Dental Resin Composites Modified with Chitosan: A Systematic Review.

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-05-01 DOI:10.3390/md23050199

Wojciech Dobrzyński, Paweł J Piszko, Jan Kiryk, Sylwia Kiryk, Mateusz Michalak, Agnieszka Kotela, Julia Kensy, Witold Świenc, Natalia Grychowska, Jacek Matys, Maciej Dobrzyński

{"title":"Dental Resin Composites Modified with Chitosan: A Systematic Review.","authors":"Wojciech Dobrzyński, Paweł J Piszko, Jan Kiryk, Sylwia Kiryk, Mateusz Michalak, Agnieszka Kotela, Julia Kensy, Witold Świenc, Natalia Grychowska, Jacek Matys, Maciej Dobrzyński","doi":"10.3390/md23050199","DOIUrl":null,"url":null,"abstract":"Objective: This systematic review aims to evaluate the impact of incorporating chitosan into dental resin composites on their mechanical, antibacterial, and physicochemical properties.Methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in March 2025 using the following keywords: resin, composite, and chitosan. The inclusion criteria comprised in vitro studies in dentistry evaluating chitosan as a composite additive with full-text availability in English. Data extraction and quality assessment were performed independently by multiple reviewers using standardized tools, and study quality was assessed based on predefined criteria.Results: Seventeen studies met the inclusion criteria. Chitosan concentrations in the composites ranged from 0.25 wt% to 20 wt%. Antibacterial activity was confirmed in six studies, especially against S. mutans, S. sanguinis, and L. acidophilus. Mechanical properties such as fracture toughness, hardness, and compressive strength were generally improved at lower concentrations of chitosan. However, increased chitosan levels were associated with decreased flexural strength and increased microleakage. Shear bond strength (SBS) was unaffected by chitosan in low concentrations (up to 0.25%), while higher concentrations reduced SBS. Fluoride release capacity was assessed in one study, with no significant differences observed.Conclusion: Chitosan-modified dental resin composites exhibit promising antibacterial and mechanical enhancements at low concentrations. However, higher chitosan levels may compromise certain mechanical and adhesive properties. These findings suggest a need for standardized methodologies and further research on long-term clinical implications and fluoride release.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113295/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Marine Drugs","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/md23050199","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: This systematic review aims to evaluate the impact of incorporating chitosan into dental resin composites on their mechanical, antibacterial, and physicochemical properties.

Methods: A comprehensive search of PubMed, Scopus, and Web of Science databases was conducted in March 2025 using the following keywords: resin, composite, and chitosan. The inclusion criteria comprised in vitro studies in dentistry evaluating chitosan as a composite additive with full-text availability in English. Data extraction and quality assessment were performed independently by multiple reviewers using standardized tools, and study quality was assessed based on predefined criteria.

Results: Seventeen studies met the inclusion criteria. Chitosan concentrations in the composites ranged from 0.25 wt% to 20 wt%. Antibacterial activity was confirmed in six studies, especially against S. mutans, S. sanguinis, and L. acidophilus. Mechanical properties such as fracture toughness, hardness, and compressive strength were generally improved at lower concentrations of chitosan. However, increased chitosan levels were associated with decreased flexural strength and increased microleakage. Shear bond strength (SBS) was unaffected by chitosan in low concentrations (up to 0.25%), while higher concentrations reduced SBS. Fluoride release capacity was assessed in one study, with no significant differences observed.

Conclusion: Chitosan-modified dental resin composites exhibit promising antibacterial and mechanical enhancements at low concentrations. However, higher chitosan levels may compromise certain mechanical and adhesive properties. These findings suggest a need for standardized methodologies and further research on long-term clinical implications and fluoride release.

查看原文本刊更多论文

壳聚糖改性牙用树脂复合材料的系统综述。

目的：研究壳聚糖对牙用树脂复合材料力学性能、抗菌性能和理化性能的影响。方法：于2025年3月综合检索PubMed、Scopus和Web of Science数据库，检索关键词：resin、composite、chitosan。纳入标准包括牙医学中评估壳聚糖作为复合添加剂的体外研究，并提供英文全文。数据提取和质量评估由多名评论者使用标准化工具独立完成，研究质量评估基于预定义的标准。结果：17项研究符合纳入标准。壳聚糖在复合材料中的浓度从0.25 wt%到20 wt%不等。在6项研究中证实了抗菌活性，特别是对变形链球菌、血源链球菌和嗜酸乳杆菌。在较低浓度的壳聚糖下，材料的断裂韧性、硬度和抗压强度等力学性能普遍得到改善。然而，壳聚糖水平的增加与弯曲强度的降低和微渗漏的增加有关。低浓度（0.25%）壳聚糖对剪切键合强度（SBS）无影响，高浓度壳聚糖可降低SBS。一项研究评估了氟化物释放能力，没有观察到显著差异。结论：壳聚糖改性牙用树脂复合材料在低浓度下具有良好的抗菌性能和力学性能。然而，较高的壳聚糖含量可能会损害某些机械和粘合性能。这些发现表明，有必要制定标准化的方法，并进一步研究长期临床影响和氟化物释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.