Marine Drugs最新文献

Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives. nades辅助工艺强化技术在微藻生物活性物可持续回收中的最新进展：挑战与未来展望。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-21 DOI: 10.3390/md24040146

Muhammad Shafiq, Sardar Ali, Liaqat Zeb

{"title":"Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives.","authors":"Muhammad Shafiq, Sardar Ali, Liaqat Zeb","doi":"10.3390/md24040146","DOIUrl":"https://doi.org/10.3390/md24040146","url":null,"abstract":"Microalgae are increasingly recognized as renewable biofactories for producing high-value bioactive molecules. However, their industrial exploitation is limited by their rigid cell walls, metabolite heterogeneity, and the energy-intensive nature of the extraction processes. Recent advances in process-intensification technologies, including microwave-assisted, ultrasound-assisted, enzymatic, pressurized liquid, and supercritical CO2-based methods, have significantly improved extraction efficiency and selectivity, with reported lipid recoveries exceeding 40-50% in some microalgal systems and carotenoid recoveries approaching 90% under optimized conditions. NADES-assisted systems further enhance mass transfer and solubilization through tailored hydrogen-bonding interactions, enabling selective extraction of polar and semi-polar metabolites under mild conditions. However, limitations remain, including high viscosity, variability in extraction performance, and challenges in solvent recovery and scale-up. This review critically evaluates the extraction efficiency, mechanistic basis, and sustainability of NADES-assisted processes, highlighting key limitations and identifying research priorities for their integration into scalable microalgal biorefinery systems.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red Macroalgae as Sources of Antioxidant and Multifunctional Ingredients for Functional Foods: A Biorefinery Approach. 红藻作为功能性食品中抗氧化和多功能成分的来源：生物精炼方法。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-21 DOI: 10.3390/md24040145

Nuno Nunes, Emmanuel Nunes, Kilian Odenthal, Miguel Â A Pinheiro de Carvalho

{"title":"Red Macroalgae as Sources of Antioxidant and Multifunctional Ingredients for Functional Foods: A Biorefinery Approach.","authors":"Nuno Nunes, Emmanuel Nunes, Kilian Odenthal, Miguel Â A Pinheiro de Carvalho","doi":"10.3390/md24040145","DOIUrl":"https://doi.org/10.3390/md24040145","url":null,"abstract":"Given the established interplay between oxidative stress, cholinergic dysfunction, and metabolic imbalance in cognitive decline, this study investigated the multifunctional potential of three red macroalgae from the Madeira Archipelago (Asparagopsis taxiformis, Grateloupia lanceola, and Nemalion elminthoides) using a sequential biorefinery approach. Marine algae represent a sustainable source of functional food ingredients due to their rich content in bioactive compounds and their compatibility with low-impact production systems. Protein, ethanolic (phenolic-rich), and polysaccharide fractions were obtained through direct extraction and scalable biorefinery processing. Antioxidant activity was evaluated using ORAC, DPPH, FRAP, and FIC assays, while functionality relevant to human health was assessed through acetylcholinesterase, butyrylcholinesterase, and α-glucosidase inhibition. Protein extracts, particularly from N. elminthoides, exhibited strong hydrogen atom transfer-based antioxidant capacity, whereas ethanolic extracts demonstrated multifunctional activity, combining radical scavenging, metal chelation, and enzyme inhibition associated with neuroprotective and glycemic-regulation potential. Polysaccharide fractions contributed mainly to iron chelation and reducing capacity. Correlation analyses highlighted the complementary nature of antioxidant and bioactivity assays. Overall, these findings support the potential of Madeira red macroalgae as functional food ingredients and emphasize the importance of optimized biorefinery strategies to maximize nutritional and health-related benefits.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced DHA Production in Aurantiochytrium by ω-3 Desaturase Integration and Fatty Acid Synthase Disruption. ω-3去饱和酶整合和脂肪酸合成酶破坏提高金钇的DHA产量。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-20 DOI: 10.3390/md24040144

Ziyu Wang, Yujian Wang, Weijian Wan, Chao Chen, Wen Wen, Xiaojin Song, Jinsong Xuan, Yingang Feng

{"title":"Enhanced DHA Production in Aurantiochytrium by ω-3 Desaturase Integration and Fatty Acid Synthase Disruption.","authors":"Ziyu Wang, Yujian Wang, Weijian Wan, Chao Chen, Wen Wen, Xiaojin Song, Jinsong Xuan, Yingang Feng","doi":"10.3390/md24040144","DOIUrl":"https://doi.org/10.3390/md24040144","url":null,"abstract":"Docosahexaenoic acid (DHA) is an essential ω-3 polyunsaturated fatty acid (PUFA) with high nutritional and pharmaceutical value. The marine protist Aurantiochytrium is a promising industrial DHA producer; however, its DHA biosynthesis via the PUFA synthase pathway co-produces ω-6 docosapentaenoic acid (DPA), limiting DHA purity. Here, we introduced an ω-3 desaturase from Phytophthora infestans (Pin-O3D) into Aurantiochytrium sp. SD116. Functional validation in an Escherichia coli system co-expressing the native PUFA synthase confirmed that Pin-O3D converts DPA to DHA, shifting the DHA/DPA ratio from 1:1 to 2:1. Pin-O3D was then integrated into the fatty acid synthase (FAS) locus, simultaneously attenuating FAS activity and enabling heterologous gene expression. The engineered strain ΔFAS-Pin-O3D exhibited significantly (p < 0.0001 in t-test) increased DHA content (55.2% of total fatty acids) and DHA/DPA ratio (5.91) in shake flasks, with no negative impact on biomass or lipid accumulation. Fed-batch fermentation confirmed the scalability of this strategy, achieving a >20% increase in DHA/DPA ratio. This study demonstrates that combining heterologous ω-3 desaturase expression with FAS attenuation is an effective approach for optimizing PUFA profiles in Aurantiochytrium.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Bioactives for Functional Cosmetics with Health-Promoting Properties. 促进健康的功能性化妆品中的海洋生物活性物质。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-19 DOI: 10.3390/md24040143

Alexandros Tsoupras

引用次数: 0

Reinforcement of Thermo-Compressed Sodium Alginate Films with Calcium Alginate Powder. 海藻酸钙粉增强热压海藻酸钠薄膜。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-17 DOI: 10.3390/md24040142

Prasong Srihanam, Wilaiwan Simchuer, Vanseng Chounlamany, Kesiny Phomkeona, Phengxay Deevanhxay, Yodthong Baimark

{"title":"Reinforcement of Thermo-Compressed Sodium Alginate Films with Calcium Alginate Powder.","authors":"Prasong Srihanam, Wilaiwan Simchuer, Vanseng Chounlamany, Kesiny Phomkeona, Phengxay Deevanhxay, Yodthong Baimark","doi":"10.3390/md24040142","DOIUrl":"https://doi.org/10.3390/md24040142","url":null,"abstract":"Alginate is a biocompatible and biodegradable polymer derived from seaweed. It has been extensively researched and developed for various applications. However, its poor mechanical properties present a significant drawback that limits its use in multiple fields. Furthermore, the fabrication of reinforced alginate films using conventional melt processing has the potential for scaling up production. This study aimed to enhance the mechanical properties of sodium alginate (SA) films by incorporating calcium alginate (CA) powder. The SA/CA biocomposite films were created using a thermo-compression technique, with glycerol acting as a plasticizer for the SA matrix. Various CA contents-2.5, 5, 10, and 20 wt%-were investigated. Scanning electron microscopy and energy dispersive spectroscopy revealed good interfacial adhesion between the SA film matrix and the CA powder. As the CA content increased, the moisture content of SA/CA biocomposite films decreased. The addition of CA powder significantly improved the tensile properties of the SA films. Based on the tensile test, SA/CA biocomposite films with 20 wt% CA powder exhibited a maximum tensile strength of 11.7 MPa and a Young's modulus of 234.7 MPa. These results indicate a substantial increase of 208% in maximum tensile strength and 907% in Young's modulus compared to SA films without CA. These findings indicated that the CA powder serves as an effective reinforcing filler for thermo-compressed SA films, which could lead to the development of high-strength alginate-based products for potential use in various applications, including biomedical, agricultural, and packaging applications.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultivation of Limnospira platensis (Spirulina) in Full Seawater with Medium Recycling: A Promising Source of Protein and Phycocyanin for Arid Coastal Regions. 在介质循环的全海水中培养螺旋藻：干旱沿海地区蛋白质和藻蓝蛋白的一个有前途的来源。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-16 DOI: 10.3390/md24040141

Monserrat Alemán, Marianna Venuleo, Juan Luis Gómez-Pinchetti, Eduardo Portillo, Flavio Guidi

{"title":"Cultivation of Limnospira platensis (Spirulina) in Full Seawater with Medium Recycling: A Promising Source of Protein and Phycocyanin for Arid Coastal Regions.","authors":"Monserrat Alemán, Marianna Venuleo, Juan Luis Gómez-Pinchetti, Eduardo Portillo, Flavio Guidi","doi":"10.3390/md24040141","DOIUrl":"https://doi.org/10.3390/md24040141","url":null,"abstract":"Protein and phycocyanin production is challenged by freshwater scarcity in arid coastal regions. This study assessed and optimized the cultivation of Limnospira platensis BEA 1257B in full seawater. Eight cultivation phases were conducted in 10,000 L raceways under a greenhouse to evaluate the effects of seawater content, nutrient availability, shading, CO2 supply, and medium recycling on biomass productivity and biochemical composition. Freshwater, energy, and fertilizer savings, together with effluent characteristics of the optimized full-seawater recirculation strategy (SWR), were evaluated against a conventional freshwater cultivation process. Lower productivity was associated with high salinity and irradiance. Under long-term optimized conditions (615 days), the strain achieved stable productivities of 4.1 ± 1.4 gDW m-2 day-1 (14.8 ± 5.0 tDW ha-1 year-1). Increasing salinity promoted carbohydrate accumulation in the biomass (26.0% AFWD), while protein (64.4%) and C-phycocyanin (9.9%) moderately decreased. Nevertheless, protein quality, phycocyanin, and essential fatty acids remained high. Spray-dried biomass exhibited nutritionally relevant contents of K, Mg, Ca, Fe, and Mn, and complied with international food safety standards. SWR reduced energy demand by 10.5% and freshwater consumption by 12% on a surface basis, although these advantages were partially offset when expressed per unit of product, while clearly supporting environmentally sustainable and regulatory-compliant Limnospira production.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Peptides from Skipjack tuna: Ameliorate Function on Cigarette Smoke Extract-Induced COPD in Cell Model by Targeting Oxidative Stress, Inflammation and Apoptosis. 鲣鱼抗氧化肽：通过靶向氧化应激、炎症和细胞凋亡改善香烟烟雾提取物诱导的COPD细胞模型的功能

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-16 DOI: 10.3390/md24040140

Yu-Hui Zeng, Yang-Yan Jin, Yan Sheng, Chang-Feng Chi, Bin Wang

{"title":"Antioxidant Peptides from Skipjack tuna: Ameliorate Function on Cigarette Smoke Extract-Induced COPD in Cell Model by Targeting Oxidative Stress, Inflammation and Apoptosis.","authors":"Yu-Hui Zeng, Yang-Yan Jin, Yan Sheng, Chang-Feng Chi, Bin Wang","doi":"10.3390/md24040140","DOIUrl":"https://doi.org/10.3390/md24040140","url":null,"abstract":"Antioxidant peptides show significant activity and can be developed into functional foods for treating chronic diseases. Cigarette smoke components can cause damage or even apoptosis of lung cells, eventually leading to chronic lung diseases. Therefore, this study aimed to investigate the protective effects and mechanisms of Skipjack tuna peptides against in vitro cigarette smoke extract (CSE)-induced chronic obstructive pulmonary disease (COPD). The results demonstrated that tuna peptides DVGRG (S1), PHPR (S5), GRVPR (S6), and SVTEV (S7) significantly enhanced the activities of SOD, CAT, and GSH-Px by upregulating the mRNA transcription levels of Keap1 and Nrf2, consequently reducing ROS and MDA levels in CSE-induced COPD model of MLE-12 cells. Molecular docking analysis revealed that S1, S6, and S7 competitively inhibited the Keap1-Nrf2 interaction by binding to the Kelch domain of Keap1, whereas S5 operated through a non-competitive mechanism. These peptides also downregulated p65 mRNA expression and upregulated IκBα mRNA expression, leading to a significant reduction in inflammatory cytokines of IL-1β, IL-6, and TNF-α, thereby alleviating inflammatory responses. Furthermore, these peptides significantly inhibited CSE-induced apoptosis by restoring mitochondrial membrane potential and upregulating the Bcl-2/Bax ratio. Additionally, S1, S5, S6, and S7 promoted MLE-12 cell migration in a concentration-dependent manner, suggesting a role in lung epithelial repair and regeneration. In conclusion, tuna peptides S1, S5, S6, and S7 exert antioxidant, anti-inflammatory, anti-apoptotic, and cell migration-promoting effects through the regulation of the Keap1/Nrf2 and NF-κB signaling pathways, as well as Bcl-2/Bax apoptotic balance, providing a promising strategy for mitigating CSE-induced lung injury.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Bioactives in Liver Aging: Mechanistic Insights and Translational Potential. 海洋生物活性在肝脏老化：机制的见解和转化潜力。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-15 DOI: 10.3390/md24040138

Ricardo Moreno Traspas, Zachariah Tman

{"title":"Marine Bioactives in Liver Aging: Mechanistic Insights and Translational Potential.","authors":"Ricardo Moreno Traspas, Zachariah Tman","doi":"10.3390/md24040138","DOIUrl":"https://doi.org/10.3390/md24040138","url":null,"abstract":"The liver is a central regulator of systemic metabolism and exhibits exceptional regenerative capacity, yet aging progressively impairs hepatic resilience through metabolic dysregulation, mitochondrial dysfunction, epigenetic instability, and chronic inflammation. Marine ecosystems constitute a vast and underexplored source of structurally diverse bioactive compounds that have evolved to modulate conserved stress response and homeostatic pathways. This review synthesizes current preclinical evidence demonstrating how marine-derived metabolites target key molecular axes implicated in liver aging, including energy sensing, redox balance, mitochondrial quality control, inflammatory signaling, and chromatin-associated regulation. Rather than focusing solely on isolated hepatoprotective effects, we frame marine bioactives within an aging biology perspective, highlighting their ability to modulate pathways associated with cellular plasticity and resilience. We further propose that this mechanistic convergence provides a theoretical framework for exploring marine compounds as potential adjunctive modulators within emerging, experimental liver rejuvenation strategies, including partial cellular reprogramming approaches that require coordinated metabolic and epigenetic control. While acknowledging that direct reversal of liver aging remains to be clinically established, integrating marine chemodiversity with contemporary aging and regenerative biology outlines a conceptual roadmap for developing liver-directed interventions targeting aging-related vulnerability as a fundamental driver of disease.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an Integrated Screening Framework for Marine-Derived Bacillus Probiotics. 海洋源益生菌芽孢杆菌综合筛选框架的建立。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-15 DOI: 10.3390/md24040137

Yaoying Lu, Xiaojing Chen, Yunjiang Feng

{"title":"Development of an Integrated Screening Framework for Marine-Derived Bacillus Probiotics.","authors":"Yaoying Lu, Xiaojing Chen, Yunjiang Feng","doi":"10.3390/md24040137","DOIUrl":"https://doi.org/10.3390/md24040137","url":null,"abstract":"Probiotics are known to improve gut microbiota balance, enhance food digestion, and support overall health. Among these, Bacillus species are particularly promising due to their safety, spore-forming ability, environmental resilience, and diverse enzymatic activities. However, most Bacillus probiotics used in industry are of terrestrial origin, leaving marine-derived strains largely unexplored. Utilising the untapped potential of marine microbial biomass, this study presents a multi-stage methodology for identifying and evaluating marine-derived Bacillus strains with probiotic potential. A structured screening pipeline was applied to 67 microbial isolates from the Great Barrier Reef sponges. Initial selection focused on essential probiotic characteristics, including growth, stability, safety, and survival under gastrointestinal conditions. Strains meeting these criteria were then assessed for desirable properties, including digestive enzyme production and pathogen inhibition. Using this workflow, three marine-derived Bacillus strains were identified as potential probiotics, one of which demonstrated strong antimicrobial activity against Salmonella enterica at 5 and 10 mg/mL (p < 0.01). These findings demonstrate the capability of marine-associated Bacillus as novel bioproducts with functional antimicrobial properties.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Omega-3 Fatty Acids from Marine Source Supplements and Enhanced Food Effects on Children's Development, Neurological and Metabolic Disorders and General Health. 海洋来源的Omega-3脂肪酸补充剂和增强食物对儿童发育、神经和代谢紊乱以及一般健康的影响的综述。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-15 DOI: 10.3390/md24040139

Maria Dimopoulou, Stavroula Savvidi, Panagiotis Madesis, Aliki Dimopoulou, Dimitrios Stagos, Olga Gortzi

{"title":"A Review of Omega-3 Fatty Acids from Marine Source Supplements and Enhanced Food Effects on Children's Development, Neurological and Metabolic Disorders and General Health.","authors":"Maria Dimopoulou, Stavroula Savvidi, Panagiotis Madesis, Aliki Dimopoulou, Dimitrios Stagos, Olga Gortzi","doi":"10.3390/md24040139","DOIUrl":"https://doi.org/10.3390/md24040139","url":null,"abstract":"Long-chain polyunsaturated fatty acids (LC-PUFAs) of omega-3 family, particularly docosahexaenoic acid and eicosapentaenoic acid, are essential nutrients that play a critical role in children's growth and health. This review examines the evidence on the effects of omega-3 supplements and omega-3-enhanced foods on children's development, as well as on neurological and metabolic disorders. Research consistently highlights the importance of DHA in brain and visual development, especially during early childhood, when rapid neural growth occurs. PubMed, Web of Science, Scopus and the Cochrane Library databases were searched for relevant articles published up to January 2026. Adequate omega-3 intake has been associated with improvements in cognitive performance, attention, and learning outcomes. In children with neurodevelopmental conditions such as attention-deficit/hyperactivity disorder and autism spectrum disorder, omega-3 supplementation shows modest but potential benefits in reducing behavioral symptoms and supporting executive function, although results remain mixed. Additionally, omega-3 fatty acids exhibit anti-inflammatory properties that may positively influence metabolic health, including lipid profiles, insulin sensitivity, and obesity-related risk factors in children. Omega-3-enhanced foods provide an alternative to supplements and may improve adherence and overall dietary quality. However, variability in dosage, study design, and baseline nutritional status limits definitive conclusions. Overall, omega-3 fatty acids appear to support healthy development and may aid in managing certain neurological and metabolic disorders in children.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0