Materials Advances最新文献

{"title":"Hydrophobic block-structured PDMS/Pt mesoporous silica catalysts for sustainable water–hydrogen isotope exchange","authors":"Daeuk Kang, Huiryung Heo, Euna Jeong, Hee-Man Yang, Dong-Yeun Koh, Chan Woo Park and Hyung-Ju Kim","doi":"10.1039/D6MA00202A","DOIUrl":"https://doi.org/10.1039/D6MA00202A","url":null,"abstract":"<p >Efficient separation of hydrogen isotopes is essential for sustainable hydrogen management and environmental protection in nuclear and other industrial systems. Conventional hydrogen isotope separation technologies, including cryogenic distillation, the Girdler sulfide process, and ammonia–hydrogen exchange, consume massive energy and involve corrosive or toxic reagents, leading to significant environmental and operational challenges. In contrast, the liquid-phase catalytic exchange (LPCE) process, based on water–hydrogen gas isotope exchange, provides an efficient and energy-conserving alternative consistent with sustainable catalytic processes. In this study, a platinum-decorated mesoporous silica-polydimethylsiloxane composite (Pt@SiO<small>₂</small>-PDMS) was developed and applied as a catalyst for the LPCE process. Physico-chemical characterizations verified the decoration of Pt into mesoporous silica without destruction of the mesoporous structure. The Pt@SiO<small>₂</small> particles were homogeneously distributed in the PDMS matrix, and the resulting composite maintained an intrinsic hydrophobic surface with a water contact angle above 108°. The catalyst composite exhibited effective hydrogen isotope exchange performance up to a column efficiency of 67.7% at 80 °C when using Pt@SiO<small>₂</small>-PDMS randomly packed with Dixon rings in a volume ratio of 2 : 1 in the LPCE process. Furthermore, stable operation was maintained continuously for 14 days at 80 °C, demonstrating the durability of the catalyst composite and its application under actual processing conditions. The selective hydrogen isotope exchange between liquid water and hydrogen gas using the Pt@SiO<small>₂</small>-PDMS catalyst is attributed to the effective porous structure of SiO<small>₂</small>, the Pt loading in Pt@SiO<small>₂</small> and the hydrophobic nature of the PDMS matrix.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6035-6044"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00202a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-healable bio-based solid polymer electrolytes incorporating ionic liquids for safer lithium–ion batteries","authors":"Kaushiki Ahuja, Shitanshu Pratap Singh, Pratiksha Joshi, Mahendra Singh Lodhi, Rajendra Kumar Singh and Sravendra Rana","doi":"10.1039/D6MA00073H","DOIUrl":"https://doi.org/10.1039/D6MA00073H","url":null,"abstract":"<p >Self-healable polymeric electrolytes are crucial for ensuring the durability, safety and sustainability of lithium–ion batteries. Herein, we report advances in the design of bio-derived, self-healable solid polymer electrolytes that overcome three well-entrenched limitations – good self-healing behaviour, limited ionic mobility, and a narrow electrochemical window. Using a blend polymeric composition of polyethylene glycol (PEG) and bio-based methyl cellulose (MC) consisting of a dynamic disulfide moiety (covalent adaptive network) and imidazolium-based ionic liquids (EMIM-TFSI, EMIM-Br, and EMIM-Ac), we present a variety of self-healable polymer electrolytes. Synergistic improvements in sustainability, flexibility, ion mobility and potential window by adding different ionic liquids were studied and demonstrated by physicochemical and electrochemical characterization, including FTIR, XRD, DSC, TGA, stress–strain analysis, SEM, ionic conductivity, dielectric study, electrochemical stability window (ESW), and lithium transference number. The prepared self-healable electrolytes possess good ionic conductivity (10<small>⁻³</small> S cm<small>⁻¹</small>) at higher temperature, a good permittivity value with respect to frequency, a wide electrochemical stability window (&gt;5.5 V), and exceptional scratch-healing efficiency (due to reversible disulfide exchange networks). The integrated self-healing mechanism and superior electrochemical properties validate the potential of the developed self-healable polymer electrolytes as robust candidates for durable solid-state lithium–ion batteries.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6254-6265"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00073h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and characterization of a bioinspired green lipoic acid–syringic acid-based hydrogel for wound healing","authors":"Navneet Thakur, Ruchika, Neha Rana, Vikram Patial and Ankit Saneja","doi":"10.1039/D6MA00175K","DOIUrl":"https://doi.org/10.1039/D6MA00175K","url":null,"abstract":"<p >In this study, we have developed a green hydrogel composed of α-lipoic acid (LA) and syringic acid (SA) for wound healing applications. LA, known for its antioxidant properties, was polymerized through thermally initiated ring-opening polymerization (ROP) to form a poly-LA hydrogel, while SA was incorporated to enhance adhesion and bioactivity. The optimal hydrogel formulation (LA : SA 1 : 0.1) exhibited improved adhesivity and gelation, as confirmed by rheological analysis. Comprehensive characterization using nuclear magnetic resonance spectroscopy (NMR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscope (SEM) verified the successful cross-linking, amorphous nature, and interconnected morphology of the hydrogel. The functional assays demonstrated that the poly-LA–SA hydrogel (LAS-G) exhibits higher antioxidant activity, as evidenced by DPPH (92.33%) and ABTS (70.92%) radical-scavenging, as well as a significant antibacterial effect against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>, compared to the native poly-LA hydrogel (LA-G). <em>In vivo</em> studies in a rat incisional wound model revealed that LAS-G accelerated wound closure, enhanced collagen deposition, and improved tissue regeneration. The synergistic effect of LA and SA contributes to improved gelation and biological properties, positioning LAS-G as a promising approach for advanced wound care. These findings indicated that LAS-G provides a safe, effective, and multifunctional strategy for promoting wound healing and tissue repair.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6285-6296"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00175k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembly, wet adhesion, and mineralization of Balcp20k-P3 derived from Balanus albicostatus cement","authors":"Biru Hu, Baoshan Li, Jiani Liu, Liangcheng Liu, Ling Zeng and Junyi Song","doi":"10.1039/D6MA00028B","DOIUrl":"https://doi.org/10.1039/D6MA00028B","url":null,"abstract":"<p >Based on the previously screened functional derivative peptide <em>Bal</em>cp20k-P3 (hereafter referred to as P3), this study systematically elucidates its environmentally responsive mechanisms and biomedical functions through multi-scale characterization techniques. Transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FT-IR) analyses revealed that under conditions mimicking the barnacle's physiological microenvironment (pH 5.0, ionic strength: 150 mM NaCl), P3 self-assembled into discrete short rod-like fibers (100–200 nm in length) with a β-sheet content of only 16.57%. In contrast, under seawater-like conditions (pH 8.0, ionic strength: 600 mM NaCl), P3 reorganized into continuous three-dimensional network structures (fiber diameter: 100 nm, length &gt; 1 µm), accompanied by a significant increase in β-sheet content to 35.76%. Quantification <em>via</em> quartz crystal microbalance with dissipation (QCM-D) demonstrated that the wet adhesion strength of P3 under seawater conditions was 11.7-fold higher than that under physiological conditions (<em>p</em> &lt; 0.001), with exceptional shear-resistant stability (only 7% mass loss post-rinsing). Furthermore, considering the inherent biomineralization function of cp20k, the mineralization efficacy of P3 under conditions of pure water, seawater, and a simulated barnacle physiological environment was characterized using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD). The results indicated that P3 effectively induces the mineralization of calcium carbonate to form crystalline structures with different morphological characteristics, and the morphological features of these mineralized products showed a certain correlation with their self-assembled structures. This study is the first to systematically demonstrate that the derived peptide P3 of the barnacle adhesive protein cp20k can undergo dynamic self-assembly driven by changes in environmental ionic strength/pH and efficiently induce calcium carbonate mineralization. The results suggest that cp20k may utilize the differences in ionic strength and pH between its internal environment and seawater to regulate its underwater wet adhesion properties <em>in situ</em> and promote the formation of a calcareous chassis. These findings not only deepen the understanding of the molecular mechanisms of barnacle adhesive proteins but also provide a strategy for designing novel biomimetic underwater adhesives.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6275-6284"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00028b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible fluorescent carbon dot-based nanoprobes for G-quadruplex targeting in cancer cells.","authors":"Teodoro García-Millán, Eliza Hunt, Nina M Allen, Guilherme A Marczak Giorio, Thomas A A Oliver, Javier Ramos-Soriano, M Carmen Galan","doi":"10.1039/d6ma00751a","DOIUrl":"10.1039/d6ma00751a","url":null,"abstract":"<p><p>Carbon-based nanomaterials with intrinsic luminescence properties have emerged as promising tools in biological and biomedical research; however, tuning their photoluminescence properties for bespoke applications remains challenging. Herein, we report the design and synthesis of a new class of pH-responsive, red-emissive carbon dot-based nanoprobes (average core size 2-5 nm) functionalised with a naphthalene diimide (NDI)-based G-quadruplex (G4) ligand. These hybrid nanoprobes combine the favourable chemical and optical properties of CDs with the high selectivity of classical molecular ligands for G4 DNA. The resulting NDI-CDs exhibit excitation-dependent emission with distinct maxima at ∼450, ∼490, and ∼590 nm upon excitation at 350, 460, and 520 nm, respectively, in contrast to the excitation-independent emission of the parent CDs (<i>λ</i> _em ≈ 450 nm). Mechanistic investigations indicate that changes in the observed emission arise primarily from covalent surface conjugation with the NDI ligand that modifies the electronic structure of the CD surface and introduces additional emissive states. Control experiments rule out significant contributions from electron transfer or aggregation effects and instead support a mechanism involving surface-state modulation and pH-dependent protonation equilibria of the NDI moiety. Importantly, the NDI-CDs retain strong G4-binding affinity (<i>K</i> _d = 1.38 ± 0.25 µg mL^-1) and simultaneously enhance ligand bioavailability and reduce cytotoxicity. Confocal microscopy studies of live cells treated with these nanoprobes show efficient cellular uptake, preferential localisation in mitochondria and nuclei, and significantly reduced cytotoxicity relative to the free ligand, confirming their suitability for biological applications, suggesting possible engagement with intracellular G4-associated structures under physiological conditions. Overall, this work establishes a versatile and biocompatible platform for the generation of carbon-based nanomaterials for multifunctional bioimaging and nucleic acid-targeting applications.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" ","pages":"6809-6817"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of tethered dopant templates on the electrochemical, nanomorphological, and nanomechanical properties of 2D conductive polymer films","authors":"Luiza A. Nascimento, Kilian S. Fraysse, Daniel P. Langley, Rosanne M. Guijt, Paul R. Stoddart, Simon E. Moulton, Saimon M. Silva and George W. Greene","doi":"10.1039/D6MA00288A","DOIUrl":"https://doi.org/10.1039/D6MA00288A","url":null,"abstract":"<p >Chemical electropolymerization can reliably produce two-dimensional (2D) and ultrathin conductive polymer films but offers limited control over nanomorphology and mechanical stiffness. To address this limitation, we investigate the use of DNA as a tethered dopant template, where the fixed charges of anionic DNA macromolecules grafted onto an electrode are used to dope and finely control electropolymerization in deionized water. The grafted layer adopts distinct conformations and stiffness depending on whether it is single- or double-stranded. Because the chemical composition of the dopant remains unaltered, variations in the resulting conductive polymer films arise solely from differences in the physical properties of the dopant layer. Our findings show that the nanomorphology of the polymer film directly reflects the morphology of the template, and that the dopant enhances mechanical stiffness with minimal impact on electrochemical performance. These results demonstrate that tethered dopant templating is a versatile platform for controlling the conductivity and electrochemical performance of molecularly engineered 2D polymer films, while dopant selection provides a powerful means for manipulating morphological and mechanical properties.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6266-6274"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00288a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A polymer wire wetware synapse with improved endurance for physical neuromorphic implementation","authors":"Adrian D. Go, Seiya Watanabe, Hiroyuki S. Kato and Megumi Akai-Kasaya","doi":"10.1039/D5MA01448D","DOIUrl":"https://doi.org/10.1039/D5MA01448D","url":null,"abstract":"<p >Neuromorphic computing requires synaptic devices that can reliably update and retain weights under repeated electrical stimulation. Among the material platforms being explored for this purpose, organic wetware synaptic systems are of interest because their switching behavior is directly influenced by the surrounding electrochemical environment. Herein, we report a two-terminal (hydroxymethyl)-3,4-ethylenedioxythiophene:sodium dodecyl benzene sulfonate (PEDOT–MeOH:SDBS) polymer-wire synaptic device operated in ethylene glycol (EG) and water. The device exhibits long-term synaptic plasticity induced by repeated voltage pulses. Under EG operation, the device endures ≥1000 bidirectional conductance switching cycles with stable cyclic voltammetry features and reduced charge-transfer resistance after cycling. In contrast, aqueous operation leads to switching endurance degradation, peak shifts in <em>I</em>–<em>V</em> curve, and increased charge-transfer resistance. Scanning electron microscopy and Raman spectroscopy showed that EG operation is associated with a granular surface morphology and comparatively preserved backbone structure, whereas aqueous operation leads to smoother, more deteriorated surface features, and increased structural disorder. To demonstrate device applicability, conductance states of the polymer wires were mapped to kernels in a convolutional neural network (CNN) for digit recognition, achieving 96% accuracy after 450 epochs. The findings show that operation in EG improves the switching endurance of PEDOT–MeOH:SDBS polymer-wire synapse and that their conductance states can be implemented as physical weights for neural networks. This work highlights electrochemical media engineering as a key design strategy for scalable neuromorphic platforms.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 5974-5984"},"PeriodicalIF":5.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d5ma01448d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-triggered and nanocarrier properties of nitrogen-doped carbon nanodots","authors":"Ludovica Maugeri, Grazia Maria Letizia Consoli, Giuseppe Forte, Giorgia Fangano, Loredana Ferreri, Giuseppe Granata, Paolo Giuseppe Bonacci, Nicolò Musso, Luca Lanzanò, Elisa Longo, Marcello Marelli, Angelo Ferlazzo, Antonino Gulino and Salvatore Petralia","doi":"10.1039/D5MA01450F","DOIUrl":"https://doi.org/10.1039/D5MA01450F","url":null,"abstract":"<p >Carbon nanodots (CDs) are an emerging class of nanomaterials that have recently attracted significant attention for applications in personalized diagnosis, therapy and theragnostics. Herein, we aimed to develop emissive and photothermal N-doped CDs obtained <em>via</em> one-pot thermal process from chitosan (CDs-chit) without the use of organic solvents and additional reagents. The CDs-chit nanostructures were characterized using spectroscopic techniques, including Nuclear Magnetic Resonance (NMR) and Fourier Transform Infrared spectroscopy (FTIR), X-rays Photoelectron spectroscopy (XPS), and Transmission Electron Microscopy (TEM). The CDs-chit showed excellent luminescence quantum yield (<em>φ</em><small>_420 nm</small> = 6%), curcumin entrapment efficiency (12%), good photothermal conversion efficiency upon blue-light excitation (<em>η</em><small>_405 nm</small> = 57.1%) and red-light excitation (<em>η</em><small>_808 nm</small> = 16.2%). The photoxidation and photoreduction properties of CDs-chit nanostructures were also demonstrated through the photodegradation of methylene blue and the photogeneration of gold-nanostructures (CDs-chit/Au<small>⁰</small>), a tentative mechanism was proposed whereby CDs-chit act as both electron source and capping agent. <em>In vitro</em> experiments using MTT assay demonstrated the low cytotoxicity of CDs-chit. Confocal laser scanning microscopy imaged the cellular uptake of curcumin-loaded car-bon dots (CDs-chit/curc), while the absence of significant changes in gene expression confirmed the biocompatibility of the carbon dots. NIR light-triggered cell damages was observed upon photoexcitation of tumoral HCT 116 cells using an 808 nm laser source through a two-photon absorption mechanism. The ease of preparation, curcumin loading capacity, effective cellular uptake, and downregulation of pro-inflammatory IL-6 gene expression, photoluminescence and hyperthermia make CDs-chit nanomaterials attractive for further investigations in the field of biomedical research.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6210-6224"},"PeriodicalIF":5.8,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d5ma01450f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and morphology control of SbSeI thin films at elevated pressure","authors":"Alejandro Navarro-Güell, Ivan Caño, David Rovira, Alex Jimenez-Arguijo, Gabriel Aygur, Joaquim Puigdollers, Joel van Embden and Edgardo Saucedo","doi":"10.1039/D6MA00048G","DOIUrl":"https://doi.org/10.1039/D6MA00048G","url":null,"abstract":"<p >SbSeI is a promising quasi-one-dimensional chalcohalide for optoelectronic applications, but its strong tendency to form needle-like structures makes thin-film morphology difficult to control. Here, we investigate the temperature- and time-dependent evolution of SbSeI formed by the reaction of Sb<small>₂</small>Se<small>₃</small> thin films with SbI<small>₃</small> vapour under elevated pressure. Systematic SEM, XRD, and cross-sectional EDS analyses reveal two distinct growth regimes. At low temperature, incomplete conversion and limited lateral mass transport yield dense, thin needles and thickness distributions that evolve towards Weibull-like behaviour. At higher temperatures, conversion occurs largely during the heating ramp, resulting in the formation of a continuous SbSeI-rich underlayer, and subsequent mass redistribution promotes thicker needles with lognormal thickness statistics. These results support a two-interface growth mechanism in which the accessibility of iodine-rich species and thermally activated surface mass transport together govern the transition from thin to thick needles. These findings provide practical guidelines for tuning the temperature, time, and pressure to engineer the morphology of SbSeI films and offer a mechanistic framework that may be transferable to other quasi-one-dimensional chalcohalides governed by anisotropic growth.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 6164-6175"},"PeriodicalIF":5.8,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00048g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized silver nanoparticles in lung cancer treatment: mechanistic insights and emerging combination strategies","authors":"Tanya Goel, Devika Jayan, Kajal Yadav, Manisha Tiwari, Ramesh Chandra and Snigdha Singh","doi":"10.1039/D6MA00007J","DOIUrl":"https://doi.org/10.1039/D6MA00007J","url":null,"abstract":"<p >Nanotechnology has emerged as a transformative frontier in contemporary medicine, offering innovative methodologies for the diagnosis and therapeutic management of diverse malignancies. Among various nanoplatforms, AgNPs have garnered significant research attention due to their distinctive physicochemical attributes and potent biological activities. This review provides a comprehensive analysis of the therapeutic potential of AgNPs in lung cancer (LC). We examine the recent advancements in AgNP synthesis techniques, surface functionalization strategies, and characterization techniques that modulate their pharmacokinetics and bioreactivity. The tumor-targeting precision of AgNPs is explored in detail through the EPR effect, along with their cellular uptake and cytotoxic action <em>via</em> oxidative stress, mitochondrial dysfunction, and DNA damage, culminating in the programmed death of lung cancer cells. Furthermore, the review discusses strategies to enhance biocompatibility and tumor selectivity through surface modification with polymers or targeting ligands. This review also evaluates the synergistic anticancer efficacy of AgNPs in combination with traditional chemotherapeutics and hybrid nanostructures, demonstrating improved therapeutic indices and reduced side effects. Despite these promising results, rigorous <em>in vivo</em> investigations and clinical trials remain imperative to validate the long-term safety, optimal dosage, and therapeutic mechanisms of these nanocomposites.</p>","PeriodicalId":18242,"journal":{"name":"Materials Advances","volume":" 12","pages":" 5907-5936"},"PeriodicalIF":5.8,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/ma/d6ma00007j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}