Materials Advances最新文献

{"title":"Microwave-assisted intercalation: exploring electronic and structural features of metastable MMo6S8 (M = Ag, Sn)†","authors":"Rose E. Smiley, Konstantina G. Mason, Rose A. Lam, Alice Giem, Daniella Ingargiola, Brian A. Wuille Bille, David Prendergast and Jesús M. Velázquez","doi":"10.1039/D4MA01090F","DOIUrl":"https://doi.org/10.1039/D4MA01090F","url":null,"abstract":"<p >Presented in this work is a synthetic approach for metastable Type I Chevrel phase sulfides, MMo<small>₆</small>S<small>₈</small> (M = Ag, Sn), utilizing rapid microwave-assisted medium temperature intercalation. Using X-ray absorption spectroscopy the electronic structure and local coordination of sulfur and molybdenum bonding environments are probed as a function of a Type I metal intercalant. Intercalant promoter-induced electron donation effects were observed through analysis of the sulfur K-edge pre-edge feature and Mo L<small>₃</small>-edge in the X-ray absorption near edge regions. Calculated electron density maps reveal more covalent interactions between Ag and S atoms <em>versus</em> more ionic interactions between Sn and S. Changes in the Chevrel phase structure upon intercalation are investigated through Mo K-edge extended X-ray absorption fine structure analysis. Evaluation of Mo–Mo intracluster distances allows the cluster anisotropy of Type I CPs to be calculated as low as 1.84%. These findings help elucidate how electronic and local structures can be modulated through intercalation and the importance of cation identity to fine tune structures.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 2048-2055"},"PeriodicalIF":5.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01090f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational design of Bax-inhibiting peptides†","authors":"Tom Vlaar, Bernadette Mayer, Lars van der Heide and Ioana M. Ilie","doi":"10.1039/D4MA01142B","DOIUrl":"https://doi.org/10.1039/D4MA01142B","url":null,"abstract":"<p >The proteins of the Bcl-2 family play crucial roles in regulating apoptosis. It is divided into pro-survival and pro-apoptotic proteins that determine cellular fate. In particular, Bax is a crucial executor of apoptosis as its activation initiates the apoptotic phenotype. Hence, targeting this protein represents an attractive therapeutic approach, which can aid in regulating apoptotic signalling and potentially contribute to the development of novel therapies against cancer and neurodegenerative diseases. Here, we introduce a digital paradigm, which relies on rational design and computer simulations to develop and validate peptide-based agents that bind to Bax, thereby inhibiting its apoptotic properties. The peptides are rationally designed and optimized to bind to Bax starting from the crystal structures of affimers in a complex with Bcl-2 proteins. Next, molecular dynamics (MD) simulations are employed to probe the stability of the Bax–peptide complexes and to estimate the binding free energies. The results show that the designed peptides bind with high affinity to Bax. Two of the designed peptides bind in the canonical hydrophobic groove (BH1 domain) of Bax and one peptide binds to the outside of the BH3 domain (α<small>₂</small>-helix). Notably, the peptides restrict the flexibility of the α<small>₁</small>–α<small>₂</small> loop, modulating the trigger bottom site associated with toxicity. All in all, the results highlight the potential of these peptides as valuable tools for further exploration in modulating apoptotic pathways and set the structural foundation for a machine learning powered engine for peptide design.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 7","pages":" 2160-2169"},"PeriodicalIF":5.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01142b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One step gamma-ray induced crosslinking and sterilization of electrospun poly(ε-caprolactone)/collagen composite scaffolds","authors":"Jin-Oh Jeong, Sung In Jeong, Jong-Seok Park, Young Min Ju, Sang Jin Lee and Youn-Mook Lim","doi":"10.1039/D4MA01046A","DOIUrl":"https://doi.org/10.1039/D4MA01046A","url":null,"abstract":"<p >Sterilizing biomaterials before implantation is crucial, but this process can sometimes alter the physical, chemical, and morphological properties of collagen-based biomaterials, potentially leading to weaknesses. To address this issue, we propose a method that combines crosslinking and sterilization of collagen-based composite scaffolds through gamma-ray irradiation. In this study, poly(ε-caprolactone) (PCL)/collagen composite scaffolds were fabricated using an electrospinning technique and exposed to gamma rays at doses ranging from 15 to 45 kGy. The radiation dose was optimized to enhance mechanical properties, which indicated a higher degree of collagen crosslinking. Additionally, we demonstrated that both Gram-positive and Gram-negative bacteria were completely and effectively sterilized during the crosslinking process. In conclusion, gamma-ray irradiation shows great promise as a method for simultaneously inducing crosslinking and sterilization in collagen-based scaffolds, offering substantial potential for biomedical applications.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1883-1888"},"PeriodicalIF":5.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01046a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memristive behaviour of PANI/Au hybrid nanocomposites synthesized via various routes†","authors":"Aldobenedetto Zotti, Salvatore Aprano, Asma Rafiq, Simona Zuppolini, Mauro Zarrelli, Maria Grazia Maglione, Paolo Tassini, Antonio Cassinese and Anna Borriello","doi":"10.1039/D4MA01218F","DOIUrl":"https://doi.org/10.1039/D4MA01218F","url":null,"abstract":"<p >Herein, hybrid nanocomposite devices based on polyaniline (PANI) nanofibers decorated with gold nanoparticles (Au), as conductive fillers, and atactic polystyrene (aPS), as insulating matrix, were developed. To assess the effect of the PANI and Au synthesis procedure on the electrical behavior of the developed devices, PANI/Au nanosystems were synthesized <em>via</em> two different routes: (1) biphasic synthesis, wherein PANI nanofibers were grown through a biphasic synthesis procedure incorporating 1-dodecanthiol-capped Au (AuDT) nanoparticles, which were previously synthesized and dispersed in the reaction environment; (2) one-pot synthesis, wherein gold nanoparticles were directly reduced, starting with auric salt precursors on the PANI nanofiber surface, which were previously synthesized <em>via</em> a rapid mixing procedure. Thermal stability and the Au/PANI weight ratio were determined using thermogravimetric analysis (TGA). Furthermore, PANI/Au nanosystems were observed using transmission electron microscopy (TEM), revealing that the synthesis route significantly affected the morphology of nanosystems. Electrical characterization showed that aPS/PANI/Au hybrid nanocomposite devices exhibited a typical non-linear current–voltage curve with a closed hysteresis loop, which is a characteristic of memristive behavior. Moreover, devices made with fibers obtained <em>via</em> rapid mixing (PANI RM/Au) exhibited conductivities higher than those produced with fibers from biphasic synthesis (PANI BF/AuDT).</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 5","pages":" 1788-1793"},"PeriodicalIF":5.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01218f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced thermal management of mats and yarns from polystyrene fibers through incorporation of exfoliated graphite†","authors":"Madhurima Das, Joanna Knapczyk-Korczak, Ahmadreza Moradi, Waldemar Pichór and Urszula Stachewicz","doi":"10.1039/D4MA01162G","DOIUrl":"10.1039/D4MA01162G","url":null,"abstract":"<p >The energy crisis, driven by modern electronics and global warming from population growth, underscores the need for advanced textiles to regulate thermal environments. Researchers stress the need to improve high-performance polymer mats with enhanced thermal conductivity. This report delves into the morphological, mechanical, and thermal properties of exfoliated graphite (EG) when incorporated into polystyrene (PS) fiber mats and yarns through blend electrospinning. The incorporation of EG inside the fibers allowed us to obtain approximately twofold improvement in maximum stress and toughness compared to pristine PS mats. Thermal camera measurement showed significant improvement in heat transport for PS–EG fibers. The heating test showed a temperature increase of ∼2.5 °C for an EG-loaded PS mat, and in the case of a resistance wire coated with a PS fiber yarn, the increase reached 17 °C. The incorporation of EG into electrospun mats enables the recovery of more energy in the form of heat by enhancing the heating of the sample through infrared radiation. The temperature increased by 2 °C for PS and by 27 °C for PS–EG, respectively. The obtained results exhibit a great potential for the application of electrospun hybrid systems with EG in further advancement in the field of next-generation thermal management.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1859-1868"},"PeriodicalIF":5.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative Ag/Cu-doped polypyrrole hybrid nanocomposite gas sensor for superior ammonia detection at room temperature","authors":"Arunima Verma, Tanuj Kumar and Rahul Singhal","doi":"10.1039/D4MA01166J","DOIUrl":"https://doi.org/10.1039/D4MA01166J","url":null,"abstract":"<p >Hybrid nanocomposites combining organic and inorganic materials offer enhanced responses to reducing and oxidizing gases. This study presents a novel polypyrrole (PPy)-based hybrid nanocomposite synthesized with varying concentrations of silver (Ag) and copper (Cu) nanoparticles for efficient ammonia sensing at room temperature. The uniform dispersion of Ag/Cu nanoparticles within the PPy matrix enables a dense, smooth surface that enhances electron transport and boosts conductivity, compatibility, and catalytic activity. Structural and surface analyses using XRD, FESEM, UV-vis, EDS, TGA, and FTIR revealed that the PPy@Ag/Cu hybrid nanocomposite sensor achieved an 86% response to 300 ppm ammonia. Selectivity was confirmed against gases like carbon dioxide, carbon monoxide, ethanol, and hydrogen sulphide. The protonation and deprotonation in the PPy@Ag/Cu heterojunction contribute to the ammonia sensing mechanism, making this nanocomposite a promising material for environmental monitoring applications.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1869-1882"},"PeriodicalIF":5.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01166j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel polydopamine/halloysite nanotube-reinforced brushite calcium phosphate cement for bone regeneration with synergistic regulation of mechanical/osteogenic capacity†","authors":"Chenhao Wang, Tao Guo, Yukang Gong, Xintian Wang, Puying An, Jie Zhang, Zheng Gao, Wenshan Gao, Yuangong Zhang and Feng Liu","doi":"10.1039/D4MA01124D","DOIUrl":"https://doi.org/10.1039/D4MA01124D","url":null,"abstract":"<p >Bone regeneration remains a clinical challenge with limited bone substitutes. Brushite calcium phosphate cements (<strong>Bru-CPCs</strong>), possessing good bioactivity and biocompatibility, are one of the widely studied bone graft materials. However, their further application in the long-term remodeling of bone is limited by the low compressive strength. Adding additives has been a promising strategy to solve the above problem. Herein, halloysite nanotubes (<strong>HNTs</strong>) with a unique rod-like structure and excellent biocompatibility were chosen as reinforced materials to fabricate bone repair materials. Inspired by the adhesive proteins in mussels, we modified the <strong>HNTs’</strong> surface with polydopamine (PDA) to improve the inorganic–inorganic phase interfacial interactions between the <strong>HNTs</strong> and <strong>Bru-CPCs</strong>. <strong>Bru-CPCs</strong>, <strong>Bru-CPCs/1.5%HNTs</strong> and <strong>Bru-CPCs/1.5%HNTs@PDA</strong> were fabricated and the mechanical properties and biological activity of the bone repair materials were evaluated in detail. All the results indicated that <strong>Bru-CPCs</strong> incorporated with <strong>1.5 wt% HNTs@PDA</strong> have good compressive strength and osteo-differentiation properties, making them a prospective biomaterial for bone-tissue repair.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1959-1964"},"PeriodicalIF":5.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01124d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly elastic polyvinyl alcohol embolic microspheres for effective transarterial embolization†","authors":"Li Liu, Xiangxian Xu, Xiaoli Zhu, Meng Dang, Yunming Zhang, Donghong Shi, Shenzhe Liu, Zhiwei Zhang, Jing Pan, Jing Zhong, Lin Ou-yang, Zhaogang Teng and Longjiang Zhang","doi":"10.1039/D5MA00057B","DOIUrl":"https://doi.org/10.1039/D5MA00057B","url":null,"abstract":"<p >Transarterial embolization therapy is a highly promising, minimally invasive interventional procedure for treating vascular and neoplastic diseases in the clinic. The use of highly elastic and deformable embolization microspheres is crucial for ensuring smooth delivery through a catheter and achieving complete endovascular embolization. In this study, a polyvinyl alcohol embolic microsphere, MegaSphere, with exceptional elasticity was used for vascular embolization. The results obtained from an <em>in vitro</em> embolization model demonstrated the good stability and elastic deformation ability of MegaSphere. These properties allow these spheres to aggregate tightly and effectively embolize blood vessels at different levels. Furthermore, in a rabbit model, we achieved highly efficient renal embolization <em>via</em> MegaSphere. These microspheres could reach the distal vessels of the renal artery and effectively embolize small arteries within the renal cortex, resulting in complete terminal embolization. Substantial necrosis of the renal parenchyma was observed within seven days after embolization, indicating an excellent embolization effect. Moreover, in a rabbit model with liver VX2 transplant tumors, the use of drug-loaded MegaSphere-doxorubicin microspheres demonstrated strong efficacy in antitumor chemoembolization therapy. Through blockade of the tumor blood supply and increased local chemotherapy, effective inhibition of liver tumor progression was achieved within seven days following transcatheter arterial chemoembolization (TACE). In conclusion, this study highlights the promising potential of MegaSphere as an embolic agent with potential for clinical translational applications.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 2056-2070"},"PeriodicalIF":5.2,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00057b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tri(oxyethylene)-functionalised perylene diimide: a promising interlayer material for enhanced organic photovoltaic performance†","authors":"Jegadesan Subbiah, Akhil Gupta, David J. Jones and Jingliang Li","doi":"10.1039/D5MA00032G","DOIUrl":"https://doi.org/10.1039/D5MA00032G","url":null,"abstract":"<p >Interface engineering of organic semiconductors is critical for efficient charge extraction from organic photoactive layers to inorganic electrodes, which is a key factor in optimising organic solar cell performance. Incorporating polar groups into electron transport layer (ETL) materials can reduce their work function by forming appropriate dipoles between the photoactive layer and the electrode. This study reports a promising ETL material, 2,9-bis(2-(2-(2-methoxyethoxy)ethoxy)ethyl)anthra[2,1,9-<em>def</em>:6,5,10-<em>d</em>′<em>e</em>′<em>f</em>′]diisoquinoline-1,3,8,10(2<em>H</em>,9<em>H</em>)-tetraone, coded <strong>PDIAO</strong>, based on a perylene diimide (PDI) core with tri(oxyethylene) chains at the imide positions. <strong>PDIAO</strong> exhibited efficient energy level alignment and good interface contact with the active layer, facilitating efficient electron extraction. Organic photovoltaic (OPV) devices with the <strong>PM6:IT-4F</strong> active layer, a <strong>PDIAO</strong> interlayer, demonstrated enhanced performance, achieving a power conversion efficiency (PCE) of 13% compared to the PCE of 10.9% for the OPV device with the <strong>PFN-Br</strong> interlayer. Various spectroscopic and electrical characterisation analyses of ETL materials and OPV device performance revealed that the <strong>PDIAO</strong> interlayer significantly reduces the work function of the active layer by forming interface dipole and enhanced charge transport for efficient electron extraction. These results suggest that tri(oxyethylene)-functionalised PDI derivatives are promising ETL materials for efficient electron extraction in OPV devices.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1965-1970"},"PeriodicalIF":5.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d5ma00032g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into the anticancer and anti-inflammatory activities of curcumin-loaded quercetin nanoparticles: in vitro bioassays coupled with synchrotron infrared microspectroscopy†","authors":"Suhair Sunoqrot, Samah Abusulieh and Lina A. Dahabiyeh","doi":"10.1039/D4MA01202J","DOIUrl":"https://doi.org/10.1039/D4MA01202J","url":null,"abstract":"<p >Curcumin (CUR) is an important phytochemical with diverse pharmacological activities, particularly in cancer treatment and inflammation management. However, its poor water solubility and rapid metabolism <em>in vivo</em> have limited its therapeutic potential, inspiring the development of delivery systems such as those based on nanotechnology. Previously, we reported that partial oxidation of the plant polyphenol quercetin (QCT) creates an amphiphilic material that self-assembles into discrete nanoparticles (NPs), either alone or with other polymers. Here we developed a nanoparticle (NP) formulation for CUR based on partially oxidized QCT (oxQCT). The NPs were co-formulated with <small>D</small>-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS) to enhance their physicochemical properties and potentially synergize with CUR in inducing cancer cell death and alleviating inflammation. CUR was entrapped in oxQCT/TPGS NPs <em>via</em> nanoprecipitation, yielding spherical NPs (87 nm) with 72% loading efficiency, high colloidal stability, and sustained release at physiological pH. The anticancer activity of CUR NPs was evaluated in MCF-7 cells as a model breast cancer cell line, where the oxQCT/TPGS vehicle synergized with free CUR in inducing cell death and promoted its cellular uptake. In RAW 264.7 macrophages, the NPs outperformed free CUR in anti-inflammatory assays by exhibiting stronger reactive oxygen species (ROS) scavenging activities and attenuating the expression of proinflammatory cytokines. We complemented the biological assays with synchrotron-Fourier transform infrared microspectroscopy (SR-μFTIR), which provided insights into biochemical changes in the lipid and protein compositions of MCF-7 and RAW 264.7 macrophages treated with CUR NPs. Our findings present a promising nanoformulation for CUR which can enhance its activity against cancer and inflammation, and highlight the importance of bioanalytical techniques such as SR-μFTIR in discerning the bioactivities of multimodal nanotherapeutics.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 6","pages":" 1971-1987"},"PeriodicalIF":5.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ma/d4ma01202j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}