Marine Drugs最新文献_第6页

Neoxanthin: A Promising Medicinal and Nutritional Carotenoid. 新黄质：一种有药用价值和营养价值的类胡萝卜素。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-01 DOI: 10.3390/md23080317

Jiarong Zhao, Gengjie Zhuang, Jinrong Zhang

引用次数: 0

Marine-Derived Collagen and Chitosan: Perspectives on Applications Using the Lens of UN SDGs and Blue Bioeconomy Strategies. 海洋胶原蛋白和壳聚糖：从联合国可持续发展目标和蓝色生物经济战略的角度看应用前景。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-01 DOI: 10.3390/md23080318

Mariana Almeida, Helena Vieira

{"title":"Marine-Derived Collagen and Chitosan: Perspectives on Applications Using the Lens of UN SDGs and Blue Bioeconomy Strategies.","authors":"Mariana Almeida, Helena Vieira","doi":"10.3390/md23080318","DOIUrl":"https://doi.org/10.3390/md23080318","url":null,"abstract":"Marine biomass, particularly from waste streams, by-products, underutilized, invasive, or potential cultivable marine species, offers a sustainable source of high-value biopolymers such as collagen and chitin. These macromolecules have gained significant attention due to their biocompatibility, biodegradability, functional versatility, and broad applicability across health, food, wellness, and environmental fields. This review highlights recent advances in the uses of marine-derived collagen and chitin/chitosan. In alignment with the United Nations Sustainable Development Goals (SDGs), we analyze how these applications contribute to sustainability, particularly in SDGs related to responsible consumption and production, good health and well-being, and life below water. Furthermore, we contextualize the advancement of product development using marine collagen and chitin/chitosan within the European Union's Blue bioeconomy strategies, highlighting trends in scientific research and technological innovation through bibliometric and patent data. Finally, the review addresses challenges facing the development of robust value chains for these marine biopolymers, including collaboration, regulatory hurdles, supply-chain constraints, policy and financial support, education and training, and the need for integrated marine resource management. The paper concludes with recommendations for fostering innovation and sustainability in the valorization of these marine resources.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiblock Metabolomics Responses of the Diatom Phaeodactylum tricornutum Under Benthic and Planktonic Culture Conditions. 底栖和浮游培养条件下三角褐藻的多区代谢组学响应。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-31 DOI: 10.3390/md23080314

Andrea Castaldi, Mohamed Nawfal Triba, Laurence Le Moyec, Cédric Hubas, Gaël Le Pennec, Marie-Lise Bourguet-Kondracki

{"title":"Multiblock Metabolomics Responses of the Diatom Phaeodactylum tricornutum Under Benthic and Planktonic Culture Conditions.","authors":"Andrea Castaldi, Mohamed Nawfal Triba, Laurence Le Moyec, Cédric Hubas, Gaël Le Pennec, Marie-Lise Bourguet-Kondracki","doi":"10.3390/md23080314","DOIUrl":"https://doi.org/10.3390/md23080314","url":null,"abstract":"This study investigates the metabolic responses of the model diatom Phaeodactylum tricornutum under different growth conditions, comparing benthic (adherent) and planktonic states. Using a multiblock metabolomics approach combining LC-HRMS2, NMR, and GC-MS techniques, we compared the metabolome of P. tricornutum cultivated on three laboratory substrates (glass, polystyrene, and polydimethylsiloxane) and under planktonic conditions. Our results revealed metabolic differences between adherent and planktonic cultures, particularly concerning the lipid and carbohydrate contents. Adherent cultures showed a metabolic profile with an increase in betaine lipids (DGTA/S), fatty acids (tetradecanoic and octadecenoic acids), and sugars (myo-inositol and ribose), suggesting modifications in membrane composition and lipid remodeling, which play a potential role in adhesion. In contrast, planktonic cultures displayed a higher content of cellobiose, specialized metabolites such as dihydroactinidiolide, quinic acid, catechol, and terpenes like phytol, confirming different membrane composition, energy storage capacity, osmoregulation, and stress adaptation. The adaptative strategies do not only concern adherent and planktonic states, but also different adherent culture conditions, with variations in lipid, amino acid, terpene, and carbohydrate contents depending on the physical properties of the support. Our results highlight the importance of metabolic adaptation in adhesion, which could explain the fouling process.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of New Everninomicin Analogs from a Marine-Derived Micromonospora sp. by Metabolomics and Genomics Approaches. 利用代谢组学和基因组学方法从一种海洋来源的小单孢子菌中发现新的依维菌素类似物。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-31 DOI: 10.3390/md23080316

Tae Hyun Lee, Nathan J Brittin, Imraan Alas, Christopher D Roberts, Shaurya Chanana, Doug R Braun, Spencer S Ericksen, Song Guo, Scott R Rajski, Tim S Bugni

{"title":"Discovery of New Everninomicin Analogs from a Marine-Derived Micromonospora sp. by Metabolomics and Genomics Approaches.","authors":"Tae Hyun Lee, Nathan J Brittin, Imraan Alas, Christopher D Roberts, Shaurya Chanana, Doug R Braun, Spencer S Ericksen, Song Guo, Scott R Rajski, Tim S Bugni","doi":"10.3390/md23080316","DOIUrl":"https://doi.org/10.3390/md23080316","url":null,"abstract":"During the course of genome mining initiatives, we identified a marine-derived Micromonospora, assigned here as strain WMMD956; the genome of WMMD956 appeared to contain a number of features associated with everninomicins, well-known antimicrobial orthosomycins. In addition, LCMS-based hierarchical clustering analysis and principal component analysis (hcapca) revealed that WMMD956 displayed an extreme degree of metabolomic and genomic novelty. Dereplication of high-resolution tandem mass spectrometry (HRMS/MS) and Global Natural Product Social molecular networking platform (GNPS) analysis of WMMD956 resulted in the identification of several analogs of the previously known everninomicin. Chemical structures were unambiguously confirmed by HR-ESI-MS, 1D and 2D NMR experiments, and the use of MS/MS data. The isolated metabolites, 1-3, were evaluated for their antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Derived Strategies Against Neurodegeneration. 海洋衍生的抗神经变性策略。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-31 DOI: 10.3390/md23080315

Vasileios Toulis, Gemma Marfany, Serena Mirra

引用次数: 0

Spermine Promotes the Formation of Conchosporangia in Pyropia haitanensis Through Superoxide Anions. 精胺通过超氧阴离子促进海地焦皮藻胆的形成。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-30 DOI: 10.3390/md23080309

Tingting Niu, Haike Qian, Lufan Cheng, Qijun Luo, Juanjuan Chen, Rui Yang, Peng Zhang, Tiegan Wang, Haimin Chen

{"title":"Spermine Promotes the Formation of Conchosporangia in Pyropia haitanensis Through Superoxide Anions.","authors":"Tingting Niu, Haike Qian, Lufan Cheng, Qijun Luo, Juanjuan Chen, Rui Yang, Peng Zhang, Tiegan Wang, Haimin Chen","doi":"10.3390/md23080309","DOIUrl":"https://doi.org/10.3390/md23080309","url":null,"abstract":"The transition from conchocelis to conchosporangia in Pyropia haitanensis represents a pivotal stage in its life cycle. As a commercially vital red alga, P. haitanensis plays a dominant role in global nori production. The transition governing its sporulation efficiency is pivotal for aquaculture success, yet the underlying regulatory mechanisms, especially their integration with metabolic cues such as polyamines, remain poorly understood. This study uncovered a critical role for the polyamine spermine (SPM) in promoting conchosporangial formation, mediated through the signaling activity of superoxide anions (O2·-). Treatment with SPM markedly elevated O2·- levels, an effect that was effectively inhibited by the NADPH oxidase inhibitor diphenyliodonium chloride (DPI), underscoring the role of O2·- as a key signaling molecule. Transcriptomic analysis revealed that SPM enhanced photosynthesis, carbon assimilation, and respiratory metabolism, while simultaneously activating antioxidant enzymes, such as superoxide dismutase (SOD), ascorbate peroxidase (APX), and catalase (CAT), to regulate hydrogen peroxide (H2O2) levels and maintain redox homeostasis. Furthermore, SPM upregulated genes associated with photosynthetic carbon fixation and the C2 oxidative photorespiration pathway, supplying the energy and metabolic resources necessary for this developmental transition. These findings suggested that SPM orchestrated O2·- signaling, photosynthetic activity, and antioxidant defenses to facilitate the transition from conchocelis to conchosporangia in P. haitanensis.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Sea Cucumber-Derived Bioactives in the Prevention and Management of Brain-Related Disorders: A Comprehensive Review. 海参衍生生物活性物质在预防和治疗脑相关疾病中的治疗潜力：综述

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-30 DOI: 10.3390/md23080310

Purnima Rani Debi, Hrishika Barua, Mirja Kaizer Ahmmed, Shuva Bhowmik

引用次数: 0

Mohangic Acid H and Mohangiol: New p-Aminoacetophenone Derivatives from a Mudflat-Derived Streptomyces sp. Mohangic Acid H和Mohangiol：一种泥滩源链霉菌的对氨基苯乙酮衍生物。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-30 DOI: 10.3390/md23080307

Juwan Son, Ju Heon Lee, Yong-Joon Cho, Kyuho Moon, Munhyung Bae

{"title":"Mohangic Acid H and Mohangiol: New p-Aminoacetophenone Derivatives from a Mudflat-Derived Streptomyces sp.","authors":"Juwan Son, Ju Heon Lee, Yong-Joon Cho, Kyuho Moon, Munhyung Bae","doi":"10.3390/md23080307","DOIUrl":"https://doi.org/10.3390/md23080307","url":null,"abstract":"Streptomyces sp. AWH31-250, isolated from a tidal mudflat in the Nakdong River estuary in Busan, Republic of Korea, was found to produce two novel p-aminoacetophenone derivatives, mohangic acid H (1) and mohangiol (2). Their planar structures were established by comprehensive 1D and 2D NMR spectroscopy, mass spectrometry, and UV analysis, possessing a shorter carbon-chain with a diene moiety, whereas known mohangic acids A-F bear a longer carbon-chain with a triene moiety. The absolute configurations of the key stereogenic centers were determined via computational DP4+ calculations and bioinformatic analysis of the ketoreductase domain sequence from the biosynthetic gene cluster. Based on the careful gene analysis along with whole-genome sequencing, the first plausible biosynthetic pathway of mohangic acids A-G and mohangiol was proposed. Mohangic acid H (1) and mohangiol (2) displayed moderate inhibitory activity against Candida albicans isocitrate lyase with IC50 values of 21.37 and 21.12 µg/mL, respectively.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Inhibitors of Human-Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model. 人-福氏奈格氏杆菌相互作用的潜在抑制剂：一个体外细胞外基质模型。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-30 DOI: 10.3390/md23080306

Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Ines Sifaoui, Ana R Díaz-Marrero, José J Fernández, Melissa Jamerson, José E Piñero, Jacob Lorenzo-Morales

{"title":"Potential Inhibitors of Human-Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model.","authors":"Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Ines Sifaoui, Ana R Díaz-Marrero, José J Fernández, Melissa Jamerson, José E Piñero, Jacob Lorenzo-Morales","doi":"10.3390/md23080306","DOIUrl":"https://doi.org/10.3390/md23080306","url":null,"abstract":"Primary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri. The adhesion to extracellular matrix (ECM) proteins is considered as one of the key steps in the success of the infection and could represent an interesting target to be explored in the prevention and treatment of the disease. In this work, the effect of two sesquiterpenes with proven anti-Naegleria activity on the adhesion of the parasite was evaluated using an in vitro ECM-based model, compared with the reference drugs amphotericin B and staurosporine. Both laurinterol and (+)-elatol inhibited the adhesion of the N. fowleri trophozoites to the main proteins of the ECM when treating them at different concentrations and exposure times. This work not only reinforces the therapeutic potential of laurinterol and (+)-elatol against N. fowleri infection but also introduces the application of ECM-based adhesion assays as a novel and valuable tool for screening candidate compounds that disrupt host-pathogen interactions critical to PAM pathogenesis.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Biosynthetic Potential of Microorganisms from the South China Sea Cold Seep Using Culture-Dependent and Culture-Independent Approaches. 利用培养依赖和非培养方法探索南海冷渗微生物的生物合成潜力。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-07-30 DOI: 10.3390/md23080313

Gang-Ao Hu, Huai-Ying Sun, Qun-Jian Yin, He Wang, Shi-Yi Liu, Bin-Gui Wang, Hong Wang, Xin Li, Bin Wei

{"title":"Exploring the Biosynthetic Potential of Microorganisms from the South China Sea Cold Seep Using Culture-Dependent and Culture-Independent Approaches.","authors":"Gang-Ao Hu, Huai-Ying Sun, Qun-Jian Yin, He Wang, Shi-Yi Liu, Bin-Gui Wang, Hong Wang, Xin Li, Bin Wei","doi":"10.3390/md23080313","DOIUrl":"https://doi.org/10.3390/md23080313","url":null,"abstract":"Cold seep ecosystems harbor unique microbial communities with potential for producing secondary metabolites. However, the metabolic potential of cold seep microorganisms in the South China Sea remains under-recognized. This study employed both culture-dependent and culture-independent approaches, including 16S rRNA amplicon sequencing and metagenomics, to investigate microbial communities and their potential for secondary metabolite production in the South China Sea cold seep. The results indicate microbial composition varied little between two non-reductive sediments but differed significantly from the reductive sediment, primarily due to Planctomycetes and Actinobacteria. Predicting the Secondary Metabolism Potential using Amplicon (PSMPA) predictions revealed 115 strains encoding more than 10 biosynthetic gene clusters (BGCs), with lower BGC abundance in reductive sediment. Culture-dependent studies showed Firmicutes as the dominant cultivable phylum, with strains from shallow samples encoding fewer BGCs. Metagenomic data confirmed distinct microbial compositions and BGC distributions across sediment types, with cold seep type having a stronger influence than geographic location. Certain BGCs showed strong correlations with sediment depth, reflecting microbial adaptation to nutrient-limited environments. This study provides a comprehensive analysis of the metabolic capabilities of South China Sea cold seep microorganisms and reveals key factors influencing their secondary metabolic potential, offering valuable insights for the efficient exploration of cold seep biological resources.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 8","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12387464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0