Marine Drugs最新文献_第9页

Identification, Expression Profiling, Microbial Binding, and Agglutination Analyses of Two Cathepsin B Genes in Black Rockfish (Sebastes schlegelii). 黑岩鱼两个组织蛋白酶B基因的鉴定、表达谱、微生物结合和凝集分析。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-18 DOI: 10.3390/md23050213

Xinghua Zhuang, Xingchun Li, Wenpeng Li, Xuan Xu, Fengjun Lin, Yiying Liu, Chonghui Chen, Xiaoxu Zhang, Pei Zhang, Chao Li, Qiang Fu

{"title":"Identification, Expression Profiling, Microbial Binding, and Agglutination Analyses of Two Cathepsin B Genes in Black Rockfish (Sebastes schlegelii).","authors":"Xinghua Zhuang, Xingchun Li, Wenpeng Li, Xuan Xu, Fengjun Lin, Yiying Liu, Chonghui Chen, Xiaoxu Zhang, Pei Zhang, Chao Li, Qiang Fu","doi":"10.3390/md23050213","DOIUrl":"10.3390/md23050213","url":null,"abstract":"As a lysosomal cysteine protease of the papain subfamily, cathepsin B (CTSB) is characterized by its innate immune functions and hydrolytic activity. However, the functions of CTSB in the immune responses of teleosts remain to be clarified. In this study, two CTSB genes in S. schlegelii, SsCTSBa and SsCTSBb, were identified. Both SsCTSBa and SsCTSBb are composed of a 993 bp ORF encoding 330 amino acids. It was found in a phylogeny analysis that both genes form monophyletic clades with their orthologous counterparts of Honeycomb rockfish (Sebastes umbrosus). A synteny analysis indicated that the CTSB homologues were comparatively conserved during vertebrate evolution. Additionally, quantitative real-time PCR revealed the ubiquitous mRNA expression of SsCTSBa and SsCTSBb in all of the examined tissues, and substantially differential expression patterns could be observed following Aeromonas salmonicida infection. A subcellular localization analysis demonstrated that the distribution of SsCTSBa and SsCTSBb was mainly in the cytoplasm. Moreover, rSsCTSBa and rSsCTSBb showed strong binding to Poly(I:C) and exhibited diverse agglutination effects on different bacteria. Overall, these findings suggest that the CTSB genes in black rockfish might show essential functions in the host defense of teleosts against bacterial infections, providing valuable insights for further investigations into the immune mechanism of teleost CTSB.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dihydrogeodin from Fennellia flavipes Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ₃ Integrins, MAPK, and PI3K/Akt Pathways. 小茴香中的二氢洋杉素通过下调钙信号、α ib β3整合素、MAPK和PI3K/Akt通路调控血小板聚集。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-17 DOI: 10.3390/md23050212

Abdul Wahab Akram, Dae-Cheol Choi, Hyung-Kyu Chae, Sung Dae Kim, Dongmi Kwak, Bong-Sik Yun, Man Hee Rhee

{"title":"Dihydrogeodin from Fennellia flavipes Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ3 Integrins, MAPK, and PI3K/Akt Pathways.","authors":"Abdul Wahab Akram, Dae-Cheol Choi, Hyung-Kyu Chae, Sung Dae Kim, Dongmi Kwak, Bong-Sik Yun, Man Hee Rhee","doi":"10.3390/md23050212","DOIUrl":"10.3390/md23050212","url":null,"abstract":"Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, frequently arising from platelet hyperactivation and subsequent thrombus formation. Although conventional antiplatelet therapies are available, challenges, such as drug resistance and bleeding complications, require the development of novel agents. In this study, dihydrogeodin (DHG) was isolated from Fennellia flavipes and evaluated using platelets derived from Sprague-Dawley rats. Platelet aggregation induced by collagen, adenosine diphosphate, or thrombin was assessed by light transmission aggregometry; DHG significantly reduced aggregation in a dose-dependent manner. Further assays demonstrated that DHG suppressed intracellular calcium mobilization, adenosine triphosphate release, and integrin αIIbβ3-dependent fibrinogen binding, thereby impairing clot retraction. Western blot analysis revealed that DHG reduced the phosphorylation of mitogen-activated protein kinases (ERK, JNK, p38) and PI3K/Akt, indicating inhibition across multiple platelet-signaling pathways. Additionally, SwissADME-assisted pharmacokinetics predicted favorable properties without violations of the Lipinski (Pfizer) filter, Muegge (Bayer) filter, Ghose filter, Veber filter, and Egan filter, and network pharmacology revealed inhibition of calcium and MAPK pathways. These results highlight the potential of DHG as a novel antiplatelet agent with broad-spectrum activity and promising drug-like characteristics. Further studies are warranted to assess its therapeutic window, safety profile, and potential for synergistic use with existing antiplatelet drugs.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12112792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery. 深层共晶系统：海洋生物活性恢复的游戏规则改变者。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-16 DOI: 10.3390/md23050211

Sandro Amador, Alice Martins, Margarida Matias, Rui Pedrosa, Susete Pinteus

{"title":"Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery.","authors":"Sandro Amador, Alice Martins, Margarida Matias, Rui Pedrosa, Susete Pinteus","doi":"10.3390/md23050211","DOIUrl":"10.3390/md23050211","url":null,"abstract":"The extraction of bioactive compounds from marine natural products has gained increasing attention due to their diverse applications, such as in pharmaceuticals, nutraceuticals, and cosmetics. Yet, low extraction yields and toxicity associated with common solvents are a major bottleneck. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs) have emerged as promising green alternatives to conventional organic solvents, offering advantages such as biodegradability, greater environmental and economic sustainability, low toxicity, and enhanced extraction selectivity. This review provides a comprehensive analysis of the principles, physicochemical properties, and applications of DESs/NADESs to obtain bioactive compounds from marine organisms. Among the most recent works, it is possible to verify the success of NADESs to extract carrageenan from the seaweed Kappaphycus alvarezii; pigments from Palmaria palmata; and polyphenols and proteins from different brown seaweeds. NADESs have also shown high potential to extract other valuable compounds from marine by-products, such as chitin from crabs and shrimp shells, and also lipids and proteins from different fish species and protein rich extracts from tilapia viscera. The challenges for DESs/NADESs use at industrial scale are also discussed, and success cases are revealed, highlighting their potential as game changers for extracting bioactive compounds from marine organisms and driving the development of innovative biotechnological products.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sesquiterpenes from Brown Algae. 褐藻中的倍半萜。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-15 DOI: 10.3390/md23050210

Irene Moreno-Gutiérrez, Sonia Berenguel-Gómez, Manuel Muñoz-Dorado, Míriam Álvarez-Corral, Ignacio Rodríguez-García

{"title":"Sesquiterpenes from Brown Algae.","authors":"Irene Moreno-Gutiérrez, Sonia Berenguel-Gómez, Manuel Muñoz-Dorado, Míriam Álvarez-Corral, Ignacio Rodríguez-García","doi":"10.3390/md23050210","DOIUrl":"10.3390/md23050210","url":null,"abstract":"Algae are the group that has managed to generate the largest number of compounds and secondary metabolites with different properties, many of them only present in the aquatic kingdom. Among them, brown algae are one of the main producers within marine ecosystems. Furthermore, one of the main groups of secondary metabolites studied are sesquiterpenes due to the great variety of properties observed, largely due to the great structural variability of these compounds. Many studies have been carried out to isolate and characterize compounds with a sesquiterpene structure from different species of brown algae. This article reviews the natural occurrence of sesquiterpene and derivatives in brown algae. A total of 51 sesquiterpenes isolated from brown algae, having monocyclic, bicyclic, or tricyclic skeletons, as well as 23 sesquiterpenoids with various chemical structures, are depicted. Moreover, there are at least eleven publications focused on the study of the profiles on volatile organic compounds (VOCs) within brown algae, derived using several analytic and extraction techniques, and in the finding of a large variety of structures of sesquiterpenes.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Anti-MRSA Peptide from Mangrove-Derived Virgibacillus chiguensis FN33 Supported by Genomics and Molecular Dynamics. 红树林赤iguensis FN33新抗mrsa肽的基因组学和分子动力学支持

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-14 DOI: 10.3390/md23050209

Namfa Sermkaew, Apichart Atipairin, Phetcharat Boonruamkaew, Sucheewin Krobthong, Chanat Aonbangkhen, Jumpei Uchiyama, Yodying Yingchutrakul, Nuttapon Songnaka

{"title":"Novel Anti-MRSA Peptide from Mangrove-Derived Virgibacillus chiguensis FN33 Supported by Genomics and Molecular Dynamics.","authors":"Namfa Sermkaew, Apichart Atipairin, Phetcharat Boonruamkaew, Sucheewin Krobthong, Chanat Aonbangkhen, Jumpei Uchiyama, Yodying Yingchutrakul, Nuttapon Songnaka","doi":"10.3390/md23050209","DOIUrl":"10.3390/md23050209","url":null,"abstract":"Antimicrobial resistance (AMR) is a global health threat, with methicillin-resistant Staphylococcus aureus (MRSA) being one of the major resistant pathogens. This study reports the isolation of a novel mangrove-derived bacterium, Virgibacillus chiguensis FN33, as identified through genome analysis and the discovery of a new anionic antimicrobial peptide (AMP) exhibiting anti-MRSA activity. The AMP was composed of 23 amino acids, which were elucidated as NH3-Glu-Gly-Gly-Cys-Gly-Val-Asp-Thr-Trp-Gly-Cys-Leu-Thr-Pro-Cys-His-Cys-Asp-Leu-Phe-Cys-Thr-Thr-COOH. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) for MRSA were 8 µg/mL and 16 µg/mL, respectively. FN33 AMP induced cell membrane permeabilization, suggesting a membrane-disrupting mechanism. The AMP remained stable at 30-40 °C but lost activity at higher temperatures and following exposure to proteases, surfactants, and extreme pH. All-atom molecular dynamics simulations showed that the AMP adopts a β-sheet structure upon membrane interaction. These findings suggest that Virgibacillus chiguensis FN33 is a promising source of novel antibacterial agents against MRSA, supporting alternative strategies for drug-resistant infections.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical Composition and Alkaline Extraction Optimization of Soluble Bioactive Compounds from the Green Algae Caulerpa cylindraceae. 绿藻中可溶性生物活性物质的生化组成及碱提取优化。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-14 DOI: 10.3390/md23050208

Amani Tahar, Haïfa Zghida, Débora Tomazi Pereira, Nathalie Korbee, Helen Treichel, Félix L Figueroa, Lotfi Achour

{"title":"Biochemical Composition and Alkaline Extraction Optimization of Soluble Bioactive Compounds from the Green Algae Caulerpa cylindraceae.","authors":"Amani Tahar, Haïfa Zghida, Débora Tomazi Pereira, Nathalie Korbee, Helen Treichel, Félix L Figueroa, Lotfi Achour","doi":"10.3390/md23050208","DOIUrl":"10.3390/md23050208","url":null,"abstract":"There is a growing interest in studying the bioactive compounds of invasive green macroalga Caulerpa cylindracea due to their potential biotechnological applications. Algal samples were collected from two sites and seasons. Elemental analysis showed the abundance of carbon in the raw material as a source of carbohydrates. The total protein content in different samples ranged from 8.17 to 9.98%. Total lipids in different samples were around 2%. Fatty acid (FA) results revealed the presence of various types, including omega-3 and omega-6 PUFA. Furthermore, an alkaline hydrolysis optimization using response surface methodology was investigated to extract soluble compounds. It showed that the best combination for polyphenols and ABTS was 12.5% sodium carbonate (SC) at 100 °C for 8 h; however, the best combination for proteins and carbohydrates was 7.5% SC at 100 °C for 5 h. A combination of ultrasound pretreatments was carried out to assess the enhancement of the contents. Thus, an increasing amount was recorded for polyphenols and antioxidant capacity. Ultrasound pretreatment results in decreasing extraction time for all compounds. Results showed that the invasive seaweeds, causing environmental impacts in the Mediterranean Sea, represent an interesting source of bioactive compounds.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector. 海洋衍生化合物与纳米颗粒结合：生物医学和制药领域的焦点。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-13 DOI: 10.3390/md23050207

Laura M Teixeira, Catarina P Reis, Rita Pacheco

{"title":"Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector.","authors":"Laura M Teixeira, Catarina P Reis, Rita Pacheco","doi":"10.3390/md23050207","DOIUrl":"10.3390/md23050207","url":null,"abstract":"The ocean is an extraordinary natural source of a wide range of bioactive compounds. These compounds, including proteins, phenolics, polysaccharides, pigments, vitamins, and fatty acids, possess unique biological properties that are increasingly being explored in the field of nanotechnology across diverse sectors. Among marine-derived nanoparticles, promising applications have emerged in the biomedical and pharmaceutical fields, particularly metallic nanoparticles and polysaccharide-based drug delivery systems. This review provides a unique perspective on the integration of two research areas: the exploration of marine bioresources as bioactive compounds sources with nanotechnological methodologies to develop sustainable, safe, stable and functional marine-derived NPs. It highlights recent advancements in the green synthesis of MNPs and the formulation of drug delivery systems using marine polysaccharides. This review also describes the recent trends over the past ten years and discusses the major challenges and limitations associated with these approaches, including variability in biological sources, batch-to-batch inconsistency, mechanistic uncertainties, and difficulties in reproducibility and scalability. Furthermore, it emphasizes the need for standardized protocols and the integration of life cycle assessments (LCA) to evaluate environmental and economic viability for effective translating marine-derives nanoparticles from research to clinical applications.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant and Anti-Inflammatory Properties of Four Native Mediterranean Seagrasses: A Review of Bioactive Potential and Ecological Context. 四种地中海原生海草的抗氧化和抗炎特性：生物活性潜力和生态背景的综述。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-12 DOI: 10.3390/md23050206

Marzia Vasarri, Lucia De Marchi, Carlo Pretti, Emanuela Barletta, Donatella Degl'Innocenti

{"title":"Antioxidant and Anti-Inflammatory Properties of Four Native Mediterranean Seagrasses: A Review of Bioactive Potential and Ecological Context.","authors":"Marzia Vasarri, Lucia De Marchi, Carlo Pretti, Emanuela Barletta, Donatella Degl'Innocenti","doi":"10.3390/md23050206","DOIUrl":"10.3390/md23050206","url":null,"abstract":"This review provides current knowledge of the potential benefits of native Mediterranean seagrasses for human health, specifically focusing on their anti-inflammatory and antioxidant properties. The four main species examined-Posidonia oceanica, Cymodocea nodosa, Zostera marina, and Zostera noltii-are integral components of marine ecosystems, providing essential habitats and supporting biodiversity. Recent studies highlight their rich bioactive compounds that show significant therapeutic potential against oxidative stress and chronic inflammation, which are prevalent in various health disorders. This overview synthesizes the current literature, emphasizing the mechanisms through which these seagrasses exert their beneficial effects. Furthermore, it addresses the environmental implications of the excessive use and abuse of conventional anti-inflammatory drugs, advocating for a shift towards natural alternatives derived from marine resources. By exploring the bioactivity of these Mediterranean seagrasses, research here collected underscores the importance of integrating marine plants into health and wellness strategies, thereby promoting both human health and ecosystem sustainability. This exploration not only enriches the understanding of their applications on human health but also stimulates further research in this promising field, paving the way for innovative approaches to combat chronic diseases and support environmental conservation.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stage-Specific Effects of TiO₂, ZnO, and CuO Nanoparticles on Green Microalga Haematococcus lacustris: Biomass and Astaxanthin Biosynthesis. TiO2、ZnO和CuO纳米颗粒对湖红球藻的阶段性影响：生物量和虾青素的生物合成。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-11 DOI: 10.3390/md23050204

Ludmila Rudi, Tatiana Chiriac, Liliana Cepoi, Svetlana Djur, Ana Valuta

{"title":"Stage-Specific Effects of TiO2, ZnO, and CuO Nanoparticles on Green Microalga Haematococcus lacustris: Biomass and Astaxanthin Biosynthesis.","authors":"Ludmila Rudi, Tatiana Chiriac, Liliana Cepoi, Svetlana Djur, Ana Valuta","doi":"10.3390/md23050204","DOIUrl":"10.3390/md23050204","url":null,"abstract":"Evaluating the effects of nanoparticles on biomass growth and astaxanthin accumulation in Haematococcus lacustris is crucial for optimizing the production of astaxanthin, a valuable carotenoid with numerous industrial applications. Identifying the life stages at which these nanoparticles exert stimulatory or toxic effects will aid in formulating effective production strategies. This study investigated the effects of titanium dioxide (TiO2), zinc oxide (ZnO), and copper oxide (CuO) nanoparticles on biomass growth, astaxanthin biosynthesis, and lipid accumulation in Haematococcus lacustris, with a focus on their stage-specific impact throughout the algal life cycle. The nanoparticles were added at the start of cultivation, and the microalgal cultures developed continuously in their presence. Sampling for biochemical analyses was performed at distinct life stages (green motile, palmella, and aplanospore), enabling the assessment of stage-dependent responses. TiO2NPs significantly stimulated biomass accumulation during the green motile stage. In the palmella stage, astaxanthin levels decreased in the presence of all nanoparticles, likely due to the absence of a stress signal required to activate pigment biosynthesis, despite ongoing biomass growth. In contrast, the aplanospore stage exhibited reactivation of astaxanthin biosynthesis and increased lipid accumulation, particularly under TiO2NPs. Astaxanthin content increased by 21.57%. This study highlights that TiO2, ZnO, and CuO nanoparticles modulate growth and astaxanthin biosynthesis in Haematococcus lacustris in a life cycle-dependent manner.","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 5","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12113255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A VioA Variant Activates Antibiotic Streptogramins in the Heterologous Host Streptomyces sp. OUC20-O. 一种VioA变异激活异源宿主链霉菌OUC20-O中的抗生素链脲蛋白。

IF 4.9 2区医学

Marine Drugs Pub Date : 2025-05-11 DOI: 10.3390/md23050205

Jie Shan, Liangguang Yue, Luyao Xu, Runyi Wang, Qingzhou Meng, Jun Feng, Joon-Hee Lee, Ming Lu, Huayue Li

引用次数: 0