Lipids in Health and Disease最新文献

{"title":"Adipose tissue aging as a risk factor for metabolic organ abnormalities: mechanistic insights and the role of exercise interventions.","authors":"Shaokai Tang, Yuanwen Geng, Qinqin Lin","doi":"10.1186/s12944-025-02695-3","DOIUrl":"10.1186/s12944-025-02695-3","url":null,"abstract":"<p><p>Aging is widely regarded as an irreversible arrest of cellular growth and proliferation, often accompanied by systemic metabolic organ abnormalities, ultimately reducing quality of life and increasing mortality in the elderly. Multi-organ transcriptomic analyses suggest that adipose tissue is among the earliest organs to respond to aging, characterized by changes in fat content and redistribution of adipose tissue, decline in thermogenic adipose function, reduced proliferation and differentiation capacity of adipose progenitor and stem cells, accumulation of senescent cells, and immunosenescence. These alterations may act synergistically and play a role in abnormalities in metabolic organs including the cardiovascular, liver, skeletal muscle, and brain. Studies have demonstrated that exercise ameliorates the effects of adipose tissue aging on metabolic organ abnormalities by inhibiting inflammation, reducing the accumulation of ectopic lipids, enhancing the browning of white adipose tissue and thermogenesis in brown adipose tissue, improving lipid metabolism, regulating the secretion of adipokines, and mitigating immunosenescence. This review summarizes the main characteristics of adipose tissue aging, the effects of adipose tissue aging on metabolic organ abnormalities, and the potential mechanisms by which exercise ameliorates the effects of adipose tissue aging on metabolic organ abnormalities. It provides theoretical support for basic and clinical research on exercise-based prevention and treatment of aging-related diseases.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"274"},"PeriodicalIF":3.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adropin as a therapeutic candidate for HFpEF: evidence of oxidative stress mitigation via Nrf2/HO-1 signaling.","authors":"Bingda Li, Jingan Rao, Wansong Hu, Yuxiu Yang, Qing Zhou, Yingxing Wu, Fangpeng Liu, Ping Li","doi":"10.1186/s12944-025-02703-6","DOIUrl":"10.1186/s12944-025-02703-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Heart failure with preserved ejection fraction (HFpEF), which accounts for more than half of all heart failure cases worldwide, has emerged as a major public health challenge characterized by substantial morbidity and mortality rates. As adropin is a key regulator of cardiovascular and metabolic homeostasis, this study investigated its therapeutic effects against HFpEF pathogenesis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;C57BL/6 mice were fed a high-fat diet (60% fat-derived calories) with NG-nitro-L-arginine methyl ester (L-NAME, 0.5 g/L) in drinking water for 8 weeks to induce HFpEF. Adropin-knockout (Ad⁻/⁻) mice were generated, and HFpEF mice received a single intraperitoneal bolus of recombinant adropin (450 nmol kg⁻¹). Cardiac structure and function were quantified by echocardiography. Metabolic status was documented (body weight, fasting glucose, lipids, and systolic/diastolic blood pressure). Myocardial morphology, fibrosis and cardiomyocyte size were examined by hematoxylin‒eosin, Masson's trichrome and wheat‒germ agglutinin staining. Oxidative stress was evaluated with dihydroethidium fluorescence (ROS) and biochemical assays for malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH). The protein expression of Nrf2, HO-1, NQO-1 and apoptosis markers (Bcl-2/Bax) was determined by immunoblotting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;HFpEF mice developed significant metabolic disturbances, diastolic dysfunction, myocardial hypertrophy, fibrosis, and increased oxidative stress, alongside markedly reduced serum and myocardial adropin levels. Adropin supplementation improved glucose and lipid metabolism, reduced cardiac hypertrophy and fibrosis, and enhanced diastolic function, whereas adropin knockout exacerbated these pathologies. Mechanistically, adropin activated the Nrf2/HO-1 signaling pathway, increased the expression of antioxidant enzymes (HO-1 and NQO-1), reduced the expression of oxidative stress markers, and regulated apoptosis by increasing Bcl-2 and decreasing Bax expression. HFpEF mice exhibited significant metabolic disturbances, diastolic dysfunction, myocardial hypertrophy, fibrosis, and elevated oxidative stress, alongside markedly reduced serum and myocardial adropin levels. Adropin treatment improved glucose/lipid metabolism, attenuated hypertrophy/fibrosis, and enhanced diastolic function, whereas adropin knockout exacerbated these pathologies. Mechanistically, adropin activated the Nrf2/HO-1 pathway, upregulated antioxidant enzymes (HO-1, NQO-1), reduced oxidative stress markers, and mitigated apoptosis by increasing Bcl-2/Bax ratio.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Adropin improves HFpEF by attenuating metabolic dysregulation, oxidative stress, and myocardial remodeling. Mechanistically, adropin activates the Nrf2/HO-1 pathway, suggesting a novel therapeutic strategy for HFpEF. These findings highlight the potential of adropin to reduce disease burden and improve quality of life in ","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"273"},"PeriodicalIF":3.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased plasma ceramide levels are associated with arterial stiffness and vascular ageing: a cross-sectional study.","authors":"Jiachi Ren, Guan Wang, Ying Wang, Lin Li, Jingru Sun, Shengmin Liu, Xiaofen Wu, Cuntai Zhang, Lei Ruan","doi":"10.1186/s12944-025-02706-3","DOIUrl":"10.1186/s12944-025-02706-3","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular (CV) events pose a substantial threat to human health. Plasma ceramides have been shown to exhibit predictive value for CV events; however, its correlation with arterial stiffness had yet to be fully elucidated. This study aimed to explore the associations of plasma ceramide levels and their ratios with arterial stiffness.</p><p><strong>Methods: </strong>This retrospective study involved participants whose ceramide levels were measured and whose arterial stiffness was assessed. Multivariate regression was used to assess the association between plasma ceramides and arterial stiffness. Restricted cubic spline (RCS) analysis was used to assess the correlation between plasma ceramide levels and arterial stiffness. Receiver operating characteristic (ROC) curves were generated to assess the diagnostic value of plasma ceramides for arterial stiffness. Subgroup analyses were also performed.</p><p><strong>Results: </strong>This study included 503 patients with a mean age of 43.7 ± 10.8 years. The results showed that plasma ceramides 24:0 and 22:0 were significantly associated with arterial stiffness, as supported by multivariate regression analysis. RCS analysis revealed a potential linear relationship between plasma 24:0 ceramide and arterial stiffness (P for nonlinearity > 0.05). In contrast, a significant nonlinear correlation was found for plasma 22:0 ceramide (P for nonlinearity = 0.04). ROC analysis revealed optimal cut-off values of 1.035 µmol/L for plasma 22:0 ceramide (68.0% specificity, 67.3% sensitivity) and 3.335 µmol/L for plasma 24:0 ceramide (64.1% specificity, 74.8% sensitivity), with area under the curve (AUC) values of 0.702 and 0.724, respectively, demonstrating acceptable diagnostic performance. Additionally, subgroup analyses revealed a marked connection between serum ceramide levels and arterial stiffness, especially in male participants and individuals with normal lipid profiles.</p><p><strong>Conclusions: </strong>Plasma ceramide levels are significantly correlated with arterial stiffness, which suggests that they play a role as biomarkers for vascular ageing assessments and highlights their potential value for early prevention strategies against CV events.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"272"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing coronary artery disease severity using the TyG index in patients with LDL-C < 2.6 mmol/l.","authors":"Jiao Li, Wenjun Jia, Yafang Chen, Yue Liu, Linlin Fang, Xin Qi, Liping Wei","doi":"10.1186/s12944-025-02691-7","DOIUrl":"https://doi.org/10.1186/s12944-025-02691-7","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"270"},"PeriodicalIF":3.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional and bioinformatics-based analysis: perirenal fat thickness as a superior predictor of kidney stone disease.","authors":"Kaifeng Mao, Xiang Xu, Yifei Zhu, Fenwang Lin, Zhenquan Lu, Bingfeng Luo, Genggeng Wei, Yuan Yuan, Sucai Liao, Yaping Xing, Wenyan Huang, Ruidong Ji, Yige Pan, Zhenda Li, Junsheng Ye, Lin Xiong","doi":"10.1186/s12944-025-02686-4","DOIUrl":"https://doi.org/10.1186/s12944-025-02686-4","url":null,"abstract":"<p><strong>Background: </strong>Kidney stone disease (KSD) is a growing global health concern, with obesity (OB) as a major risk factor linked to metabolic dysfunction and chronic inflammation. Although the common method for evaluating OB is body mass index (BMI), it is not specific enough when it comes to reflecting visceral fat. The perirenal fat thickness (PFT) might present better predictive capabilities. The goal of this research was to assess the clinical usefulness of PFT in the diagnosis of KSD and to clarify the molecular mechanisms connecting OB to KSD.</p><p><strong>Methods: </strong>Analysis was carried out on a retrospective cohort of 413 patients (265 having KSD and 148 controls). Abdominal computed tomography was used to measure PFT. Three machine-learning methods, weighted gene co-expression network analysis, and differential expression analysis were used to evaluate gene expression data for key gene identification. Internal and external datasets were used to develop and validate a diagnostic nomogram. Also, pathway enrichment analysis was carried out.</p><p><strong>Results: </strong>KSD patients exhibited greater PFT versus controls, with significantly enhanced diagnostic accuracy compared to BMI. Multivariate analysis confirmed PFT as an independent predictor of KSD (OR = 1.20, P < 0.001). Eight genes that are differentially expressed in relation to OB were identified, among which FAM20A and DHRS9 were found to be central hub genes. The nomogram exhibited a high level of predictive accuracy. Analysis of enrichment pointed to the IL-6/JAK/STAT3 and TNF-α/NF-κB signaling pathways in the connection between perirenal fat and KSD.</p><p><strong>Conclusions: </strong>PFT serves as a practical and dependable marker for the risk of KSD. It is superior to BMI and can be conveniently incorporated into routine clinical practice. Stone formation may be linked to perirenal fat by FAM20A and DHRS9 via inflammatory pathways, which provides potential targets for the management of OB-related KSD.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"269"},"PeriodicalIF":3.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the metabolic score for insulin resistance trajectory and new-onset metabolic syndrome: a retrospective cohort study based on health check-up data in China.","authors":"Jianan Song, Su Yan, Youxiang Wang, Peimeng Zhu, Suying Ding, Jingfeng Chen","doi":"10.1186/s12944-025-02690-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02690-8","url":null,"abstract":"<p><strong>Background: </strong>The Metabolic Score for Insulin Resistance (METS-IR) is a novel biomarker for evaluation of insulin resistance (IR). Emerging evidence suggests this metric may be able to predict the onset of metabolic syndrome (MetS). The aim of this study was to determine whether there is a correlation between sustained METS-IR values and the future risk of MetS.</p><p><strong>Methods: </strong>Data for 3,750 individuals who attended a tertiary hospital in Zhengzhou for a health check-up between 2017 and 2022 were analyzed. The METS-IR was used to evaluate IR. A latent class trajectory model was created by dividing the subjects into high-stability and low-stability categories based on three consecutive years of data. The incidence of MetS between 2020 and 2022 was calculated using the Kaplan-Meier method and Cox regression modeling.</p><p><strong>Results: </strong>Over a median follow-up of 2.13 years, we identified 430 cases of MetS (11.47%). The incidence rate was 35.48% in the high-stability group and 8.32% in the low-stability group (P < 0.001). Multivariate Cox regression, controlling for sex, age, hypertension status, diabetes status, and serum uric acid, low-density lipoprotein cholesterol, and gamma-glutamyl transferase levels, revealed that the risk of MetS was significantly higher in the high-stability group (hazard ratio [HR] = 4.77, 95% confidence interval [CI]: 3.714-6.126, P < 0.001). Stratified analysis by age showed that the risk of MetS was also significantly higher in individuals aged < 45 years (HR = 6.202, 95% CI: 4.312-8.921) and in those aged ≥ 45 years (HR = 3.89, 95% CI: 2.720-5.566) in the high-stability group. Receiver operating characteristic (ROC) curve analysis showed that the trajectory of METS-IR could predict MetS. The respective areas under the ROC curve for the 1-year, 2-year, and 3-year risk of MetS were 0.575, 0.641, and 0.628. Sensitivity analyses showed that an elevated METS-IR value was associated with an increased risk of new-onset MetS.</p><p><strong>Conclusions: </strong>In this study, there was a significant correlation between the METS-IR value and the future risk of MetS. METS-IR measurement over time may allow early detection of individuals at high risk of MetS, which would lessen the impact of chronic disease.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"271"},"PeriodicalIF":3.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Inverted l‑shape association between a body shape index and peak expiratory flow among middle‑aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).","authors":"Guosong Jiang, Licheng Feng, Xiaoxiao Qu, Jia Wang, Yun Li","doi":"10.1186/s12944-025-02678-4","DOIUrl":"https://doi.org/10.1186/s12944-025-02678-4","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"268"},"PeriodicalIF":3.9,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the triglyceride to high-density lipoprotein cholesterol ratio and positive blood or pus cultures in patients with pyogenic liver abscess.","authors":"Qian Huang, Zi-Xuan Huang, Hou-Xiong Lin, Yong Xu, Xiao-Xu Xie, Meng-Xin Lin, Da-Wu Zeng","doi":"10.1186/s12944-025-02682-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02682-8","url":null,"abstract":"<p><strong>Background/aims: </strong>High triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C), and an elevated TG/HDL-C ratio are linked to increased systemic inflammation and impaired immune function. However, the clinical significance of the TG/HDL-C ratio in pyogenic liver abscess (PLA) remains poorly defined.</p><p><strong>Methods: </strong>In this multicenter, cross-sectional study of 2,201 cases of PLA, logistic regression, smoothed curve fitting, and comprehensive sensitivity analyses were employed to assess the relationship between the baseline TG/HDL-C ratio and positive blood or pus cultures. Subgroup analyses and interaction tests were performed to evaluate the robustness of the findings.</p><p><strong>Results: </strong>Logistic regression showed that the TG/HDL-C ratio was positively associated with blood or pus culture positivity in PLA [odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P < 0.001. Smoothed curve fitting revealed a nonlinear dose-response relationship, with an inflection point at 9.2. Below this threshold, the TG/HDL-C ratio remained significantly associated with culture positivity (OR = 1.1, 95% CI: 1.1-1.2, P < 0.001). Sensitivity analyses and interaction tests confirmed these results.</p><p><strong>Conclusions: </strong>The TG/HDL-C ratio demonstrates a nonlinear relationship with the risk of positive blood or pus cultures in patients with PLA, with a pivotal threshold value identified at 9.2. This readily obtainable ratio may help clinicians individualize management strategies and facilitate timely interventions for PLA patients in this at-risk group, leading to improved health outcomes for this vulnerable population.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"267"},"PeriodicalIF":3.9,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.","authors":"Xiuqin Fan, Yuanyuan Wang, Ping Li, Rui Wang, Tiantian Tang, Kemin Qi","doi":"10.1186/s12944-025-02680-w","DOIUrl":"https://doi.org/10.1186/s12944-025-02680-w","url":null,"abstract":"<p><strong>Background: </strong>RNA-binding proteins (RBPs) have been proved to play essential roles in post-transcriptional regulation of genes associated with adipogenesis. However, the role of the RBP human antigen R (HuR) in the pathogenesis of obesity remains to be clarified.</p><p><strong>Methods: </strong>Adipocyte-specific HuR knockout (HuR^-/-) and HuR floxed (HuR^f/f) mice were fed a high-fat diet (HFD), or a paired normal control diet (NC) for 16 weeks. Moreover, 8-week-old HuR^-/- or HuR^f/f mice were subjected to cold exposure or CL316,243 treatments. The mouse body weight was recorded and the histological changes in adipose tissue were examined. RNA sequencing analysis and RT-qPCR were used to identify potential target genes for HuR. The regulation of HuR on the uncoupling protein 1 (Ucp1) expression was determined using RNA immunoprecipitation (RIP), RNA pull-down, and Luciferase assays.</p><p><strong>Results: </strong>Adipocyte-specific HuR deletion inhibited body weight gain with HFD feeding, being accompanied by less BAT whitening and more WAT browning, and up-regulated expressions of adipose thermogenic genes (Pgc-1α, Ucp1, etc.). HuR could bind to the 3'UTR of the Ucp1 mRNA, and thus downregulated its expression. In addition, although the HuR expression was not changed in obesity, there was an enhanced transfer of HuR protein from the nuclear to cytoplasm, thus impacting the expression of target genes including the Ucp1.</p><p><strong>Conclusions: </strong>These findings indicate that adipose tissue-specific HuR deletion alleviates HFD-induced obesity by promoting adipose thermogenesis through upregulating Ucp1 expression.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"264"},"PeriodicalIF":3.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese.","authors":"Shouxin Wei, Sijia Yu, Chuan Qian, Zhengwen Xu, Yindong Jia, Bo Chen","doi":"10.1186/s12944-025-02684-6","DOIUrl":"https://doi.org/10.1186/s12944-025-02684-6","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"266"},"PeriodicalIF":3.9,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}