Lipids in Health and Disease最新文献

{"title":"Relationships of triglyceride-glucose-related indices with colorectal cancer incidence and mortality in an American population: a dose-response meta-analysis and cohort study.","authors":"Lan Luo, Zhu Liu, Quan Gan, Jing Feng, Lingyun Wang, Weiwei Ouyang","doi":"10.1186/s12944-025-02574-x","DOIUrl":"https://doi.org/10.1186/s12944-025-02574-x","url":null,"abstract":"<p><strong>Background: </strong>The degree to which the triglyceride-glucose (TyG) index might interact with colorectal cancer (CRC) incidence and mortality is undefined. This systematic analysis was conducted through meta-analyses and large-scale databases.</p><p><strong>Methods: </strong>A meta-analysis was conducted through database search up to April 1, 2025, and articles investigating the incidence of CRC with clearly reported TyG index values, focusing on their dose-response relationship, were included. To validate the findings, data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) were utilized to explore links of TyG levels with CRC-linked mortality. Analyses involving restricted cubic splines (RCSs), weighted logistic regression (WLR), and multivariate Cox proportional hazards models were performed. Receiver operating characteristic (ROC) analyses explored predictive potential. Subgroup evaluation was subsequently conducted for detecting the susceptible populations.</p><p><strong>Results: </strong>Multivariate logistic regression showcased a greater CRC incidence among individuals in quartiles two, three, and four of TyG and TyG-body mass index (TyG-BMI) (95% confidence intervals (CIs): 1.14-1.5, 1.07-1.45; 1.39-1.83, 1.11-1.64; and 1.60-2.12, 1.19-1.93, respectively; P < 0.001). In contrast, multivariate Cox regression indicated a significant increase in CRC-related mortality only in the second quartile of TyG (95% CI: 1.22-7.47; P < 0.05). Analysis of the RCS curves demonstrated that the incidence of CRC displayed a nonlinear association with TyG (P = 0.045 for nonlinearity) but a positive linear association with TyG-BMI (P = 0.385 for nonlinearity). The TyG and associated indices did not exhibit any obvious dose-response association with CRC-related mortality (P > 0.05). ROC analyses exploring CRC risk revealed that TyG-BMI outperformed all indicators (area under the curve (AUC) = 0.71). Subgroup analysis revealed statistically significant links of CRC incidence with both TyG-BMI and female sex.</p><p><strong>Conclusion: </strong>TyG and TyG-BMI may function as dependable markers for predicting CRC likelihood, and TyG-BMI outperformed all other predictors considered herein. However, TyG and associated indices showed no significant interrelationships with the mortality of CRC.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"151"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose index in early pregnancy and risk of preeclampsia: a multicenter retrospective cohort study.","authors":"Qiong Li, Chenyang Zhao, Miao Liu, Meng Li, Ying Zhang, Chaoyan Yue","doi":"10.1186/s12944-025-02556-z","DOIUrl":"10.1186/s12944-025-02556-z","url":null,"abstract":"<p><strong>Background: </strong>Previous evidence has indicated that insulin resistance may be an early pathological state of preeclampsia (PE). As a novel biomarker, the triglyceride glucose (TyG) index can reflect the level of insulin resistance in the body. The present study aimed to investigate the association between the TyG index and risk of PE.</p><p><strong>Methods: </strong>This study included 41,694 singleton pregnant women, comprising 2,308 PE patients and 39,386 healthy controls from three tertiary hospitals from January 2019 to June 2024. Datas were retrospectively collected via medical record review. The TyG index was measured before 20 weeks of gestation, and participants were grouped via the TyG index quartiles. The primary outcome was PE, and the secondary outcomes were preterm birth and low birth weight (LBW). Multivariable logistic regression was used to calculate the odds ratios (ORs) for the TyG index quartiles compared to the lowest quartile for the primary and secondary outcomes. Subgroup analyses were conducted to evaluate the effect of age, body mass index (BMI), parity and TyG test week on these associations. The predictive efficacy of the TyG index for PE was assessed using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>After adjusting for confounders, compared to TyG index Q1, a higher TyG index was positively associated with PE (TyG index Q3 OR = 1.23, 95% confidence interval (CI): 1.06-1.43, P = 0.0067; TyG index Q4 OR = 1.31, 95% CI: 1.11-1.53, P = 0.0011) and preterm birth (TyG index Q4 OR = 1.18, 95% CI: 1.01-1.37, P = 0.0376), negatively associated with LBW (TyG index Q3 OR = 0.84, 95% CI: 0.74-0.97, P = 0.0147). In Model I, a significant association was observed between higher TyG quartiles and preterm birth (P = 0.0472 for Q3 and P = 0.0000 for Q4), but this association was not significant in Model II after adjusting for confounders. Subgroup analyses revealed that age, pre-pregnancy BMI, parity and test week did not influence these associations (interaction P > 0.05). The area under the ROC curve (AUC) for the predictive model was 0.596 (95% CI: 0.584-0.608), with a sensitivity of 65.4% and a specificity of 49.6%.</p><p><strong>Conclusion: </strong>The present findings suggested that the TyG index associated with a high risk of PE. Clinical evaluation incorporating the TyG index during early pregnancy may help in screening for patients at high risk of PE.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"152"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Oil from pumpkin (Cucurbita pepo L.) seeds: evaluation of its functional properties on wound healing in rats.","authors":"Sana Bardaa, Nihed Ben Halima, Fatma Aloui, Riadh Ben Mansour, Hazem Jabeur, Mohamed Bouaziz, Zouheir Sahnoun","doi":"10.1186/s12944-025-02569-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02569-8","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"148"},"PeriodicalIF":3.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative, oncological, and cardiovascular diseases.","authors":"Mohamad Warda, Samet Tekin, Mahmoud Gamal, Nagwa Khafaga, Fikret Çelebi, Giovanni Tarantino","doi":"10.1186/s12944-025-02563-0","DOIUrl":"https://doi.org/10.1186/s12944-025-02563-0","url":null,"abstract":"<p><p>Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in cellular organization, signaling, and homeostasis. This review highlights their involvement in protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, and apoptosis. These findings clarify their influence on signaling, trafficking, and adhesion while interacting with the extracellular matrix, cytoskeleton, and ion channels, making them pivotal in the progression of various diseases. This review further addresses their contributions to immune responses, including autoimmune diseases, chronic inflammation, and cytokine storms. Additionally, their role as entry points for pathogens has been demonstrated, with raft-associated receptors being exploited by viruses and bacteria to increase infectivity and evade immune defenses. Disruptions in lipid raft dynamics are linked to oxidative stress and cellular signaling defects, which contribute to metabolic, neurodegenerative, and cardiovascular diseases. This review underscores their potential as therapeutic targets, discussing innovations such as engineered lipid raft transplantation. Advances in analytical techniques such as mass spectrometry have expanded our understanding of lipid raft composition and dynamics, opening new directions for research. By consolidating the current insights, we highlight the therapeutic potential of lipid rafts and highlight the need for further exploration of their molecular mechanisms.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"147"},"PeriodicalIF":3.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cerebral atherosclerotic stenosis: a retrospective study.","authors":"Yating Han, Yuting Gao, Mengyuan Qiu, Yida Wang, Shenjie Li, Mengmeng Guo, Tao Zheng, Zunjing Liu","doi":"10.1186/s12944-025-02555-0","DOIUrl":"https://doi.org/10.1186/s12944-025-02555-0","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. Early identification of dyslipidemia associated with cerebral atherosclerosis is of great importance for reducing the risk of IS. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel lipid biomarker to assess atherosclerosis. The aim of this study is to investigate the association between NHHR and cerebral atherosclerotic stenosis using DSA imaging data, including intracranial/extracranial stenosis, anterior/posterior circulation stenosis, severe stenosis, and symptomatic stenosis.</p><p><strong>Methods: </strong>Patients who underwent DSA examination from July 2022 to December 2024 were included. Participants were divided into four groups based on NHHR levels. Univariable and multivariable logistic regression were applied to assess the association between NHHR and cerebral atherosclerotic stenosis, including intracranial and extracranial stenosis, anterior and posterior circulation stenosis, severe stenosis, and symptomatic stenosis. Restricted cubic splines (RCS) were applied to analyze and visualize the association between NHHR and cerebral atherosclerotic stenosis.</p><p><strong>Results: </strong>A total of 853 patients were included in the final analysis. After adjusting for covariables, compared to patients in the lower NHHR groups, those in the higher NHHR groups had a significantly higher occurrence rate of extracranial stenosis, posterior circulation stenosis, severe stenosis, and symptomatic stenosis. Multivariable-adjusted RCS showed a nonlinear association between NHHR and posterior circulation stenosis, and a linear positive association between NHHR and symptomatic stenosis.</p><p><strong>Conclusions: </strong>NHHR may serve as a lipid management indicator for patients with extracranial stenosis, posterior circulation stenosis, severe stenosis, or symptomatic stenosis. NHHR could be an independent risk factor for symptomatic stenosis, which can aid in risk stratification and treatment decision-making for cerebral atherosclerotic stenosis patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"145"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between conicity index (C-index), relative fat mass (RFM), and osteoarthritis (OA): evidence from NHANES 2003-2018.","authors":"Xiaodong Ren, Junxiang Wang, Jiachen Wang, Guoqiang Wang, Honghao Ren, Peng Xu, Mingyi Yang, Ke Xu","doi":"10.1186/s12944-025-02558-x","DOIUrl":"https://doi.org/10.1186/s12944-025-02558-x","url":null,"abstract":"<p><strong>Background: </strong>Obesity is considered an important risk factor for osteoarthritis (OA), with conicity index (C-index), relative fat mass (RFM) are two novel anthropometric measures of obesity. To investigate the association between OA and these two indicators, we conducted this study.</p><p><strong>Methods: </strong>We used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association between C-index, RFM, and OA. First, the participants were divided into two groups according to whether they had OA, and we compared the baseline characteristics of the two groups. Then, C-index and RFM were divided into quartiles (Q1, Q2, Q3, Q4) for multivariate regression analysis. Additionally, we applied restricted cubic spline (RCS) to assess whether the relationship is non-linear. Finally, we conducted a subgroup interaction analysis to investigate whether this relationship varies across different subgroups.</p><p><strong>Results: </strong>The study included 34,707 participants, with a weighted OA prevalence of 7.7%. Significant differences in C-index and RFM were observed between OA and non-OA groups. Treating C-index and RFM as categorical variables, logistic regression showed significantly higher OA risk in Q4 compared to Q1: for C-index, Q4 (OR = 1.60; 95% CI: 1.33-1.93; P < 0.001); for RFM, Q4 (OR = 2.07; 95% CI: 1.57-2.73; P < 0.001). The RCS results show that the relationship between C-index and OA is non-linear, while the relationship between RFM and OA is linear. Subgroup interaction analysis showed some interaction effects.</p><p><strong>Conclusions: </strong>This study reveals detailed relationships between C-index, RFM, and OA, which may be better indicators of obesity in assessing OA risk.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"140"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the uric acid-to-HDL-cholesterol ratio (UHR) and the risk of cardiovascular disease and dyslipidemia: a population-based study.","authors":"Yanfeng Yi, Qin Luo, Jingfei Chen, Zewei Chen, Hacı Ahmet Aydemir, Pengfei Chen, Jianjun Tang, Fei Luo, Zhenfei Fang","doi":"10.1186/s12944-025-02551-4","DOIUrl":"https://doi.org/10.1186/s12944-025-02551-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and aims: &lt;/strong&gt;The uric acid-to-HDL-cholesterol ratio (UHR), a novel marker of metabolism and inflammation, has been investigated in various diseases. However, its potential associations with the incidence of cardiovascular disease (CVD) and dyslipidemia remain unclear. This study aimed to examine the relationships between the UHR and the incidence of CVD and dyslipidemia. The primary objective was to evaluate the role of the UHR in predicting CVD and dyslipidemia, whereas the secondary objective was to analyze the predictive effects of the UHR in different subgroups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a cross-sectional analysis using data from the 2001-2018 National Health and Nutrition Examination Survey (NHANES), which included 6,370 adults aged 18-80 years. Weighted binary logistic regression and subgroup analyses were performed to evaluate the independent associations between the UHR and the risk of various cardiovascular conditions, including overall CVD, congestive heart failure, myocardial infarction, angina, coronary heart disease, and dyslipidemia. To investigate potential nonlinear relationships between the UHR and these outcomes, restricted cubic spline modeling was applied to further elucidate the associations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among the 6,370 participants included in the study, 559 were diagnosed with CVD. Elevated UHR values were strongly associated with a greater incidence of CVD and its subtypes, including congestive heart failure, myocardial infarction, angina, and coronary heart disease (all P &lt; 0.001). After accounting for weighted factors, participants in the higher UHR quartiles presented progressively higher rates of CVD: Quartile 1 (4.7%), Quartile 2 (6.3%), Quartile 3 (7.4%), and Quartile 4 (11%). A nonlinear relationship between the UHR and the risk of developing CVD was identified through restricted cubic spline (RCS) analysis. Among the subgroup of 4,117 participants with dyslipidemia, multivariable linear regression analysis demonstrated a significant positive association between the UHR and dyslipidemia (OR 17.38, 95% CI 16.24-18.60). This association remained robust even after adjusting for covariates (OR 11.65, 95% CI 8.995-15.17). RCS analysis further confirmed the nonlinear nature of this relationship. Subgroup analysis revealed no significant interaction between the UHR and overall CVD or CVD-related variables, such as congestive heart failure, myocardial infarction, angina, or coronary heart disease. However, for dyslipidemia, BMI showed a significant interaction, indicating that the positive association between the UHR and dyslipidemia risk is influenced by participants' BMI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A high UHR is associated with an increased risk of various cardiovascular conditions and dyslipidemia. The incorporation of routine UHR monitoring into clinical practice can support the early identification of high-risk individuals, facilitate timely int","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"143"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients.","authors":"Bowen Wang, Liping Zuo, Jinlei Fan, Wei Zhao, Yueming An, Wangshu Cai, Dexin Yu","doi":"10.1186/s12944-025-02564-z","DOIUrl":"https://doi.org/10.1186/s12944-025-02564-z","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"141"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study.","authors":"Adrian Post, Mirthe H Links, Wouter T Zandee, Margery A Connelly, Thera P Links, Robin P F Dullaart","doi":"10.1186/s12944-025-02561-2","DOIUrl":"https://doi.org/10.1186/s12944-025-02561-2","url":null,"abstract":"<p><strong>Background: </strong>Hypothyroidism may affect triglyceride-rich lipoprotein (TRL) subfractions and low-density lipoprotein (LDL) and their averaged sizes. The present study aimed to determine whether increases in remnant particles were larger than other TRL subfractions and whether changes in remnant particles were related to changes in the TRL cholesterol/triglyceride ratio.</p><p><strong>Methods: </strong>An observational study was conducted to assess the impact of short term (4-6 weeks) hypothyroidism consequent to thyroidectomy on TRL subfractions, including remnant lipoproteins, LDL subfractions, and the TRL cholesterol and triglyceride content. Seventeen patients were studied: (1) during hypothyroidism, 4-6 weeks after total thyroidectomy for differentiated thyroid carcinoma (thyroid stimulating hormone (TSH) ranging from 59 to 371 mU/L) and free thyroxine (ranging from 0.8 to 6.8 pmol/L) and (2) after approximately 20 weeks of thyroid hormone supplementation, aimed at TSH levels below the reference range (TSH ranging from 0.01 to 2.15 mU/L). TRL, LDL subfractions, and the cholesterol and triglyceride content in TRL were measured by nuclear magnetic resonance spectroscopy.</p><p><strong>Results: </strong>Hypothyroidism led to substantial increases (> 30%, p < 0.001) in total cholesterol, LDL cholesterol, non-HighDensity Lipoproteins, triglycerides, TRL particle concentrations, and LDL particle concentrations. Among TRL subfractions, very small TRL particles (24-29 nm), corresponding to remnant lipoproteins, showed the most pronounced reduction (59%, 95% confidence interval (CI): 70-45%) after thyroid hormone supplementation (P < 0.001). TRL cholesterol content and the TRL cholesterol/triglyceride ratio were also higher during hypothyroidism (P < 0.001). Changes in TRL cholesterol correlated with changes in very small TRL particles (r = 0.70, 95% CI: 0.34-0.88, P = 0.002).</p><p><strong>Conclusions: </strong>Profound hypothyroidism confers increases in TRL and LDL particles, with the most pronounced effect on very small TRL (remnant) particles. These effects on remnants coincide with an increase in TRL cholesterol and the TRL cholesterol/triglyceride ratio.</p><p><strong>Trial registration number: </strong>NTR ID 7228, 20-08-2018.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"142"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation induced dermatitis by increasing triglyceride levels to induce autophagy and inhibit the PI3K/Akt/mTOR signaling pathway.","authors":"Yafang Hong, Hongdan Guan, Yunhao Chen, Yao Wang, Junjian Lin, Ying Wang, Yang Zhang, Rong Zheng, Xingchen Ding, Zihan Zhou, Benhua Xu","doi":"10.1186/s12944-025-02553-2","DOIUrl":"https://doi.org/10.1186/s12944-025-02553-2","url":null,"abstract":"<p><strong>Background: </strong>Radiodermatitis (RD) is the primary acute adverse effect experienced by patients receiving radiotherapy (RT) for head and neck cancer (HNC). This study aimed to investigate the correlation between triglyceride (TG) levels and the severity of RD, as well as the underlying mechanisms involved.</p><p><strong>Methods: </strong>Data were collected from 248 patients with locally advanced HNC treated with intensity-modulated radiation therapy (IMRT). Clinical characteristics and blood profiles prior to RT were collected. After RT, RD severity was assessed. A binary logistic regression analysis was used to determine risk factors. Mouse models of RD were established by administering radiating at a dose of 9 Gy over two consecutive days. TG levels in the mice and cells were quantified using an automatic biochemical analyzer and a TG assay kit, respectively. Cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay, while apoptotic cell percentages were measured via flow cytometry. Western blotting assay was used to analyze the protein levels in the cells of interest.</p><p><strong>Results: </strong>The TG level was the sole independent risk factor for grade 3 or higher (grade 3+) RD. Radiation was found to increase the TG content in both mouse blood and skin cells. Skin cells with high TG contents presented more severe radiation-induced damage when the radiation dose administered was 9 Gy over two consecutive days. The administration of 200 µmol/L palmitic acid (PA) or 2 Gy radiation independently did not affect HaCaT cell proliferation or apoptosis rates. Their combination was shown to induce skin cell injury. Mechanistically, autophagy was excessively activated. Furthermore, the protein concentrations of phospho-PI3K, phospho-Akt, and phospho-mTOR were notably decreased.</p><p><strong>Conclusions: </strong>TGs are crucially involved in the development of RD. Increased TG levels after radiation treatment suppress the PI3K/Akt/mTOR pathway, induce autophagy, and exacerbate RD.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"146"},"PeriodicalIF":3.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}