Materials Advances最新文献

{"title":"Utilization of a cadmium sulfide/nickel–ferric layered double hydroxide nanocomposite decorated with silver nanoparticles for efficient adsorption and photocatalytic degradation of 2,4-dichlorophenoxyacetic acid†","authors":"Walaa A. Shaltout, Asaad F. Hassan, Maha S. Elsayed and H. Hafez","doi":"10.1039/D5MA00332F","DOIUrl":"https://doi.org/10.1039/D5MA00332F","url":null,"abstract":"<p >This study examined the efficacy of the hydrotalcite-like materials of Zn–Fe, Mg–Fe, and Ni–Fe layered double hydroxides as adsorbents of 2,4-dichlorophenoxyacetic acid (2,4-D) by synthesizing them using a coprecipitation process at an M<small>²⁺</small>/M<small>³⁺</small> molar ratio of 3. This study presents a novel cadmium sulfide/Ni–Fe LDH and its decorated form with silver nanoparticles as a plasmonic element, Ag@CdS/Ni–Fe LDH, to overcome conventional photocatalyst limitations such as weak photoresponsivity and unstable structure. The physicochemical characteristics of Ag@CNFL were analyzed, revealing a hierarchical pore structure, a large specific surface area (113.10 m<small>²</small> g<small>⁻¹</small>), a particle size of 68 nm, a total pore volume of 0.1658 cm<small>³</small> g<small>⁻¹</small>, an average pore size of 5.8638 nm, a pH<small>_PZC</small> of 8.34, and a band gap of 1.96 eV. Our findings showed a notable maximum adsorption capacity of 203.75 mg g<small>⁻¹</small> at 23 °C for NFL and fast adsorption kinetics within 8 h. The exothermic and spontaneous adsorption process was well described by Avrami and pseudo-second-order kinetics, Redlich–Peterson, and Langmuir isotherms. Under visible irradiation, the Ag@CNFL heterojunction demonstrated remarkable photocatalytic activity in the 2,4-D degradation, reaching a 100% degradation percentage at 15 mg L<small>⁻¹</small> and 110 min. Additionally, following eight cycles of 2,4-D photodegradation, the efficiency of NFL, C, CNFL, and Ag@CNFL was only decreased by 8.4, 3.4, 3.2, and 7.0%, respectively. It was shown that the produced materials were very effective at removing 2,4-D from water.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4418-4437"},"PeriodicalIF":5.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00332f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced transport, dielectric and magnetic properties of Ni-doped (YFeO3)0.5(BaTiO3)0.5 perovskite for NTC thermistor and multifunctional applications","authors":"Harshavardhan Chouhan, Saurabh Prasad, B. N. Parida and R. K. Parida","doi":"10.1039/D4MA01233J","DOIUrl":"https://doi.org/10.1039/D4MA01233J","url":null,"abstract":"<p >The solid-state reaction method was successfully employed to synthesize the environmentally friendly polycrystalline perovskite (Y<small>_0.5</small>Ni<small>_0.5</small>FeO<small>₃</small>)<small>_0.5</small>(BaTiO<small>₃</small>)<small>_0.5</small>. X-ray diffraction (XRD) analysis, complemented by Rietveld refinement, confirms its multiphase crystalline structure, comprising two cubic and one orthorhombic phase. Field-emission scanning electron microscopy (FE-SEM) reveals a well-defined surface morphology, while energy-dispersive spectroscopy (EDS) and elemental mapping validate the homogeneous distribution of constituent elements. Raman and FTIR spectroscopy further confirm the vibrational and atomic structural integrity of the material. Dielectric studies indicate a high dielectric constant (∼338 at 100 Hz, room temperature), with strong frequency and temperature-dependent relaxation effects. Impedance spectroscopy reveals non-Debye relaxation behaviour, NTCR characteristics and impedance in the megaohm range at lower temperatures. AC conductivity results align well with Jonscher's power law. The thermistor coefficient (<em>β</em>) reaches 4778.61 at 450 °C, demonstrating excellent potential for thermistor applications. Magnetic studies confirm a prominent ferromagnetic response at room temperature, with a saturation magnetization of 3.654 emu g<small>⁻¹</small> and coercive field of 196.4 Oe. These combined properties make (Y<small>_0.5</small>Ni<small>_0.5</small>FeO<small>₃</small>)<small>_0.5</small>(BaTiO<small>₃</small>)<small>_0.5</small> a promising candidate for multifunctional applications.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 14","pages":" 4778-4794"},"PeriodicalIF":5.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01233j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectivity and twist: engineering high-performance green phosphorescent OLEDs using unipolar symmetric bicarbazole regioisomers†","authors":"Kalidass Kollimalaian, Jia-Fan Wu, Yu Hsuan Lin, Ya-Hsin Cheng, Premkumar Gnanasekaran, Sudhakar Maddala, Mandy M. Lee, Shih-Sheng Sun, Chih-Hao Chang, Yuan Jay Chang and Venkatakrishnan Parthasarathy","doi":"10.1039/D4MA01003E","DOIUrl":"https://doi.org/10.1039/D4MA01003E","url":null,"abstract":"<p >Molecular structural differences by position can be crucial in developing promising materials for device applications. We synthesized four regioisomeric symmetric bicarbazoles (<strong>BCzPh</strong>) with distinct dihedral angle twists using oxidative C–C coupling or transition-metal catalyzed Suzuki coupling methods. The structural differences in connectivity manifested in fine-tuning of the photophysical, thermal, and electrochemical properties of the materials, as well as the device performance. Particularly, understanding the balance between the resonance and conjugation effects seems crucial for manipulation of triplet energy levels. Our findings indicate that bicarbazoles with greater twist angles exhibit larger singlet–triplet/HOMO–LUMO energy gaps, and improved power and luminance efficiencies, benefiting phosphorescent organic light-emitting diode (PhOLED) devices. The external quantum efficiencies of PhOLEDs were over 23.4% and 23.9% for <strong>BCzPh</strong>-based devices B and D, with device C reaching a maximum brightness of 203 490 cd m<small>⁻²</small>, followed by device A at 96 953 cd m<small>⁻²</small>. Notably, all <strong>BCzPh</strong> compounds served as excellent host materials, demonstrating stable, high-purity green-color emission in devices that turned on at voltages as low as 2.2 V.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4456-4470"},"PeriodicalIF":5.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01003e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Void engineering to promote the self-cleaning properties of bactericidal zinc oxide nanopillar array coatings†","authors":"Amir Hassanpour, Marie-Christine Groleau, Dalya Messaoudi, Andrea A. Greschner, Katharina Kohlmann, Andreas Ruediger, Eric Déziel, Shuhui Sun and Marc A. Gauthier","doi":"10.1039/D5MA00180C","DOIUrl":"https://doi.org/10.1039/D5MA00180C","url":null,"abstract":"<p >Bacterial infections are easily spread by touch, and some bacteria can survive for months on certain surfaces. Current disinfection approaches and self-sanitizing coatings have limitations, which provides the impetus for developing new inexpensive coatings that combine bactericidal activity and self-cleaning properties. One way to achieve this is to mimic natural arrays of nano-pillars, such as those found on insect wings and plant leaves. Accordingly, arrays of zinc oxide nano-pillars display self-sanitizing properties, which are influenced by their dimensions, shape, and spacing. However, a key characteristic of these coatings is their water wettability, which increases the tendency for water-borne contaminants to attach. This wettability is caused by the voids between the nano-pillars that form a network of capillaries. To address this issue, this study introduces modifications to the current hydrothermal production method to adjust the characteristics of these voids, without altering the nano-pillar density in the array. A new hierarchical ‘nano-porcupine’ morphology is also reported. These modifications to the void structure significantly affected the surface chemistry and wettability of the coatings, improving their self-cleaning properties without compromising their bactericidal activity, as demonstrated by five different tests.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 14","pages":" 4687-4695"},"PeriodicalIF":5.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00180c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic study of CVD-growth parameters in NaCl-assisted growth of MoSe2 nanostructures: nanoribbons, dendrites and spirals†","authors":"Mahima Tyagi, Srijata Dey, Pinky Sahoo and Deshdeep Sahdev","doi":"10.1039/D5MA00121H","DOIUrl":"https://doi.org/10.1039/D5MA00121H","url":null,"abstract":"<p >MoSe<small>₂</small>, a two-dimensional (2D) transition metal dichalcogenide (TMDC), has garnered significant interest in recent years due to its semiconducting properties and tunable band gap with potential applications in optoelectronics, photocatalysis and atomically thin devices. In this study, we report the controlled synthesis of MoSe<small>₂</small> nanocrystals using a custom 12-zone atmospheric pressure chemical vapour deposition (APCVD) system. NaCl is used as a seed promoter to facilitate the growth of monolayer, bilayer, and multilayer films, often as large as 200 μm. Additionally, the morphological evolution of the MoSe<small>₂</small> nanostructures is controlled by tuning different growth parameters based on insights, which we discuss in detail. The growth of dominant nanostructures, which include nanoribbons, snowflakes, monolayers and multilayer domains, among others, are discussed. High-resolution optical microscopy, field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) are used to image the as-grown crystals. Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) are used to verify the quality and elemental composition of our as-grown MoSe<small>₂</small> crystals. Our findings brighten the prospect of growing novel 1D and 2D TMDC nanostructures with sufficient control to make them suitable for advanced optoelectronic and catalytic devices.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 14","pages":" 4833-4846"},"PeriodicalIF":5.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00121h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic properties of a non-centrosymmetric polymorph of FeCl3†","authors":"Joshua J. B. Levinsky, Ankit Labh, Vladimir Pomjakushin, Uwe Keiderling, Alexander C. Komarek, Li Zhao, Jacob Baas, Catherine Pappas and Graeme R. Blake","doi":"10.1039/D4MA00635F","DOIUrl":"10.1039/D4MA00635F","url":null,"abstract":"<p >The growth of single crystals of FeCl<small>₃</small>, through sublimation and from the melt, is presented alongside a thorough investigation of their magnetostructural properties through a combination of DC magnetization and AC magnetic susceptibility measurements, single crystal X-ray diffraction (SCXRD), neutron powder diffraction (NPD) and small-angle neutron scattering (SANS). A new chiral polymorph of FeCl<small>₃</small> is identified, crystallizing in the non-centrosymmetric space group <em>P</em>3<small>₁</small>. NPD and SANS reveal that a weakly first-order magnetic phase transition occurs from a paramagnetic phase with significant short-range correlations to an antiferromagnetic phase at <em>T</em><small>_N</small> = 8.6 K, best described by the magnetic propagation vector <strong><em>k</em></strong> = (1/2, 0, 1/3) which differs from the previously reported magnetic structure of the well-known centrosymmetric polymorph (space group <em>R</em><img>). We show that disordered crystallographic models including a large number of stacking faults are required to accurately reproduce the scattering observed in NPD patterns, preventing full determination of the magnetic structure. The magnetic field and temperature-dependent behavior of the intensities of the <strong><em>k</em></strong> = (1/2, 0, 2/3) and (1/2, 0, 5/3) magnetic Bragg peaks measured by SANS suggest that a field-induced spin reorientation occurs at <em>H</em> = 40 kOe when <strong><em>H</em></strong>‖<em>c</em>-axis and at a significantly lower field of <em>H</em> ≈ 25 kOe when <strong><em>H</em></strong>⊥<em>c</em>-axis. Above these magnetic fields in both cases the spins lie predominantly in the basal plane. The long-range magnetic ordering and the field-induced transitions observed in the neutron scattering experiments coincide with anomalies observed in the magnetisation <em>versus</em> both temperature and applied field along the principal crystal directions.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4471-4482"},"PeriodicalIF":5.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced properties of bamboo short fiber reinforced polymer composites with alkali and graphene oxide","authors":"Md. Ariful Islam, Mainul Islam, Md. Shariful Islam and Tarikul Islam","doi":"10.1039/D5MA00158G","DOIUrl":"https://doi.org/10.1039/D5MA00158G","url":null,"abstract":"<p >Bamboo short fibers (BSFs) have become popular as sustainable alternatives to synthetic fibers because of their present affordable performance levels and environmentally friendly solutions. The main challenge with bamboo fiber composites is their weak interfacial bonding and insufficient mechanical strength. This research investigated mechanical and interfacial performance optimization of BSFs by applying alkali treatment and graphene oxide (GO) coating methods. The alkali treatment successfully eliminated non-cellulosic contaminants and strengthened the bond between fiber and matrix, and then the sequential GO coating operation brought additional reinforcing benefits to the system. Various tests analyzed the prepared composites, including tensile, flexural, impact, hardness, FTIR, DMA, TGA, water absorption, and SEM analyses. The tensile strength of alkali-treated and GO-coated BSFs composites surpassed untreated fibers by ∼113%, and their flexural strength achieved ∼93% increase. Impact resistance also improved significantly. Definitive signs point to the modified BSFs having potential as high-performance, environmentally sustainable reinforcements for polymer composites because of their strengthened interface bond and improved thermal stability. The study brings forward valuable information for developing sustainable composite materials that can serve structural needs and industrial processing demands.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 14","pages":" 4738-4754"},"PeriodicalIF":5.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00158g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A ZnS–SnS2/S–rGO ternary heterostructure for electrochemical detection of azo toxic dye sunset yellow in food samples†","authors":"Hanieh Ghaedi, Khadijeh Ghanbari and Sepideh Bonyadi","doi":"10.1039/D5MA00148J","DOIUrl":"https://doi.org/10.1039/D5MA00148J","url":null,"abstract":"<p >High consumption of azo dyes such as sunset yellow (SY), widely used to improve the color and taste of some food products, is harmful and leads to diseases and problems in humans. Therefore, one of the important missions of scientists and researchers is to invent a fast and low-cost method to detect the amount of SY in food products. Here, we synthesized ZnS–SnS<small>₂</small>/S–rGO and modified a carbon paste electrode to design a sensor for SY determination in an aqueous environment and some real food samples. The morphology and structure of the ZnS–SnS<small>₂</small>/S–rGO were investigated by FE-SEM, HR-TEM, XPS, EDS, ATR-IR, Raman, and XRD techniques. Differentiated pulse voltammetry (DPV), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS) methods were used to study the electrochemical section. The designed sensor had a detection limit of 140 nM (S/N = 3) and a wide linear range of 3–100 μM and was used for SY determination in some real food samples with excellent recoveries (between 95.09 and 108.28%). This sensor has a high sensitivity and selectivity compared to the analog molecules with a similar structure for SY. It has commendable stability and satisfactory reproducibility.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4378-4388"},"PeriodicalIF":5.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00148j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Ce/Ag/N-doped ZnO–MWCNT nanocomposites for efficient photocatalytic wastewater remediation with visible light†","authors":"Manisha Dagar, Suresh Kumar, Amit Jain, Anil Vohra, Manohar Singh, Jasvir Dalal, Sanjeev Kumar and Sandeep Kaushal","doi":"10.1039/D5MA00258C","DOIUrl":"https://doi.org/10.1039/D5MA00258C","url":null,"abstract":"<p >This study reports an approach for enhancing the photocatalytic efficiency of ZnO by co-doping with cerium (Ce), silver (Ag), and nitrogen (N), supported by multi-walled carbon nanotubes (MWCNTs). The Ce/Ag/N-doped ZnO–MWCNT nanocomposites were synthesized <em>via</em> a hydrothermal method, resulting in a significant reduction in the band gap from 3.19 eV to 2.89 eV. This change enabled higher visible light absorption, achieving enhanced photocatalytic degradation efficiencies of 92.12% for Congo red and 87.5% for methylene blue within 80 minutes. Comprehensive characterization using XRD, FTIR, BET, and PL analyses revealed enhanced surface area, increased oxygen vacancies, and improved charge separation dynamics due to the synergistic effects of multi-element doping and MWCNT integration. The strategic incorporation of Ce, Ag, and N not only reduced the electron–hole recombination rate but also facilitated the generation of reactive oxygen species (ROS) that are crucial for efficient dye degradation. These findings indicate the significant potential of the synthesized nanocomposites as advanced photocatalysts for environmental remediation under visible light irradiation.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4522-4537"},"PeriodicalIF":5.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00258c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, characterisation and neuroprotective effects of polymer–drug conjugate nano-polyplex: working towards a multi-target treatment for neurodegenerative diseases†","authors":"Nuruddin Mahadik, Gemma A. Barron, Paul Kong Thoo Lin and Colin J. Thompson","doi":"10.1039/D5MA00174A","DOIUrl":"https://doi.org/10.1039/D5MA00174A","url":null,"abstract":"<p >Neurodegenerative diseases (NDs) are complex, multifaceted conditions that require novel, multi-targeted therapeutic approaches. This study aimed to develop a multifunctional polymer–drug conjugate (PDC) by employing a novel strategy of utilizing PDC-based nano-polyplexes as a multi-target treatment for NDs. The nano-polyplex (N5NM15) was formulated by combining polyallylamine hydrochloride-vanillin (NM15) and polyacrylic acid–naphthalimidohexylamine (N5) conjugates. Antioxidant capacity was measured <em>via</em> ORAC assay, and cholinesterase inhibition was evaluated using Ellman's assay. Cytotoxicity, neuroprotective effects, and anti-inflammatory activity were tested in undifferentiated SH-SY5Y and BV-2 cells <em>via</em> MTT assay. Amyloid-beta aggregation was assessed using Thioflavin T assay and TEM imaging in a cell-free system. The results demonstrated that N5NM15 resulted in uniform nanoparticles with an average size of 30.5 ± 7.9 nm, confirmed <em>via</em> cryo-TEM. Cytotoxicity studies indicated high biocompatibility with SH-SY5Y cells (viability &gt;90%) and moderate toxicity in BV-2 cells (viability 75%, <em>p</em> ≤ 0.001). Furthermore, N5NM15 demonstrated significantly enhanced <em>in vitro</em> antioxidant activity (<em>p</em> ≤ 0.001, after adjustment) and cholinesterase inhibition (<em>p</em> ≤ 0.0001 for AChE and <em>p</em> ≤ 0.01 for BuChE, after adjustment) compared to starting materials. N5NM15 also protected SH-SY5Y cells from hydrogen peroxide-induced oxidative stress (<em>p</em> ≤ 0.0001), reduced lipopolysaccharide-induced inflammation in BV-2 cells (<em>p</em> ≤ 0.05), inhibited BuChE activity in SH-SY5Y cells (<em>p</em> ≤ 0.01), and reduced amyloid-beta aggregation (<em>p</em> ≤ 0.01). Notably, polyacrylic acid demonstrated protective and anti-inflammatory effects in both cell lines (<em>p</em> ≤ 0.0001) and inhibited amyloid-beta aggregation (<em>P</em> ≤ 0.001). These findings suggest the potential use of N5NM15 and polyacrylic acid as treatment options for NDs.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 13","pages":" 4438-4455"},"PeriodicalIF":5.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00174a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}