Lipids in Health and Disease最新文献

{"title":"Association between cardiometabolic index and postmenopausal stress urinary incontinence: a cross-sectional study from NHANES 2013 to 2018.","authors":"Ting Yin, Yue He, Huifang Cong","doi":"10.1186/s12944-025-02601-x","DOIUrl":"10.1186/s12944-025-02601-x","url":null,"abstract":"<p><strong>Background: </strong>Stress urinary incontinence (SUI) is a common condition affecting the genitourinary system in postmenopausal women. Obesity and dyslipidemia are recognized as significant factors that contribute to the onset of SUI. The cardiometabolic index (CMI), a reliable indicator of health risks associated with obesity, is crucial in assessing these risks. This study aims to investigate the relationship between CMI and the occurrence of SUI in postmenopausal women across the United States.</p><p><strong>Methods: </strong>This cross-sectional study employed data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2018, concentrating on postmenopausal women aged 40 years and above in the United States. Multiple regression models were utilized to evaluate the association between CMI and postmenopausal SUI, while controlling for pertinent confounding variables. Smooth curve fitting (SCF) techniques were utilized to evaluate the correlation between postmenopausal SUI incidence and CMI. To enhance the robustness of the findings, analyses of subgroups and assessments of interactions were performed.</p><p><strong>Results: </strong>542 postmenopausal women participated in the study, with 237 of them indicating the presence of symptoms associated with stress urinary incontinence. The findings from the multiple regression analysis consistently demonstrated a positive correlation between CMI and SUI in all adjusted models. In particular, a one-unit increase in CMI correlated with a 63% greater probability of encountering postmenopausal SUI in fully adjusted models (OR = 1.63, 95% CI: 1.07-2.48). Additionally, a direct correlation was noted between CMI levels and the occurrence of SUI within this population. Subgroup analysis by the number of vaginal deliveries showed a significant interaction (P for interaction = 0.0471).</p><p><strong>Conclusions: </strong>The findings emphasize the importance of managing CMI levels to identify postmenopausal women at increased risk for SUI. This study confirms the strong predictive value of CMI for SUI in this population.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"184"},"PeriodicalIF":3.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverted L-shape association between a body shape index and peak expiratory flow among middle-aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).","authors":"Guosong Jiang, Licheng Feng, Xiaoxiao Qu, Jia Wang, Yun Li","doi":"10.1186/s12944-025-02599-2","DOIUrl":"10.1186/s12944-025-02599-2","url":null,"abstract":"<p><strong>Background: </strong>Peak expiratory flow (PEF) serves as a direct indicator of the functional status of the respiratory system. Higher body fat content, especially abdominal obesity, may relate to a deterioration in long-term respiratory function. The \"A Body Shape Index\" (ABSI) better assesses abdominal obesity, but its association with PEF is poorly understood.</p><p><strong>Methods: </strong>The analysis demonstrated data from 14,386 middle-aged and older adults from the 2015 China Health and Retirement Longitudinal Study (CHARLS). ABSI, a sex-specific metric integrating waist circumference, weight, and height via allometric modeling derived from Chinese anthropometrics, was analyzed against PEF/PEF _prediction using multivariable linear and spline regressions to characterize nonlinear associations. Threshold effects, subgroup, and sensitivity analyses ensured robustness.</p><p><strong>Results: </strong>This research showed a negative relationship between ABSI and both PEF and PEF _predictions. An inverted L-shaped curve in the spline analysis characterized the association between ABSI and PEF/PEF _prediction across the sexes. The ABSI threshold was 0.0782 and 0.0691 in males and females, respectively.</p><p><strong>Conclusions: </strong>Abdominal obesity negatively affects respiratory function, with ABSI thresholds varying by sex. Therefore, weight management should focus on a healthy ABSI to reduce abdominal obesity and safeguard respiratory health.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"181"},"PeriodicalIF":3.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green tea epigallocatechin gallate attenuate metabolic dysfunction-associated steatotic liver disease by regulation of pyroptosis.","authors":"Jie Zhang, Shuangshuang Wang, Ting Zhang, Minghui Zi, Shuxiang Wang, Qiao Zhang","doi":"10.1186/s12944-025-02596-5","DOIUrl":"10.1186/s12944-025-02596-5","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease, with other fat-liver diseases potentially progressing to cirrhosis and hepatocellular carcinoma. Our study aimed to alleviate MASLD by EGCG inhibiting oxidative stress-mediated pyroptosis in zebrafish.</p><p><strong>Methods: </strong>The one month old wild-type zebrafh larval (50 per group) and three months old adult male zebrafish (15 per group) were treated with high-fat diet (HFD) feeding (powdered egg yolk) following by treatment with 25 μM EGCG for 15 days. Indicators related to liver damage, oxidative stress, inflammation, pyroptosis and aging were assessed using Oil Red O staining, H&E staining, commercial assay kits, enzyme-linked immunosorbent assay (ELISA) kits, and Western blot analysis.</p><p><strong>Results: </strong>The results suggest that EGCG significantly reduced fatness, severe lipid deposition, triglyceride (TG), total cholesterol (TC) and free fatty acid (FFA) levels (p < 0.05). EGCG markedly reduced serum ALT, AST and ameliorated liver injury in zebrafish (p < 0.05). EGCG also showed an antioxidant effect by reducing reactive oxygen species (ROS) production malondialdehyde (MDA) and increasing superoxide dismutase (SOD) levels (p < 0.05). Moreover, EGCG obviously down-regulated the pro-inflammatory factors like tumor necrosis factor-a (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-18 (IL-18) levels (p < 0.05). EGCG indicated a significant upregulation involved in pyroptosis pathway, such as nuclear factor erythroid 2-related factor 2 (NRF2) and downregulated the expressions of nuclear factor-κB (NF-κB), NOD-like receptor thermal protein domain associated protein 3 (NLRP3), apoptosis-associated speck-like protein containing a CARD (ASC), cysteinyl aspartate specific proteinase-1 (caspase-1), as well as gasdermin D (GSDMD) (p < 0.01). Moreover, EGCG significantly improved aging-related markers induced by a HFD, including the level of senescence-associated β-Galactosidase (SA β-Gal) and expression of p53, p16, and p21 (p < 0.05), while ameliorating liver function in zebrafish.</p><p><strong>Conclusions: </strong>These results suggest that EGCG may attenuate MASLD in larval and adult zebrafish induced by 15 consecutive days HFD, which is potentially mediated by modulating the Nrf2/NF-κB/NLRP3 signaling pathway which relieve pyroptosis.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"180"},"PeriodicalIF":3.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease risk factors are associated with conventional lipids and apolipoproteins in South African adults of African ancestry.","authors":"Anri Vorster, Ruan Kruger, Catharina Mc Mels, Yolandi Breet","doi":"10.1186/s12944-025-02591-w","DOIUrl":"10.1186/s12944-025-02591-w","url":null,"abstract":"<p><strong>Background: </strong>Although conventional lipids (high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), total cholesterol (TC) and triglycerides (TG)) are therapeutic targets to manage and prevent atherosclerotic cardiovascular disease (CVD), apolipoprotein (Apo) levels have sparked interest for their potential to improve CVD risk prediction. This study explored the relationships of traditional CVD risk factors with conventional lipids, as well as ApoA1, ApoB and its ratio (ApoB: ApoA1) in South African adults of African ancestry.</p><p><strong>Methods: </strong>This study included 1697 adults (aged 29 to 94) from the Prospective Urban Rural Epidemiology (PURE) study. The CVD risk markers included body mass index (BMI), physical activity index, tobacco use, dietary fat intake, γ-glutamyl transferase (γGT) and glycated haemoglobin (HbA1C). Conventional lipids were measured in serum samples using standard methodology, while ApoA1 and ApoB were measured using a multiplex magnetic bead immunoassay.</p><p><strong>Results: </strong>Stratified into tertiles of conventional lipid and Apo levels, trends emerged across multiple CVD risk markers, including BMI, tobacco use, fat intake, γGT and HbA1C levels. Higher tertiles of LDLC, TC, TG, ApoB and ApoB: ApoA1, along with the lowest tertiles of HDLC and ApoA1 exhibited higher prevalence of Type II diabetes mellitus (all p ≤ 0.024) and overweight or obesity (all except for TC, p ≤ 0.024). HDLC was negatively associated and LDLC, TC, and TG were positively associated with BMI (all p < 0.001) and HbA1C (all except for TC, p ≤ 0.005). Similarly, ApoA1 associated negatively with BMI (β=-0.067 (-0.125; -0.010), p = 0.022) and HbA1C (β=-0.071 (-0.122; -0.020), p = 0.007), while ApoB associated positively with BMI (β = 0.168 (0.117; 0.218), p < 0.001). The ApoB: ApoA1 showed positive associations with BMI (β = 0.213 (0.163; 0.263), p < 0.001) and HbA1C (β = 0.123 (0.074; 0.172), p < 0.001).</p><p><strong>Conclusions: </strong>In South African adults of African ancestry, ApoA1, ApoB and ApoB: ApoA1 levels are associated with various established CVD risk markers and suggests that these apolipoproteins may provide additional mechanistic insights beyond the conventional lipids to understand the aetiology of early cardiometabolic disease development.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"177"},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the relationship between the non-HDL/HDL cholesterol ratio (NHHR) and endometriosis: a cross-sectional analysis utilizing the NHANES dataset.","authors":"Panpan Jiang, Xingruo Zhang, Haili Huang, Zhuoran Sun, Wenjun Hu, Yuhong Li","doi":"10.1186/s12944-025-02590-x","DOIUrl":"10.1186/s12944-025-02590-x","url":null,"abstract":"<p><strong>Background: </strong>Numerous previous studies have suggested dyslipidemia is possibly linked to endometriosis (EMs). The connection between endometriosis and NHHR remains largely unexplored. Thus, this investigation examined whether NHHR is correlated with endometriosis development among adult women in the United States of America.</p><p><strong>Methods: </strong>Data from the 1999-2006 National Health and Nutrition Examination Survey (NHANES) were analyzed in a cross-sectional study, with a final sample of 4,990 participants. To investigate the potential association between NHHR and the likelihood of developing endometriosis, we employed two statistical models: a weighted multivariate logistic regression model and a restricted cubic spline model. Data visualization included scatter plots with locally estimated scatterplot smoothing (LOESS) curves to illustrate the relationship between NHHR and the probability of endometriosis. To ensure the reliability of our findings, we subsequently conducted subgroup analyses and interaction tests to assess their stability.</p><p><strong>Results: </strong>In this study, after accounting for all potential confounders, it was found that for every one-point elevation in NHHR, the risk of developing endometriosis increased by 17% (95% CI: 1.05-1.35, p = 0.04). A linear dose-response association was identified that connected NHHR with the risk of endometriosis (P for nonlinear = 0.1315). Interaction results from subgroup analyses suggested that an association between NHHR and risk of endometriosis was largely unaffected by race, educational background, or marital status, among others.</p><p><strong>Conclusion: </strong>NHHR and the probability of developing endometriosis are significantly correlated in the U.S. population, suggesting that further research on NHHR could assist in non-invasive diagnosis of endometriosis.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"179"},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of omega-3, omega-6 fatty acids intakes and omega-6: omega-3 ratio with the prevalence of suicidal ideation: mediating role of C-reactive protein.","authors":"Hao Lin, Zhibin Bai, Daoke Wu, Qi Yang, Shuangshuang Qu","doi":"10.1186/s12944-025-02587-6","DOIUrl":"10.1186/s12944-025-02587-6","url":null,"abstract":"<p><strong>Background: </strong>Although dietary omega fatty acids have been recognized for positive effects on mental health, the specific association between omega fatty acids intake and suicidal ideation remains ambiguous. This study aims to explore the potential association between the prevalence of suicidal ideation and dietary omega fatty acids intake in American adults.</p><p><strong>Methods: </strong>The data of 27,944 American adults collected from National Health and Nutrition Examination Survey (NHANES) were analyzed in this study. To assess the association between dietary omega fatty acids intake and suicidal ideation as measured by Item 9 of PHQ-9, logistic regression, restricted cubic spline regression, and stratified analyses, mediation analyses were employed.</p><p><strong>Results: </strong>Logistic regression analyses indicate that the intakes of omega-3 and omega-6 fatty acids were inversely associated with the prevalence of suicidal ideation, and dietary omega-6/omega-3 ratio was positively associated with the prevalence of suicidal ideation. Subgroup analyses further revealed a stronger association between suicidal ideation and omega fatty acids intake in individuals with a history of stroke. Furthermore, a saturation effect and non-linear association were identified between omega-3 and omega-6 fatty acids intake and the prevalence of suicidal ideation, characterized by an L-shaped curve with an inflection point at 1.36 g/d, 13.69 g/d, respectively. Notably, C-reactive protein (CRP) partially mediated the association between omega-6, omega-3 fatty acids intake and suicidal ideation by a proportion of 3.8% and 4.0%.</p><p><strong>Conclusion: </strong>The findings of this study suggest that higher omega-3 and omega-6 fatty acids intake and lower omega-6/omega-3 ratio is associated with a declined prevalence of suicidal ideation.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"178"},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM).","authors":"Ziying Su, Lei Cao, Hailong Chen, Peng Zhang, Chunwei Wu, Jing Lu, Ze He","doi":"10.1186/s12944-025-02589-4","DOIUrl":"https://doi.org/10.1186/s12944-025-02589-4","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzes data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES) to explore the relationship between the Aggregate Index of Systemic Inflammation (AISI), also referred to as the pan-immune-inflammation value (PIV), and Type 2 Diabetes Mellitus (T2DM) among adults in the United States. Furthermore, it evaluates the mediating effect of obesity indicators on this association.</p><p><strong>Methods: </strong>This study included 9,947 individuals from NHANES and applied appropriate weighting techniques. To examine the relationship between AISI and T2DM, we used various statistical models, including weighted multivariable logistic regression, smooth curve fitting, threshold effect analysis, subgroup analysis, trend tests, mediation analysis, and Shapley additive explanations (SHAP) models.</p><p><strong>Results: </strong>This research included a total of 9,947 participants, with 3,220 diagnosed with T2DM, while 6,727 remained undiagnosed. Weighted multiple logistic regression with all covariates adjusted indicated that with every one-unit increment in AISI/1000, there was an 88.3% likelihood of T2DM occurrence (OR: 1.883, 95% CI: 1.378-2.571). The stratified analysis identified significant differences in this association based on age, biological sex, level of education, poverty-income ratio (PIR), tobacco consumption status, and body mass index (BMI). Interaction tests revealed a positive association between AISI and T2DM, apart from PIR, BMI, age, education attainment, race, gender, tobacco use status, Estimated Glomerular Filtration Rate(eGFR), platelet count, and high blood pressure, with none of the interaction p-values falling below 0.05. Nevertheless, the occurrence of cardiovascular disease (CVD) among participants may affect the strength of this relationship, where an interaction p-value was less than 0.05. Additionally, smoothing curve fitting revealed a nonlinear relationship between AISI and T2DM, marking a significant change at AISI/1000 of 0.21. Mediation analysis indicated that five obesity-related indicators-LAP, VAI, WHtR, WWI and ABSI - partly mediated the association between AISI/1000 and T2DM.</p><p><strong>Conclusion: </strong>An increase in AISI is associated with an elevated probability of T2DM, with obesity indicators potentially mediating this relationship. Reducing AISI and managing obesity may help prevent T2DM. However, with the cross-sectional design of this study, causal relationships cannot be established. Future research should utilize longitudinal studies to confirm these findings.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"176"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific associations between per- and polyfluoroalkyl substances exposure and metabolic syndrome: a cross-sectional study.","authors":"Luanxun Lin, Xiaoqin Lin, Shuaidan Chang, Yiqing Xing, Tao Zhou, Chunxue Yang","doi":"10.1186/s12944-025-02582-x","DOIUrl":"https://doi.org/10.1186/s12944-025-02582-x","url":null,"abstract":"<p><strong>Background: </strong>The widespread presence of per-and polyfluoroalkyl substances (PFAS) has raised global health concerns. This study aims to determine the age-specific relationships of PFAS compounds with metabolic syndrome (MetS) and its components.</p><p><strong>Methods: </strong>We used data from the National Health and Nutrition Examination Survey (NHANES) in 2003-2018. Modified Poisson regression was employed to estimate associations between individual PFAS compounds and prevalence of MetS, as well as its components. Multiple linear regression analyses were performed to examine the associations between PFAS congeners and metabolic markers, including lipid and glucose homeostasis traits. Additionally, weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models were conducted to investigate the joint effects of PFAS mixtures on the prevalence of MetS and its components across different age groups.</p><p><strong>Results: </strong>A total of 5850 participants were included for analysis. In the Modified Poisson regression model, ln-transformed perfluorononanoic acid (PFNA) level was positively correlated with MetS prevalence in adolescents (prevalence ratio [PR] = 1.42; 95% CI: 1.01-1.99). Conversely, ln-transformed perfluorohexanesulfonic acid (PFHxS) and ln-transformed 2-(N-Methylperfluorooctane sulfonamido) acetic acid (MeFOSAA) were negatively associated with the risks of MetS in young adults (PR = 0.86, 95% CI: 0.76-0.98) and middle-aged adults (PR = 0.88, 95% CI: 0.79-0.98), respectively. Notably, individual PFAS exposure was positively associated with levels of total cholesterol, low-density lipoprotein, non-high-density lipoprotein, and high-density lipoprotein in young and middle-aged adults. However, overall effect analyses using WQS and BKMR showed no significant associations of PFAS mixture with MetS in any age group. Nonetheless, in middle-aged adults, PFAS mixture was adversely correlated with hypertriglyceridemia and positively linked to a greater risk of hypertension and increased high-density lipoprotein cholesterol levels.</p><p><strong>Conclusions: </strong>Our study highlighted the complex relationships between PFAS exposure and the risks of MetS and its components across different age groups. Co-exposure to PFAS was particularly linked to dyslipidemia in young and middle-aged adults. Prospective studies are needed for better comprehension of the causative impact of PFAS on the risks of MetS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"174"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic index of plasma and triglyceride-glucose index mediate the association between stroke and all-cause mortality: insights from the lipid paradox.","authors":"Jinhua Qian, Qinjie Chi, Chengqun Qian, Xian Fan, Wenbing Ding, Tianle Wang, Li Zhu","doi":"10.1186/s12944-025-02586-7","DOIUrl":"https://doi.org/10.1186/s12944-025-02586-7","url":null,"abstract":"<p><strong>Background: </strong>The \"lipid paradox\" describes the counterintuitive observation that traditionally unfavorable lipid profiles may be associated with improved outcomes in stroke patients. Non-traditional lipid markers such as the atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index have been proposed to better reflect the complex metabolic disturbances following stroke. This study aims to investigate the mediating role of AIP and TyG index in the association between stroke and all-cause mortality and elucidate the potential mechanisms underlying the lipid paradox.</p><p><strong>Methods: </strong>This cohort study used data from the China Health and Retirement Longitudinal Study (CHARLS), including 10,220 participants enrolled from 2011 to 2020, with a maximum follow-up of 10 years. AIP and TyG index were calculated from baseline serum measurements. U-test, chi-square test, restricted cubic spline analysis (RCS), cox proportional hazards regression and mediation model were used to analyze the relationship between baseline AIP, TyG index, stroke and all-cause mortality.</p><p><strong>Results: </strong>A total of 1,421 deaths (13.90%) occurred during an average follow-up of 9.21 years. Compared to survivors, non-survivors were older, had a higher prevalence of stroke, and lower AIP levels (P < 0.05), while TyG index showed no significant group difference. RCS analysis revealed a nonlinear association between the TyG index and mortality, but no significant nonlinearity for AIP. Cox regression analysis identified age, gender, marital status, smoking history, hypertension, diabetes, lung disease, stroke, AIP, and the highest TyG quartile (Q4) as independent predictors of all-cause mortality (all P < 0.05). Notably, AIP showed a negative association with mortality (HR = 0.87, 95% CI: 0.77-0.98),demonstrating a lipid paradox phenomenon. Furthermore, in the chain mediation model, both AIP (β=-0.03, 95%CI: -0.072 to -0.002) and TyG index (β=-0.016, 95%CI: -0.036 to -0.002) independently mediated the association between stroke and all-cause mortality in a negative manner. However, the positive chain mediating effect of AIP through TyG index (β = 0.028, 95%CI: 0.003-0.066) offset this negative mediation, rendering the overall mediating effect insignificant.</p><p><strong>Conclusions: </strong>AIP and the TyG index independently or jointly influence the risk of all-cause mortality after stroke. Notably, AIP demonstrates a significant lipid paradox phenomenon. Moreover, the chain mediating effect of AIP and TyG significantly increases post-stroke mortality risk. These findings highlight the complex interplay between lipid and glucose metabolism in stroke prognosis and offer a novel perspective for post-stroke metabolic management.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"173"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between saturated and polyunsaturated fatty acid proportions in total fat intake and mortality risk: mediation by the neutrophil percentage-to-albumin ratio.","authors":"Yanyan Liu, Jiaxuan Wang, Xiaona Chang, Xiaoying Ren, Guang Wang, Jia Liu","doi":"10.1186/s12944-025-02592-9","DOIUrl":"https://doi.org/10.1186/s12944-025-02592-9","url":null,"abstract":"<p><strong>Background: </strong>For over half a century, dietary guidelines have consistently advocated for the substitution of saturated fatty acids (SFA) with monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA) as a cornerstone strategy for health life, but evidence on independent associations between specific fatty acids and mortality remains inconsistent.</p><p><strong>Methods: </strong>This prospective cohort study from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 analyzed 21,823 participants aged 20-80 years. Survey-weighted Cox regression assessed associations between SFA, MUFA, PUFA intake, and their ratios to the total fat (TFAT) intake quantity, and all-cause mortality. Mediation analyses examined whether the neutrophil percentage-to-albumin ratio (NPAR) mediated the effects of fatty acid-related parameters on mortality risk.</p><p><strong>Results: </strong>In multivariable-adjusted models, no significant trends were observed for all-cause mortality across tertiles of SFA, MUFA, or PUFA intake. In multivariable-adjusted Cox models, the highest tertile of SFA/TFAT ratio was significantly associated with elevated mortality risk (HR = 1.23, p for trend < 0.01). Conversely, the highest PUFA/TFAT tertile demonstrated a protective association (HR = 0.86, p for trend < 0.01). However, the MUFA/TFAT ratio showed no significant mortality association across tertiles (p for trend = 0.137). Mediation analysis revealed that NPAR mediated 9.8% and 11.8% of SFA/TFAT and PUFA/TFAT effects on mortality risk, suggesting partial mediation through a shared inflammatory pathway.</p><p><strong>Conclusion: </strong>This study provides the novel evidence that the proportional composition of dietary fatty acids within total fat intake-rather than their absolute intake levels-is a critical determinant of longevity. By demonstrating that replacing SFA with PUFA reduces mortality risk through NPAR-mediated inflammatory pathways, our findings inform the World Health Organization's 2023 guidelines on dietary fat modification. These results shift the paradigm from isolated nutrient restrictions to balanced fatty acid ratios, offering a novel mechanistic basis for public health strategies aimed at extending healthy lifespan.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"175"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}