Marine Drugs最新文献

{"title":"Anthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral <i>Anthothela grandiflora</i>.","authors":"Stine S H Olsen, Sam Afoullouss, Ezequiel Cruz Rosa, Ryan M Young, Mark Johnson, A Louise Allcock, Bill J Baker","doi":"10.3390/md23010044","DOIUrl":"10.3390/md23010044","url":null,"abstract":"<p><p>New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral <i>Anthothela grandiflora,</i> we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and ¹H NMR-guided approaches. One-/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations of the anthoteibinenes. The metabolites were screened against the Respiratory Syncytial Virus (RSV), ESKAPE pathogens, five <i>Candida albicans</i> strains, and one strain of <i>C. auris</i>.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Molecules from the Invasive Blue Crab <i>Callinectes sapidus</i> Exoskeleton: Evaluation of Reducing, Radical Scavenging, and Antitumor Activities.","authors":"Francesco Longo, Alessandro Attanzio, Laura Marretta, Claudio Luparello, Serena Indelicato, David Bongiorno, Giampaolo Barone, Luisa Tesoriere, Ilenia Concetta Giardina, Giulia Abruscato, Manuela Perlotti, Lucie Branwen Hornsby, Vincenzo Arizza, Mirella Vazzana, Aiti Vizzini, Chiara Martino, Angelica Listro, Vinicius Queiroz, Antonio Fabbrizio, Paolo Salvatore Francesco Ciaccio, Stella Maria Cascioferro, Francesca Di Gaudio, Manuela Mauro","doi":"10.3390/md23010045","DOIUrl":"10.3390/md23010045","url":null,"abstract":"<p><p>In recent years, the invasive Atlantic blue crab (<i>Callinectes sapidus</i>) has increased its spread throughout the Mediterranean Sea, threatening native biodiversity and local economies. This study aimed to valorize <i>C. sapidus</i> sampled in Sicily by utilizing its exoskeleton as a source of chitosan, astaxanthin, and bio-phenolic compounds. These biomolecules were evaluated for their reducing, radical scavenging, and antitumor activity. The ferric ion reducing antioxidant power (FRAP) and the free radical scavenging activity against radical 2,2-Diphenyl-1-picrylhydrazyl (DPPH) were significantly higher for chitosan (3.16 ± 0.10 mg AAE/g and 8.1 ± 0.10 µmol TE/g). No significant differences were observed among the tested biomolecules in their activity in scavenging the radical 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Both bio-phenolic compounds and astaxanthin exhibited dose-dependent cytotoxicity on CaCo-2 (IC₅₀ = 12.47 and 18 µg/mL) and HepG2 (IC₅₀ = 10.25 and 1.26 µg/mL) cell lines, while only bio-phenols showed no cytotoxic effect on differentiated CaCo-2 cells up to 20 µg/mL. These findings highlight the value of blue crab by-products in supporting a circular economy, offering a sustainable approach to managing this invasive species while providing bioactive compounds with promising medical and nutraceutical applications.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of the Extraction Protocol for Pacific Ciguatoxins from Marine Products Prior to Analysis Using the Neuroblastoma Cell-Based Assay.","authors":"Thomas Yon, Philippe Cruchet, Jérôme Viallon, J Sam Murray, Emillie Passfield, Mireille Chinain, Hélène Taiana Darius, Mélanie Roué","doi":"10.3390/md23010042","DOIUrl":"10.3390/md23010042","url":null,"abstract":"<p><p>Ciguatera poisoning (CP) is caused by the consumption of marine products contaminated with ciguatoxins (CTXs) produced by dinoflagellates of the genus <i>Gambierdiscus</i>. Analytical methods for CTXs, involving the extraction/purification of trace quantities of CTXs from complex matrices, are numerous in the literature. However, little information on their effectiveness for nonpolar CTXs is available, yet these congeners, contributing to the risk of CP, are required for the establishment of effective food safety monitoring programs. An evaluation of six extraction/purification protocols, performed with CTX3C spiked on fish flesh and a neuroblastoma cell-based assay (CBA-N2a), revealed recoveries from 6 to 45%. This led to the development of an optimized 3-day protocol designed for a large number of samples, with CTX1B and CTX3C eluting in a single fraction and showing recoveries of 73% and 70%, respectively. In addition, a reduction in adverse matrix effects in the CBA-N2a analyses was demonstrated with naturally contaminated specimens, increasing the sensitivity of the method, which now meets the very low guidance level recommended by international agencies. However, efforts are still required to reduce the signal suppression observed in LC-MS/MS analysis. This optimized protocol contributes to the technological advancement of detection methods, promoting food safety and improving CP risk assessment in marine products.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review.","authors":"Cintia Cristina Santi Martignago, Camila de Souza Barbosa, Homero Garcia Motta, Beatriz Soares-Silva, Erica Paloma Maso Lopes Peres, Lais Caroline Souza E Silva, Mirian Bonifácio, Karolyne Dos Santos Jorge Sousa, Amanda Sardeli Alqualo, Júlia Parisi, Olivier Jordan, Ana Claudia Muniz Renno, Anna Caroline Campos Aguiar, Viorica Patrulea","doi":"10.3390/md23010043","DOIUrl":"10.3390/md23010043","url":null,"abstract":"<p><p>The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting <i>Pseudomonas aeruginosa</i>, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Insights into the Nobilamide Family from a Deep-Sea <i>Bacillus</i>: Chemical Diversity, Biosynthesis and Antimicrobial Activity Towards Multidrug-Resistant Bacteria.","authors":"Vincenza Casella, Gerardo Della Sala, Silvia Scarpato, Carmine Buonocore, Costanza Ragozzino, Pietro Tedesco, Daniela Coppola, Giovanni Andrea Vitale, Donatella de Pascale, Fortunato Palma Esposito","doi":"10.3390/md23010041","DOIUrl":"10.3390/md23010041","url":null,"abstract":"<p><p>With rising concerns about antimicrobial resistance, the identification of new lead compounds to target multidrug-resistant bacteria is essential. This study employed a fast miniaturized screening to simultaneously cultivate and evaluate about 300 marine strains for biosurfactant and antibacterial activities, leading to the selection of the deep-sea <i>Bacillus halotolerans</i> BCP32. The integration of tandem mass spectrometry molecular networking and bioassay-guided fractionation unveiled this strain as a prolific factory of surfactins and nobilamides. Particularly, 84 nobilamide congeners were identified in the bacterial exometabolome, 71 of them being novel metabolites. Among these, four major compounds were isolated, including the known TL-119 and nobilamide I, as well as the two new nobilamides T1 and S1. TL-119 and nobilamide S1 exhibited potent antibiotic activity against various multidrug-resistant <i>Staphylococcus</i> strains and other Gram-positive pathogens, including the foodborne pathogen <i>Listeria monocytogenes</i>. Finally, in silico analysis of <i>Bacillus halotolerans</i> BCP32 genome revealed nobilamide biosynthesis to be directed by a previously unknown heptamodular nonribosomal peptide synthetase.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of a Sonotrode Extraction Method and New Insight of Phenolic Composition of <i>Fucus vesiculosus</i>.","authors":"Lidia Gil-Martínez, Alejandro Santos-Mejías, José Manuel De la Torre-Ramírez, Alberto Baños, Vito Verardo, Ana M Gómez-Caravaca","doi":"10.3390/md23010040","DOIUrl":"10.3390/md23010040","url":null,"abstract":"<p><p>The optimization of bioactive compound extraction from <i>Fucus vesiculosus</i> using ultrasound-assisted extraction (UAE) via sonotrode was investigated to maximize phenolic recovery and antioxidant activity while promoting a sustainable process. Optimal conditions (40% <i>v</i>/<i>v</i> ethanol in water, 38 min, 36% amplitude) were selected to maximize phenolic recovery while considering environmental and energy sustainability by optimizing extraction efficiency and minimizing solvent and energy usage. HPLC-ESI-QTOF-MS analysis tentatively identified 25 phenolic compounds, including sulfated phenolic acids, phlorotannins, flavonoids, and halophenols, with some reported for the first time in <i>F. vesiculosus</i>, underscoring the complexity of this alga's metabolome. The antioxidant activity of the optimized extract was evaluated through FRAP (143.7 µmol TE/g), DPPH (EC₅₀ 105.6 µg/mL), and TEAC (189.1 µmol Trolox/g) assays. The optimized process highlights <i>F. vesiculosus</i> as a valuable source of natural antioxidants, with potential applications in biotechnology, cosmetics, and food industries.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants.","authors":"Blanca Hey Díez, Cristiana A V Torres, Susana P Gaudêncio","doi":"10.3390/md23010039","DOIUrl":"10.3390/md23010039","url":null,"abstract":"<p><p>Pigment production has a substantial negative impact on the environment, since mining for natural pigments causes ecosystem degradation, while synthetic pigments, derived from petrochemicals, generate toxic by-products that accumulate and persist in aquatic systems due to their resistance to biodegradation. Despite these challenges, pigments remain essential across numerous industries, including the cosmetic, textile, food, automotive, paints and coatings, plastics, and packaging industries. In response to growing consumer demand for sustainable options, there is increasing interest in eco-friendly alternatives, particularly bio-based pigments derived from algae, fungi, and actinomycetes. This shift is largely driven by consumer demand for sustainable options. For bio-pigments, actinomycetes, particularly from the <i>Streptomyces</i> genus, have emerged as a promising green source, aligning with global sustainability goals due to their renewability and biodegradability. Scale-up of production and yield optimization challenges have been circumvented with the aid of biotechnology advancements, including genetic engineering and innovative fermentation and extraction methods, which have enhanced these bio-pigments' viability and cost-competitiveness. Actinomycete-derived pigments have successfully transitioned from laboratory research to commercialization, showcasing their potential as sustainable and eco-friendly alternatives to synthetic dyes. With the global pigment market valued at approximately USD 24.28 billion in 2023, which is projected to reach USD 36.58 billion by 2030, the economic potential for actinomycete pigments is extensive. This review explores the environmental advantages of actinomycete pigments, their role in modern industry, and the regulatory and commercialization challenges they face, highlighting the importance of these pigments as promising solutions to reduce our reliance on conventional toxic pigments. The successful commercialization of actinomycete pigments can drive an industry-wide transition to environmentally responsible alternatives, offering substantial benefits for human health, safety, and environmental sustainability.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp.","authors":"Lin-Mao Ke, Zi-Ru Zhang, Song-Wei Li, Yan-Bo Zeng, Ming-Zhi Su, Yue-Wei Guo","doi":"10.3390/md23010036","DOIUrl":"10.3390/md23010036","url":null,"abstract":"<p><p>A chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (<b>3</b>). Compounds <b>1</b>-<b>3</b> were derived from the soft coral <i>Lobophytum</i> sp., while <b>4</b> and <b>5</b> were obtained from the sponge <i>Xestospongia</i> sp. The structures of these compounds were determined by extensive spectroscopic analysis, the time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculation method, and comparison with the spectral data previously reported in the literature. The antibacterial and anti-inflammatory activities of isolated compounds were evaluated in vitro. Compounds <b>1</b>-<b>3</b>, <b>4</b>, and <b>5</b> exhibited weak antibacterial activity against vancomycin-resistant <i>Enterococcus faecium</i> G1, <i>Streptococcus parauberis</i> KSP28, <i>Photobacterium damselae</i> FP2244, <i>Lactococcus garvieae</i> FP5245, and <i>Pseudomonas aeruginosa</i> ZJ028. Moreover, compound <b>3</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with an IC₅₀ value of 13.48 μM.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Acids in Cnidaria: Distribution and Specific Functions.","authors":"Vasily I Svetashev","doi":"10.3390/md23010037","DOIUrl":"10.3390/md23010037","url":null,"abstract":"<p><p>The phylum Cnidaria comprises five main classes-Hydrozoa, Scyphozoa, Hexacorallia, Octocorallia and Cubozoa-that include such widely distributed and well-known animals as hard and soft corals, sea anemones, sea pens, gorgonians, hydroids, and jellyfish. Cnidarians play a very important role in marine ecosystems. The composition of their fatty acids (FAs) depends on food (plankton and particulate organic matter), symbiotic photosynthetic dinoflagellates and bacteria, and de novo biosynthesis in host tissues. In cnidarian lipids, besides the common FA characteristics of marine organisms, numerous new and rare FAs are also found. All Octocorallia species and some Scyphozoa jellyfish contain polyunsaturated FAs (PUFAs) with 24 and 26 carbon atoms. The coral families can be distinguished by specific FA profiles: the presence of uncommon FAs or high/low levels of common fatty acids. Many of the families have characteristic FAs: Acroporidae are characterized by 18:3n6, eicosapentaenoic acid (EPA) 20:5n3, 22:4n6, and 22:5n3; Pocilloporidae by 20:3n6, 20:4n3, and docosahexaenoic acid 22:6n3 (DHA); and Poritidae by arachidonic acid (AA) and DHA. The species of Faviidae show elevated concentrations of 18:3n6 and 22:5n3 acids. Dendrophylliidae, being azooxanthellate corals, have such dominant acids as EPA and 22:5n3 and a low content of DHA, which is the major PUFA in hermatypic corals. The major and characteristic PUFAs for Milleporidae (class Hydrozoa) are DHA and 22:5n6, though in scleractinian corals, the latter acid is found only in trace amounts.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polysaccharide Fraction Isolated from <i>Saccharina japonica</i> Exhibits Anti-Cancer Effects Through Immunostimulating Activities.","authors":"Min Seung Park, Seung-U Son, Tae Eun Kim, Se Hyun Shim, Bong-Keun Jang, Sunyoung Park, Kwang-Soon Shin","doi":"10.3390/md23010038","DOIUrl":"10.3390/md23010038","url":null,"abstract":"<p><p>The present research aimed to assess the anti-cancer effects of the polysaccharide fraction (SJP) isolated from <i>Saccharina japonica</i>. The release of immune-activating cytokines, including IL-6, IL-12, and TNF-α, was markedly stimulated by the SJP in a concentration-dependent manner within the range of 1 to 100 µg/mL. Furthermore, the prophylactic intravenous (<i>p.i.v.</i>) and per os (<i>p.p.o.</i>) injection of SJP boosted the cytolytic activity mediated by NK cells and CTLs against tumor cells. In a study involving Colon26-M3.1 carcinoma as a lung cancer model, both <i>p.i.v.</i> and <i>p.p.o.</i> exhibited significant anti-lung-cancer effects. Notably, <i>p.i.v.</i> and <i>p.p.o.</i> administration of SJP at a dose of 50 mg/kg reduced tumor colonies by 84% and 40%, respectively, compared to the control. Moreover, the anti-lung-cancer effects of SJP remained substantial, even when NK cell function was inhibited using anti-asialo-GM1. Fractionation with CaCl₂ suggested that SJP is a mixture of alginate and fucoidan. The fucoidan fraction stimulated the immune response of macrophages more strongly than the alginate fraction. Consequently, this finding suggested that SJP from <i>S. japonica</i> possesses remarkable anti-cancer effects through the activation of various immunocytes. In addition, this finding indicates that the potent biological activity of SJP may be attributed to fucoidan.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}