Marine Drugs最新文献

{"title":"Dehydrothyrsiferol Against Cutaneous Leishmaniasis: Treatment Outcome in a Murine Model.","authors":"Atteneri López-Arencibia, Carlos J Bethencourt-Estrella, Desirée San Nicolás-Hernández, Rubén L Rodríguez-Expósito, Angélica Domínguez-de-Barros, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, Francisco Cen-Pacheco, Ana R Díaz-Marrero, José J Fernández, Elizabeth Córdoba-Lanús, Jacob Lorenzo-Morales, José E Piñero","doi":"10.3390/md23010013","DOIUrl":"10.3390/md23010013","url":null,"abstract":"<p><p>One of the most important steps in preclinical drug discovery is to demonstrate the in vivo efficacy of potential leishmanicidal compounds and good characteristics at the level of parasite killing prior to initiating human clinical trials. This paper describes the use of dehydrothyrsiferol (DT), isolated from the red alga <i>Laurencia viridis</i>, in a pharmaceutical form supported on Sepigel, and the in vivo efficacy against a mouse model of cutaneous leishmaniasis. Studying the ultrastructural effect of DT was also carried out to verify the suspected damage at the cellular level and determine the severity of damages produced in the homeostasis of promastigotes. BALB/c mice infected with <i>Leishmania amazonensis</i> were divided into four groups: untreated mice, mice treated with miltefosine orally and mice treated topically with 1% and 0.5% DT-Sepigel; treatment was carried out for two weeks. Treatment with DT significantly reduced the parasite load in skin, liver and spleen compared with the untreated group. In addition, DT-Sepigel at the lowest concentration (0.5%) showed the best results, reducing lesion size by 87% at 3 weeks post-treatment. DT-Sepigel has demonstrated to be a potent topical treatment that, in combined drug trials, may aim at combating cutaneous leishmaniasis.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review.","authors":"Chunhao Gao, Nengyun Gong, Fangtian Chen, Shiran Hu, Qingxin Zhou, Xiang Gao","doi":"10.3390/md23010009","DOIUrl":"10.3390/md23010009","url":null,"abstract":"<p><p>Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach.","authors":"Ohana Leticia Tavares Silva, Monique Gabriela das Chagas Faustino Alves, Hugo Alexandre Oliveira Rocha","doi":"10.3390/md23010006","DOIUrl":"10.3390/md23010006","url":null,"abstract":"<p><p>Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated. This study aimed to employ computational tools to investigate the pharmacological properties and molecular targets pertinent to cancer of the disaccharides derived from the primary carrageenans. Analyses of pharmacological properties predicted by the pkCSM and SwissADME servers indicated that the disaccharides possess a favorable pharmacokinetic profile, although they encounter permeability challenges primarily due to their high polarity and low lipophilicity. Target prediction using SwissTarget and PPB2 identified five carbonic anhydrases, which are also targets of oncology drugs, as common targets for the disaccharides. Molecular docking performed with AutoDock Vina revealed that the binding energies of the disaccharides with carbonic anhydrases were comparable to or greater than those of existing drugs that target these lyases. Notably, six of the complexes formed exhibited interactions between the disaccharides and the zinc cofactor, which represents a primary mechanism of inhibition for these targets. Furthermore, molecular dynamics simulations conducted using GROMACS demonstrated a stable interaction between the disaccharides and carbonic anhydrases. These findings offer new insights into the pharmacological properties and mechanisms of action of carrageenan-derived disaccharides, highlighting their potential for further exploration in clinical trials and experimental studies.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi <i>Penicillium</i> spp.: Chemical Diversity and Biological Activity.","authors":"Guojun Zhou, Jin Cai, Bin Wang, Wenjiao Diao, Yu Zhong, Shaodan Pan, Weijia Xiong, Guolei Huang, Caijuan Zheng","doi":"10.3390/md23010007","DOIUrl":"10.3390/md23010007","url":null,"abstract":"<p><p>Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well as being partly anoxic and periodically soaked by tides. Mangrove plants, soil, or sediment-derived fungi, especially the <i>Penicillium</i> species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. This paper reviews the structural diversity and biological activity of secondary metabolites isolated from mangrove ecosystem-derived <i>Penicillium</i> species over the past 5 years (January 2020-October 2024), and 417 natural products (including 170 new compounds, among which 32 new compounds were separated under the guidance of molecular networking and the OSMAC approach) are described. The structures were divided into six major categories, including alkaloids, polyketides, terpenoids, benzene derivatives, steroids, and other classes. Among these natural products, the plausible biosynthetic pathways of 37 compounds were also proposed; 11 compounds have novel skeleton structures, and 26 compounds contain halogen atoms. A total of 126 compounds showed biological activities, such as cytotoxic, antifungal, antibacterial, anti-inflammatory, and <i>α</i>-glucosidase-inhibitory activities, and 11 compounds exhibited diverse biological activities. These new secondary metabolites with novel structures and potent bioactivities will continue to guide the separation or synthesis of structurally novel and biologically active compounds and will offer leading compounds for the development and innovation of pharmaceuticals and pesticides.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compounds of Marine Origin with Possible Applications as Healing Agents.","authors":"Nektaria-Ioanna Karma, Fotini Mellou, Panagoula Pavlou, Angeliki Siamidi, Athanasia Varvaresou","doi":"10.3390/md23010005","DOIUrl":"10.3390/md23010005","url":null,"abstract":"<p><p>It is well established that marine organisms consist of a great variety of active compounds that appear exclusively in the marine environment while having the ability to be vastly reproduced, irrespective of the existing conditions. As a result, marine organisms can be used in many scientific fields, including the ones of pharmaceutics, nutrition, and cosmetic science. As for the latter, marine ingredients have been successfully included in cosmetic formulations for many decades, providing numerous benefits for the skin. In the present review, the contribution of marine compounds in wound healing is thoroughly discussed, focusing on their role both as active ingredients in suitable formulations, designed to contribute to different stages of skin regeneration and restoration and also, indirectly, as a tool for facilitating wound closure as part of a wound dressing. Additionally, the advantages of these marine ingredients are presented, as well as ways of incorporating them effectively in formulations, so as to enhance their performance. Numerous studies have been referenced, showcasing their efficacy in wound healing. Finally, important data in regard to their stability, limitations, and challenges to their use, safety issues, and the existing legislative framework are extensively reviewed.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Structural Diversity and Biotechnological Potential of the Rhodophyte Phycolectome.","authors":"Éllen F Rodrigues, Flavia Alves Verza, Felipe Garcia Nishimura, Renê Oliveira Beleboni, Cedric Hermans, Kaat Janssens, Maarten Lieven De Mol, Paco Hulpiau, Mozart Marins","doi":"10.3390/md23010008","DOIUrl":"10.3390/md23010008","url":null,"abstract":"<p><p>Lectins are non-covalent glycan-binding proteins found in all living organisms, binding specifically to carbohydrates through glycan-binding domains. Lectins have various biological functions, including cell signaling, molecular recognition, and innate immune responses, which play multiple roles in the physiological and developmental processes of organisms. Moreover, their diversity enables biotechnological exploration as biomarkers, biosensors, drug-delivery platforms, and lead molecules for anticancer, antidiabetic, and antimicrobial drugs. Lectins from Rhodophytes (red seaweed) have been extensively reported and characterized for their unique molecular structures, carbohydrate-binding specificities, and important biological activities. The increasing number of sequenced Rhodophyte genomes offers the opportunity to further study this rich source of lectins, potentially uncovering new ones with properties significantly different from their terrestrial plant counterparts, thus opening new biotechnological applications. We compiled literature data and conducted an in-depth analysis of the phycolectomes from all Rhodophyta genomes available in NCBI datasets. Using Hidden Markov Models capable of identifying lectin-type domains, we found at least six different types of lectin domains present in Rhodophytes, demonstrating their potential in identifying new lectins. This review integrates a computational analysis of the Rhodophyte phycolectome with existing information on red algae lectins and their biotechnological potential.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five New Indole Alkaloid Derivatives from Deep-Sea Fungus <i>Aspergillus fumigatus</i> AF1.","authors":"Lai-Hui Dai, Gao-Rong Zhang, Yang-Hui Ou, Xiao-Jing Liu, Hong-Liang Yao, Wen-Hao Hu, Hou-Jin Li, Wen-Jian Lan","doi":"10.3390/md23010004","DOIUrl":"10.3390/md23010004","url":null,"abstract":"<p><p>One new gliotoxin derivative fumianthrogliotoxin (<b>1</b>), one new indoquizoline alkaloid <i>N</i>3-(methyl propionate) indoquizoline (<b>2</b>), and three novel indole alkaloids, anthroxyindole (<b>3</b>), (±)-asperfumiindole A (<b>4</b>), and (±)-asperfumiindole B (<b>5</b>), together with 16 known compounds (<b>6</b>-<b>21</b>), were isolated from the culture of deep-sea derived fungus <i>Aspergillus fumigatus</i> AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds <b>2</b>-<b>11</b> and <b>13</b>-<b>21</b> were evaluated for anti-pulmonary fibrosis activity. Compounds <b>8</b> and <b>13</b> displayed significant downregulation of the mRNA expression levels of all three molecular markers (COL1A1, α-SMA and FN1), with compound <b>13</b> exhibiting the best performance among all the tested compounds.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Significant Are Marine Invertebrate Collagens? Exploring Trends in Research and Innovation.","authors":"Mariana Almeida, Tiago Silva, Runar Gjerp Solstad, Ana I Lillebø, Ricardo Calado, Helena Vieira","doi":"10.3390/md23010002","DOIUrl":"10.3390/md23010002","url":null,"abstract":"<p><p>This review is focused on the research, innovation and technological breakthroughs on marine invertebrate collagens and their applications. The findings reveal that research dates back to the 1970s, and after a period of reduced activity, interest in collagens from several marine invertebrate groups was renewed around 2008, likely driven by the increased commercial interest in these biomolecules of marine origin. Research and development are predominantly reported from China and Japan, highlighting significant research interest in cnidarians (jellyfish), echinoderms (sea cucumbers, sea urchins and starfish), molluscs (squid and cuttlefish) and sponges. Co-word analysis of the literature highlights applications in regenerative medicine, the properties of hydrolysates, and biology and biochemistry studies. Innovation and the technological landscape, however, focus on fewer taxonomic groups, possibly reflecting the challenge of sustainably sourcing raw materials, with a higher number of patents coming from Asia. Globally, jellyfish collagen is the most prominent marine invertebrate source, while Asia also emphasizes the use of collagens derived from molluscs and sea cucumbers. Europe, despite fewer patents, explores a broader range of taxonomic groups. Globally, key applications registered are mostly in medical, dental and toiletry areas, with peptide preparations spanning multiple animal groups. The food domain is notably relevant for molluscs and sea cucumbers. Market trends show a strong presence of cosmetic and supplement products, aligning with market reports that predict a growing demand for marine collagens in cosmetics and personalized nutrition, particularly in targeted health supplements.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential.","authors":"Marlene B Cunha, André F Jorge, Maria João Nunes, Joana R Sousa, Maria João Lança, Marco Gomes da Silva, Susana P Gaudêncio","doi":"10.3390/md23010001","DOIUrl":"10.3390/md23010001","url":null,"abstract":"<p><p>This study investigated the fatty acids (FA) profile of 54 actinomycete strains isolated from marine sediments collected off the Portugal continental coast, specifically from the Estremadura Spur pockmarks field, by GC/MS. Fatty acid methyl esters (FAMEs) were prepared from the ethyl acetate lipidic extracts of these strains and analyzed by gas chromatography-mass spectrometry (GC/MS), with FA identification performed using the NIST library. The identified FAs varied from C12:0 to C20:0, where 32 distinct FAs were identified, including 7 branched-chain fatty acids (BCFAs), 9 odd-chain fatty acids (OCFAs), 8 monounsaturated fatty acids (MUFAs), 6 saturated fatty acids (SFAs), 1 polyunsaturated fatty acid (PUFA), and 1 cyclic chain fatty acid (CCFA). The average expressed content was BCFA (47.54%), MUFA (28.49%), OCFA (26.93%), and SFA (22.16%), of which i-C16:0, C18:1ω9, and C16:0 were predominant, while PUFA (3.58%) and CCFA (0.41%) were identified as minor components. The identified BCFA were i-C16:0, a-C15:0, i-C15:0, i-C15:1ω6, a-C16:0, a-C14:0, and i-C17:0, which include combined branching and unsaturation and branching and odd. SFAs were present in all species, with C16:0 and C18:0 being the most representative. Rare OCFAs C19:1ω9, C17:1ω7, C15:0, and C17:0 were expressed. PUFA C18:1ω9 was detected; within this class, omega families ω9, ω7, ω6, and ω5 were identified, and no ω3 was detected. The only CCFA was benzene-butanoic acid (benzene-C4:0). These findings highlight the metabolic versatility of actinomycetes, providing valuable insights into microbial chemotaxonomy and offering promising biochemical leads for the development of biofuel, nutraceutical, and antifungal agents. Furthermore, these results underline the diversity and biotechnological potential of FAs in actinomycetes, uncovering their potential to be used as microbial cell factories, and paving the way for innovations in biofuels, pharmaceuticals, and eco-friendly industrial products.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure Diversity and Properties of Some Bola-like Natural Products.","authors":"Valentin A Stonik, Tatyana N Makarieva, Larisa K Shubina, Alla G Guzii, Natalia V Ivanchina","doi":"10.3390/md23010003","DOIUrl":"10.3390/md23010003","url":null,"abstract":"<p><p>In their shapes, molecules of some bipolar metabolites resemble the so-called bola, a hunting weapon of the South American inhabitants, consisting of two heavy balls connected to each other by a long flexible cord. Herein, we discuss the structures and properties of these natural products (bola-like compounds or bolaamphiphiles), containing two polar terminal fragments and a non-polar chain (or chains) between them, from archaea, bacteria, and marine invertebrates. Additional modifications of core compounds of this class, for example, interchain and intrachain cyclization, hydroxylation, methylation, etc., expand the number of known metabolites of this type, providing their great structural variety. Isolation of such complex compounds individually is problematic, since they usually exist as mixtures of regioisomers and stereoisomers, that are very difficult to be separated. The main approaches to the study of their structures combine various methods of HPLC/MS or GC/MS, 2D-NMR experiments and organic synthesis. The recent identification of new enzymes, taking part in their biosynthesis and metabolism, made it possible to understand molecular aspects of their origination and some features of evolution during geological times. The promising properties of these metabolites, such as their ability to self-assemble and stabilize biological or artificial membranes, and biological activities, attract additional attention to them.</p>","PeriodicalId":18222,"journal":{"name":"Marine Drugs","volume":"23 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}