Xinsheng Huang, Jiajin Wu, Luning Zhou, Zhengjie Wang, Qian Che, Liangzhen Chen, Wenxue Wang, Tianjiao Zhu, Dehai Li
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引用次数: 0
摘要
通过OSMAC法从深海冷源真菌Talaromyces amestolkiae HDN21-0307中分离得到6个新的生物碱化合物，包括2个稀有芳香腈化合物talaronitriles a - b（1-2）、1个新的肟功能化氮杂二酮类似物talarooxime a(3)、1个新的苯基腙生物碱talarohydrazone E(4)和2个新的二肽化合物talarodizone a - b（5-6）。化合物1是第一个含氰基的天然萘化合物。化合物3是第一个含有肟功能化氮杂二酮支架的天然产物。通过光谱数据分析和量子化学计算阐明了它们的结构和绝对构型。值得注意的是，化合物3具有中等的DPPH自由基清除活性，IC50值为29.41 μM。
OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus Talaromyces amestolkiae HDN21-0307.
Six new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A-B (1-2), a novel oxime-functionalized azadiphilone analogue talarooxime A (3), a new phenylhydrazone alkaloid talarohydrazone E (4), and two new dipeptide compounds talarodipeptides A-B (5-6), were isolated from the deep-sea cold-seep-derived fungus Talaromyces amestolkiae HDN21-0307 via OSMAC approach. Compound 1 is the first natural naphthalene compound with cyano groups. Compound 3 represents the first natural product containing an oxime-functionalized azadiphilone scaffold. Their structures and absolute configurations were elucidated through spectroscopic data analysis and quantum chemical calculations. Notably, compound 3 demonstrated moderate DPPH free-radical-scavenging activity, with an IC50 value of 29.41 μM.
期刊介绍：
Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.
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