Marine Drugs最新文献_第3页

Anti-Inflammatory and Neuroprotective Effects of Undaria pinnatifida Fucoidan. 裙带菜岩藻多糖的抗炎和神经保护作用。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-29 DOI: 10.3390/md23090350

Cheng Yang, Corinna Dwan, Barbara C Wimmer, Sayed Koushik Ahamed, Fionnghuala James, Jigme Thinley, Richard Wilson, Luke Johnson, Vanni Caruso

{"title":"Anti-Inflammatory and Neuroprotective Effects of Undaria pinnatifida Fucoidan.","authors":"Cheng Yang, Corinna Dwan, Barbara C Wimmer, Sayed Koushik Ahamed, Fionnghuala James, Jigme Thinley, Richard Wilson, Luke Johnson, Vanni Caruso","doi":"10.3390/md23090350","DOIUrl":"10.3390/md23090350","url":null,"abstract":"Undaria pinnatifida fucoidan (UPF), a sulphated polysaccharide derived from brown seaweed, has attracted scientific and clinical interest for its wide-ranging anti-inflammatory and neurodegenerative properties. A growing body of research shows that UPF inhibits NF-κB and MAPK signalling pathways, reduces pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), decreases ROS production, and suppresses iNOS and COX-2 activity, thereby mitigating oxidative and inflammatory damage in vitro. In vivo studies confirm these actions, demonstrating reduced systemic inflammation, promoted antioxidant defence, modulated gut microbiota composition, and improved production of beneficial microbial metabolites. In parallel, emerging evidence highlights UPF's neuroprotective potential, characterised by protection against neuroinflammation and oxidative stress, the attenuation of amyloid-beta deposition, and improvement in neuronal function. Importantly, low- to medium-molecular-weight and highly sulphated UPF fractions consistently exhibit stronger bioactivities, suggesting a structural basis for its therapeutic potential. This review integrates mechanistic evidence from cellular, preclinical, and emerging clinical studies, highlighting UPF as a versatile marine-derived agent with therapeutic relevance for inflammatory and neurodegenerative diseases, and outlines future research directions toward clinical translation.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the Potential of Red Seaweeds: A Special Focus on Grateloupia turuturu Yamada and Porphyra umbilicalis Kütz. 释放红海藻的潜力：特别关注山田紫菜和脐卟啉k<e:1>。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-29 DOI: 10.3390/md23090347

João Ferreira, Mário Pacheco, Amélia M Silva, Isabel Gaivão

{"title":"Unlocking the Potential of Red Seaweeds: A Special Focus on Grateloupia turuturu Yamada and Porphyra umbilicalis Kütz.","authors":"João Ferreira, Mário Pacheco, Amélia M Silva, Isabel Gaivão","doi":"10.3390/md23090347","DOIUrl":"10.3390/md23090347","url":null,"abstract":"Earth hosts a remarkable diversity of life, with oceans covering over 70% of its surface and supporting the greatest abundance and variety of species, including a vast range of seaweeds. Among these, red seaweeds (Rhodophyta) represent the most diverse group and are particularly rich in bioactive compounds. Grateloupia turuturu Yamada and Porphyra umbilicalis Kütz. are two species with significant biotechnological and functional food potential. They contain high levels of phycobiliproteins, sulfated polysaccharides (e.g., carrageenan, agar, porphyran), mycosporine-like amino acids (MAAs), phenols, minerals, and vitamins, including vitamin B12 (rare among non-animal sources). Several analytical methods, such as spectrophotometry, chromatography, and mass spectrometry, have been used to characterize their chemical composition. In vitro and in vivo studies have demonstrated their antioxidant, anti-inflammatory, neuroprotective, immunostimulatory, anti-proliferative, and photoprotective effects. These bioactive properties support its application in the food, pharmaceutical, and cosmetic sectors. Given the growing demand for sustainable resources, these algae species stand out as promising candidates for aquaculture and the development of functional ingredients. Their incorporation into novel food products, such as snacks and fortified dairy and meat products, underscores their potential to support health-promoting diets. This review highlights G. turuturu and P. umbilicalis chemical richness, bioactivities, and applications, reinforcing their value as sustainable marine resources.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic and Nutraceutical Potential of Sargassum Species: A Narrative Review. 马尾藻的治疗和营养潜力：叙述综述。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-28 DOI: 10.3390/md23090343

Alejandra Torres-Narváez, Andrea Margarita Olvera-Ramírez, Karen Castaño-Sánchez, Jorge Luis Chávez-Servín, Tércia Cesária Reis de Souza, Neil Ross McEwan, Roberto Augusto Ferriz-Martínez

引用次数: 0

Structural and Immunological Insights into the Lipooligosaccharide of the Marine Bacterium Kangiella japonica KMM 3897. 海洋细菌日本Kangiella japonica kmm3897脂寡糖的结构和免疫学研究。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-28 DOI: 10.3390/md23090345

Alina P Filshtein, Vlada S Belova, Alexandra S Kuzmich, Lyudmila A Romanenko, Maxim S Kokoulin

{"title":"Structural and Immunological Insights into the Lipooligosaccharide of the Marine Bacterium Kangiella japonica KMM 3897.","authors":"Alina P Filshtein, Vlada S Belova, Alexandra S Kuzmich, Lyudmila A Romanenko, Maxim S Kokoulin","doi":"10.3390/md23090345","DOIUrl":"10.3390/md23090345","url":null,"abstract":"The lipooligosaccharide (LOS) of the marine bacterium Kangiella japonica KMM 3897 was structurally characterized using chemical analysis, NMR spectroscopy, and MALDI-TOF mass spectrometry. The oligosaccharide core consists of a monophosphorylated trisaccharide containing 2-amino-2-deoxy-D-glucose, D-glycero-D-manno-heptose, and 3-deoxy-D-manno-oct-2-ulosonic acid. The penta-acylated lipid A moiety features a glucosamine disaccharide backbone with phosphate groups and amide- and ester-linked primary fatty acids [i11:0 (3-OH)], along with a secondary acyl chain (i11:0 or 11:0). Immunostimulatory assays revealed that K. japonica KMM 3897 LOS induced significantly weaker cytokine production in human peripheral blood mononuclear cells (PBMCs) compared with E. coli LPS. Notably, it exhibited potent antagonistic activity against E. coli LPS-mediated toxicity and suppressed caspase-4 activation in LPS-treated PBMCs. These findings highlight its anti-inflammatory and protective properties.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implantable Bioresorbable Scaffold with Fucosylated Chondroitin Sulfate as a Promising Device for Delayed Stimulation of Hematopoiesis. 可植入式生物可吸收支架聚焦硫酸软骨素作为一种有前途的延迟刺激造血装置。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-28 DOI: 10.3390/md23090344

Natalia Y Anisimova, Olga V Rybalchenko, Natalia S Martynenko, Georgy V Rybalchenko, Elena A Lukyanova, Maria I Bilan, Anatolii I Usov, Mikhail V Kiselevskiy, Nikolay E Nifantiev

{"title":"Implantable Bioresorbable Scaffold with Fucosylated Chondroitin Sulfate as a Promising Device for Delayed Stimulation of Hematopoiesis.","authors":"Natalia Y Anisimova, Olga V Rybalchenko, Natalia S Martynenko, Georgy V Rybalchenko, Elena A Lukyanova, Maria I Bilan, Anatolii I Usov, Mikhail V Kiselevskiy, Nikolay E Nifantiev","doi":"10.3390/md23090344","DOIUrl":"10.3390/md23090344","url":null,"abstract":"The aim of this study was to evaluate the prospects of using natural fucosylated chondroitin sulfate (FCS) from the sea cucumber Cucumaria japonica as the active component of an implantable biodegradable scaffold to stimulate hematopoiesis in mice with cyclophosphamide (CPh)-induced myelosuppression. The scaffolds were based on bioresorbable Fe-Mn-C and Fe-Mn-Pd alloys after equal-channel angular pressing (ECAP). The efficiency of the developed constructs with FCS was compared with the activity of the same scaffolds loaded with recombinant human granulocyte colony stimulating factor, as well as solutions of these active compounds administered subcutaneously after the end of the cyclophosphamide (CPh) course. It was found that implantation of the Fe-Mn-C scaffold loaded with FCS most effectively stimulated hematopoiesis, providing a complex effect. This design of the developed constructs contributed to an increase in the concentration not only of leukocytes and neutrophils, but also platelets in the blood, promoted the proliferation of bone marrow cells, increasing the concentration of Ki-67(+) cells, and contributed to the restoration of the morphology of the animals' spleen.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Marine Algae for Sustainable Agriculture: Natural Bioactive Compounds as Eco-Friendly Pesticidal Agents. 利用海藻促进可持续农业：天然生物活性化合物作为生态友好型杀虫剂。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-28 DOI: 10.3390/md23090346

Georgi Beev, Diyana Dermendzhieva, Zvezdelina Yaneva, Georgi Kalaydzhiev, Nikolina Naydenova, Daniela Stoeva, Denitsa Georgieva, Silviya Hristova, Zornitsa Beeva, Nikolay Petrov

{"title":"Harnessing Marine Algae for Sustainable Agriculture: Natural Bioactive Compounds as Eco-Friendly Pesticidal Agents.","authors":"Georgi Beev, Diyana Dermendzhieva, Zvezdelina Yaneva, Georgi Kalaydzhiev, Nikolina Naydenova, Daniela Stoeva, Denitsa Georgieva, Silviya Hristova, Zornitsa Beeva, Nikolay Petrov","doi":"10.3390/md23090346","DOIUrl":"10.3390/md23090346","url":null,"abstract":"Currently, marine algae are capturing the attention of both farmers and researchers eager to integrate sustainable methods to safeguard their crops. Instead of relying exclusively on synthetic pesticides, which often have negative environmental effects, some growers are now exploring algae-based products in hopes of reducing pest pressures. Various natural compounds sourced from algae-such as specific fatty acids and complex sugars-are believed to inhibit pest development, although their precise mechanisms are yet to be fully understood. Furthermore, there is some evidence suggesting that these compounds may bolster the plant's own immune responses, thus enhancing crop resilience. Despite certain limitations on field applications, various techniques, including spraying, amending soil, or pre-treating seeds, are currently being evaluated. The results from the laboratory present a positive outlook, but implementing these discoveries to ensure consistent efficacy in practical settings is a major challenge. Variables such as climatic fluctuations, product durability, and formulation standards all elevate this complexity. In every instance, the approach of incorporating algae to lessen chemical dependence while securing uniform yields persists in being of interest, particularly in the area of organic or low-input farming.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microalgae-Based 3D Bioprinting: Recent Advances, Applications and Perspectives. 基于微藻的生物3D打印：最新进展、应用和前景。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-27 DOI: 10.3390/md23090342

Jinhui Tang, Jiahui Sun, Jinyu Cui, Xiangyi Yuan, Guodong Luan, Xuefeng Lu

{"title":"Microalgae-Based 3D Bioprinting: Recent Advances, Applications and Perspectives.","authors":"Jinhui Tang, Jiahui Sun, Jinyu Cui, Xiangyi Yuan, Guodong Luan, Xuefeng Lu","doi":"10.3390/md23090342","DOIUrl":"10.3390/md23090342","url":null,"abstract":"Three-dimensional bioprinting integrating living cells and bioactive materials enables the fabrication of scaffold structures supporting diverse cellular growth and metabolism. Microalgae are among the most promising microbial platforms for the construction of photosynthetic cell factories, while the current industrial-scale cultivation of microalgae remains predominantly dependent on traditional liquid submerged systems, imposing limitations on commercial viability due to both process and economic constraints. Encapsulation of microalgae within bioactive matrices combined with 3D bioprinting to fabricate customized structures has been explored to address the limitations of submerged cultivation, which are expected to expand microalgal applications and establish new research directions in microalgal biotechnology. This review analyzes both matrices and methods of 3D bioprinting, summarizing the advancement of microalgae-based 3D bioprinting into six main domains including living building materials, biophotovoltaics, photosynthetic biosynthesis, bioremediation, tissue engineering, and food engineering. Lastly, synthetic biology-informed perspectives are provided on future developments of 3D bioprinting technologies and their potential in microalgal research.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12471347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Moray Eel (Gymnothorax javanicus), a Long-Living Apex Predator That Poses a Food Safety Risk in the Pacific. 巨型海鳗（Gymnothorax javanicus），一种长寿的顶级捕食者，对太平洋的食品安全构成威胁。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-26 DOI: 10.3390/md23090341

Emillie M F Passfield, Kirsty F Smith, D Tim Harwood, Joshua D Fitzgerald, Phoebe A Argyle, Jacob Thomson-Laing, J Sam Murray

{"title":"Giant Moray Eel (Gymnothorax javanicus), a Long-Living Apex Predator That Poses a Food Safety Risk in the Pacific.","authors":"Emillie M F Passfield, Kirsty F Smith, D Tim Harwood, Joshua D Fitzgerald, Phoebe A Argyle, Jacob Thomson-Laing, J Sam Murray","doi":"10.3390/md23090341","DOIUrl":"10.3390/md23090341","url":null,"abstract":"The giant moray eel (GME; Gymnothorax javanicus) is an important marine species that plays a key ecological role in reef systems and is a valued food source for indigenous communities. However, it is well-known that GMEs pose a food safety risk due to their ability to accumulate high levels of ciguatoxins (CTXs), the toxins known to cause ciguatera poisoning. This study assessed the age, CTX levels, elemental composition, and nutritional profile of seven GME specimens collected from Muri Lagoon, Rarotonga (Cook Islands), representing the most detailed compositional investigation on this species. Age was determined for the three largest specimens, with the oldest being 39 years old. All specimens contained ciguatoxins, with Type I (CTX4A derivatives), Type II (CTX3C derivatives), algal-ciguatoxins, and biotransformed metabolites being detected. There was a higher CTX content in the liver samples compared to flesh samples, with the longest-heaviest specimen containing the highest levels. The CTX1B level observed in flesh samples of all seven eel specimens exceeded the recommended safe guidance level proposed by the USFDA. A similar ciguatoxin profile was observed across flesh sections, with the belly flap or top loin containing the highest levels of CTXs in most specimens. No bioactive metabolites produced by co-occurring harmful microalgae, including regulated shellfish toxins, were detected. Elemental analysis determined the presence of 21 elements, including arsenic, low levels of mercury, and the volcanic elements rubidium and strontium. Nutritionally, the GMEs were shown to be a lean protein source; however, due to the ubiquitous bioaccumulation of CTXs, they pose a food safety risk to consumers.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145149715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total Syntheses of Marine Natural Products Lyngbyabellin O and Lyngbyabellin P. 海洋天然产物水杨酸O和水杨酸P的全合成。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-26 DOI: 10.3390/md23090340

Jing Chen, Shiyu Li, Chao Xu, Tao Ye

引用次数: 0

OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus Talaromyces amestolkiae HDN21-0307. osmac驱动下从冷渗源真菌Talaromyces amestolkiae HDN21-0307中发现六种新的生物碱。

IF 5.4 2区医学

Marine Drugs Pub Date : 2025-08-25 DOI: 10.3390/md23090337

Xinsheng Huang, Jiajin Wu, Luning Zhou, Zhengjie Wang, Qian Che, Liangzhen Chen, Wenxue Wang, Tianjiao Zhu, Dehai Li

引用次数: 0