Lipids in Health and Disease最新文献

{"title":"Stress hyperglycemia ratio and incident hypertension in chinese middle-aged and older adults: mediating roles of lipids in a prospective cohort.","authors":"Guosong Jiang, Huibo Wang, Xiaoxiao Qu, Jing Zhang, Chengya Feng, Yinxin Li, Jinping Li","doi":"10.1186/s12944-025-02681-9","DOIUrl":"https://doi.org/10.1186/s12944-025-02681-9","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"263"},"PeriodicalIF":3.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Tracking of serum lipids from prepuberty to young adulthood: results from the KiGGS cohort study.","authors":"Julia Truthmann, Anja Schienkiewitz, Antje Kneuer, Yong Du, Christa Scheidt-Nave","doi":"10.1186/s12944-025-02685-5","DOIUrl":"https://doi.org/10.1186/s12944-025-02685-5","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"265"},"PeriodicalIF":3.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between atherogenic index of plasma and ICU 28-day mortality in geriatric diabetes: an EICU-based retrospective analysis.","authors":"Zhenzhen Li, Tong Zhang, Lei Zhang, Jianhong Zhu, Shuangyu Liu, Yue Zhang","doi":"10.1186/s12944-025-02669-5","DOIUrl":"10.1186/s12944-025-02669-5","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"261"},"PeriodicalIF":3.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental cadmium exposure aggravates renal fibrosis and reduced renal lipid accumulation in diabetic mice.","authors":"Changhao Li, Fuda Dong, Yilimilai Dilixiati, Yunbin Bai, Zengli Zhang","doi":"10.1186/s12944-025-02557-y","DOIUrl":"10.1186/s12944-025-02557-y","url":null,"abstract":"<p><strong>Background: </strong>Cadmium (Cd) is a heavy metal with nephrotoxicity. While the harmful effects of Cd exposure on the kidney have been extensively studied, the nephrotoxicity of Cd exposure on diabetic individual remain largely unexplored. Given the widespread Cd pollution and the high prevalence of diabetes, it is imperative to explore the nephrotoxicity and underlying mechanism of Cd exposure on diabetic individual.</p><p><strong>Methods: </strong>In current study, established diabetic mouse and high glucose cultured HK-2 cells were exposed to CdCl₂ (50 ppm in vivo, 10 µM in vitro). Renal fibrosis and renal lipid accumulation were studied in Cd-exposed diabetic mice and high glucose cultured HK-2 cells. Additionally, qRT-PCR and Western blot were used to evaluate renal fibrosis and lipid metabolism related gene and protein.</p><p><strong>Results: </strong>Present study showed no significant nephrotoxicity in Cd-exposed healthy mice and Cd-exposed HK-2 cells. However, same dosing Cd activated TGF/SMAD signaling pathway and increased collagen deposition in kidney of diabetic mice and high glucose cultured HK-2 cells. Intriguingly, Cd reduced renal lipids deposition and inhibited fatty acid synthesis both in diabetic mice and high glucose cultured HK-2 cells.</p><p><strong>Conclusions: </strong>Overall, our findings demonstrate that low dosing Cd significantly aggravated renal fibrosis in diabetic mice and high glucose cultured HK-2 cells. It is recommended that diabetic individuals should avoid working in Cd pollution environment and consuming cadmium-contaminated food. Furthermore, we found that Cd reduced lipid deposition in kidney of diabetic mice and high glucose cultured HK-2 cells. The results provide novel insights into renal lipid metabolism in Cd-exposed diabetic individuals.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"262"},"PeriodicalIF":3.9,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global variations in omega-3 fatty acid status and omega-6:omega-3 ratios: insights from > 500,000 whole-blood dried blood spot samples.","authors":"Martina Torrissen, Emmalee Gisslevik, Thomas E Gundersen, Tore Bolstad, Ola Eide, Angela Maria Rizzo, Paul Clayton, Colin Robertson","doi":"10.1186/s12944-025-02676-6","DOIUrl":"10.1186/s12944-025-02676-6","url":null,"abstract":"<p><p>Omega-3 (n-3) fatty acids are critical for human health, with the omega-6 (n-6) to n-3 fatty acid ratio and the omega-3 levels recognized as contributing to the risk of many chronic non-communicable diseases. Direct measurement of fatty acid levels in blood provides the most accurate assessment of fatty acid status and balance, with fingertip dried blood spot (DBS) analysis offering a practical and cost-effective assessment method. This study analyses more than 590,000 globally sourced DBS samples, providing fatty acid profiles in whole blood across diverse populations. Results reveal significant global and demographic disparities in n-3 levels and n-6:n-3 ratios, with suboptimal n-3 levels and imbalanced n-6:n-3 ratios prevalent worldwide. While the findings align with general trends reported in previous global mapping studies on omega-3 status in red blood cells (RBC), they are based on whole blood measurements and highlight the utility of DBS testing for large-scale monitoring. These results underscore the need to enhance n-3 fatty acid intakes to help mitigate multiple global health challenges and demonstrate the utility of fingertip DBS testing as a practical approach to design dietary interventions to promote overall well-being.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"260"},"PeriodicalIF":3.9,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12335782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of aggressive versus intermediate LDL-C goal achievement in Asian adults: a retrospective cohort study using national health insurance service-senior cohort.","authors":"Yu-Cheol Lim, Suk-Chan Jang, Eui-Kyung Lee, Mi-Hai Park","doi":"10.1186/s12944-025-02677-5","DOIUrl":"10.1186/s12944-025-02677-5","url":null,"abstract":"<p><strong>Background: </strong>Optimal low-density lipoprotein cholesterol (LDL-C) targets remain a subject of debate for Asian adults, whose cardiovascular risk profiles and treatment responses may differ physiologically from Western populations. Clarifying appropriate LDL-C management goals could enhance the clinical effectiveness of cardiovascular care, ultimately improving health outcomes in Asia. This study evaluated the impact of achieving intermediate versus aggressive LDL-C targets on the incidence of atherosclerotic cardiovascular disease (ASCVD) and all-cause death among Asian adults.</p><p><strong>Methods: </strong>This retrospective cohort study used data from the senior cohort of the Korean National Health Insurance Service. Patients who had initiated statin therapy were included in the study. Patients were categorised into two groups based on the achieved LDL-C targets: intermediate and aggressive. The incidence rate ratios (IRRs) and hazard ratios (HRs) for ASCVD and all-cause death were calculated using multivariable time-dependent Cox regression and marginal structural models.</p><p><strong>Results: </strong>A propensity score-matched retrospective cohort of 951 patients aged 52 years or older per group was identified. No significant differences were observed in the incidence of ASCVD events (IRR, 1.182; 95% confidence interval [CI], 0.926-1.507) or all-cause death (IRR, 1.223; 95% CI, 0.735-2.034) between individuals who achieved intermediate and aggressive LDL-C goals. Similarly, the HRs showed no significant differences in the risk of ASCVD events (HR, 0.943; 95% CI, 0.698-1.276) or all-cause death (HR, 1.082; 95% CI, 0.597-1.959) in the time-dependent Cox model or in the marginal structural model for ASCVD events (HR, 0.945; 95% CI, 0.699-1.279) and all-cause death (HR, 1.072; 95% CI, 0.592-1.941).</p><p><strong>Conclusion: </strong>These findings underscore the need for LDL-C management strategies tailored to the unique physiological and clinical characteristics of Asian populations. Such an individualized approach may facilitate more effective and patient-centered cardiovascular care, ultimately leading to improved health outcomes in Asia.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"259"},"PeriodicalIF":3.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive investigation of the relationship between dietary fatty acid intake and preserved ratio impaired spirometry: multimethodology based on NHANES.","authors":"Chenyuan Deng, Yu Jiang, Yuechun Lin, Hengrui Liang, Wei Wang, Jianxing He, Ying Huang","doi":"10.1186/s12944-025-02674-8","DOIUrl":"10.1186/s12944-025-02674-8","url":null,"abstract":"<p><strong>Background: </strong>Preserved ratio impaired spirometry (PRISm) has been identified as a potential precursor to chronic obstructive pulmonary disease (COPD) and demonstrates a significant correlation with unfavorable clinical outcomes. Modification of PRISm-related risk factors is a higher priority in public health than treating PRISm itself. Dietary fatty acids (FAs) affect human health through a variety of physiological pathways. However, no prior research has investigated the associations of FAs and their subclasses with PRISm, particularly the combined effects of different types of FAs.</p><p><strong>Methods: </strong>Data analysis was conducted on 8,836 individuals drawn from the NHANES dataset spanning the years 2007 to 2012. Logistic regression and smooth curve fitting were first used to assess relationships of individual FA intake with PRISm. Multiple comparisons were adjusted using the Benjamini-Hochberg (BH) correction. Threshold effect analysis was conducted to explore potential nonlinear associations. Subsequently, innovative implementation of the principal component analysis (PCA), Weighted Quantile Sum (WQS) regression, and Bayesian Kernel Machine Regression (BKMR) approaches were employed to assess the joint impact of the various intake of FAs, as well as total saturated, monounsaturated, and polyunsaturated FAs on PRISm. To facilitate the prediction of PRISm, six distinct machine learning algorithms were constructed, followed by the application of SHAP analysis to elucidate the contribution of individual predictors. For improved clinical utility, the most effective model was further implemented as an online tool.</p><p><strong>Results: </strong>The weighted prevalence of PRISm observed in this study was 8.81%. The results from the single-exposure models demonstrated that most FAs were negatively associated with PRISm, and these associations remained significant after BH correction. In all three models, saturated FAs revealed impressive protective associations with PRISm. LightGBM was identified as the most effective machine learning model. Among all variables, race was the most influential factor and butyric acid (SFA 4:0) was identified as the most critical FA subclass.</p><p><strong>Conclusions: </strong>Adequate dietary intake of FAs may reduce the prevalence of PRISm. Furthermore, an interactive Web-based application enables healthcare professionals to estimate individuals' odds of having PRISm and to design personalized dietary interventions based on their specific needs.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"258"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D immune modulation of the anti-inflammatory effects of HDL-associated proteins.","authors":"Hanaa Mousa, Susu M Zughaier","doi":"10.1186/s12944-025-02639-x","DOIUrl":"10.1186/s12944-025-02639-x","url":null,"abstract":"<p><p>Vitamin D is a crucial element in bone metabolism and plays a role in innate immunity and inflammation suppression. Deficiency in this vitamin leads to disturbances in many biological functions, including the lipid profile. The decrease in HDL levels is associated with disruptions in its function and dynamic modifications in its components, such as apolipoproteins, including ApoM, ApoA-1, and ApoD. Consequently, the anti-inflammatory potential of HDL and HDL-associated proteins is reduced, resulting in heightened inflammation. However, the relationship between modifications in lipid profile, apolipoproteins, inflammation, and vitamin D remains unclear. This review highlights the connection between vitamin D status and its possible effects on the lipid profile, specifically HDL-associated proteins.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"257"},"PeriodicalIF":3.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in mass spectrometry of lipids for the investigation of Niemann-pick type C disease.","authors":"Roshan Javanshad, Wenping Li, Koralege C Pathmasiri, Stephanie M Cologna","doi":"10.1186/s12944-025-02675-7","DOIUrl":"10.1186/s12944-025-02675-7","url":null,"abstract":"<p><p>Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the late endosome/lysosome system, a hallmark of the disease. Due to aberrant lipid trafficking in NPC, various techniques have been employed to study cholesterol and lipid dysregulation. Among them, mass spectrometry (MS)-based lipidomics has emerged as a state-of-the-art approach, providing valuable insights into disease pathophysiology, progression, and therapeutic target development. This review highlights the MS instruments used for lipidomics studies and discusses lipid biomarkers identified using MS in the context of NPC disease. Furthermore, integrating lipidomics with other -omics approaches, and leveraging the power of artificial intelligence, should be prioritized in future studies to holistically understand NPC disease.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"254"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the Neutrophil-to-Lymphocyte Ratio(NLR), Triglyceride-Glucose Index (TyG), and TyG-derived indices with vitality decline in older adults in China: a study within the Integrated Care for Older People (ICOPE) framework.","authors":"Jiaxiu Zhao, Xueying Ji, Yixin Chen, Jiaofeng Wang, Jie Chen, Yiqin Huang, Zhijun Bao","doi":"10.1186/s12944-025-02671-x","DOIUrl":"10.1186/s12944-025-02671-x","url":null,"abstract":"<p><strong>Background/objectives: </strong>Aging populations have led to numerous health challenges. The World Health Organization (WHO) proposed \"Healthy Aging\" to promote elderly health by optimizing Intrinsic Capacity (IC) with vitality as a core component of metabolic homeostasis. The relationships between vitality decline and inflammatory-metabolic indicators (the NLR and TyG index) remain to be investigated.</p><p><strong>Methods: </strong>This study recruited 986 community-dwelling adults ≥ 60 years old at the Beixingjing Street Community from March 25, 2024, to June 17, 2024, in Shanghai, China. Participants underwent comprehensive face‒to-face assessments with IC evaluations conducted according to the Integrated Care for Older People (ICOPE) guidelines. Vitality was evaluated using the Mini Nutritional Assessment-Short Form (MNA-SF). The study population was divided into two groups based on vitality decline (scores < 12). Multivariable logistic regression was used to analyze associations between vitality decline and other IC domains as well as between vitality decline and inflammatory (NLR) and metabolic indices (TyG, TyG-WC, TyG-BMI, and TyG-WHtR). Three logistic regression models constructed with progressive adjustments were used to assess associations between indices (NLR, TyG, TyG-WC, TyG-BMI, and TyG-WHtR) and vitality decline. Restricted cubic spline (RCS) analyses explored potential nonlinear relationships and threshold effects. Receiver Operating Characteristic (ROC) curve analysis was used to assess the discriminative capacity of different models.</p><p><strong>Results: </strong>The prevalence of vitality decline was 16.43%. Vitality decline was strongly associated with psychological and locomotor capacity decline in fully adjusted models (p < 0.05). An elevated NLR showed a significant association with greater vitality decline (OR = 1.233, p = 0.045). Participants in the highest NLR quartile (Q4) demonstrated significantly greater odds of vitality decline compared to those in the lowest quartile (Q1) (OR = 1.886, p = 0.043). Conversely, unit increases in TyG-derived indices demonstrated protective effects as follows: TyG-WC (OR = 0.988, p < 0.001), TyG-BMI (OR = 0.952, p < 0.001) and TyG-WHtR (OR = 0.120, p < 0.001). In contrast, TyG alone did not reach statistical significance (OR = 0.622, p = 0.078). The highest-quartile (Q4) participants presented a significantly lower risk of vitality decline than the lowest-quartile (Q1) participants as follows: TyG-WC (OR = 0.104, p < 0.001), TyG-BMI (OR = 0.052, p < 0.001), and TyG-WHtR (OR = 0.070, p < 0.001). Interaction terms between NLR, TyG and its indicators were analyzed in separate models and across quartiles. These terms did not show consistent significant associations with vitality decline. RCS analysis with vitality decline as the dependent variable identified threshold effects at TyG-WC = 794.358, TyG-BMI = 209.179, and TyG-WHtR = 4.476. The analysis revealed significant posi","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"256"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}