normal and melanoma cells to SPIONs in the presence of an alternating magnetic field leads to a significant reduction in cell viability, with a more pronounced effect in melanoma cells. These results demonstrate the high potential of this synthesis technique for producing SPIONs for cancer treatment <em>via</em> magnetic hyperthermia.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1726-1743"},"PeriodicalIF":5.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01120a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to exploring the progress in fundamental, functional material and health aspects of melanins and related materials
IF 5.2
Materials Advances Pub Date : 2025-02-10 DOI: 10.1039/D4MA90120G
A. Bernardus Mostert, Pooi See Lee and Carlos F. O. Graeff
{"title":"Introduction to exploring the progress in fundamental, functional material and health aspects of melanins and related materials","authors":"A. Bernardus Mostert, Pooi See Lee and Carlos F. O. Graeff","doi":"10.1039/D4MA90120G","DOIUrl":"https://doi.org/10.1039/D4MA90120G","url":null,"abstract":"<p >A graphical abstract is available for this content</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1552-1553"},"PeriodicalIF":5.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma90120g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gigantic enhancement of optoelectrical properties in polythiophene thin films via MoS2 nanosheet-induced aggregation and ordering
IF 5.2
Materials Advances Pub Date : 2025-02-07 DOI: 10.1039/D4MA01087F
Mitu Chauhan, Anand Kumar Singh, Vivek Chaudhary, Rajiv Kumar Pandey and Arun Kumar Singh
{"title":"Gigantic enhancement of optoelectrical properties in polythiophene thin films via MoS2 nanosheet-induced aggregation and ordering","authors":"Mitu Chauhan, Anand Kumar Singh, Vivek Chaudhary, Rajiv Kumar Pandey and Arun Kumar Singh","doi":"10.1039/D4MA01087F","DOIUrl":"https://doi.org/10.1039/D4MA01087F","url":null,"abstract":"<p >Conducting polymers (CPs), such as poly(3,3-dialkylquarterthiophene) (PQT-12), are attractive candidates for flexible thin-film electronics due to their cost-effectiveness and mechanical flexibility. However, the industrial application of CPs is limited by poor crystallinity and disordered polymer chain orientation. Herein, we report the enhancement in optical, structural, and electronic properties of PQT-12 by incorporating MoS<small><sub>2</sub></small> nanosheets in the polymer matrix. The PQT-12/MoS<small><sub>2</sub></small> nanocomposite exhibits improved crystallinity, molecular ordering, and charge transport properties, as evidenced by enhanced UV-visible absorption, quenched photoluminescence, and increased coherence length in X-ray diffraction. The floating-film transfer method (FTM), a scalable technique for large-area film fabrication has been used for thin film deposition. The nanocomposite film reveals a more ordered nano-fibrillar network in atomic force microscopy images, which is crucial for efficient charge transport. The charge transport has been studied by fabricating organic field-effect transistors (OFETs) and Schottky diodes. The nanocomposite based OFETs have shown mobility up to 3.6 × 10<small><sup>−3</sup></small> cm V<small><sup>−1</sup></small> s<small><sup>−1</sup></small> with an on/off ratio of 10<small><sup>4</sup></small>, while Schottky diodes exhibit enhanced ideality factor, rectification ratio, and barrier height. These improvements are attributed to charge transfer interactions and enhanced polymer chain alignment induced by MoS<small><sub>2</sub></small> nanosheets, demonstrating their potential for high-performance flexible electronics.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1822-1830"},"PeriodicalIF":5.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01087f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hierarchical intrafibrillar mineralization with EGaIn nanocapsules through a one-step collagen self-assembly approach†
IF 5.2
Materials Advances Pub Date : 2025-02-07 DOI: 10.1039/D4MA01186D
Kevin H. Mwangi, Yue Qu, Sengpav Tong, Xiaodan Sun, Lingyun Zhao and XiuMei Wang
{"title":"Hierarchical intrafibrillar mineralization with EGaIn nanocapsules through a one-step collagen self-assembly approach†","authors":"Kevin H. Mwangi, Yue Qu, Sengpav Tong, Xiaodan Sun, Lingyun Zhao and XiuMei Wang","doi":"10.1039/D4MA01186D","DOIUrl":"https://doi.org/10.1039/D4MA01186D","url":null,"abstract":"<p >Inspired by nature, various engineered mineralized collagen composites have been successfully synthesized through biomimetic processes, providing insights into the underlying mechanisms of natural biomineralization. Due to its low toxicity, EGaIn liquid metal has garnered attention in a wide range of emerging areas and is increasingly being studied at the frontiers. Collagen fibrils serve as templates for the creation of modern models of intrafibrillar biomineralization mechanisms. In order to create a potent osteoinductive biomimetic, this study looked at the collagen-EGaIn matrix adoption in intrafibrillar biomineralization of collagen matrix constructs. To the best of our knowledge, it is the first time that intrafibrillar mineralization of PEG-EGaIn-Col-Ap matrices was achieved <em>via</em> a one-step approach, where collagen fibrils served as a templating matrix, and as a surfactant. The result showed that PEG-EGaIn nanocapsules with collagen microfibrils formed an efficient matrix for the growth of acicular apatite. Electron microscopy and characterization analyses revealed that the presence of ethanol significantly enhanced the infiltration of mineral nucleation precursors into the interior spaces of collagen fibrils, which facilitated hierarchical intrafibrillar mineralization. The integration of novel materials holds promise for enhancing the osteogenic properties of these biomaterials, ultimately contributing to improved orthopedic treatments.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1914-1930"},"PeriodicalIF":5.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01186d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure-induced multi-functional property analysis of lead-free tin based halide perovskites ASnCl3 (A = Ga, In, Tl) for advanced optoelectronic applications†
IF 5.2
Materials Advances Pub Date : 2025-02-06 DOI: 10.1039/D5MA00039D
Md. Ratul Hasan, Imtiaz Ahamed Apon, Md. Mafidul Islam, Asab Uzzaman Azad, Md. Solayman and Md. Salman Haque
{"title":"Pressure-induced multi-functional property analysis of lead-free tin based halide perovskites ASnCl3 (A = Ga, In, Tl) for advanced optoelectronic applications†","authors":"Md. Ratul Hasan, Imtiaz Ahamed Apon, Md. Mafidul Islam, Asab Uzzaman Azad, Md. Solayman and Md. Salman Haque","doi":"10.1039/D5MA00039D","DOIUrl":"https://doi.org/10.1039/D5MA00039D","url":null,"abstract":"<p >This work examines the structural, electrical, and optical characteristics of lead-free tin-based halide perovskites, ASnCl<small><sub>3</sub></small> (A = Ga, In, and Tl), as environmentally friendly substitutes for lead-based perovskites in solar applications. Hydrostatic pressures ranging from 0 to 8 GPa cause all three compounds – GaSnCl<small><sub>3</sub></small>, InSnCl<small><sub>3</sub></small>, and TlSnCl<small><sub>3</sub></small> – to display a 3D-cubic perovskite structure. When pressure is applied, lattice parameters and unit cell volumes decrease as follows. For GaSnCl<small><sub>3</sub></small>, they decrease from 5.554 Å and 171.346 A<small><sup>3</sup></small> to 5.161 Å and 137.515 A<small><sup>3</sup></small>; for InSnCl<small><sub>3</sub></small>, they are from 5.568 Å and 172.623 A<small><sup>3</sup></small> to 5.178 Å and 138.891 A<small><sup>3</sup></small>; and for TlSnCl<small><sub>3</sub></small>, they are from 5.573 Å and 173.146 A<small><sup>3</sup></small> to 5.184 Å and 139.352 A<small><sup>3</sup></small>. This suggests that the structure is stable under compression. These compound's formation enthalpies attest to their thermodynamic stability over the investigated pressure range. All three Sn-based compounds exhibit a direct bandgap at 0 GPa, and as pressure increases the band gap decreases, which suggests a tunable electronic structure. TlSnCl<small><sub>3</sub></small> demonstrates a significant change from semiconductor to metallic behavior at higher pressures. The optical absorption spectra of the materials shift towards longer wavelengths (redshift) as pressure increases, enhancing the light absorption capabilities of these compounds. The compounds exhibit enhanced mechanical stability and ductility with increasing pressure, as indicated by their bulk, shear, and Young's modulus. Poisson's ratio values for these materials are in the range of 0.372 to 0.441 for GaSCl<small><sub>3</sub></small>, 0.355 to 0.418 for InSnCl<small><sub>3</sub></small>, and 0.349 to 0.413 for TlSnCl<small><sub>3</sub></small>, which highlights their ductile nature. GaSnCl<small><sub>3</sub></small>, InSnBr<small><sub>3</sub></small>, and TlSnCl<small><sub>3</sub></small> exhibit diamagnetic behavior both under normal conditions and with increased pressure. Thermal conductivity and stability are enhanced with increased pressure, making these materials suitable for high-temperature applications. The ability to tune the properties of these compounds through pressure makes them promising candidates for next-generation optoelectronic devices, energy storage, and conversion systems.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1794-1821"},"PeriodicalIF":5.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00039d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facile, selective and cost-effective detection of creatinine from human urine using a cyclometalated dinuclear iridium(iii) complex through creatinine-triggered emission†
IF 5.2
Materials Advances Pub Date : 2025-02-06 DOI: 10.1039/D4MA01084A
Pramod C. Raichure, Bharat Kaushik, Annu Agarwal and Inamur Rahaman Laskar
{"title":"Facile, selective and cost-effective detection of creatinine from human urine using a cyclometalated dinuclear iridium(iii) complex through creatinine-triggered emission†","authors":"Pramod C. Raichure, Bharat Kaushik, Annu Agarwal and Inamur Rahaman Laskar","doi":"10.1039/D4MA01084A","DOIUrl":"https://doi.org/10.1039/D4MA01084A","url":null,"abstract":"<p >A new cyclometalated oxalyl-bridged dinuclear iridium(<small>III</small>)-based phosphorescent complex (<strong>M3</strong>) was synthesized, which detected creatinine in the solid phase by increasing the emission intensity with a blue shift. The probe <strong>M3</strong> was synthesized in a straightforward synthetic route by forming a dichloro-bridged iridium(<small>III</small>) intermediate. The creatinine detection process was developed on a low-cost filter paper strip impregnated with <strong>M3</strong>, and it was successfully tested on human urine samples. It was observed that the probe was highly selective towards creatinine, and no response was observed with most of the other components present in human urine. Furthermore, the mechanism of creatinine detection was rationally explored.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1950-1958"},"PeriodicalIF":5.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01084a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of bovine serum albumin (BSA) variants on the photophysical and biological properties of a NIR-responsive BSA–indocyanine green complex†
IF 5.2
Materials Advances Pub Date : 2025-02-06 DOI: 10.1039/D5MA00066A
Jayashree Roy, Devendra Tiwari, Sahely Saha, Raviraj Vankayala, Shanmuga Sharan Rathnam Vuppaladadium, Abhijeet Joshi and Indranil Banerjee
{"title":"Effect of bovine serum albumin (BSA) variants on the photophysical and biological properties of a NIR-responsive BSA–indocyanine green complex†","authors":"Jayashree Roy, Devendra Tiwari, Sahely Saha, Raviraj Vankayala, Shanmuga Sharan Rathnam Vuppaladadium, Abhijeet Joshi and Indranil Banerjee","doi":"10.1039/D5MA00066A","DOIUrl":"https://doi.org/10.1039/D5MA00066A","url":null,"abstract":"<p >In this study, we have investigated the effect of variants of BSA on the NIR-induced phototherapeutic performance of the BSA–ICG complex to identify the best BSA variant for complexing with ICG. Three variants of BSA, namely BSA-A7030 (protease, fatty acid, and globulin free), BSA-A3059 (protease &amp; globulin free), and BSA-A3294 (only protease free), were chosen. UV-vis-NIR absorption, fluorescence, and CD spectroscopy studies showed no significant difference in the spectra of all the BSAs, but in the presence of Cu<small><sup>2+</sup></small>, a differential reactivity of the three BSA variants was noticed. The biophysical study of the BSA–ICG complexes (1 : 1 molar ratio) showed that post-binding, there was a significant red shift of the ICG peak (both absorption and fluorescence) for BSA-A7030 with a widening of the excitation–emission hotspot. The photothermal properties of the BSA–ICG complexes under NIR (808 nm) exposure were similar to those of free ICG, whereas the photodynamic property increases for BSA-A3059. All the BSA–ICG complexes were found to be cytocompatible when tested with the NIH 3T3 cell line <em>in vitro</em>. The effect of the BSA type on the 808 nm NIR-mediated phototherapeutic properties of the BSA–ICG complex was tested <em>in vitro</em> on lung cancer cell line A549 (2D model) and a 3D osteosarcoma spheroid model. The study showed a NIR-induced cytoskeletal disruption of A549 cells with maximum damage caused by the BSA-A7030–ICG complex. The same complex was found to show the highest phototherapeutic effect on the 3D spheroid model. This study implied that an appropriate BSA variant is crucial for BSA–ICG complex-mediated NIR phototherapy.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1621-1634"},"PeriodicalIF":5.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00066a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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