Lipids in Health and Disease最新文献

{"title":"Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study.","authors":"Yongho Jee, Jong Won Shin, Mikyung Ryu, Tae-Jin Song","doi":"10.1186/s12944-025-02502-z","DOIUrl":"10.1186/s12944-025-02502-z","url":null,"abstract":"<p><strong>Background: </strong>High LDL-cholesterol (LDL-C) is a well-known risk factor for coronary artery disease (CAD). PCSK9, HMGCR, NPC1L1, ACLY, and LDLR gene have been reported as lipid lowering drug genes related to LDL-C lowering. However relevant Asian studies were rare.</p><p><strong>Methods: </strong>We examined the causality between LDL-c drug target genes and CAD using Korean and Japanese data using the two sample Mendelian Randomization (MR) method. We conducted two-sample MR analysis of LDL-c lowering drug target genes (7 Single-nucleotide polymorphisms (SNP) in PCSK9, 6 SNPs in HMGCR, 5 SNPs in NPC1L1, 9 SNPs in ACLY, 3 SNPs in LDLR) and CAD. We used summary statistics data from the Korean Genome Epidemiology Study (KOGES) for LDL-C data, and Biobank of Japan (BBJ) for CAD data.</p><p><strong>Results: </strong>For every 10 mg/dl decrease in LDL-C determined by four significant SNPs in the PCSK9 gene, the risk of CAD decreased by approximately 20% (OR = 0.80, 95% CI: 0.75-0.86). The risk of CAD decreased by 10% for every 10 mg/dl decrease in LDL-C due to the six significant SNPs in the HMGCR gene (OR = 0.90, 95% CI: 0.86-0.94). Due to the two significant SNPs in the gene LDLR, the risk of CAD decreased by approximately 26% for every 10 mg/dl decrease in LDL-C (OR = 0.74, 95% CI: 0.66-0.82). The combined effect on CAD showed the largest effect size for the PCSK9 gene and LDLR gene, and the reduced CAD risk induced by these two genes together was OR = 0.78 (95%CI, 0.74-0.83). Finally, the combined effect of all three genes (PCSK9, HMGCR, and LDLR) was OR = 0.85 (95%CI, 0.79-0.91).</p><p><strong>Conclusion: </strong>LDL-C reduction estimated by SNPs in LDL-C lowering drug target genes significantly reduced the risk of CAD. We found the potential of using of proxy research design for clinical trials using LDL-C lowering drugs.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"92"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Examining the dietary contributions of lipids to pancreatic cancer burden (1990-2021): incidence trends and future projections.","authors":"Kexin Jiang, Zhirong Zhao, Mu Yuan, Hua Ji, Yiwen Zhao, Hanyu Ding, Jiajie Feng, Yongjiang Zhou, Ruiwu Dai","doi":"10.1186/s12944-025-02505-w","DOIUrl":"10.1186/s12944-025-02505-w","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"90"},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder.","authors":"Martina Nicole Modesti, Jan Francesco Arena, Antonio Del Casale, Giovanna Gentile, Marina Borro, Giovanna Parmigiani, Maurizio Simmaco, Cecilia Guariglia, Stefano Ferracuti","doi":"10.1186/s12944-025-02512-x","DOIUrl":"10.1186/s12944-025-02512-x","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review explores the hypothesis that various lipid categories and lipid metabolism-related genomic variations link to mental disorders, seeking potential clinically useful markers.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, and PsycInfo databases until October 12th, 2024, using terms related to lipidomics, lipid-related genomics, and different mental disorders, i.e., Major Depressive Disorder (MDD), Bipolar Disorder (BD), Schizophrenia (SCZ), and Obsessive-Compulsive Disorder (OCD). Eligible studies were assessed. Extracted data included author, year, methodology, outcomes, genes, and lipids linked to disorders. Bias and evidence certainty were evaluated. The systematic review adhered to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and a registered protocol (PROSPERO: CRD42023438862).</p><p><strong>Results: </strong>A total of 27 studies were included. SCZ showed alterations in 77 lipids, including triglycerides (TG), ceramides, and phosphatidylcholine, while MDD and BD exhibited 97 and 47 altered lipids, respectively, with overlap among disorders. Shared genes, such as ABCA13, DGKZ, and FADS, and pathways involving inflammation, lipid metabolism, and mitochondrial function were identified. OCD was associated with sphingolipid signaling and peroxisomal metabolism.</p><p><strong>Discussion: </strong>Lipid signatures in MDD, BD, and SCZ shed light on underlying processes. Further research is needed to validate biomarkers and refine their clinical applications in precision psychiatry.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"89"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomized study.","authors":"Christine Dawczynski, Timo Drobner, Thomas Weidauer, Peter Schlattmann, Michael Kiehntopf, Daniela Weber, Tilman Grune, Winfried März, Marcus E Kleber, Stefan Lorkowski","doi":"10.1186/s12944-025-02500-1","DOIUrl":"10.1186/s12944-025-02500-1","url":null,"abstract":"<p><strong>Background and aim: </strong>The MoKaRi study aims to evaluate the impact of two nutritional concepts on cardiometabolic risk factors.</p><p><strong>Methods: </strong>For our 20-week intervention study, 65 participants with moderate elevated low-density lipoprotein cholesterol (LDL-C; ≥ 3 mmol/l) and without lipid-lowering therapy were recruited. The intervention to improve nutritional behavior was based on individualized menu plans which were characterized by defined energy and nutrient intake. To improve compliance, individual nutritional counselling sessions were held every two weeks. In addition to motivation, cooking skills were strengthened and nutritional knowledge was imparted. Follow-up visits were carried out after 10 and 20 weeks.</p><p><strong>Results: </strong>The MoKaRi diet lowered the concentrations of total cholesterol (menu plan group (MP): -15%; menu plan plus fish oil group (MP-FO): -11%), LDL-C (MP: -14%; MP-FO: -16%) and non-high-density lipoprotein cholesterol (MP: -16%; MP-FO: -13%) (p < 0.001). Body weight (MP: -5%; MP-FO: -8%; p < 0.05), waist circumference (MP: -6%; MP-FO: -9%) as well as diastolic blood pressure (MP: -8%; MP-FO: -8%), apolipoprotein A1 (MP: -15%; MP-FO: -20%), apolipoprotein B (MP: -15%; MP-FO: -6%) and glycated hemoglobin A_1c (HbA1c) (MP: -1.8%; MP-FO: -3.6%) were also reduced in both groups after 20 weeks (p < 0.05). In both intervention groups, a maximum reduction in LDL-c of approx. 26% was achieved within the 20 weeks of intervention. Individual participants achieved a reduction of 45-49%. The supplementation of fish oil on top of the menu plans resulted in more substantial effects on body weight (MP: -5% vs. MP-FO: -8%), body fat (MP: -11% vs. MP-FO: -20%), triglycerides (MP: -14% vs. MP-FO: -28%), high-sensitivity C-reactive protein (MP: -19% vs. MP-FO: -43%) and HbA1c (MP: -1.8% vs. MP-FO:-3.6%; p < 0.05).</p><p><strong>Conclusions: </strong>The MoKaRi diet resulted in a significant reduction of cardiometabolic risk factors. Our data highlights the additional benefit of the combination between menu plans and fish oil supplementation, which resulted in more substantial effects on body weight, BMI, TG, HbA1c and hs-CRP.</p><p><strong>Clinicaltrials: </strong></p><p><strong>Gov identifier: </strong>NCT02637778.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"88"},"PeriodicalIF":3.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ratio of perirenal fat thickness to renal parenchymal thickness, a novel indicator of fat accumulation associated with kidney stones.","authors":"Dekai Hu, Guoxiang Li, Defeng Ge, Leilei Ke, Hongmin Shu, Yang Chen, Zongyao Hao","doi":"10.1186/s12944-025-02497-7","DOIUrl":"10.1186/s12944-025-02497-7","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome, identified by increased visceral fat accumulation, is notably linked to a heightened risk of nephrolithiasis. Despite this, the influence of the perirenal fat thickness relative to renal parenchymal thickness on kidney stones (KS) development remains ambiguous. This study investigated the clinical characteristics of perirenal fat on both the left and right sides and explored the association between the aforementioned ratio and KS.</p><p><strong>Methods: </strong>The study enrolled 161 participants who underwent computed tomography (CT) scans. In this study, kidneys were segregated into two categories based on the presence of stones: stone-bearing and non-stone-bearing for both the left and right kidneys. Perirenal fat parameters were extracted from the imaging workstation database. Both univariate and multivariate logistic regression analyses were conducted to explore the correlation between metrics related to perirenal fat and the occurrence of KS.</p><p><strong>Results: </strong>Among the 161 participants, significant variations in perirenal fat were observed between the left and right kidneys, as well as between genders. Subsequent to adjustments for several confounding variables, the multivariable logistic regression model demonstrated a significant correlation between the ratio of perirenal fat thickness to renal parenchymal thickness and stone bearing kidney (P < 0.001).</p><p><strong>Conclusions: </strong>The ratio of perirenal fat thickness to renal parenchymal thickness was significantly correlated with kidney stones.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"86"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between triglyceride-glucose index combined with waist circumference and heart failure in individuals with different body mass indices: a cross-sectional study using NHANES 2011-2020 data.","authors":"Chengyi Wang, Jinxi Wang, Xinqing Li, Ping Zhou, Xuemei Zhao, Anran Xin, Guangzhi Liao, Yan Huang, Yuhui Zhang","doi":"10.1186/s12944-025-02476-y","DOIUrl":"10.1186/s12944-025-02476-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The incidence of heart failure (HF), a cardiovascular disease, has been widely reported to be gradually increasing. Although the triglyceride-glucose (TyG) index is associated with the risk of HF, this relationship may be affected by differences in nutritional status among individuals with varying levels of obesity. Waist circumference combined with the TyG index may be more accurately associated with HF.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study analyzed data from 8769 participants from the 2011-2020 National Health and Nutrition Examination Survey (NHANES). After weighting the data, multivariable logistic regressions were used to calculate the associations between HF and the TyG and TyG-waist circumference (TyG-WC) indices in adults with different body mass indices (BMIs). Restricted cubic splines were employed to assess for linear or nonlinear relationships. Receiver operating characteristic (ROC) curves were used to demonstrate the efficacy of the models for different indices. The Net Reclassification Index (NRI) was used to measure the improvement in the TyG-WC index relative to the TyG index in the different models. The Integrated Discriminant Improvement Index (IDI) supports this conclusion.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;TyG and TyG-WC indices were positively associated with HF (TyG: odds ratio [OR], 1.765; 95% CI], 1.390-2.242; P &lt; 0.001; TyG-WC: OR, 1.003; 95% CI, 1.002-1.004; P &lt; 0.001), except In Model 4 for the TyG index (OR, 1.238; 95% CI, 0.941-1.629; P = 0.124). BMI was used to categorize the study population into normal or underweight and overweight or obese groups. In the overweight and obese groups, the odds ratio (OR) increased as the index value increased. However, in the normal and underweight groups, high TyG indices were associated with low ORs. According to the ROC, NRI, and IDI analyses, the TyG-WC index was associated with HF in the normal weight or underweight groups (area under the curve [AUC]: 0.6724; 95% CI: 0.4991-0.6400), whereas the TyG index alone was not (AUC: 0.5695; 95% CI: 0.6115-0.7334). In Model 4, adjusted for all covariates, the TyG index had a slightly better ability than the TyG-WC index (NRI: -0.4112; 95% CI: -0.6818- -0.1406; P &lt; 0.05; IDI: -0.0072; 95%CI: -0.0228-0.0083; P = 0.36256). In the overweight and obese populations, the TyG-WC index was slightly better than the TyG index (NRI: 0.3089; 95% CI: 0.1726-0.4451; P &lt; 0.001; IDI: 0.0084; 95% CI: 0.0017-0.0151; P &lt; 0.05). However, the sensitivity of the TyG-WC index alone was only 41.8%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The association between HF and these two indices was influenced by BMI. In normal-weight and underweight populations, higher TyG indices may imply improved nutritional status. Therefore, the TyG index should be combined with WC to assess the risk of HF. In overweight or obese populations, both indices can be used to assess the risk of HF; however, the TyG-WC index is less sensitive when used alo","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"87"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the atherogenic index of plasma with frailty in U.S. adults: a cross-sectional study based on NHANES.","authors":"Shaohua Yan, Ke Chai, Jiefu Yang, Hua Wang","doi":"10.1186/s12944-025-02504-x","DOIUrl":"10.1186/s12944-025-02504-x","url":null,"abstract":"<p><strong>Background: </strong>Frailty is a multifactorial syndrome associated with adverse health outcomes. The metabolic underpinnings of frailty, particularly lipid metabolism, are not fully understood. Unlike isolated lipid fractions or inflammatory markers, atherogenic index of plasma (AIP) integrates atherogenic lipid profiles and systemic inflammation. However, its association with frailty has not been extensively studied.</p><p><strong>Methods: </strong>Six thousand four hundred participants from the National Health and Nutrition Examination Survey (NHANES) were enrolled. Frailty was calculated with the frailty index (FI), with scores ≥ 0.21 indicating frailty. Logistic regression adjusted for demographic, socioeconomic, and lifestyle factors evaluated the association between AIP and frailty. Restricted cubic splines (RCS) explored nonlinear associations, and subgroup analyses assessed interactions across age, sex, race, poverty income ratio, smoking status, drinking status, and marital status.</p><p><strong>Results: </strong>This study demonstrated a strong dose-response relationship between AIP and frailty. After full adjustment, Individuals in quartile 3 and 4 showed higher odds of frailty than those in lowest quartile, with ORs (95% CI) of 1.26(1.01,1.57) and 1.73(1.34,2.23), respectively. Continuous AIP measures also exhibited significant associations (OR: 1.82, 95% CI: 1.34-2.47). RCS analysis showed that AIP exhibited a nonlinear association with the risk of frailty. Subgroup analyses showed the associations were more pronounced in the females. The sensitivity analyses substantiated the stability and strength of the results.</p><p><strong>Conclusions: </strong>Our findings suggest that elevated AIP levels are independently associated with frailty risk, particularly in females, highlighting its potential as a cost-effective biomarker for risk stratification. Future longitudinal studies are needed to validate AIP's predictive utility and uncover the underlying mechanisms.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"84"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough.","authors":"Changfen Wang, Xuecheng Liao, Jiulin Chen, Ying Lan, Jun Wen","doi":"10.1186/s12944-025-02498-6","DOIUrl":"10.1186/s12944-025-02498-6","url":null,"abstract":"<p><strong>Background: </strong>Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a new biomarker, reflects blood lipid status. Nevertheless, the association between NHHR and chronic cough remains uncertain.</p><p><strong>Method: </strong>This investigation included 9725 individuals from the NHANES. This research employed multiple statistical models to illustrate the association between NHHR and chronic cough. These models included logistic regression models, the Shapley Additive Explanations (SHAP) model, trend tests, mediation analysis, restricted cubic splines (RCS), and subgroup analyses.</p><p><strong>Result: </strong>The logistic regression model, adjusting all covariables, showed a positive association between NHHR with chronic cough (OR: 1.08; 95% CI: 1.02-1.14). Trend tests and RCS further proved that NHHR and chronic cough had a linear and positive association. The mediation analysis proved that systemic immune inflammation index (SII) and systemic inflammatory response index (SIRI) partially mediated the association between NHHR and chronic cough. The SHAP model suggested that the top five important markers for predicting chronic cough were SII, smoking, NHHR, BMI, and SIRI.</p><p><strong>Conclusion: </strong>This investigation discovered that NHHR was positively associated with chronic cough. Regular NHHR monitoring may serve as a potential tool for identifying individuals at higher risk of chronic cough.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"85"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between preoperative neutrophil to high-density lipoprotein ratio and postoperative systemic inflammatory response syndrome in elderly patients: a retrospective cohort study.","authors":"Jingjing Chen, Xiaorui Chen, Hanbin Xie, Ziqing Hei, Zifeng Liu, Chaojin Chen","doi":"10.1186/s12944-025-02460-6","DOIUrl":"10.1186/s12944-025-02460-6","url":null,"abstract":"<p><strong>Background: </strong>Systemic inflammatory response syndrome (SIRS) remains a serious health problem that consumes a large amount of medical resources. The objective of the study was to investigate whether older patients with a high neutrophil to high-density lipoprotein ratio (NHR) before surgery were more susceptible to postoperative SIRS.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted on patients older than 65 years admitted to the two campuses of the Third Affiliated Hospital of Sun Yat-sen University between January 2015 and September 2020. Patient baseline characteristics such as demographic information, medical history, laboratory test results, and variables related to postoperative SIRS were obtained from the electronic health record system. The main outcome was the occurrence of postoperative SIRS during the initial three days after surgery. The main exposure was the NHR, divided into two groups according to the optimal receiver operating characteristic (ROC) cut-off value: NHR < 4.82 and NHR ≥ 4.82.</p><p><strong>Results: </strong>The study involved 5696 older patients, among whom 1419 (24.91%) developed SIRS. The ROC analysis showed that the NHR had the largest curve area for predicting postoperative SIRS. The NHR ≥ 4.82 was independently linked to a higher risk of postoperative SIRS (aOR = 1.29, 95% CI: 1.10-1.52, P = 0.002). This association remained robust in various sensitivity and subgroup analyses. The NHR ≥ 4.82 was correlated with an elevated risk of hospital mortality, prolonged postoperative hospital stays, and increased direct medical expenses.</p><p><strong>Conclusions: </strong>The study found that older patients undergoing general anesthesia with NHR ≥ 4.82 were associated with an increased risk of postoperative SIRS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"82"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TSH-stimulated hepatocyte exosomes modulate liver-adipose triglyceride accumulation via the TGF-β1/ATGL axis in mice.","authors":"Shizhan Ma, Yayun Wang, Shuteng Fan, Wanli Jiang, Mingliang Sun, Mengzhe Jing, Wenkai Bi, Meng Zhou, Dongming Wu","doi":"10.1186/s12944-025-02509-6","DOIUrl":"10.1186/s12944-025-02509-6","url":null,"abstract":"<p><p>Subclinical hypothyroidism (SCH) contributes to obesity, with the liver acting as a crucial metabolic regulator. Thyroid-stimulating hormone (TSH) affects systemic lipid balance, potentially linking SCH to obesity. While the direct impact of TSH on hepatic lipid metabolism has been extensively documented, its role in modulating lipid dynamics in peripheral organs through liver-mediated pathways remains insufficiently understood. This study identifies TSH-stimulated hepatocyte-derived exosomes (exosomes^TSH) as key mediators in liver-adipose communication, promoting triglyceride accumulation in adipocytes via the transforming growth factor-beta 1 (TGF-β1)/adipose triglyceride lipase (ATGL) axis. Exosomes^TSH enhance lipid storage in adipocytes, significantly increasing triglyceride content and lipid droplet formation while reducing lipolysis, effects that are dependent on TSH receptor (TSHR) activation in hepatocytes. In vivo, exosomes^TSH induce weight gain and adipose tissue expansion, impairing glucose metabolism in both chow- and high-fat diet-fed mice. Mechanistically, exosomes^TSH upregulate TGF-β1 and downregulate ATGL in adipocytes, establishing the TGF-β1/ATGL pathway as essential for exosome-mediated lipid accumulation. Further, miR-139-5p is identified as a modulator of TGF-β1 expression within this pathway, with overexpression of miR-139-5p alleviating exosomes^TSH-induced lipid accumulation in adipocytes. This study elucidates a novel miR-139-5p-dependent mechanism through which TSH modulates lipid metabolism via liver-derived exosomes, highlighting the pivotal role of miR-139-5p in linking SCH to adipose lipid accumulation through the TGF-β1/ATGL signaling axis.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"81"},"PeriodicalIF":3.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}