Marine Drugs最新文献_第2页

Discovery of Secondary Metabolites from the Sponge-Derived Fungus Aspergillus templicola. 海绵来源真菌天曲曲霉次生代谢物的发现。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-09 DOI: 10.3390/md23070285

Kai Li, Yue Zhang, Lei Li, Sen Wang, Cili Wang, Pinglin Li

引用次数: 0

Metabolomic Profiling and Anti-Helicobacter pylori Activity of Caulerpa lentillifera (Sea Grape) Extract. 海葡萄提取物代谢组学分析及抗幽门螺杆菌活性研究

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-07 DOI: 10.3390/md23070282

Chananchida Thacharoen, Thisirak Inkaewwong, Watthanachai Jumpathong, Pornchai Kaewsapsak, Thiravat Rattanapot, Tippapha Pisithkul

{"title":"Metabolomic Profiling and Anti-Helicobacter pylori Activity of Caulerpa lentillifera (Sea Grape) Extract.","authors":"Chananchida Thacharoen, Thisirak Inkaewwong, Watthanachai Jumpathong, Pornchai Kaewsapsak, Thiravat Rattanapot, Tippapha Pisithkul","doi":"10.3390/md23070282","DOIUrl":"https://doi.org/10.3390/md23070282","url":null,"abstract":"Helicobacter pylori is a gastric pathogen implicated in peptic ulcer disease and gastric cancer. The increasing prevalence of antibiotic-resistant strains underscores the urgent need for alternative therapeutic strategies. In this study, we investigated the chemical composition and antibacterial activity of an aqueous extract from Caulerpa lentillifera (sea grape), a farm-cultivated edible green seaweed collected from Krabi Province, Thailand. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) revealed that the extract was enriched in bioactive nucleosides and phenolic compounds. In vitro assays demonstrated dose-dependent inhibition of H. pylori growth following exposure to sea grape extract. Furthermore, untargeted intracellular metabolomic profiling of H. pylori cells treated with the extract uncovered significant perturbations in central carbon and nitrogen metabolism, including pathways associated with the tricarboxylic acid (TCA) cycle, one-carbon metabolism, and alanine, aspartate, and glutamate metabolism. Pyrimidine biosynthesis was selectively upregulated, indicating a potential stress-induced shift toward nucleotide salvage and DNA repair. Of particular note, succinate levels were markedly reduced despite accumulation of other TCA intermediates, suggesting disruption of electron transport-linked respiration. These findings suggest that bioactive metabolites from C. lentillifera impair essential metabolic processes in H. pylori, highlighting its potential as a natural source of antimicrobial agents targeting bacterial physiology.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoautotrophic Batch Cultivation of Limnospira (Spirulina) platensis: Optimizing Biomass Productivity and Bioactive Compound Synthesis Through Salinity and pH Modulation. 和光自养分批培养平螺旋藻：通过盐度和pH调节优化生物量生产力和生物活性化合物合成。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-05 DOI: 10.3390/md23070281

Matteo Rizzoli, Giovanni Antonio Lutzu, Luca Usai, Giacomo Fais, Debora Dessì, Robinson Soto-Ramirez, Bartolomeo Cosenza, Alessandro Concas

{"title":"Photoautotrophic Batch Cultivation of Limnospira (Spirulina) platensis: Optimizing Biomass Productivity and Bioactive Compound Synthesis Through Salinity and pH Modulation.","authors":"Matteo Rizzoli, Giovanni Antonio Lutzu, Luca Usai, Giacomo Fais, Debora Dessì, Robinson Soto-Ramirez, Bartolomeo Cosenza, Alessandro Concas","doi":"10.3390/md23070281","DOIUrl":"https://doi.org/10.3390/md23070281","url":null,"abstract":"This study investigates the effects of salinity and pH modulation on the growth, biochemical composition, and bioactive compound production of Limnospira platensis under photoautotrophic batch cultivation. Cultures were grown in cylindrical photobioreactors using modified Jourdan medium, with controlled variations in NaCl concentrations (0.2-10 g L-1) and pH levels (9-11) to simulate moderate environmental stress. Maximum biomass productivity (1.596 g L-1) was achieved at pH 11 with 10 g L-1 NaCl, indicating that L. platensis can tolerate elevated stress conditions. Phycocyanin (PC) content peaked at 9.54 g 100 g-1 dry weight (DW) at pH 10 and 5 g L-1 NaCl, triple the value at pH 9, highlighting optimal physiological conditions for pigment synthesis. Protein fraction dominated biomass composition (40-60%), while total lipid content increased significantly under high pH and salinity. Polyphenol content reached 19.5 mg gallic acid equivalents (GAE) gDW-1 at pH 10 with 0.2 g L-1 NaCl, correlating with the highest antioxidant activity (Trolox equivalent antioxidant capacity). These findings underscore the potential of L. platensis as a valuable source of proteins, pigments, and antioxidants, and emphasize the utility of moderate environmental stress in enhancing biomass quality, defined by protein, pigment, and antioxidant enrichment. While this study focused on physiological responses, future research will apply omics approaches to elucidate stress-response mechanisms. This study provides insights into optimizing cultivation strategies for large-scale production exploitable in food, pharmaceutical, and bio-based industries.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Secondary Metabolites from Penicillium sp. NX-S-6. 抗炎青霉菌NX-S-6次生代谢物。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-04 DOI: 10.3390/md23070280

Hanyang Peng, Jiawen Sun, Rui Zhang, Yuxuan Qiu, Yu Hong, Fengjuan Zhou, Chang Wang, Yang Hu, Xiachang Wang

{"title":"Anti-Inflammatory Secondary Metabolites from Penicillium sp. NX-S-6.","authors":"Hanyang Peng, Jiawen Sun, Rui Zhang, Yuxuan Qiu, Yu Hong, Fengjuan Zhou, Chang Wang, Yang Hu, Xiachang Wang","doi":"10.3390/md23070280","DOIUrl":"https://doi.org/10.3390/md23070280","url":null,"abstract":"Five new natural products, including two sorbicillinoids (1-2), one indolinone alkaloid (10), one tetracyclic steroid (11), and one α-pyrone derivative (14), were identified from the endophytic Penicillium sp. NX-S-6, together with thirteen known natural products. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analyses (NMR, MS), as well as electronic circular dichroism (ECD) calculation. Notably, quinosorbicillinol (1) was identified as a rare hybrid sorbicillinoid incorporating a quinolone moiety, representing a unique structural scaffold in this natural product class. Biological evaluation revealed that Compounds 1, 4 and 8 potently inhibited the production of nitric oxide and interleukin 6 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Mechanistic studies furthermore demonstrated that Compounds 4 and 8 effectively suppressed interleukin-1β secretion in LPS-induced immortalized mouse bone marrow-derived macrophages (iBMDMs) by blocking NLRP3 inflammasome activation. This inhibition was attributed to their ability to disrupt the assembly of the NLRP3-caspase-1 complex, a key event in the pathogenesis of inflammatory disorders. These findings not only expand the structural diversity of endophyte-derived natural products but also highlight their potential as lead compounds for developing anti-inflammatory therapeutics targeting the NLRP3 pathway.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into Natural Products from Marine-Derived Fungi with Antimycobacterial Properties: Opportunities and Challenges. 对具有抗细菌特性的海洋真菌天然产物的见解：机遇与挑战。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-03 DOI: 10.3390/md23070279

Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti

{"title":"Insights into Natural Products from Marine-Derived Fungi with Antimycobacterial Properties: Opportunities and Challenges.","authors":"Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti","doi":"10.3390/md23070279","DOIUrl":"https://doi.org/10.3390/md23070279","url":null,"abstract":"Tuberculosis (TB) poses a persistent global health threat exacerbated by the emergence of drug-resistant strains; hence, there is a continuous quest for novel antimicrobial agents. Despite efforts to develop effective therapies, existing treatments require a relatively long duration of therapy to eradicate the pathogen due to its virulence factors, pathogenesis patterns, and ability to enter dormant states. This can lead to a higher risk of treatment failure due to poor patient adherence to the complex regimen. As a result, considerable research is necessary to identify alternative antituberculosis agents. The marine environment, particularly marine-derived fungi, has recently gained interest due to its potential as an abundant source of bioactive natural products. This review covers 19 genera of marine-derived fungi and 139 metabolites, 131 of which exhibit antimycobacterial activity. The integrated dataset pinpoints the fungal genera and chemical classes that most frequently yield potent antimycobacterial hits while simultaneously exposing critical gaps, such as the minimal evaluation of compounds against dormant bacilli and the presence of underexplored ecological niches and fungal genera. Several compounds exhibit potent activity through uncommon mechanisms, including the inhibition of mycobacterial protein tyrosine phosphatases (MptpB/MptpA), protein kinase PknG, ATP synthase and the disruption of mycobacterial DNA via G-quadruplex stabilization. Structure-activity relationship (SAR) trends are highlighted for the most potent agents, illuminating how specific functional groups underpin target engagement and potency. This review also briefly proposes a dereplication strategy and approaches for toxicity mitigation in the exploration of marine-derived fungi's natural products. Through this analysis, we offer insights into the potency and challenges of marine-derived fungi's natural products as hit compounds or scaffolds for further antimycobacterial research.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging. 大藻启发的溴化查尔酮作为化妆品成分与潜在的目标皮肤炎症。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-02 DOI: 10.3390/md23070278

Ana Jesus, Sara Gimondi, Sónia A Pinho, Helena Ferreira, Nuno M Neves, Andreia Palmeira, Emília Sousa, Isabel F Almeida, Maria T Cruz, Honorina Cidade

{"title":"Macroalgae-Inspired Brominated Chalcones as Cosmetic Ingredients with the Potential to Target Skin Inflammaging.","authors":"Ana Jesus, Sara Gimondi, Sónia A Pinho, Helena Ferreira, Nuno M Neves, Andreia Palmeira, Emília Sousa, Isabel F Almeida, Maria T Cruz, Honorina Cidade","doi":"10.3390/md23070278","DOIUrl":"https://doi.org/10.3390/md23070278","url":null,"abstract":"Skin aging is mainly caused by external factors like sunlight, which triggers oxidative stress and chronic inflammation. Natural halogenated flavonoids have demonstrated anti-inflammatory properties. Inspired by the macroalgae-derived bromophenol BDDE, we investigated the anti-inflammatory potential of structure-related chalcones (1-7). Chalcones 1 and 7 showed the least cytotoxicity in keratinocyte and macrophage cells. Chalcones 1, 2, 4, and 5 exhibited the most significant anti-inflammatory effects in murine macrophages after lipopolysaccharide stimulation, with chalcone 1 having the lowest IC50 value (≈0.58 μM). A SNAP assay confirmed that chalcones do not exert their effects through direct NO scavenging. Symmetrical bromine atoms and 3,4-dimethoxy groups on both aromatic rings improved the anti-inflammatory activity, indicating a relevant structure-activity relationship. Chalcones 1 and 2 were selected for study to clarify their mechanisms of action. At a concentration of 7.5 μM, chalcone 2 demonstrated a rapid and effective inhibitory action on the protein levels of inducible nitric oxide synthase (iNOS), while chalcone 1 exhibited a gradual inhibitory action. Moreover, chalcone 1 effectively activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway with around a 3.5-fold increase at the end of 24 h at 7.5 μM, highlighting its potential as a modulator of oxidative stress responses. These findings place chalcone 1 as a promising candidate for skincare products targeting inflammation and skin aging.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications. 蛤蚌毒素：其历史、结构、毒理学、生物合成、检测和预防意义的综合综述。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-02 DOI: 10.3390/md23070277

Huiyun Deng, Xinrui Shang, Hu Zhu, Ning Huang, Lianghua Wang, Mingjuan Sun

{"title":"Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications.","authors":"Huiyun Deng, Xinrui Shang, Hu Zhu, Ning Huang, Lianghua Wang, Mingjuan Sun","doi":"10.3390/md23070277","DOIUrl":"https://doi.org/10.3390/md23070277","url":null,"abstract":"Saxitoxin (STX) is a potent toxin produced by marine dinoflagellates and freshwater or brackish water cyanobacteria, and is a member of the paralytic shellfish toxins (PSTs). As a highly specific blocker of voltage-gated sodium channels (NaVs), STX blocks sodium ion influx, thereby inhibiting nerve impulse transmission and leading to systemic physiological dysfunctions in the nervous, respiratory, cardiovascular, and digestive systems. Severe exposure can lead to paralysis, respiratory failure, and mortality. STX primarily enters the human body through the consumption of contaminated shellfish, posing a significant public health risk as the causative agent of paralytic shellfish poisoning (PSP). Beyond its acute toxicity, STX exerts cascading impacts on food safety, marine ecosystem integrity, and economic stability, particularly in regions affected by harmful algal blooms (HABs). Moreover, the complex molecular structure of STX-tricyclic skeleton and biguanide group-and its diverse analogs (more than 50 derivatives) have made it the focus of research on natural toxins. In this review, we traced the discovery history, chemical structure, molecular biosynthesis, biological enrichment mechanisms, and toxicological actions of STX. Moreover, we highlighted recent advancements in the potential for detection and treatment strategies of STX. By integrating multidisciplinary insights, this review aims to provide a holistic understanding of STX and to guide future research directions for its prevention, management, and potential applications.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthelmintic Potential of Agelasine Alkaloids from the Australian Marine Sponge Agelas axifera. 澳大利亚海绵Agelas axifera中ageline生物碱的驱虫潜能。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-07-01 DOI: 10.3390/md23070276

Kanchana Wijesekera, Aya C Taki, Joseph J Byrne, Darren C Holland, Ian D Jenkins, Merrick G Ekins, Anthony R Carroll, Robin B Gasser, Rohan A Davis

{"title":"Anthelmintic Potential of Agelasine Alkaloids from the Australian Marine Sponge Agelas axifera.","authors":"Kanchana Wijesekera, Aya C Taki, Joseph J Byrne, Darren C Holland, Ian D Jenkins, Merrick G Ekins, Anthony R Carroll, Robin B Gasser, Rohan A Davis","doi":"10.3390/md23070276","DOIUrl":"https://doi.org/10.3390/md23070276","url":null,"abstract":"A recent high-throughput screening of the NatureBank marine extract library (7616 samples) identified an extract from the Australian marine sponge Agelas axifera with in vitro activity against an economically important parasitic nematode, Haemonchus contortus (barber's pole worm). The bioassay-guided fractionation of the CH2Cl2/MeOH extract from A. axifera led to the purification of a new diterpene alkaloid, agelasine Z (1), together with two known compounds agelasine B (2) and oxoagelasine B (3). Brominated compounds (-)-mukanadin C (4) and 4-bromopyrrole-2-carboxylic acid (5) were also isolated from neighbouring UV-active fractions. All compounds, together with agelasine D (6) from NatureBank's pure compound library, were tested for in vitro anthelmintic activity against exsheathed third-stage (xL3s) and fourth-stage larvae (L4s) of H. contortus and young adult Caenorhabditis elegans. Compounds 1, 2 and 6 induced an abnormal \"skinny\" phenotype, while compounds 2 and 6 also reduced the motility of H. contortus L4s by 50.5% and 51.8% at 100 µM, respectively. The minimal activity of agelasines against C. elegans young adults suggests a possible species-specific mechanism warranting further investigation. For the first time, the unexpected lability of agelasine H-8' was explored using kinetic studies, revealing rapid deuterium exchange in MeOH-d4 at room temperature.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation and Characterization of Secondary Metabolites from Hydractinia-Associated Fungus, Penicillium brevicompactum MSW10-1, and Their Inhibitory Effects on Hepatic Lipogenesis. 水葫芦菌相关真菌短孔青霉菌MSW10-1次生代谢产物的分离、鉴定及其对肝脏脂肪生成的抑制作用。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-06-30 DOI: 10.3390/md23070275

Hyeon-Jeong Hwang, Hyeokjin Lim, Jae Sik Yu, Eun Seo Jang, Youngsang Nam, Yeo Jin Lee, Eun La Kim, Seonghwan Hwang, Seoung Rak Lee

{"title":"Isolation and Characterization of Secondary Metabolites from Hydractinia-Associated Fungus, Penicillium brevicompactum MSW10-1, and Their Inhibitory Effects on Hepatic Lipogenesis.","authors":"Hyeon-Jeong Hwang, Hyeokjin Lim, Jae Sik Yu, Eun Seo Jang, Youngsang Nam, Yeo Jin Lee, Eun La Kim, Seonghwan Hwang, Seoung Rak Lee","doi":"10.3390/md23070275","DOIUrl":"https://doi.org/10.3390/md23070275","url":null,"abstract":"Marine organism-associated microbes are an important source of structurally diverse and biologically active secondary metabolites exhibiting antimicrobial, anticancer, and anti-inflammatory activities. In this study, we investigated Penicillium brevicompactum MSW10-1, isolated from Hydractinia echinata, a marine invertebrate adapted to extreme intertidal and subtidal environments with variable temperature, salinity, and oxygen conditions. Through a combination of LC/MS-guided chemical analysis and chromatographic purification, eight secondary metabolites were isolated, including brevicolactones A (1) and B (2). The absolute chemical structures of 1 and 2 were determined based on NMR spectroscopic experiments, HR-ESIMS data, and quantum chemical ECD calculations. The isolated compounds (1-8) were evaluated for their ability to inhibit hepatic lipogenesis, a key process in lipid metabolism that is dysregulated in metabolic-dysfunction-associated steatotic liver disease. Furthermore, the inhibitory effects of the isolated compounds on lipid accumulation were further evaluated in primary mouse hepatocytes, using Oil Red O staining. These findings suggested that the isolated compounds may serve as promising candidates for the treatment of metabolic liver diseases associated with lipid dysregulation.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Mechanisms of Red Algae-Derived Bioactive Compounds in Alzheimer's Disease: An Overview of Novel Insights. 红藻衍生的生物活性化合物在阿尔茨海默病中的神经保护机制：新见解综述。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-06-30 DOI: 10.3390/md23070274

Tianzi Wang, Wenling Shi, Zijun Mao, Wei Xie, Guoqing Wan

{"title":"Neuroprotective Mechanisms of Red Algae-Derived Bioactive Compounds in Alzheimer's Disease: An Overview of Novel Insights.","authors":"Tianzi Wang, Wenling Shi, Zijun Mao, Wei Xie, Guoqing Wan","doi":"10.3390/md23070274","DOIUrl":"https://doi.org/10.3390/md23070274","url":null,"abstract":"Alzheimer's disease (AD) is characterized by β-amyloid plaques, neurofibrillary tangles, neuroinflammation, and oxidative stress-pathological features that pose significant challenges for the development of therapeutic interventions. Given these challenges, this review comprehensively evaluates the neuroprotective mechanisms of bioactive compounds derived from red algae, including polysaccharides and phycobiliproteins, which are considered a promising source of natural therapeutics for AD. Red algal constituents exhibit neuroprotective activities through multiple mechanisms. Sulfated polysaccharides (e.g., carrageenan, porphyran) suppress NF-κB-mediated neuroinflammation, modulate mitochondrial function, and enhance brain-derived neurotrophic factor (BDNF) expression. Phycobiliproteins (phycoerythrin, phycocyanin) and peptides derived from their degradation scavenge reactive oxygen species (ROS) and activate antioxidant pathways (e.g., Nrf2/HO-1), thus mitigating oxidative damage. Carotenoids (lutein, zeaxanthin) improve cognitive function through the inhibition of acetylcholinesterase and pro-inflammatory cytokines (TNF-α, IL-1β), while phenolic compounds (bromophenols, diphlorethol) provide protection by targeting multiple pathways involved in dopaminergic system modulation and Nrf2 pathway activation. Emerging extraction technologies-including microwave- and enzyme-assisted methods-have been shown to optimize the yield and maintain the bioactivity of these compounds. However, the precise identification of molecular targets and the standardization of extraction techniques remain critical research priorities. Overall, red algae-derived compounds hold significant potential for multi-mechanism AD interventions, providing novel insights for the development of therapeutic strategies with low toxicity.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0