Lipids in Health and Disease最新文献

{"title":"Increased thyroid hormone sensitivity is correlated with visceral obesity in patients with type 2 diabetes.","authors":"Lu Yu, Yujia Liu, Yingxuan Wang, Gang Wang, Xianchao Xiao, Huan Wang, Hanyu Wang, Hui Sun, Guixia Wang","doi":"10.1186/s12944-024-02320-9","DOIUrl":"https://doi.org/10.1186/s12944-024-02320-9","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to assess whether thyroid hormone (TH) sensitivity is related to visceral fat area (VFA) and visceral obesity in euthyroid subjects with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>750 euthyroid patients with T2D were enrolled. A VFA of 80 cm² or more was considered visceral obesity. Central TH sensitivity was conducted using thyrotrophic thyroxine resistance index (TT4RI), thyrotropin index (TSHI), and thyroid feedback quantile-based index (TFQI). Free triiodothyronine to free thyroxine (FT3/FT4) was utilized for assessing peripheral TH sensitivity.</p><p><strong>Results: </strong>The subjects had a mean age of 51.5 ± 11.1 years, and 540 (72.0%) of them were men. In multivariable regression analyses, there was a positive correlation of FT3/FT4 tertile with visceral obesity, after full adjustment for confounding variables (P < 0.05). The middle and highest FT3/FT4 tertiles were correlated with a 134% [95% CI (1.24, 4.44)] and 98% [95% CI (1.04, 3.78)] higher prevalence of visceral obesity than the lowest tertile, respectively. Conversely, elevated TFQI levels were linked to a decreased prevalence of visceral obesity. Stratified analysis revealed that these associations were particularly pronounced in participants who are neither overweight nor obese and those aged less than 60 years (all P < 0.05).</p><p><strong>Conclusions: </strong>Higher TH sensitivity is correlated with visceral obesity and elevated VFA in euthyroid patients with T2D, particularly among those younger than 60 years and individuals who are neither overweight nor obese.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"337"},"PeriodicalIF":3.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective role of brown adipose tissue in cardiac cell damage after myocardial infarction and heart failure.","authors":"Zhe Xu, Hong Li, Guojie Cao, Panpan Li, Haitao Zhou, Yang Sun","doi":"10.1186/s12944-024-02326-3","DOIUrl":"https://doi.org/10.1186/s12944-024-02326-3","url":null,"abstract":"<p><p>Acute myocardial infarction (AMI) and related cardiovascular disease complications are the leading causes of mortality worldwide. Brown adipose tissue (BAT) is thermogenic and characterized by the uncoupling protein expression. Recent studies have found that in cardiovascular diseases, activated BAT can effectively improve the prognosis of AMI and concurrent heart failure through intercellular communication. However, a clear and systematic understanding of the myocardial protective mechanism of BAT after AMI is lacking, especially in the endocrine function of BAT. This review describes the effects of BAT on various cells in the heart after AMI. BAT plays a protective role on cardiac cells and fibroblasts during ischemia/reperfusion (I/R), myocardial remodeling, and myocardial fibrosis. This review also discusses the changes caused by BAT activation in different stages of heart failure. Finally, this review summarizes the treatment methods that target BAT to improve AMI. Further in-depth researches are still needed to clarify the underlying mechanism of the connection between BAT and different cells in cardiac tissue in order to identify potential therapeutic targets.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"338"},"PeriodicalIF":3.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11481725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between different leisure-time physical activity patterns and the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in adults: national health and nutrition examination survey 2007-2018.","authors":"Yanxue Lian, Pincheng Luo","doi":"10.1186/s12944-024-02278-8","DOIUrl":"https://doi.org/10.1186/s12944-024-02278-8","url":null,"abstract":"<p><strong>Background: </strong>Despite the potential superiority of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) as a diagnostic and predictive marker, no study has investigated the link between different leisure-time physical activity (LTPA) patterns and the NHHR. This study aims to explore this relationship.</p><p><strong>Methods: </strong>Data was extracted from the National Health and Nutrition Examination Survey (NHANES) cycles spanning from 2007 to 2008 to 2017-2018. Participants (N = 14,211) were classified into four groups based on their LTPA patterns: (1) inactive (LTPA = 0 min/week); (2) insufficiently active (LTPA < 150 min/week); (3) weekend warrior (LTPA ≥ 150 min/week within 1 or 2 sessions); and (4) regularly active (LTPA ≥ 150 min/week in more than 2 sessions). Weighted multiple linear regression analysis was employed twice, using inactive and regular active groups as reference groups, respectively. Weighted stratification analyses and interaction tests were performed by demographics.</p><p><strong>Results: </strong>Compared to the inactive group, each additional unit of LTPA time was associated with a significant 0.23-unit greater decrease in the NHHR in the regularly active group [-0.23 (-0.29; -0.16)]. However, no significant decrease was observed in the \"Weekend Warrior\" [-0.11 (-0.22; 0.008)] or insufficiently active groups [-0.03 (-0.11; 0.04)]. Moreover, compared to the regularly active group, the insufficiently active [0.21 (0.13; 0.29)], \"Weekend Warrior\" [0.13 (0.004; 0.25)], and inactive [0.26 (0.20; 0.32)] groups had significantly higher NHHR. The associations between the NHHR and various LTPA patterns did not significantly differ by demographic factors, except for race.</p><p><strong>Conclusion: </strong>The regularly active pattern is significantly associated with a lower NHHR, but no significant difference in the NHHR was detected between the insufficiently active and \"Weekend Warriors\" patterns. The study suggests that frequency and regularity of PA are crucial for optimal lipid management, supporting clinical recommendations to meet or exceed 150 min of PA in more than two sessions per week.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"336"},"PeriodicalIF":3.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of novel lipid indices with the white matter hyperintensities in cerebral small vessel disease: a cross-sectional study.","authors":"Chen Rao, Lei Zhu, Chuanqin Yu, Simin Zhang, Zhiwen Zha, Tong Gu, Xuke Zhang, Meihai Wen","doi":"10.1186/s12944-024-02318-3","DOIUrl":"https://doi.org/10.1186/s12944-024-02318-3","url":null,"abstract":"<p><strong>Background: </strong>Lipids are associated with atherosclerosis, and novel lipid indices have been recently identified to be closely linked to cardiovascular diseases. This study explored the association between four novel lipid indices and the white matter hyperintensities (WMHs) in patients diagnosed with cerebral small vessel disease (CSVD).</p><p><strong>Methods: </strong>Between January 2023 and February 2024, 219 patients were recruited, including 165 patients with CSVD WMHs and 54 healthy controls. Based on WMHs severity, patients with CSVD were categorised into mild and moderate-to-severe cohorts using the Fazekas rating scale. The plasma levels of four novel lipid indices (low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio [LDL-C/HDL-C], triglyceride/high-density lipoprotein cholesterol ratio [TG/HDL-C], total cholesterol/high-density lipoprotein cholesterol ratio [TC/HDL-C], and non-high-density lipoprotein cholesterol [Non-HDL-C]), were rigorously monitored in the enrolled patients.</p><p><strong>Results: </strong>A total of 165 patients with CSVD WMHs were enrolled, including 94 with mild WMHs and 71 with moderate-to-severe WMHs. Multivariable logistic regression analysis revealed that LDL-C/HDL-C, TG/HDL-C, TC/HDL-C, and Non-HDL-C levels were significantly associated with WMHs (all P ≤ 0.001). Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of plasma lipid levels for WMHs in patients with CSVD. The novel lipid indicators outperformed traditional lipid indicators in assessing the diagnostic capability of WMHs. The combined index of the four blood lipid indices had an optimal cutoff point (OCP) of 0.489, with 88.3% sensitivity and 60.6% specificity. The area under the curve (AUC) is 0.800 (95% confidence interval [CI], 0.731-0.869; P < 0.001). Compared with males (OR = 1.126, 95% CI = 0.779-1.628), females (OR = 2.484, 95% CI = 1.398-4.414; P for interaction = 0.023) had a higher risk of developing WMHs.</p><p><strong>Conclusion: </strong>This study demonstrates a significant association between four novel lipid indices and the cerebral WMHs in CSVD, highlighting the potential of these markers as novel plasma biomarkers and predictive indicators for assessing CSVD progression and guiding clinical management.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"333"},"PeriodicalIF":3.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between body roundness index and risk of osteoarthritis: a cross-sectional study.","authors":"Xudong Wang, Zijian Guo, Meng Wang, Chuan Xiang","doi":"10.1186/s12944-024-02324-5","DOIUrl":"https://doi.org/10.1186/s12944-024-02324-5","url":null,"abstract":"<p><strong>Background: </strong>The link between body roundness index (BRI) and osteoarthritis (OA) has yet to be validated. Our aim was to explore this connection between BRI and OA risk.</p><p><strong>Methods: </strong>This cross-sectional study utilized the 1999-2018 National Health and Nutrition Examination Survey retrieved data. To assess the association between BRI and OA risk, we performed weighted multivariable regression analysis (MVRA), with smooth curve fitting for potential nonlinear association and subgroup analysis and interaction tests for relationships in specific subgroups. A 7:3 ratio was adopted for the random division of the acquired data into training and validation sets. Subsequently, least absolute shrinkage and selection operator regression, along with MVRA, were conducted for the training set to isolate variables for a prediction model. This model was visualized using the nomogram and was followed by evaluation. Finally, the validation set was utilized to validate the model.</p><p><strong>Results: </strong>This study enrolled 12,946 individuals. Following the adjustment for all covariables, OA risk increased by 18% with every unit rise in BRI (odd ratio [OR] = 1.18; 95% confidence interval [CI]: 1.13-1.23; P < 0.0001). Upon regarding BRI as a categorical variable, it was divided into quartiles for subsequent analysis. In comparison to quartile 1, the risk of OA was increased in quartile 2 (OR = 1.58; 95% CI: 1.22-2.03; P = 0.0006), quartile 3 (OR = 1.83; 95% CI: 1.40-2.40; P < 0.0001) and quartile 4 (OR = 2.70; 95% CI: 1.99-3.66; P < 0.0001). Smooth curve fitting revealed no non-linear relationships. None of the subgroups showed a statistically significant interaction (all P > 0.05). After selecting the variables, a prediction model was developed. The prediction model exhibited favorable discriminatory power, high accuracy, and potential clinical benefits in training and validation sets.</p><p><strong>Conclusions: </strong>The BRI was positively associated with OA risk. Our predictive model demonstrated that combining BRI with other easily accessible factors was helpful in assessing and managing high-risk OA groups.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"334"},"PeriodicalIF":3.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHACTR1 and APOC1 genetic variants are associated with multi-vessel coronary artery disease.","authors":"Cynthia Al Hageh, Siobhán O'Sullivan, Andreas Henschel, Antoine Abchee, Mireille Hantouche, Nantia Iakovidou, Taly Issa, Stephanie Chacar, Moni Nader, Pierre A Zalloua","doi":"10.1186/s12944-024-02327-2","DOIUrl":"https://doi.org/10.1186/s12944-024-02327-2","url":null,"abstract":"<p><strong>Background: </strong>Severe coronary artery disease (CAD) represents an advanced arterial narrowing, often associated with critical complications like myocardial infarction and angina. This study aimed to comprehensively investigate determinants of severe and multi-vessel CAD manifestations.</p><p><strong>Methods: </strong>One thousand nine hundred patients with severe and multivessel CAD (stenosis > 70%) were recruited along with 1,056 controls without stenosis. Associations using a genotyping panel comprising 159 Single Nucleotide Polymorphisms (SNPs) previously implicated in CAD pathogenesis were examined and these associations were replicated using the UK Biobank cohort (N = 29,970).</p><p><strong>Results: </strong>The investigation identified 14 genetic associations with severe CAD, of which 7 were also associated with multivessel disease. Notably, PHACTR1 SNP (rs9349379*G) showed a higher association with severe and multivessel CAD in individuals aged ≤ 65, indicating a higher risk of early disease onset. Conversely, the APOC1/APOE SNP (rs445925*T) is associated with reduced susceptibility to severe CAD and multivessel disease in individuals aged over 65, indicating a persistent negative association.</p><p><strong>Conclusions: </strong>Following replication of the associations in the large UK Biobank dataset, it was found that patients carrying the rs9349379*G variant in the PHACTR1 gene are at risk of developing severe or multivessel disease. Conversely, the rs445925*T variant in APOC1/APOE is associated with reduced susceptibility to severe CAD and multivessel disease, highlighting the significance of this genetic variant in these specific CAD presentations. This study contributes to a better understanding of CAD heterogeneity, paving the way for tailored management strategies based on genetic profiles.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"332"},"PeriodicalIF":3.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of diabetic retinopathy with plasma atherosclerotic index, visceral obesity index, and lipid accumulation products: NHANES 2005-2008.","authors":"Bin Wei, Lin Zhou, Ben-Liang Shu, Qin-Yi Huang, Hua Chai, Hao-Yu Yuan, Xiao-Rong Wu","doi":"10.1186/s12944-024-02325-4","DOIUrl":"10.1186/s12944-024-02325-4","url":null,"abstract":"<p><strong>Background: </strong>Abdominal obesity, a significant risk factor for the progression of diabetic retinopathy (DR), may lead to improved visual outcomes through early assessment. This study aims to evaluate any potential associations between DR and novel lipid metabolism markers, including the Atherogenic Index of Plasma (AIP), Visceral Adiposity Index (VAI), and Lipid Accumulation Product (LAP).</p><p><strong>Methods: </strong>This study aimed to elucidate the association between various lipid markers and DR by screening the National Health and Nutrition Examination Survey (NHANES) database in the United States from 2005 to 2008. To examine the correlation, multifactor logistic regression analysis, subgroup analysis, threshold effect analysis, interaction test, and smooth curve fitting were used.</p><p><strong>Results: </strong>Among the 2591 participants included, the incidence of DR was 13.6% and the mean age was 59.55 ± 12.26 years. After adjusting for important confounding covariates, logistic regression studies suggested a possible positive association between LAP, VAI, AIP, and DR occurrence (odds ratio [OR] = 1.004; 95% confidence interval [CI]: 1.002, 1.006; P < 0.0001; [OR] = 1.090; 95% [CI]: 1.037, 1.146; P = 0.0007; [OR] = 1.802; 95% [CI]: 1.240, 2.618; P = 0.0020). The nonlinear association between LAP and DR was further illustrated using an S-shaped curve by smoothing curve fitting, with the inflection point of the curve located at 63.4. Subgroup analyses and interaction tests were performed with full variable adjustment (P > 0.05 for all interactions).</p><p><strong>Conclusion: </strong>Studies have shown that elevated levels of LAP, VAI, and AIP increase the likelihood of DR, suggesting that they have the potential to be predictive markers of DR, emphasizing their potential utility in risk assessment and prevention strategies, and advocating for early intervention to mitigate the likelihood of DR.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"331"},"PeriodicalIF":3.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of oxylipins and lipid mediators in pulmonary embolism.","authors":"Fei Chen, Daibao Peng, Yanyan Xia, Haixuan Sun, Han Shen, Mao Xia","doi":"10.1186/s12944-024-02315-6","DOIUrl":"10.1186/s12944-024-02315-6","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the role of oxylipins and lipid mediators in Pulmonary Embolism (PE), a serious cardiovascular condition associated with high morbidity and mortality rates.</p><p><strong>Methods: </strong>A total of 6,365 hospitalized patients with thrombosis and 200 healthy individuals were recruited as the control group from 2015 to 2023. Thrombus type, coagulation, and lipid-related parameters were statistically analysed. Additionally, lipidomic characteristics of serum samples from the PE and control groups were examined via LC-MS/MS for the first time.</p><p><strong>Results: </strong>Among the 6,365 hospitalized patients with thrombosis, 72.1% (4,587/6,365) had venous thromboembolism (VTE). Within the VTE group, the incidence of PE was 12.1% (555/4,587). In comparison to the healthy control (HC) group, the PE group exhibited significant elevations in coagulation-related parameters, such as factor VIII (F VIII) and von Willebrand factor (vWF) activities, while antithrombin III (AT III) and factor XII (F XII) activities were notably reduced. Lipid-related parameters, including serum cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A (apoA), were significant reductions in PE patients (P < 0.0001), with areas under the curve (AUCs) exceeding 0.9. LC-MS/MS analysis of serum samples revealed 118 oxidized lipid metabolites. Compared to the HC group, the PE group exhibited 10 upregulated oxidized lipid metabolites, with the most significant difference observed in 20-hydroxyPGF2α derived from arachidonic acid (ARA). The study identified upregulated oxidized lipid metabolites primarily linked to the ARA metabolism signalling pathway.</p><p><strong>Conclusion: </strong>This research indicates a notable correlation between lipid metabolism and the occurrence and development of PE. Specifically, upregulation of the arachidonic acid metabolism signalling pathway may be an important pathogenic factor for PE, and 20-hydroxyPGF2α derived from ARA has potential as a biomarker for PE disease.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"330"},"PeriodicalIF":3.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans.","authors":"Ewa Karwatowska-Prokopczuk, Anastasia Lesogor, Jing-He Yan, Angelika Hoenlinger, Alison Margolskee, Lu Li, Sotirios Tsimikas","doi":"10.1186/s12944-024-02297-5","DOIUrl":"10.1186/s12944-024-02297-5","url":null,"abstract":"<p><strong>Background: </strong>Olezarsen is a GalNAc₃-conjugated, hepatic-targeted antisense oligonucleotide that lowers apolipoprotein C-III (apoC-III) and triglyceride levels. The efficacy and safety of olezarsen has not previously been studied in ethnically diverse American populations. The aim of this study is to assess the effect of olezarsen in healthy Japanese Americans.</p><p><strong>Methods: </strong>A randomized, placebo-controlled, double-blind phase 1 study was performed in 28 healthy Japanese American participants treated with olezarsen in single-ascending doses (SAD; 30, 60, 90 mg) or multiple doses (MD; 60 mg every 4 weeks for 4 doses). The primary, secondary, and exploratory objectives were safety and tolerability, pharmacokinetics, and effects of olezarsen on fasting serum triglycerides and apoC-III, respectively.</p><p><strong>Results: </strong>There were 20 participants (16 active:4 placebo) in the SAD part of the study, and 8 participants (6 active:2 placebo) in the MD part of the study. For the primary endpoint, no serious adverse events or clinically relevant laboratory abnormalities were reported. The majority of olezarsen plasma exposure occurred within 24 h post-dose. In the SAD cohorts at Day 15 the percentage reduction in apoC-III/TG was - 39.4%/ - 17.8%, - 60.8%/ - 52.7%, and - 68.1%/ - 39.2% in the 30, 60 and 90 mg doses, respectively, vs 2.3%/44.5% increases in placebo. In the MD cohort, at Day 92 the percentage reduction in apoC-III/TG was - 81.6/ - 73.8% vs - 17.2/ - 40.8% reduction in placebo. Favorable changes were also present in VLDL-C, apoB and HDL-C.</p><p><strong>Conclusions: </strong>Single- and multiple-dose administration of olezarsen was safe, was well tolerated, and significantly reduced apoC-III and triglyceride levels in healthy Japanese Americans.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"329"},"PeriodicalIF":3.9,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiometabolic Index (CMI) and endometriosis: a cross-sectional study on NHANES.","authors":"Jiameng Wang, Boyu Wang, Ting Liu, Jingying Shang, Xumeng Gu, Tianchan Zhang, Huifang Cong","doi":"10.1186/s12944-024-02314-7","DOIUrl":"10.1186/s12944-024-02314-7","url":null,"abstract":"<p><strong>Background: </strong>Endometriosis is intricately linked to metabolic health. The Cardiometabolic Index (CMI), a novel and readily accessible indicator, is utilized to evaluate metabolic status. This study seeks to investigate the potential correlation between CMI and endometriosis.</p><p><strong>Methods: </strong>Data from four consecutive survey cycles of the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2006 were utilized. This included adult females with self-reported diagnoses of endometriosis and complete information required for calculating the CMI. The calculation formula for CMI is Triglycerides(TG) / High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference / height). A multivariable logistic regression model was employed to investigate the linear association between CMI and endometriosis. Subgroup analyses were performed to explore potential influencing factors. Additionally, the linear relationship was validated using restricted cubic spline (RCS) curve plotting and threshold effect analysis.</p><p><strong>Results: </strong>This study, based on the National Health and Nutrition Examination Survey (NHANES), included a cohort of 2,224 adult women. The multivariable logistic regression analysis demonstrated that in the fully adjusted model, individuals with the highest CMI exhibited a 78% elevated likelihood of endometriosis compared to those with the lowest CMI (OR = 1.78; 95% CI, 1.02-3.11, P < 0.05). The subgroup analysis indicated that there were no significant interactions between CMI and specific subgroups (all interaction P > 0.05), except for the subgroup stratified by stroke status (P < 0.05). Additionally, the association between CMI and endometriosis was linear, with a 20% increase in the association for each unit increase in CMI when CMI > 0.67 (OR = 1.20; 95% CI, 1.05-1.37, P < 0.01).</p><p><strong>Conclusion: </strong>The study found that CMI levels are closely correlated with endometriosis, with this correlation increasing when the CMI exceeds 0.67. This finding implies that by regularly monitoring CMI levels, physicians may be able to screen women at risk for endometriosis at an earlier stage, thereby enabling the implementation of early interventions to slow the progression of the disease. To further validate these findings, larger-scale cohort studies are required to support the results of this research.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"328"},"PeriodicalIF":3.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11446041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}