Marine Drugs最新文献_第10页

Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule. 南海软珊瑚中的樟脑类二萜。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-29 DOI: 10.3390/md22120536

Hanyang Peng, Yanbo Zeng, Rui Zhang, Li Yang, Fei Wu, Cuijuan Gai, Jingzhe Yuan, Wenjun Chang, Haofu Dai, Xiachang Wang

{"title":"Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule.","authors":"Hanyang Peng, Yanbo Zeng, Rui Zhang, Li Yang, Fei Wu, Cuijuan Gai, Jingzhe Yuan, Wenjun Chang, Haofu Dai, Xiachang Wang","doi":"10.3390/md22120536","DOIUrl":"10.3390/md22120536","url":null,"abstract":"Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (1-5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6-10). The structures and absolute configuration for new compounds 1-5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue. 马甲古酰胺D的构效关系研究：用氟类似物克服代谢不稳定和严重毒性。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-29 DOI: 10.3390/md22120537

Xiuhe Zhao, Xiaonan Xi, Mingxiao Zhang, Mengxue Lv, Xiang Zhang, Yaxin Lu, Liang Wang, Yue Chen

{"title":"Structure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.","authors":"Xiuhe Zhao, Xiaonan Xi, Mingxiao Zhang, Mengxue Lv, Xiang Zhang, Yaxin Lu, Liang Wang, Yue Chen","doi":"10.3390/md22120537","DOIUrl":"10.3390/md22120537","url":null,"abstract":"Majusculamide D, isolated from the marine cyanobacterium Moorea producens, is an anticancer lipopentapeptide consisting of fatty acid, tripeptide, and pyrrolyl proline moieties. In this work, by utilizing a convergent synthetic approach, late-stage modification, and bioisostere strategy, 26 majusculamide D analogues were synthesized, and two (1i and 1j) demonstrated IC50 values < 1 nM against PANC-1 cancer cells. The results summarized a preliminary structure-activity relationship mainly at the C23, C4, C34, and C10 sites. A series of in vitro assays, including wound healing, transwell, clone formation, EdU, and western blot, confirmed that majusculamide D inhibited the migration, invasion, and proliferation of pancreatic cancer cells. The optimized fluorinated analogue 1n demonstrated a notable enhancement in stability during the mouse plasma assay (>50% left after 24 h), exhibited tumor-suppressive effects (51.5% at a dosage of 5 mg/kg), and successfully mitigated the severe toxicity (no mouse dead) observed in the group treated with majusculamide D (3 mice dead) in a xenografted mouse model.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Pediococcus sp. M21F004 for Biocontrol of Bacterial and Fungal Phytopathogens. 探索Pediococcus sp. M21F004对细菌和真菌植物病原体的生物防治作用。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-28 DOI: 10.3390/md22120534

Van Thi Nguyen, Yong Min Kwon, Ae Ran Park, Nan Hee Yu, Grace Choi, Jin-Cheol Kim

{"title":"Exploring Pediococcus sp. M21F004 for Biocontrol of Bacterial and Fungal Phytopathogens.","authors":"Van Thi Nguyen, Yong Min Kwon, Ae Ran Park, Nan Hee Yu, Grace Choi, Jin-Cheol Kim","doi":"10.3390/md22120534","DOIUrl":"10.3390/md22120534","url":null,"abstract":"This study explores the biocontrol potential of Pediococcus sp. M21F004, a lactic acid bacteria (LAB) isolated from marine environments, against several bacterial and fungal phytopathogens. Out of 50 marine bacterial isolates, Pediococcus sp. M21F004 was selected for its exceptional antimicrobial activity. The strain, isolated from the intestine of a starry flounder, was identified as Pediococcus sp. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that oleic acid (OA) is a key antimicrobial compound produced by Pediococcus sp. M21F004. In vitro assays showed that the culture broth (CB) of Pediococcus sp. M21F004, as well as OA, exhibited significant inhibitory effects against pathogens such as Fusarium oxysporum, Clarireedia homoeocarpa, and Pectobacterium carotovorum subsp. carotovorum. In vivo tests on cucumber Fusarium wilt, creeping bentgrass dollar spot, tomato bacterial wilt, and kimchi cabbage soft rot further demonstrated the strain's efficacy in reducing disease severity. Moreover, OA had the highest control value of 74% against tomato bacterial wilt, followed by 64.1% against cucumber fusarium wilt, 42.5% against kimchi cabbage soft rot, and 16.5% against creeping bentgrass dollar spot. These findings suggest that Pediococcus sp. M21F004 and its metabolite OA offer promising alternatives to chemical pesticides, contributing to sustainable plant disease management by promoting resistance induction and providing an eco-friendly approach to agriculture.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Novel Squid Gladius Biomaterials for Cornea Tissue Engineering. 新型鱿鱼角斗士角膜组织工程生物材料的研制。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-28 DOI: 10.3390/md22120535

Ingrid Garzón, Juan Muñoz-Hurtado, Juan Pereira-Martínez, Ana M Ionescu, Juan de la Cruz Cardona, María Tejada-Casado, María Del Mar Pérez, Fernando Campos, Jesús Chato-Astrain, Miguel Alaminos

{"title":"Development of Novel Squid Gladius Biomaterials for Cornea Tissue Engineering.","authors":"Ingrid Garzón, Juan Muñoz-Hurtado, Juan Pereira-Martínez, Ana M Ionescu, Juan de la Cruz Cardona, María Tejada-Casado, María Del Mar Pérez, Fernando Campos, Jesús Chato-Astrain, Miguel Alaminos","doi":"10.3390/md22120535","DOIUrl":"10.3390/md22120535","url":null,"abstract":"Cornea tissue engineering is strictly dependent on the development of biomaterials that fulfill the strict biocompatibility, biomechanical, and optical requirements of this organ. In this work, we generated novel biomaterials from the squid gladius (SG), and their application in cornea tissue engineering was evaluated. Results revealed that the native SG (N-SG) was biocompatible in laboratory animals, although a local inflammatory reaction was driven by the material. Cellularized biomaterials (C-SG) demonstrated that the SG provides an adequate substrate for cell attachment and growth, and corneal epithelial cells cultured on this biomaterial were able to express crystallin alpha, a marker for this type of cells. Biomechanical analyses showed that N-SG biomaterials have higher Young modulus and lower traction deformation than control native corneas (CTR), and C-SG showed a similar Young modulus than CTR. Analysis of the optical properties of these samples revealed that the diffuse transmittance of N-SG and C-SG were higher than CTR, with the diffuse reflectance showing the opposite behavior. These results confirm the putative usefulness of this abundant marine-derived biomaterial that can be obtained as a byproduct of the fishing industry.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Lucknolide Derivative Induces Mitochondrial ROS-Mediated G2/M Arrest and Apoptotic Cell Death in B16F10 Mouse Melanoma Cells. Lucknolide衍生物诱导线粒体ros介导的G2/M阻滞和B16F10小鼠黑色素瘤细胞凋亡

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-28 DOI: 10.3390/md22120533

Jae Hyeop Lee, Byeoung-Kyu Choi, Minsoo Kim, Hee Jae Shin, Sun Joo Park

{"title":"A Lucknolide Derivative Induces Mitochondrial ROS-Mediated G2/M Arrest and Apoptotic Cell Death in B16F10 Mouse Melanoma Cells.","authors":"Jae Hyeop Lee, Byeoung-Kyu Choi, Minsoo Kim, Hee Jae Shin, Sun Joo Park","doi":"10.3390/md22120533","DOIUrl":"10.3390/md22120533","url":null,"abstract":"Melanoma is an aggressive skin cancer with a high risk of cancer-related deaths, and inducing apoptosis in melanoma cells is a promising therapeutic strategy. This study investigates the anti-tumor potential of a novel lucknolide derivative LA-UC as a therapeutic candidate for melanoma. Lucknolide A (LA), a tricyclic ketal-lactone metabolite isolated from marine-derived Streptomyces sp., was chemically modified by introducing a 10-undecenoyl group to synthesize LA-UC. LA-UC preferentially inhibited the proliferation of melanoma cells, including B16F10, while exerting minimal effects on normal melanocytes or other tumor cell types, indicating the selective action of LA-UC against melanoma cells. LA-UC decreased G2/M checkpoint proteins, including cyclin B1 and Cdc2, while activating caspase-3 and caspase-9, resulting in G2/M cell cycle arrest and inducing apoptotic cell death in B16F10 cells. The addition of a pan-caspase inhibitor confirmed the caspase-dependent mechanism of LA-UC-induced cell death. Additionally, LA-UC elevated mitochondrial ROS levels, leading to mitochondrial membrane disruption, upregulation of pro-apoptotic proteins, and DNA damage in melanoma cells. The ROS scavenger N-acetylcysteine reduced LA-UC-induced mitochondrial ROS accumulation, mitochondrial membrane disruption, DNA damage, and apoptosis. Collectively, these findings suggest that LA-UC induces G2/M cell cycle arrest and caspase-dependent apoptosis in B16F10 cells through excessive mitochondrial ROS generation, membrane impairment, and DNA damage, highlighting its potential as a promising therapeutic candidate for melanoma treatment.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triglochin maritima Extracts Exert Anti-Melanogenic Properties via the CREB/MAPK Pathway in B16F10 Cells. 三叶甘油三酯提取物通过CREB/MAPK途径在B16F10细胞中发挥抗黑素生成的作用。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-27 DOI: 10.3390/md22120532

Won-Hwi Lee, Yuna Ha, Jeong-In Park, Won Bae Joh, Mira Park, Jang Kyun Kim, Hee-Kyung Jeon, Youn-Jung Kim

{"title":"Triglochin maritima Extracts Exert Anti-Melanogenic Properties via the CREB/MAPK Pathway in B16F10 Cells.","authors":"Won-Hwi Lee, Yuna Ha, Jeong-In Park, Won Bae Joh, Mira Park, Jang Kyun Kim, Hee-Kyung Jeon, Youn-Jung Kim","doi":"10.3390/md22120532","DOIUrl":"10.3390/md22120532","url":null,"abstract":"Triglochin maritima, a salt-tolerant plant, has demonstrated antioxidant effects, the ability to prevent prostate enlargement, antifungal properties, and skin moisturizing benefits. This study aimed to explore the anti-melanogenic potential of the 70% ethanol extract of T. maritima (TME) along with its ethyl acetate (TME-EA) and water (TME-A) fractions. TME (10-200 µg/mL), TME-EA (1-15 µg/mL), and TME-A (100-1000 µg/mL) were prepared and applied to B16F10 cells with or without α-MSH for 72 h. MTT assays were used to assess cytotoxicity, and anti-melanogenesis activity was determined by measuring melanin content, conducting a tyrosinase activity assay, and evaluating the expression of melanogenesis-related genes and proteins via RT-PCR and Western blotting. HPLC-PDA was used to analyze TME and TME-EA. The IC20 cytotoxicity values of TME, TME-A, and TME-EA without α-MSH, were 198.426 μg/mL, 1000 μg/mL, and 18.403 μg/mL, respectively. TME and TME-EA significantly decreased melanin and tyrosinase activity in α-MSH-stimulated B16F10 cells, with TME-EA showing comparable effects to arbutin, while TME-A showed no influence. TME-EA down-regulated melanogenesis genes (Tyr, Trp1, Dct, Mitf, Mc1r) and reduced CREB, p-38, and JNK phosphorylation while increasing ERK phosphorylation, suggesting the CREB/MAPK pathway's role in the anti-melanogenic effect. Luteolin was identified as a potential active ingredient. TME-EA may serve as an effective cosmeceutical for hyperpigmentation improvement due to its anti-melanogenic properties.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment. 河豚毒素：表征、检测、生物合成和转运富集的最新进展。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-26 DOI: 10.3390/md22120531

Xinxin Zhang, Kun Qiao, Ruimin Cui, Min Xu, Shuilin Cai, Qilin Huang, Zhiyu Liu

引用次数: 0

Impact of Ultrasound- and Microwave-Assisted Extraction on Bioactive Compounds and Biological Activities of Jania rubens and Sargassum muticum. 超声和微波辅助提取对红草和马尾藻生物活性成分及生物活性的影响。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-25 DOI: 10.3390/md22120530

Kahina Hamamouche, Zoubida Elhadj, Latifa Khattabi, Wafa Zahnit, Brahim Djemoui, Omar Kharoubi, Walid Boussebaa, Mouhamed Bouderballa, Mohammed El Moustapha Kallouche, Sabry M Attia, Sheikh F Ahmad, Maria Atanassova, Mohammed Messaoudi

{"title":"Impact of Ultrasound- and Microwave-Assisted Extraction on Bioactive Compounds and Biological Activities of Jania rubens and Sargassum muticum.","authors":"Kahina Hamamouche, Zoubida Elhadj, Latifa Khattabi, Wafa Zahnit, Brahim Djemoui, Omar Kharoubi, Walid Boussebaa, Mouhamed Bouderballa, Mohammed El Moustapha Kallouche, Sabry M Attia, Sheikh F Ahmad, Maria Atanassova, Mohammed Messaoudi","doi":"10.3390/md22120530","DOIUrl":"10.3390/md22120530","url":null,"abstract":"This study represents the first investigation into the ultrasonic and microwave extraction of bioactive metabolites from Jania rubens (J. rubens) (red seaweed) and Sargassum. muticum (S. muticum) (brown seaweed), with a focus on their biological activities. The research compares ultrasound-assisted extraction (UAE) with microwave-assisted extraction (MAE) utilizing a hydromethanolic solvent to evaluate their effects on these seaweeds' bioactive compounds and biological activities. The assessment included a series of antioxidant essays: DPPH, ABTS, phenanthroline, and total antioxidant capacity, followed by enzyme inhibition activities: alpha-amylase and urease. Results revealed significant proportions of phenolic compounds, ranging from 48.31 ± 0.32 to 74.42 ± 0.80 μg GAE/mg, depending on the extraction method. The extracts demonstrated a high antioxidant activity, with IC50 values ranging from 26.58 ± 0.39 to 87.55 ± 0.69 μg/mL. Notably, the MAE extract of S. muticum showed a value of 48.11 ± 2.75 μg/mL for alpha-amylase inhibition, which is strictly superior to the reference acarbose with an IC50 equal to 3431.01 μg/mL. UPLC-ESI-MS/MS analysis identified 14 bioactive compounds. The proportion of riboflavin with MAE was 70.58% and 59.11% for J. rubens and S. muticum fractions, respectively. These findings underscore the critical influence of extraction technique selection on bioactive compounds' yield and efficiency, highlighting the potential of algal biomass as a sustainable alternative in various applications.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11679299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis. 低聚岩藻糖聚糖缓解腹膜透析相关纤维化的治疗潜力。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-25 DOI: 10.3390/md22120529

Yu-Wei Chen, Mei-Yi Wu, Nai-Jen Huang, Mai-Szu Wu, Yung-Ho Hsu, Chia-Te Liao, Cheng-Hsien Chen

{"title":"Therapeutic Potential of Oligo-Fucoidan in Mitigating Peritoneal Dialysis-Associated Fibrosis.","authors":"Yu-Wei Chen, Mei-Yi Wu, Nai-Jen Huang, Mai-Szu Wu, Yung-Ho Hsu, Chia-Te Liao, Cheng-Hsien Chen","doi":"10.3390/md22120529","DOIUrl":"10.3390/md22120529","url":null,"abstract":"Peritoneal dialysis (PD) serves as a home-based kidney replacement therapy with increasing utilization across the globe. However, long-term use of high-glucose-based PD solution incites repeated peritoneal injury and inevitable peritoneal fibrosis, thus compromising treatment efficacy and resulting in ultrafiltration failure eventually. In the present study, we utilized human mesothelial MeT-5A cells for the in vitro experiments and a PD mouse model for in vivo validation to study the pathophysiological mechanisms underneath PD-associated peritoneal fibrosis. High-glucose PD solution (Dianeal 4.25%, Baxter) increased protein expression of mesothelial-mesenchymal transition (MMT) markers, such as N-cadherin and α-SMA in MeT-5A cells, whereas it decreased catalase expression and stimulated the production of reactive oxygen species (ROS). Furthermore, macrophage influx and increased serum pro-inflammatory cytokines, such as IL-1β, MCP-1, and TNF-α, were observed in the PD mouse model. Interestingly, we discovered that oligo-fucoidan, an oligosaccharide extract from brown seaweed, successfully prevented PD-associated peritoneal thickening and fibrosis through antioxidant effect, downregulation of MMT markers, and attenuation of peritoneal and systemic inflammation. Hence, oligo-fucoidan has the potential to be developed into a novel preventive strategy for PD-associated peritoneal fibrosis.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Obesity Effects of Sulphated Polysaccharides Derived from Marine Macro Algae or Seaweeds: A Systematic Review and Meta-Analysis. 从海洋大型藻类或海藻中提取的硫酸多糖的抗肥胖作用：系统综述和meta分析。

IF 4.9 2区医学

Marine Drugs Pub Date : 2024-11-25 DOI: 10.3390/md22120528

S'thandiwe Nozibusiso Magwaza, Vunene Nkateko Chabalala, Nothando Philile Hlongwane, Huda Ismail, Md Shahidul Islam

{"title":"Anti-Obesity Effects of Sulphated Polysaccharides Derived from Marine Macro Algae or Seaweeds: A Systematic Review and Meta-Analysis.","authors":"S'thandiwe Nozibusiso Magwaza, Vunene Nkateko Chabalala, Nothando Philile Hlongwane, Huda Ismail, Md Shahidul Islam","doi":"10.3390/md22120528","DOIUrl":"10.3390/md22120528","url":null,"abstract":"Sulphated polysaccharides (SPs) are negatively charged compounds found in the cell wall of seaweeds or marine macro algae. These compounds exhibit a range of pharmacological activities, including anti-obesity effects. The aim of this systematic review as well as meta-analysis was to assess the potentials of seaweed-derived SPs to mitigate obesity through a systematic review and meta-analysis of animal model-based studies. A comprehensive summary of the included articles was conducted, focusing on the following obesity-related parameters: food intake, body weight gain, epididymal fat size, adipocyte size, liver weight, serum alanine transaminase (ALT) and aspartate transaminase (AST), insulin and tumour necrosis factor-α (TNF-α), and the lipid profile (total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)). The systematic review demonstrated that seaweed-derived SPs exhibit ameliorative effects against obesity, as evidenced by reductions in food intake, body weight gain, epididymal fat and adipocyte size, liver weight, ALT and AST levels, serum insulin and TNF-α, LDL-c, total cholesterol, and triglycerides and an increase in HDL-c in obese rats administered with seaweed-derived SPs. However, the meta-analysis revealed statistically significant anti-obesity effects of seaweed-derived SPs for most, but not all the parameters tested. Further research in human subjects is necessary not only to ascertain the results of preclinical studies but also to provide conclusive evidence of the anti-obesity potential of SPs in humans.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"22 12","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0