Marine Drugs最新文献

{"title":"Multifaceted Marine Peptides and Their Therapeutic Potential.","authors":"Svetlana V Guryanova, Tatiana V Ovchinnikova","doi":"10.3390/md23070288","DOIUrl":"10.3390/md23070288","url":null,"abstract":"<p><p>Marine peptides, derived from a great number of aquatic organisms, exhibit a broad spectrum of biological activities that hold a significant therapeutic potential. This article reviews the multifaceted roles of marine peptides, focusing on their antibacterial, antibiofilm, antifungal, antiviral, antiparasitic, cytotoxic, anticancer, immunomodulatory, chemotactic, opsonizing, anti-inflammatory, antiaging, skin-protective, and wound-healing properties. By elucidating mechanisms of their action and highlighting key research findings, this review aims to provide a comprehensive understanding of possible therapeutic applications of marine peptides, underscoring their importance in developing novel drugs as well as in cosmetology, food industry, aquatic and agriculture biotechnology. Further investigations are essential to harness their therapeutic potential and should focus on detailed mechanism studies, large-scale production, and clinical evaluations with a view to confirm their efficacy and safety and translate these findings into practical applications. It is also important to investigate the potential synergistic effects of marine peptide combinations with existing medicines to enhance their efficacy. Challenges include the sustainable sourcing of marine peptides, and therefore an environmental impact of harvesting marine organisms must be considered as well.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosmarinic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Suppressing Ferroptosis and Oxidative Stress Through Nrf2/HO-1 Activation in Mice.","authors":"Liqin Wu, Li Lv, Yifei Xiang, Dandan Yi, Qiuling Liang, Min Ji, Zhaoyou Deng, Lanqian Qin, Lingyi Ren, Zhengmin Liang, Jiakang He","doi":"10.3390/md23070287","DOIUrl":"10.3390/md23070287","url":null,"abstract":"<p><p>Liver injury caused by the irrational use of acetaminophen (APAP) represents a significant challenge in the field of public health. In clinical treatment, apart from N-acetylcysteine (NAC), the only approved antidote, there are extremely limited effective intervention measures for APAP-induced hepatotoxicity. Therefore, exploring novel liver-protecting drugs and elucidating their mechanisms of action is of great scientific significance and clinical value. Rosmarinic acid (RA), as a natural polyphenolic compound, has been proven to have significant antioxidant activity. Previous studies have shown that it has a protective effect against drug-induced liver injury. Nevertheless, the precise protective mechanism of RA in APAP-induced acute liver injury (AILI) has not been fully defined. This study was based on an AILI mouse model to systematically explore the liver-protecting effect of RA and its underlying molecular mechanisms. The research results showed that pretreatment with RA could notably mitigate liver pathological injury. It could decrease the activities of ALT and AST in the serum, suppress the liver inflammatory reaction, and reverse the decline in the levels of CAT, T-AOC, SOD, and GSH caused by APAP. Meanwhile, RA could enhance antioxidant defense capabilities by activating the Keap1/Nrf2/HO-1 signaling pathway, regulate the <i>xCT</i>/GPX4 axis to inhibit lipid peroxidation, and thus block the process of ferroptosis. In conclusion, this study confirmed that RA exerts a protective effect against AILI by regulating the Keap1/Nrf2/HO-1 axis to enhance antioxidant capacity and inhibit ferroptosis through the <i>xCT</i>/GPX4 pathway. Our research provides a theoretical basis for RA as a potential therapeutic agent for APAP-induced liver injury.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Isolation of ω-3 Polyunsaturated Fatty Acids from the Marine Dinoflagellate <i>Prorocentrum lima</i> Using DeepSAT and LC-MS/MS and Their High Activity in Promoting Microglial Functions.","authors":"Chang-Rong Lai, Meng-Xing Jiang, Dan-Mei Tian, Wei Lu, Bin Wu, Jin-Shan Tang, Yi Zou, Song-Hui Lv, Xin-Sheng Yao","doi":"10.3390/md23070286","DOIUrl":"10.3390/md23070286","url":null,"abstract":"<p><p>In this study, we integrated HSQC-based DeepSAT with UPLC-MS/MS to guide the isolation of omega-3 polyunsaturated fatty acid derivatives (PUFAs) from marine resources. Through this approach, four new (<b>1</b>-<b>4</b>) and nine known (<b>5</b>-<b>13</b>) PUFA analogues were obtained from large-scale cultures of the marine dinoflagellate <i>Prorocentrum lima</i>, with lipidomic profiling identifying FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and FA22:6 methyl ester (<b>11</b>) as major constituents of the algal oil extract. Structural elucidation was achieved through integrated spectroscopic analyses of IR, 1D and 2D NMR, and HR-ESI-MS data. Given the pivotal role of microglia in Alzheimer's disease (AD) pathogenesis, we further evaluated the neuroprotective potential of these PUFAs by assessing their regulatory effects on critical microglial functions in human microglia clone 3 (HMC3) cells, including chemotactic migration and amyloid-β42 (Aβ42) phagocytic clearance. Pharmacological evaluation demonstrated that FA20:5 butanediol ester (<b>1</b>), FA18:5 (<b>5</b>), FA18:4 (<b>7</b>), FA22:6 (<b>8</b>), and (<i>Z</i>)-10-nonadecenoic acid (<b>13</b>) significantly enhanced HMC3 migration in a wound-healing assay. Notably, FA18:4 (<b>7</b>) also significantly promoted Aβ42 phagocytosis by HMC3 microglia while maintaining cellular viability and avoiding pro-inflammatory activation at 20 μM. Collectively, our study suggests that FA18:4 (<b>7</b>) modulates microglial function in vitro, indicating its potential to exert neuroprotective effects.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marine-Derived Compounds: A New Horizon in Cancer, Renal, and Metabolic Disease Therapeutics.","authors":"Jinwei Zhang","doi":"10.3390/md23070283","DOIUrl":"10.3390/md23070283","url":null,"abstract":"<p><p>Marine-derived compounds represent a rich source of structurally diverse molecules with therapeutic potential for cancer, renal disorders, metabolic-associated fatty liver disease (MAFLD), and atherosclerosis. This review systematically evaluates recent advances, highlighting compounds such as Microcolin H, Benzosceptrin C, S14, HN-001, Equisetin, glycosides (e.g., cucumarioside A₂-2), ilimaquinone, and Aplidin (plitidepsin). Key mechanisms include autophagy modulation, immune checkpoint inhibition, anti-inflammatory effects, and mitochondrial homeostasis. Novel findings reveal glycosides' dual role in cytotoxicity and immunomodulation, ilimaquinone's induction of the DNA damage response, and Aplidin's disruption of protein synthesis via eEF1A2 binding. Pharmacokinetic challenges and structure-activity relationships are critically analyzed, emphasizing nanodelivery systems and synthetic analog development. This review bridges mechanistic insights with translational potential, offering a cohesive framework for future drug development.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>κ</i>/<i>ι</i>-Carrageenan Blends in Plant Capsules: Achieving Harmony Between Mechanical and Disintegration Properties.","authors":"Zhenyu Liu, Chuqi He, Zhibin Yang, Qing Zhao, Yuting Dong, Jing Ye, Bingde Zheng, Ranjith Kumar Kankala, Xueqin Zhang, Meitian Xiao","doi":"10.3390/md23070284","DOIUrl":"10.3390/md23070284","url":null,"abstract":"<p><p>The fast-disintegrating capsules rapidly disintegrate in various physiological environments, ensuring therapeutic efficacy. The formulation of plant-based capsules with balanced mechanical and fast disintegration characteristics continues to present technical challenges in pharmaceutical development. In this study, natural marine polysaccharides were utilized to achieve both rapid disintegration and excellent mechanical properties by combining <i>κ</i>-Carrageenan (<i>κ</i>-C) and <i>ι</i>-Carrageenan (<i>ι</i>-C). Additionally, the selection of KCl + NaCl mixed coagulants, along with the evaluation of their types, mass fractions, and ratios, enhanced the mechanical properties and transmittance of the capsules. FTIR analysis revealed that the membrane with a 5:5 <i>κ</i>-C/<i>ι</i>-C ratio formed hydrogen bonds, which were beneficial to its fast disintegration. SEM analysis revealed a dense microstructure in this formulation, contributing to its improved mechanical properties. Finally, this study hypothesizes that the disintegration behaviors of the capsules exhibited significant pH dependence, with ion exudation predominating in pH 1.2 and pH 7.0 media, while swelling dominated under pH 4.5 and pH 6.8 media. The prepared carrageenan blend-based capsules exhibited fast disintegration properties while maintaining excellent mechanical and barrier properties, thereby broadening the application of plant-based capsules in the field of medicine.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Secondary Metabolites from the Sponge-Derived Fungus <i>Aspergillus templicola</i>.","authors":"Kai Li, Yue Zhang, Lei Li, Sen Wang, Cili Wang, Pinglin Li","doi":"10.3390/md23070285","DOIUrl":"10.3390/md23070285","url":null,"abstract":"<p><p>Combining biosynthetic gene cluster analysis with the OSMAC strategy, fractionation of the fermentation extract of <i>Aspergillus templicola</i> from the sponge <i>Agelas</i> sp. led to the isolation of four novel cytochalasins, colachalasins J-M (<b>1</b>-<b>4</b>), a novel cyclic pentapeptide, avellanin P (<b>5</b>), together with five known compounds (<b>6</b>-<b>10</b>). The structures of <b>1</b>-<b>9</b> were elucidated using spectroscopic data, single crystal X-ray diffraction, and Marfey's analysis. Compound <b>2</b> exhibited potent anti-inflammatory activity in zebrafish assays. Additionally, Compounds <b>4</b> and <b>6</b> showed modest cytotoxicity against several human cancer cell lines with IC₅₀ values ranging from 2.6 to 11.2 μm.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Profiling and Anti-<i>Helicobacter pylori</i> Activity of <i>Caulerpa lentillifera</i> (Sea Grape) Extract.","authors":"Chananchida Thacharoen, Thisirak Inkaewwong, Watthanachai Jumpathong, Pornchai Kaewsapsak, Thiravat Rattanapot, Tippapha Pisithkul","doi":"10.3390/md23070282","DOIUrl":"10.3390/md23070282","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> is a gastric pathogen implicated in peptic ulcer disease and gastric cancer. The increasing prevalence of antibiotic-resistant strains underscores the urgent need for alternative therapeutic strategies. In this study, we investigated the chemical composition and antibacterial activity of an aqueous extract from <i>Caulerpa lentillifera</i> (sea grape), a farm-cultivated edible green seaweed collected from Krabi Province, Thailand. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) revealed that the extract was enriched in bioactive nucleosides and phenolic compounds. In vitro assays demonstrated dose-dependent inhibition of <i>H. pylori</i> growth following exposure to sea grape extract. Furthermore, untargeted intracellular metabolomic profiling of <i>H. pylori</i> cells treated with the extract uncovered significant perturbations in central carbon and nitrogen metabolism, including pathways associated with the tricarboxylic acid (TCA) cycle, one-carbon metabolism, and alanine, aspartate, and glutamate metabolism. Pyrimidine biosynthesis was selectively upregulated, indicating a potential stress-induced shift toward nucleotide salvage and DNA repair. Of particular note, succinate levels were markedly reduced despite accumulation of other TCA intermediates, suggesting disruption of electron transport-linked respiration. These findings suggest that bioactive metabolites from <i>C. lentillifera</i> impair essential metabolic processes in <i>H. pylori</i>, highlighting its potential as a natural source of antimicrobial agents targeting bacterial physiology.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoautotrophic Batch Cultivation of <i>Limnospira</i> (Spirulina) <i>platensis</i>: Optimizing Biomass Productivity and Bioactive Compound Synthesis Through Salinity and pH Modulation.","authors":"Matteo Rizzoli, Giovanni Antonio Lutzu, Luca Usai, Giacomo Fais, Debora Dessì, Robinson Soto-Ramirez, Bartolomeo Cosenza, Alessandro Concas","doi":"10.3390/md23070281","DOIUrl":"10.3390/md23070281","url":null,"abstract":"<p><p>This study investigates the effects of salinity and pH modulation on the growth, biochemical composition, and bioactive compound production of <i>Limnospira platensis</i> under photoautotrophic batch cultivation. Cultures were grown in cylindrical photobioreactors using modified Jourdan medium, with controlled variations in NaCl concentrations (0.2-10 g L^-1) and pH levels (9-11) to simulate moderate environmental stress. Maximum biomass productivity (1.596 g L^-1) was achieved at pH 11 with 10 g L^-1 NaCl, indicating that <i>L. platensis</i> can tolerate elevated stress conditions. Phycocyanin (PC) content peaked at 9.54 g 100 g^-1 dry weight (DW) at pH 10 and 5 g L^-1 NaCl, triple the value at pH 9, highlighting optimal physiological conditions for pigment synthesis. Protein fraction dominated biomass composition (40-60%), while total lipid content increased significantly under high pH and salinity. Polyphenol content reached 19.5 mg gallic acid equivalents (GAE) gDW^-1 at pH 10 with 0.2 g L^-1 NaCl, correlating with the highest antioxidant activity (Trolox equivalent antioxidant capacity). These findings underscore the potential of <i>L. platensis</i> as a valuable source of proteins, pigments, and antioxidants, and emphasize the utility of moderate environmental stress in enhancing biomass quality, defined by protein, pigment, and antioxidant enrichment. While this study focused on physiological responses, future research will apply omics approaches to elucidate stress-response mechanisms. This study provides insights into optimizing cultivation strategies for large-scale production exploitable in food, pharmaceutical, and bio-based industries.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Secondary Metabolites from <i>Penicillium</i> sp. NX-S-6.","authors":"Hanyang Peng, Jiawen Sun, Rui Zhang, Yuxuan Qiu, Yu Hong, Fengjuan Zhou, Chang Wang, Yang Hu, Xiachang Wang","doi":"10.3390/md23070280","DOIUrl":"10.3390/md23070280","url":null,"abstract":"<p><p>Five new natural products, including two sorbicillinoids (<b>1</b>-<b>2</b>), one indolinone alkaloid (<b>10</b>), one tetracyclic steroid (<b>11</b>), and one α-pyrone derivative (<b>14</b>), were identified from the endophytic <i>Penicillium</i> sp. NX-S-6, together with thirteen known natural products. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analyses (NMR, MS), as well as electronic circular dichroism (ECD) calculation. Notably, quinosorbicillinol (<b>1</b>) was identified as a rare hybrid sorbicillinoid incorporating a quinolone moiety, representing a unique structural scaffold in this natural product class. Biological evaluation revealed that Compounds <b>1</b>, <b>4</b> and <b>8</b> potently inhibited the production of nitric oxide and interleukin 6 in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Mechanistic studies furthermore demonstrated that Compounds <b>4</b> and <b>8</b> effectively suppressed interleukin-1β secretion in LPS-induced immortalized mouse bone marrow-derived macrophages (iBMDMs) by blocking NLRP3 inflammasome activation. This inhibition was attributed to their ability to disrupt the assembly of the NLRP3-caspase-1 complex, a key event in the pathogenesis of inflammatory disorders. These findings not only expand the structural diversity of endophyte-derived natural products but also highlight their potential as lead compounds for developing anti-inflammatory therapeutics targeting the NLRP3 pathway.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into Natural Products from Marine-Derived Fungi with Antimycobacterial Properties: Opportunities and Challenges.","authors":"Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti","doi":"10.3390/md23070279","DOIUrl":"10.3390/md23070279","url":null,"abstract":"<p><p>Tuberculosis (TB) poses a persistent global health threat exacerbated by the emergence of drug-resistant strains; hence, there is a continuous quest for novel antimicrobial agents. Despite efforts to develop effective therapies, existing treatments require a relatively long duration of therapy to eradicate the pathogen due to its virulence factors, pathogenesis patterns, and ability to enter dormant states. This can lead to a higher risk of treatment failure due to poor patient adherence to the complex regimen. As a result, considerable research is necessary to identify alternative antituberculosis agents. The marine environment, particularly marine-derived fungi, has recently gained interest due to its potential as an abundant source of bioactive natural products. This review covers 19 genera of marine-derived fungi and 139 metabolites, 131 of which exhibit antimycobacterial activity. The integrated dataset pinpoints the fungal genera and chemical classes that most frequently yield potent antimycobacterial hits while simultaneously exposing critical gaps, such as the minimal evaluation of compounds against dormant bacilli and the presence of underexplored ecological niches and fungal genera. Several compounds exhibit potent activity through uncommon mechanisms, including the inhibition of mycobacterial protein tyrosine phosphatases (MptpB/MptpA), protein kinase PknG, ATP synthase and the disruption of mycobacterial DNA via G-quadruplex stabilization. Structure-activity relationship (SAR) trends are highlighted for the most potent agents, illuminating how specific functional groups underpin target engagement and potency. This review also briefly proposes a dereplication strategy and approaches for toxicity mitigation in the exploration of marine-derived fungi's natural products. Through this analysis, we offer insights into the potency and challenges of marine-derived fungi's natural products as hit compounds or scaffolds for further antimycobacterial research.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 7","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}