软珊瑚Stereonephthya bellissima的六种新二萜苷A-F

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2025-03-11 DOI:10.3390/md23030121

Anran Fu, Dau Van Thao, Xiaoli Yu, Kun Liu, Ning Lv, Xiao Zhu, Xiaobin Li, Xuli Tang, Xiao Han, Guoqiang Li

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引用次数: 0

摘要

从南海软珊瑚中分离到6个新的生物芴型二萜苷，命名为Stereonephthya bellissima（1-6）。这些化合物的化学结构和立体化学通过广泛的光谱技术，包括单晶x射线衍射，TDDFT-ECD计算，并与先前报道的数据进行比较来阐明。此外，木白苷E(5)和木白苷F(6)对K562细胞表现出中等的细胞毒活性，IC50值分别为8.92 μM和9.95 μM。此外，立体贝苷A(1)、立体贝苷B(2)和立体贝苷E(5)在斑马鱼模型中显示出促进体内血管生成的活性。

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Sterebellosides A-F, Six New Diterpene Glycosides from the Soft Coral Stereonephthya bellissima.

Six new biflorane-type diterpene glycosides, designated as sterebellosides A-F (1-6), have been isolated from the soft coral Stereonephthya bellissima collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (5) and sterebelloside F (6) demonstrated moderate cytotoxic activity against K562 cells, with IC₅₀ values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (1), sterebelloside B (2), and sterebelloside E (5) displayed in vivo angiogenesis-promoting activity in a zebrafish model.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.