Marine Drugs最新文献_第2页

Macroalgal Bloom Biomass as a Source of Bioactive Compounds and Antimicrobial Peptides. 大藻华生物量作为生物活性化合物和抗菌肽的来源。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-15 DOI: 10.3390/md24040136

Nedeljka Rosic, Isidora Skrlin, Carol Thornber

{"title":"Macroalgal Bloom Biomass as a Source of Bioactive Compounds and Antimicrobial Peptides.","authors":"Nedeljka Rosic, Isidora Skrlin, Carol Thornber","doi":"10.3390/md24040136","DOIUrl":"https://doi.org/10.3390/md24040136","url":null,"abstract":"Macroalgal species are widely distributed throughout the world's oceans and are well recognised for their biotechnological, ecological, and pharmacological potentials, containing a wide range of diverse bioactive compounds. In many coastal habitats worldwide, excessive accumulations of algal biomass (including rapidly growing blooms and drift accumulations resulting from dislodgement from benthic habitats) are commonplace and can pose environmental and economic challenges. In this study, we report occurrences of algal blooms and drift accumulations during 2024 and 2025 involving three major macroalgal clades, Chlorophyta, Phaeophyceae, and Rhodophyta, from two distinct marine regions: the North Atlantic Ocean and the South Pacific Ocean. Species identified included Grateloupia turuturu, Polyides rotundus, Ascophyllum nodosum, Ulva spp., Sargassum spp. and Fucus spp., among others. The indicated species are known for their diverse pharmacological properties, including antimicrobial, antioxidant, and anti-inflammatory effects. Specialised bioinformatic tools were employed to assess the potential of identified macroalgae as a source of antimicrobial peptides (AMPs). For selected macroalgal species, in silico screening of publicly available databases was performed to identify previously reported and characterised AMPs associated with these species. This in silico approach presents a promising strategy for discovering novel antimicrobial agents with potential activity, especially against drug-resistant bacteria. Finally, applying proteomics methodologies for in silico evaluation of the selected algal species advances modern technologies for the sustainable use of natural resources.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Freeze-Drying Blue Crab Roe, Sea Urchin, and Beluga Caviar: Impact on Nutritional, Biochemical, and Sensory Properties. 冷冻干燥的蓝蟹籽、海胆和白鲸鱼子酱：对营养、生化和感官特性的影响。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-12 DOI: 10.3390/md24040135

Antonia Angou, Spyros Didos, Konstantina Tsotsouli, Ioannis S Boziaris, Anagnostis Argiriou

{"title":"Freeze-Drying Blue Crab Roe, Sea Urchin, and Beluga Caviar: Impact on Nutritional, Biochemical, and Sensory Properties.","authors":"Antonia Angou, Spyros Didos, Konstantina Tsotsouli, Ioannis S Boziaris, Anagnostis Argiriou","doi":"10.3390/md24040135","DOIUrl":"https://doi.org/10.3390/md24040135","url":null,"abstract":"The growing demand for clean-label food ingredients drives interest in novel marine flavorings. This study evaluated the physicochemical, antioxidant, volatile (GC-MS), and sensory profiles of freeze-dried powders from blue crab roe (Callinectes sapidus), sea urchin roe (Paracentrotus lividus), and beluga caviar (Huso huso) to assess their culinary potential. Results revealed that sensory quality is governed by the synergy between a matrix's lipid composition and endogenous antioxidant capacity. Sea urchin powder, possessing a low polyunsaturated fatty acid (PUFA) profile and high carotenoid content, exhibited exceptional oxidative stability, yielding a concentrated marine aldehyde signature and top consumer scores. Blue crab roe demonstrated a robust PUFA matrix buffered by high phenolic content, facilitating controlled lipid peroxidation into desirable savory volatiles (ketones and aldehydes). Conversely, the high-fat, monounsaturated-dominant beluga caviar lacked sufficient antioxidants, leading to lipid degradation, oxidized hydrocarbons, earthy off-flavors, and poor texture. Both crab and caviar powders exhibited favorable Atherosclerosis and Thrombogenicity indices. Ultimately, balancing lipid composition and endogenous antioxidants is crucial for flavor stability, highlighting the commercial and environmental potential of transforming underutilized or invasive species like blue crab into stable, nutrient-dense marine flavoring agents.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human and Marine Host Defense Peptides for Healthy Skin. 健康皮肤的人类和海洋宿主防御肽。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-10 DOI: 10.3390/md24040134

Svetlana V Guryanova, Oksana Yu Belogurova-Ovchinnikova, Tatiana V Ovchinnikova

{"title":"Human and Marine Host Defense Peptides for Healthy Skin.","authors":"Svetlana V Guryanova, Oksana Yu Belogurova-Ovchinnikova, Tatiana V Ovchinnikova","doi":"10.3390/md24040134","DOIUrl":"https://doi.org/10.3390/md24040134","url":null,"abstract":"The skin serves as the first line barrier of innate immunity, protecting the body from external influences and maintaining its homeostasis. Exogenous and endogenous stress factors alter the structure and functional properties of the skin. The search for compounds capable of counteracting these processes has allowed the identification of peptides as promising ingredients of products for medicinal and cosmetic applications. This review comprehensively examines the mechanisms of action and dermatological applications of two distinct classes of natural products-endogenous human peptides and those derived from marine organisms. Human peptides exhibit numerous biological functions, including antimicrobial and immunomodulatory ones, as well as promoting antioxidant protection and wound healing. Microbiome-associated peptides are an underestimated but powerful regulator of skin aging through immunomodulation, inflammation control, barrier function maintenance, and selection of the proper microbial community. Peptides from marine organisms exhibit significant structural diversity and a broad spectrum of biological activity, including regenerative effects and effects on antibiotic-resistant microorganisms. This review summarizes current data obtained from in vitro, ex vivo, and clinical studies demonstrating a broad potential of peptides for maintaining skin health. Both peptide classes represent powerful, targeted strategies for innovative dermatological interventions aimed at promoting skin rejuvenation, protection, and overall homeostasis.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine Pharmacology in 2022-2023: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities, Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action. 2022-2023年的海洋药理学：具有抗菌、抗糖尿病、抗真菌、抗炎、抗原虫、抗结核和抗病毒活性的海洋化合物，影响免疫和神经系统，以及其他各种作用机制。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-09 DOI: 10.3390/md24040133

Alejandro M S Mayer, Veronica A Mayer, Michelle Swanson-Mungerson, Marsha L Pierce, Cai M Roberts, Abimael D Rodríguez, Fumiaki Nakamura, Orazio Taglialatela-Scafati

{"title":"Marine Pharmacology in 2022-2023: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities, Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.","authors":"Alejandro M S Mayer, Veronica A Mayer, Michelle Swanson-Mungerson, Marsha L Pierce, Cai M Roberts, Abimael D Rodríguez, Fumiaki Nakamura, Orazio Taglialatela-Scafati","doi":"10.3390/md24040133","DOIUrl":"https://doi.org/10.3390/md24040133","url":null,"abstract":"During 2022-2023, research groups from 40 nations contributed to the preclinical pharmacology of 173 structurally defined marine-derived compounds, unveiling innovative mechanisms of action. Peer-reviewed publications in the field of marine natural product pharmacology during 2022-2023 included mechanism-of-action studies with 43 compounds showing antibacterial, antifungal, antiprotozoal, antitubercular, and antiviral activity. Additional mechanism-of-action studies were reported for 74 marine compounds that exhibited antidiabetic and anti-inflammatory properties, as well as significant effects on both the immune and nervous systems. Finally, while 65 marine compounds revealed unique and diverse pharmacological mechanisms, further investigation will be required to determine whether they will contribute to a particular therapeutic category. Collectively, the pharmacology of 2022-2023 preclinical marine natural products demonstrated robust activity, offering both novel mechanistic insights and promising chemical scaffolds to enrich the 2026 marine pharmaceutical development pipeline (https://www.marinepharmacology.org/) which currently consists of 17 marine-derived pharmaceuticals approved for clinical use and 29 compounds in either Phase I, II or III of clinical pharmaceutical development.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary Metabolites Isolated from the Genus Psammocinia Sponges: Mapping Their Chemistry and Biological Activities. 海绵沙风菌属次生代谢产物的化学和生物学活性研究。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-04-01 DOI: 10.3390/md24040132

Dele Abdissa Keneni, Tarryn Swart, Alyson Bennett, Michelle Isaacs, Rosemary Dorrington

引用次数: 0

Recent Advance in Marine Polysaccharides: Structure, Anti-Inflammatory Mechanisms, and Functional Applications. 海洋多糖的结构、抗炎机制及功能应用研究进展。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-03-31 DOI: 10.3390/md24040129

Yuchen Wang, Jingyi Luo, Chao Xu, Dongyu Hu, Yimeng Li, Yanzuo Ye, Jun Yang, Xianxiang Chen, Chuan Li, Kexue Zhu

{"title":"Recent Advance in Marine Polysaccharides: Structure, Anti-Inflammatory Mechanisms, and Functional Applications.","authors":"Yuchen Wang, Jingyi Luo, Chao Xu, Dongyu Hu, Yimeng Li, Yanzuo Ye, Jun Yang, Xianxiang Chen, Chuan Li, Kexue Zhu","doi":"10.3390/md24040129","DOIUrl":"https://doi.org/10.3390/md24040129","url":null,"abstract":"Inflammation is pivotal to the pathogenesis of chronic disorders, including diabetes and cardiovascular disorders. Conventional pharmaceuticals used in the treatment of inflammation and related diseases face several challenges. In recent years, polysaccharides isolated from marine organisms have attracted extensive research attention due to their good safety profile, easy availability, and powerful anti-inflammatory properties. However, there is still a lack of systematic elucidation of their anti-inflammatory mechanisms and functional effects. In this review, the sources and structural characteristics of marine polysaccharides were reviewed. Moreover, the anti-inflammatory mechanisms of marine polysaccharides and their advanced applications were discussed. Finally, the current challenges of marine polysaccharides in anti-inflammatory research and food industry applications, as well as future research directions, were proposed. This review deepens the understanding of the anti-inflammatory effects of marine polysaccharides and provides feasible guidance for the development and clinical application of novel anti-inflammatory drugs.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phaseolorin J Alleviates Cellular Inflammation and Oxidative Stress by Inhibiting NLRP3 Inflammasome Expression via the Nrf2/HO-1 Pathway. Phaseolorin J通过Nrf2/HO-1通路抑制NLRP3炎性体表达，减轻细胞炎症和氧化应激

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-03-31 DOI: 10.3390/md24040130

Yuanjie Chen, Ting Feng, Xiaojing Li, Jing Xu, Juren Cen

{"title":"Phaseolorin J Alleviates Cellular Inflammation and Oxidative Stress by Inhibiting NLRP3 Inflammasome Expression via the Nrf2/HO-1 Pathway.","authors":"Yuanjie Chen, Ting Feng, Xiaojing Li, Jing Xu, Juren Cen","doi":"10.3390/md24040130","DOIUrl":"https://doi.org/10.3390/md24040130","url":null,"abstract":"Phaseolorin J (TT-55), a chromone compound isolated and purified from the fermentation products of Phomopsis asparagi DHS-48, is an endophytic fungus obtained from mangrove forests. Preliminary experimental studies have revealed its potent antioxidant and anti-inflammatory activities, though its mechanism of action remains unclear. In this study, we aimed to investigate the molecular mechanisms underlying the antioxidant and anti-inflammatory effects of TT-55, following initial evidence of its potency, by employing an LPS-induced RAW264.7 macrophage model in vitro. The results revealed that in the LPS-induced inflammatory model of RAW264.7 cells, the TT-55 dose dependently inhibited the expression of LPS-induced inflammatory cytokines (TNF-α, IL-18, IL-1β, IL-6) and the production of oxidative stress markers (reactive oxygen species, SOD, MDA). Following combined treatment with the Nrf2 pathway inhibitor ML385 and TT-55, the inhibitory effects of TT-55 on inflammatory cytokines and oxidative stress markers were reversed by ML385. Meanwhile, ML385 also attenuated the ability of TT-55 to suppress LPS-induced upregulation of NLRP3 inflammasome-related genes. In conclusion, TT-55 may exert its antioxidant and anti-inflammatory effects by activating the Nrf2/HO-1 signaling pathway and suppressing the upregulation of NLRP3 inflammasome-related genes.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Diversity and Antitumor Metabolites from Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031 via OSMAC Strategy. 软珊瑚源真菌菌核曲霉SCSIO 41031化学多样性及抗肿瘤代谢物的OSMAC研究

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-03-31 DOI: 10.3390/md24040128

Juan Gao, Jieyi Long, Xiaoyan Pang, Xuefeng Zhou, Yonghong Liu, Bin Yang

{"title":"Chemical Diversity and Antitumor Metabolites from Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031 via OSMAC Strategy.","authors":"Juan Gao, Jieyi Long, Xiaoyan Pang, Xuefeng Zhou, Yonghong Liu, Bin Yang","doi":"10.3390/md24040128","DOIUrl":"https://doi.org/10.3390/md24040128","url":null,"abstract":"Microorganisms provide critical lead compounds for drug development, yet most biosynthetic gene clusters remain silent under standard culture conditions. The OSMAC strategy activates these clusters by adjusting cultivation parameters, thereby enabling the discovery of novel compounds from a single strain. Here, we applied OSMAC to explore the metabolic potential of the soft coral-derived fungus Aspergillus sclerotiorum SCSIO 41031. Three different culture media were employed for the large-scale fermentation process. After isolation by chromatography, the compounds were structurally characterized using NMR, MS, and X-ray single-crystal diffraction, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. In total, three new compounds, named 6,6'-diacetyl-1,1'-dihydroxy-3,3'-dimethoxydibenzyl ether (1), esterwortmannolol (17) and pestalpolyol I (20), along with 19 known compounds (2-16, 18-19 and 21-22) were obtained. This study validates the efficacy of the OSMAC strategy and underscores that A. sclerotiorum SCSIO 41031 serves as a valuable resource for producing structurally diverse natural products with potent biological activities.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfated Polysaccharides in Cancer Therapy: A Focus on Algal-Derived Bioactive. 硫酸盐多糖在癌症治疗中的应用：藻类生物活性的研究。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-03-31 DOI: 10.3390/md24040131

N M Liyanage, D S Dissanayake, Yiqiao Li, Kyung Yuk Ko, D P Nagahawatta, You-Jin Jeon

{"title":"Sulfated Polysaccharides in Cancer Therapy: A Focus on Algal-Derived Bioactive.","authors":"N M Liyanage, D S Dissanayake, Yiqiao Li, Kyung Yuk Ko, D P Nagahawatta, You-Jin Jeon","doi":"10.3390/md24040131","DOIUrl":"https://doi.org/10.3390/md24040131","url":null,"abstract":"Sulfated polysaccharides (SPs), biologically active macromolecules from marine and terrestrial organisms, hold significant potential in revolutionizing cancer therapy. Characterized by their unique sulfate ester groups and structural diversity, SPs exhibit a broad spectrum of bioactivities, including immunomodulation, apoptosis induction, metastasis suppression, and angiogenesis inhibition. Prominent SPs, such as fucoidan from brown algae and carrageenan from red algae, have shown remarkable anticancer properties, either as standalone agents or in synergy with conventional therapies like chemotherapy and radiotherapy. Their mechanisms of action involve targeting critical pathways such as NF-kB, VEGF, and PI3K/Akt, disrupting cancer cell proliferation, invasion, and tumor microenvironment dynamics. SPs also enhance immune system responses, reduce chemotherapy-induced side effects, and exhibit antioxidant properties, making them versatile candidates in cancer treatment. Innovations like SP-based nanoparticles are addressing bioavailability and drug delivery challenges, providing targeted and sustained therapeutic effects while minimizing off-target toxicity. Despite their promise, challenges such as structural complexity, scalability, and clinical validation hinder their widespread adoption. This review provides a comprehensive analysis of SPs' therapeutic potential, mechanisms, and emerging applications in oncology. It emphasizes the need for advanced extraction, characterization techniques, and clinical research to unlock their full potential, paving the way for novel, efficient, and safer cancer therapies.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Alginate Oligosaccharides by Autoclaving Pretreatment Combined with Enzymatic Method. 热压灭菌预处理-酶促法制备海藻酸盐低聚糖。

IF 5.4 2区医学

Marine Drugs Pub Date : 2026-03-30 DOI: 10.3390/md24040127

Feiyu Niu, Ziqiang Gu, Zihan Yu, Zhi Bao, Jichao Li, Peng Yang, Dongyu Li, Haijin Mou, Changliang Zhu

{"title":"Preparation of Alginate Oligosaccharides by Autoclaving Pretreatment Combined with Enzymatic Method.","authors":"Feiyu Niu, Ziqiang Gu, Zihan Yu, Zhi Bao, Jichao Li, Peng Yang, Dongyu Li, Haijin Mou, Changliang Zhu","doi":"10.3390/md24040127","DOIUrl":"https://doi.org/10.3390/md24040127","url":null,"abstract":"The enzymatic method is the primary focus for alginate oligosaccharide (AOS) production. However, the high viscosity of sodium alginate (SA) substrate often limits enzymatic efficiency. Pretreatment strategies aimed at reducing SA viscosity offer a promising and innovative solution to enhance process efficiency. This study compared the effects of three pretreatment methods-high-pressure vapor (HP-v), high-pressure solution (HP-s), and atmospheric-pressure air (AP-a)-on the physicochemical properties of SA. These pretreatments reduced SA viscosity and induced visible color changes in the order HP-v > HP-s > AP-a. Additionally, the effects of high-pressure treatments on molecular weight, M/G ratio, and chemical structure of SA were analyzed, confirming the feasibility of pretreatment-assisted enzymolysis. Molecular weight distribution and ESI-MS analysis of AOS after enzymolysis demonstrated that brief HP-v treatment maximizes the catalytic potential of alginate lyase, facilitating efficient AOS production without altering its structural characteristics.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"24 4","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0