海洋黏附蛋白中的淀粉样结构。

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-09-19 DOI:10.3390/md23090363

Mariana Rodrigues Santos, Bárbara Joana Henriques, Romana Santos

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引用次数: 0

摘要

淀粉样结构的形成通常与神经退行性疾病有关，如帕金森病和阿尔茨海默病。然而，蛋白质在非病理情况下可以形成淀粉样结构，称为功能性淀粉样。我们回顾了目前关于几种海洋生物产生的黏附分泌物（永久性和非永久性）中呈现淀粉样结构的蛋白质存在的进化和生态意义的知识；此外，我们分析了使它们非常适合这项任务的分子和结构特性以及它们可能的仿生和工业应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Amyloid-like Structures in Marine Adhesive Proteins.

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Amyloid-like Structures in Marine Adhesive Proteins.

The formation of amyloid-like structures is commonly linked to neurodegenerative diseases, such as Parkinson's and Alzheimer's. However, proteins can form amyloid-like structures in non-pathological contexts, referred to as functional amyloids. We review the current knowledge on the evolutionary and ecological significance of the presence of proteins presenting amyloid-like structures in adhesive secretions (both permanent and non-permanent) produced by several marine organisms; in addition, we analyze the molecular and structural properties that make them well suited for this task and their possible biomimetic and industrial applications.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.