Marine Drugs最新文献

Meat Nutritional Value and Exoskeleton Valorisation of Callinectes sapidus from Three Sites of Biological and Ecological Interest in Morocco: Scientific Insights Toward a Management Strategy in the Mediterranean Sea. 肉类营养价值和外骨骼的价值，从摩洛哥的三个地点的生物和生态利益：对地中海管理策略的科学见解。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-21 DOI: 10.3390/md23090367

Kamal Gourari, Youness Mabrouki, Abdelkhaleq Fouzi Taybi, Abdessadek Essadek, Valentina Tanduo, Fabio Crocetta, Ilyesse Rahhou, Chaouki Belbachir, Lucia Rizzo, Bouchra Legssyer

{"title":"Meat Nutritional Value and Exoskeleton Valorisation of Callinectes sapidus from Three Sites of Biological and Ecological Interest in Morocco: Scientific Insights Toward a Management Strategy in the Mediterranean Sea.","authors":"Kamal Gourari, Youness Mabrouki, Abdelkhaleq Fouzi Taybi, Abdessadek Essadek, Valentina Tanduo, Fabio Crocetta, Ilyesse Rahhou, Chaouki Belbachir, Lucia Rizzo, Bouchra Legssyer","doi":"10.3390/md23090367","DOIUrl":"https://doi.org/10.3390/md23090367","url":null,"abstract":"Biological invasions threaten biodiversity worldwide. The American blue crab Callinectes sapidus Rathbun, 1896, among the Mediterranean's most damaging invaders, takes up the challenge to transform this threat into gain. To turn its impact into economic value and guide control efforts, we analysed separately the meat composition and exoskeleton biopolymers of adult crabs from three Moroccan protected Sites of Biological and Ecological Interest: Marchica Lagoon (S1), Moulouya Estuary (S2), and Al Hoceima National Park (S3). Marchica specimens exhibited the highest protein content (21.87 ± 1.15 g 100 g-1, p < 0.001) and an elevated lipid fraction, yielding nutrient-dense meat suitable for premium markets. Moulouya crabs were noted for their taste potential, with a higher concentration of fat (1.73 ± 0.09%) and carbohydrates (0.91 ± 0.1%). Al Hoceima individuals displayed markedly mineralised exoskeletons producing lean and low-fat meat, valued in dietary applications. Exoskeleton organic-to-mineral (OM/MM) ratios and proximate composition revealed three adaptive profiles, opportunistic (S1), acclimatory (S2), and conservative (S3), presumably correlated to local salinity, productivity, and substrate conditions, underscoring the species' phenotypic plasticity. X-ray diffraction confirmed the α-chitin polymorph, while FTIR analysis indicated degrees of deacetylation consistent with high-purity chitosan. These findings support the development of a site-specific circular economy framework and may contribute to the ecological resilience of Morocco's protected coastal areas.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities. 具有抗癌活性的海洋类维甲酸X受体-α拮抗剂苯并噻唑衍生物的合成及生物学评价

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-21 DOI: 10.3390/md23090368

Yingting Lin, Ming Peng, Renjing Yang, Guanghui Wang, Junjie Chen, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen

{"title":"Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities.","authors":"Yingting Lin, Ming Peng, Renjing Yang, Guanghui Wang, Junjie Chen, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen","doi":"10.3390/md23090368","DOIUrl":"10.3390/md23090368","url":null,"abstract":"Retinoid X receptor α (RXRα) plays a vital role in multiple biological and pathological processes and represents a promising therapeutic target for anti-tumor drug design. Inspired by the marine-derived RXRα antagonist meroterpenthiazole A, 21 undescribed benzothiazole derivatives were designed and synthesized. The inhibitory effects of 21 derivatives on RXRα transactivation and their anti-tumor activities against MDA-MB-231 cells were evaluated. Compounds 4a-4h, 6a-6b, 7c-7f, and 7h-7i inhibited 9-cis-retinoic acid-induced RXRα transactivation, while compounds 3b, 4f-4h, 7a, 7c, 7f, and 7h-7i exhibited inhibitory effects on the proliferation of MDA-MB-231 cells. Meanwhile, the structure-activity relationships governing both the RXRα antagonist effects and the anti-proliferative activities against MDA-MB-231 cells were discussed. Compound 7i exhibited the most potent inhibitory effects on the proliferation of MDA-MB-231 cells with an IC50 value of 16.5 μM. Further mechanism studies revealed that compound 7i induced G2/M phase arrest in MDA-MB-231 cells, accompanied by dose-dependent downregulation of Cyclin B1 and CDK1 protein expression. However, these effects were abolished in RXRα-knockout MDA-MB-231 cells, indicating that the anti-proliferative and cell cycle arrest activities of 7i were RXRα-dependent. Cellular Thermal Shift Assay (CETSA) and molecular docking studies further confirmed that 7i directly bound to RXRα, thereby mediating its anti-cancer efficacy.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid-like Structures in Marine Adhesive Proteins. 海洋黏附蛋白中的淀粉样结构。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090363

Mariana Rodrigues Santos, Bárbara Joana Henriques, Romana Santos

引用次数: 0

Enhancing Phycoerythrin Production of Marine Red Microalga Porphyridium purpureum with Low Salinity and Semi-Continuous Culture Strategy. 低盐半连续培养提高海洋红微藻紫卟啉的藻红蛋白产量

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090361

Chulin Li, Houbo Wu, Hualian Wu, Wenzhou Xiang, Jin Xu, Tao Li

{"title":"Enhancing Phycoerythrin Production of Marine Red Microalga Porphyridium purpureum with Low Salinity and Semi-Continuous Culture Strategy.","authors":"Chulin Li, Houbo Wu, Hualian Wu, Wenzhou Xiang, Jin Xu, Tao Li","doi":"10.3390/md23090361","DOIUrl":"10.3390/md23090361","url":null,"abstract":"Porphyridium purpureum can synthesize a high phycoerythrin content, which has strong potential application in nutrition, pharmaceuticals, and cosmetics. An effective culture strategy is the key to producing biomass of P. purpureum rich in phycoerythrin. However, there are still bottlenecks in the large-scale production of Porphyridium, such as nutrient supplementation and cultivation mode. In this study, P. purpureum SCS-02, isolated from the South China Sea, was used as experimental microalga strain. The effects of different salinity (10, 20 and 34 ppt) and semi-continuous culture on accumulation of biomass and phycoerythrin were investigated. The semi-continuous culture modes include recycled culture medium mode (RM) and fresh culture medium mode (FM). The results showed that low salinity (10 ppt) could enhance the accumulation of phycoerythrin, the content and yield of which were 8.39% DW and 160 mg L-1, respectively. The yield of phycoerythrin of P. purpureum in semi-continuous culture with a 30% renewal rate of fresh culture medium was 253% higher than the batch culture. In summary, the semi-continuous culture strategy with fresh medium renewal under low salinity conditions increased the phycoerythrin yield to 641.47 mg after 30 days of cultivation, while exopolysaccharide accumulation was significantly reduced compared with batch culture. These results provide useful reference for optimizing culture strategies of P. purpureum, and may serve as a basis for future attempts to scale phycoerythrin production under industrially relevant conditions.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy. 新型ph响应pss负载壳聚糖基质纳米颗粒改善压力过载诱导的心肌肥厚。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090365

Meijie Xu, Zhen Fan, Dingfu Wang, Dan Li, Haimiao Zou, Yiting Xue, Shixin Wang, Chunxia Li

{"title":"Novel pH-Responsive PSS-Loaded Chitosan Matrix Nanoparticles Ameliorate Pressure Overload-Induced Cardiac Hypertrophy.","authors":"Meijie Xu, Zhen Fan, Dingfu Wang, Dan Li, Haimiao Zou, Yiting Xue, Shixin Wang, Chunxia Li","doi":"10.3390/md23090365","DOIUrl":"10.3390/md23090365","url":null,"abstract":"Cardiac hypertrophy is a critical contributor to cardiac dysfunction and the development of heart failure, yet effective therapeutic strategies remain limited. Propylene glycol alginate sulfate sodium (PSS) is a marine sulfated polysaccharide drug used in the treatment of cardiovascular diseases and has shown cardiac function benefits. Here, we designed a pH-responsive PSS-loaded nanoparticle drug delivery system. It was self-assembled by negatively charged PSS with positively charged trimethyl chitosan glycocholic acid (TMC-GA) via electrostatic interaction, and further stabilized the nanoparticles with Hydroxypropyl methylcellulose phthalate (HP55) excipients. The prepared TMC-GA/HP55@PSS nanoparticles were spherical, with a mean particle size of 361.5 ± 1.26 nm, zeta potential of -30.3 ± 0.9 mV, and encapsulation efficiency of 92.52 ± 2.4%. In vitro release study demonstrated the pH-responsive property of TMC-GA/HP55@PSS under intestinal conditions and facilitated nanoparticles absorption in the intestinal epithelium. In vitro experiments confirmed the biocompatibility of PSS and its ability to improve myocardial cell hypertrophy. In vivo, both PSS and its nanoparticles significantly ameliorated pressure overload-induced cardiac hypertrophy in mice, with TMC-GA/HP55@PSS exhibiting better cardioprotective efficacy. This study is the first to integrate pH-responsiveness and bile acid transport-mediated uptake into PSS nanocarrier systems. The findings provide valuable data and enlightenment for designing novel formulations and expanding the clinical applications of PSS.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction of Marine Bioactive Compounds from Seaweed: Coupling Environmental Concerns and High Yields. 从海藻中提取海洋生物活性化合物：兼顾环境问题和高产率。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090366

Carlos Cardoso, Joana Matos, Cláudia Afonso

{"title":"Extraction of Marine Bioactive Compounds from Seaweed: Coupling Environmental Concerns and High Yields.","authors":"Carlos Cardoso, Joana Matos, Cláudia Afonso","doi":"10.3390/md23090366","DOIUrl":"10.3390/md23090366","url":null,"abstract":"This review examines recent advances in the extraction of valuable compounds from seaweed biomass, focusing on practical feasibility and environmental sustainability. There is a growing importance of seaweed biomass in terms of the study and acknowledgment of its untapped biotechnological potential (multiple compounds and biological activities) and in terms of economic impact. Conventional extraction techniques largely fail to address this challenge, even if optimized. This has led to the development and testing of innovative technologies as solutions for a 'green' and effective extraction of components from seaweed biomass and to biorefinery processes. There are large differences in outcomes between alternative processes, depending on the matrix, operational parameters, and targeted compounds and activities. Despite the positive results of some techniques, such as those based on physical mechanisms, namely Microwave-Assisted Extraction (MAE) and Ultrasound-Assisted Extraction (UAE), and on enzymatic selectivity, i.e., Enzyme-Assisted Extraction (EAE), there is no universally effective technique and approach, thus justifying integrated approaches combining different techniques. The application of 'green' solvents was also assessed and proven to harbor a large potential, just as the wet route. Although technical difficulties, outcome variability, and economic viability problems are relevant, recent progress in seaweed processing paves the way for a future blue economy.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Precipitated Extracellular Marennine on Angiogenesis and Tumour Cell Proliferation. 沉淀的胞外马林碱对血管生成和肿瘤细胞增殖的影响。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090364

Mostefa Fodil, Javier Muñoz-Garcia, Amel-Khitem Benali, Jasmina Rogozarski, Virginie Mignon, Honora Labrana, Anna Lokajczyk, Pamela Pasetto, Jean-Luc Mouget, Catherine Boisson-Vidal, Dominique Heymann

{"title":"Effect of Precipitated Extracellular Marennine on Angiogenesis and Tumour Cell Proliferation.","authors":"Mostefa Fodil, Javier Muñoz-Garcia, Amel-Khitem Benali, Jasmina Rogozarski, Virginie Mignon, Honora Labrana, Anna Lokajczyk, Pamela Pasetto, Jean-Luc Mouget, Catherine Boisson-Vidal, Dominique Heymann","doi":"10.3390/md23090364","DOIUrl":"10.3390/md23090364","url":null,"abstract":"Angiogenesis is a fundamental biological process involved in the formation of new blood vessels from the pre-existing vascular network. In addition to physiological processes, angiogenesis is also implicated in pathological conditions such as tumour growth and metastatic progression. Research on marennine, a water-soluble blue-green pigment produced by the marine diatom Haslea ostrearia, has highlighted various promising biological activities. In vivo studies have suggested the potential of marennine in cancer treatment. However, these studies were conducted with crude extracts, the exact composition of which remained poorly defined. In this context, our study aimed to explore the effects of marennine on angiogenesis and tumour proliferation by using a Precipitated Extracellular Marennine (PEMn) extract. Our results confirmed the antiproliferative properties of PEMn on several cancer cell lines associated with angiogenic tumours. We then analysed its impact on the key steps of the angiogenic process, including Endothelial Colony-Forming Cells (ECFCs) proliferation, migration, and tubulogenesis. In parallel, we investigated the underlying mechanisms of its action, notably by assessing its effects on cell cycle regulation, senescence, and apoptosis. PEMn significantly inhibited tumour cell proliferation, induced ECFC senescence and apoptosis, impaired migration and tubulogenesis, and downregulated VEGFR-1 expression, highlighting its potential as a novel marine-derived antiangiogenic compound. These findings provide deeper insights into the mechanisms of action of marennine, identifying this bioactive natural compound as a novel bioactive compound in cancer treatment.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101. 深海链霉菌B188M101生物活性卤化代谢物的集成组学发现

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-19 DOI: 10.3390/md23090362

Emmanuel Tope Oluwabusola, Stephen A Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J Clarke, Rainer Ebel, Marcel Jaspars, Alan D W Dobson

{"title":"Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101.","authors":"Emmanuel Tope Oluwabusola, Stephen A Jackson, Cristina Brunati, Stefanie Gackstatter, Hannah Vedder, Marianna Iorio, Gargee Chawande, Lekha Menon Margassery, Giang-Son Nguyen, David J Clarke, Rainer Ebel, Marcel Jaspars, Alan D W Dobson","doi":"10.3390/md23090362","DOIUrl":"10.3390/md23090362","url":null,"abstract":"Using the one-strain-many-compounds (OSMAC) culturing approach, metabolomic studies, and bioassay-guided purification, we have isolated and characterised three new chlorinated natural products, agelolines B-D (1-3), together with two known compounds, ageloline A (4) and gausemycin A (5), which have been identified by high-resolution mass spectrometry and 1D and 2D NMR analyses. The preliminary evaluation of three small-scale extracts (M400, R358 and SGG) against the fish pathogen, Aeromonas salmonicida subsp. achromogenes KELDUR265-87, showed that the R358 extract displayed significant activity. Furthermore, the natural products (1-5) were evaluated against the fish pathogen Aeromonas salmonicida and human pathogens (Stenotrophomonas maltophilia L2125, Staphylococcus aureus ATCC6538P, and S. pneumoniae L44) using a serial dilution assay. Compound 3 displayed activity against Staphylococcus aureus ATCC6538P, S. maltophilia L2125, and S. pneumoniae L44 with MIC values of 6, 32, and 64 µg/mL, respectively. Interestingly, only gausemycin A (5) exhibited considerable inhibition against A. salmonicida with an MIC value of 32 µg/mL, and the activity increased by two-fold when supplemented with 0.45 mM calcium salt, while 2 and 4 showed moderate inhibition against S. maltophilia L2125. The biosynthetic pathways of compounds 1-4 were proposed. This is the first report of specific inhibition of A. salmonicida by 5.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-Culture of Auxenochlorella protothecoides and Serratia liquefaciens Promotes Lutein Accumulation. 原绿葡萄球菌与液化沙雷菌共培养促进叶黄素积累。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-18 DOI: 10.3390/md23090360

Weiwei Xue, Zhen Li, Yanhong Qiu, Yong Ma, Yongchang Xue, Zongshen Zhang, Changbin Liu

{"title":"Co-Culture of Auxenochlorella protothecoides and Serratia liquefaciens Promotes Lutein Accumulation.","authors":"Weiwei Xue, Zhen Li, Yanhong Qiu, Yong Ma, Yongchang Xue, Zongshen Zhang, Changbin Liu","doi":"10.3390/md23090360","DOIUrl":"10.3390/md23090360","url":null,"abstract":"Lutein, a crucial carotenoid with diverse biological roles, is in high demand in the market. Current production predominantly relies on plant extraction, which is hindered by low yield and seasonal limitations. Microalgae, such as Chlorella and Chlamydomonas, known for their efficient lutein production due to high photosynthetic efficiency, rapid growth, and ease of cultivation, still require enhanced yields. This study presents a novel finding that co-cultivating A. protothecoides with S. liquefaciens significantly boosts lutein production. Optimization of carbon and nitrogen sources, nitrogen-to-phosphorus (N:P) ratio, and algal-bacterial inoculation ratio using BG11 medium was systematically conducted. The results indicate that supplementing with 3.0 g/L sodium acetate as the carbon source, 2.0 g/L sodium nitrate as the nitrogen source, sodium dihydrogen phosphate to achieve an N:P ratio of 12:1, and an algal:bacterial inoculation ratio of 10:1, resulted in an A. protothecoides biomass of 21.72 g/L (DWt) and a lutein yield significantly increased to 56.86 mg/g (DWt), a ninefold rise compared to monoculture. This co-cultivation approach offers a promising avenue for sustainable industrial lutein production.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contamination Characteristics of 21 PFAS in Shellfish and Crustaceans of Zhejiang Province and Exposure Risk Assessment for Adult Dietary Consumers. 浙江省贝类和甲壳类动物中21种PFAS污染特征及成人膳食消费者暴露风险评价

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-09-15 DOI: 10.3390/md23090359

Hexiang Zhang, Haoyi Zhang, Ronghua Zhang, Dong Zhao, Bing Zhu, Xiaojuan Qi, Lili Chen, Jiang Chen, Jikai Wang, Yibin Zheng, Zhewei Feng

{"title":"Contamination Characteristics of 21 PFAS in Shellfish and Crustaceans of Zhejiang Province and Exposure Risk Assessment for Adult Dietary Consumers.","authors":"Hexiang Zhang, Haoyi Zhang, Ronghua Zhang, Dong Zhao, Bing Zhu, Xiaojuan Qi, Lili Chen, Jiang Chen, Jikai Wang, Yibin Zheng, Zhewei Feng","doi":"10.3390/md23090359","DOIUrl":"10.3390/md23090359","url":null,"abstract":"This study investigated the occurrence, sources, and health risks of 21 per- and polyfluoroalkyl substances (PFAS) in commercially available shellfish and crustaceans from Zhejiang Province, China. Among the 306 samples analyzed, 87.9% contained at least one detectable PFAS. Perfluorooctanoic acid (PFOA) was the most frequently detected PFAS (64.7%), followed by perfluorooctanesulfonic acid (PFOS) (53.8%), perfluorononanoic acid (PFNA) (52.9%), and perfluorodecanoic acid (PFDA) (50.0%). The total PFAS in shellfish and crustaceans ranged from ND to 0.86 to 173 ng/g wet weight, with a median of 4.11 ng/g ww; the median concentration of total PFAS followed this order: marine crustaceans > fresh-water crustaceans > bivalves. Estimation of the human intake of adult consumers, the estimated daily intake (EDI) of Σ21 PFAS ranged from 0.01 to 15.7 ng/kg bw/day; 0.31% of the adult study population had Σ4PFAS exposure levels resulting in Hazard Quotient (HQ) values > 1, which may represent a potential public health concern for these individuals. Long-term exposure risks for specific PFCAs such as perfluoroundecanoic acid (PFUdA) and perfluorotridecanoic acid (PFTrDA) merit concern.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0