Lipids in Health and Disease最新文献

{"title":"The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.","authors":"Alessandro Medoro, Francesca Graziano, Gaetano Cardinale, Serena Voccola, Tiziana Zotti, Mariano Intrieri, Giovanni Scapagnini, Sergio Davinelli","doi":"10.1186/s12944-025-02513-w","DOIUrl":"10.1186/s12944-025-02513-w","url":null,"abstract":"<p><strong>Background: </strong>Unhealthy dietary habits have been recognized as key contributors to the increasing incidence of non-communicable diseases. Among the healthy nutrients studied, omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have received considerable attention for their benefits in cardiovascular health and inflammation management. Their synthesis is regulated by enzymes encoded by FADS1 and ELOVL2 genes. Single nucleotide polymorphisms (SNPs) within these genes can modify the efficiency of fatty acid conversion, thereby influencing the Omega-3 Index, which reflects omega-3 status, particularly EPA and DHA. This study aimed to assess the impact of FADS1 (rs174537) and ELOVL2 (rs953413) polymorphisms on the effects on fatty acids profiles of fish oil supplementation in healthy individuals.</p><p><strong>Methods: </strong>Eighty-six healthy adults aged 20-70 participated in a quasi-experimental intervention involving a 4-week fish oil supplementation rich in EPA and DHA. Dried-blood spots (DBS) were collected before and after the intervention to evaluate lipid profiles. Genotyping for FADS1 and ELOVL2 SNPs was performed using high-resolution melting analysis.</p><p><strong>Results: </strong>Post-supplementation, the percentage of EPA and DHA increased significantly (p < 0.001), leading to an improved Omega-3 Index. Baseline omega-3 percentages did not differ significantly between FADS1 and ELOVL2 genotypes. However, individuals with the ELOVL2 minor allele (GA + AA) genotype benefited more from the fish oil supplementation with increased EPA and DBS Omega-3 Index, indicating a more favorable metabolic response.</p><p><strong>Conclusions: </strong>Genetic variability may influence the metabolic response to fish oil supplementation. These findings underscore the importance of personalized nutrition strategies to optimize health outcomes and prevent non-communicable diseases.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"102"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum.","authors":"Silmara de Melo Carmona, Daniele Pereira Jardim, Maria Aparecida Dalboni, Renata Nakamichi, Mariana Kuniyoshi, Mauro Marrocos, Beata Marie Redublo Quinto, Marcelo Costa Batista","doi":"10.1186/s12944-024-02420-6","DOIUrl":"10.1186/s12944-024-02420-6","url":null,"abstract":"<p><p>The high incidence of cardiovascular events in chronic kidney disease (CKD) exhibits an epidemic character, affecting patients in predialysis, hemodialysis, and post-transplant stages, accounting for approximately 50% of deaths, with a mortality rate around 9% per year. Statins are primarily used in the treatment of dyslipidemia and possess pleiotropic effects that are not yet fully understood. Moreover, there is insufficient evidence to support their use in attenuating cardiovascular outcomes or their potential role in modulating the ABCA-1 transporter in CKD. Thus, the aim of this study was to investigate the effect of statins on ABCA-1 modulation in cultures of human umbilical vein endothelial cells (HUVEC) incubated with uremic serum from CKD patients. The results demonstrate that statins influence the inflammatory response of HUVEC exposed to a uremic environment by reducing TNF-α secretion compared to baseline levels. Furthermore, the uremic environment was found to decrease the expression of LxR-β and RxR-α, leading to a consequent reduction in ABCA-1 expression in HUVEC. Cells pre-treated with simvastatin exhibited increased expression of ABCA-1, LxR-β, and RxR-α, along with a significant increase in the transcription of ABCA-1, LXR-β, and RxR-α, indicating that statins may exert a positive modulation on LxR-β and RxR-α receptors, activating ABCA-1 transcription.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"100"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding metabolic connections: the role of salivary amylase activity in modulating visceral fat and triglyceride glucose index.","authors":"Gita Erta, Gita Gersone, Antra Jurka, Peteris Tretjakovs","doi":"10.1186/s12944-025-02524-7","DOIUrl":"10.1186/s12944-025-02524-7","url":null,"abstract":"<p><strong>Background: </strong>Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This study investigates the relationship between SAA, visceral fat (VF), and the triglyceride-glucose (TyG) index to clarify the pathways linking SAA to metabolic risk factors.</p><p><strong>Methods: </strong>This cross-sectional study analysed data from women of reproductive age who were classified as overweight. Linear regression models were used to assess associations between salivary amylase activity (SAA), visceral fat (VF) and the triglyceride-glucose (TyG) index, while adjusting for confounding variables such as age, body mass index (BMI), physical activity and dietary patterns. Mediation analysis was conducted to determine whether VF mediates the relationship between SAA and the TyG index.</p><p><strong>Results: </strong>Higher SAA was inversely associated with VF (β = -0.45, 95% CI: -0.65 to -0.25, p < 0.001). No direct association was observed between SAA and TyG index (β = -0.10, 95% CI: -0.25 to 0.05, p = 0.18) after adjustment for covariates. Mediation analysis revealed that visceral fat significantly mediated the relationship between SAA and the TyG index. The indirect effect of SAA on the TyG index through VF (A × B) was statistically significant (β = -0.16, 95% CI: -0.26 to -0.08), accounting for 45% of the total effect.</p><p><strong>Conclusions: </strong>These findings suggest that higher SAA may confer metabolic benefits by reducing VF, thereby indirectly influencing the TyG index. This highlights the critical role of VF in mediating the protective effects of SAA on metabolic health and provides insights into potential pathways for intervention.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"98"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep duration as a mediator in the association between dietary intake of live microbes and insulin resistance: a cross-sectional study.","authors":"Lei Peng, Yanmei Liu, Yujun Deng, Jianan Jing, Gaohuang Chen, Yang Liu, Maofeng Wu, Jinduan Lin, Weiguo Yin","doi":"10.1186/s12944-025-02507-8","DOIUrl":"10.1186/s12944-025-02507-8","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance and associated metabolic health symptoms remain a primary global health concern. In addition to healthy dietary and nutritional programs, sleep duration is closely related to and has been linked to healthy metabolism. This study aimed to determine the link between insulin resistance and sleep duration and the dietary intake of live microbes.</p><p><strong>Methods: </strong>Data were collected from 15,927 participants in the National Health and Nutrition Examination Survey database from 2005 to 2018; this sample is equivalent to 209,316,590 individuals in the United States. The participants were categorized according to their consumption of foods containing live microbes: low, medium, high, and medium-high. The relationship between diets containing live microbes and the triglyceride-glucose index was analysed using a weighted multivariate linear regression model with a multistage sampling approach. The individuals were deemed to have insulin resistance if their homeostatic model assessment score for insulin resistance was ≥ 2. The relationship between diets containing live microbes and insulin resistance status was assessed using weighted multivariate logistic regression analyses. The mediating role of sleep duration on the relationship between diets containing live microbes and the triglyceride-glucose index was also examined.</p><p><strong>Results: </strong>After accounting for potential confounders, diets containing live microbes at medium and medium-high levels were significantly associated with a reduced triglyceride-glucose index. The medium and medium-high levels of live microbial intake were also associated with a lower risk of insulin resistance. Within the 6-9 hours' sleep duration range, the indirect effect of medium and medium-high levels of live microbes on the triglyceride-glucose index was observed, accounting for 2.95% and 6.08% of the overall change, respectively.</p><p><strong>Conclusions: </strong>This study suggests an association between a diet rich in medium and medium-high viable microbes, lower triglyceride-glucose index values, and a reduced risk of developing insulin resistance. Additionally, a sleep duration of 6-9 h may mediate this association.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"97"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the hypercholesterolemia care cascade and compliance with NCEP-ATP III guidelines in Iran based on the WHO STEPS survey.","authors":"Shirin Djalalinia, Sepehr Khosravi, Moein Yoosefi, Sarvenaz Salahi, Zahra Shokri Varniab, Ali Golestani, Nazila Rezaei, Ameneh Kazemi, Arezou Dilmaghani-Marand, Negar Rezaei, Erfan Ghasemi, Naser Ahmadi, Mohammad-Mahdi Rashidi, Yosef Farzi, Kamyar Rezaee, Maryam Nasserinejad, Sina Azadnajafabad, Elham Abdolhamidi, Rosa Haghshenas, Arefeh Alipour Derouei, Azadeh Momen Nia Rankohi, Farshad Farzadfar","doi":"10.1186/s12944-025-02506-9","DOIUrl":"10.1186/s12944-025-02506-9","url":null,"abstract":"<p><strong>Introduction: </strong>Noncommunicable diseases (NCDs), particularly cardiovascular disease (CVD), are the leading cause of death worldwide, with hypercholesterolemia being a major risk factor for CVD. This study evaluated the hypercholesterolemia care cascade in Iran-including prevalence, diagnosis, treatment coverage, and effectiveness-using the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guidelines.</p><p><strong>Methods: </strong>This cross-sectional study drew on data from the 2021 Iran STEPS survey, which employed a systematic cluster sampling of adults aged ≥ 18 years across all provinces in Iran. Hypercholesterolemia was defined per NCEP-ATP III thresholds (LDL ≥ 160 mg/dL, total cholesterol ≥ 240 mg/dL, HDL ≤ 40 mg/dL, or ongoing lipid-lowering therapy). Weighted descriptive statistics were calculated, and Poisson regression with robust variance estimated crude and adjusted prevalence ratios for optimal lipid control among those treated. The 10-year CVD risk was determined using the Framingham Risk Score, stratifying participants into low (< 10%), intermediate (10-20%), and high (> 20%) risk categories.</p><p><strong>Results: </strong>Out of 18,074 participants, 10,582 (55.32%, 95% CI: 54.29-56.35) met NCEP-ATP III criteria for hypercholesterolemia. Among these, only 20.61% (19.55-21.72) were receiving pharmacological treatment. Treatment coverage was notably lower in males (13.15%, 11.98-14.40) than females (29.12%, 27.35-30.96). Statins were the most commonly used medication (11.43% of males, 25.87% of females). Of those receiving treatment, 52.85% (females) and 53.93% (males) achieved optimal LDL, while 76.98% (females) and 81.06% (males) attained total cholesterol < 200 mg/dL. However, only 19.89% (females) and 3.97% (males) met the HDL > 60 mg/dL goal. The 10-year CVD risk was < 10% in 57.79% of participants, 10-20% in 33.27%, and > 20% in 8.94%.</p><p><strong>Conclusion: </strong>Despite a high prevalence of hypercholesterolemia in Iran, treatment coverage remains suboptimal, particularly among males and working-age adults. Although most treated individuals achieve favorable LDL and total cholesterol levels, gaps persist in achieving optimal HDL targets. These findings underscore the need for strengthened screening, treatment, and adherence strategies-alongside broader preventive measures-to reduce the burden of hypercholesterolemia and CVD in Iran.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"99"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear relationship between triglyceride glucose index and new-onset diabetes among individuals with non-alcoholic fatty liver disease: a cohort study.","authors":"Xiaomin Liang, Kai Lai, Xiaohong Li, Ying Li, Zemao Xing, Shuiqing Gui","doi":"10.1186/s12944-025-02518-5","DOIUrl":"10.1186/s12944-025-02518-5","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the triglyceride glucose (TyG) values and the development of diabetes in non-alcoholic fatty liver disease (NAFLD) patients is not yet well researched. This study aims to examine how the baseline TyG levels correlate with the incidence of new-onset diabetes in this specific cohort.</p><p><strong>Methods: </strong>This cohort included 2,506 normoglycemic Japanese adults with NAFLD who underwent routine health check-ups at Murakami Memorial Hospital between 2004 and 2015. Several statistical approaches, including restricted cubic splines and two-piecewise linear regression, were utilized to assess the relation between the TyG levels and diabetes risk.</p><p><strong>Results: </strong>Among the 2,506 participants (mean age: 44.78 ± 8.32 years; 81.09% male), 203 individuals (8.10%) developed diabetes over the course of the 11-year follow-up period. A U-shaped relationship was observed between the levels of TyG and the onset of diabetes, with an inflection point identified at a TyG value of 7.82 (95% CI: 7.72-8.00). Below this threshold, each one-unit elevation in TyG values reduced the probability of diabetes by 93% (HR = 0.07, 95% CI: 0.01-0.32, P = 0.001). Conversely, above this threshold, each one-unit elevation increased the probability of diabetes by 70% (HR = 1.70, 95% CI: 1.19-2.44, P = 0.004).</p><p><strong>Conclusions: </strong>The findings validate a U-shaped association between TyG levels and new-onset diabetes in adults with NAFLD. Both low and high TyG levels increase diabetes probability in such a group.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"94"},"PeriodicalIF":3.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the cardiometabolic index and atherosclerotic cardiovascular disease acorss different glucose metabolism statuses: insights from NHANES, 1999-2020.","authors":"Qiong Wei, Xu Cheng, Min Li, Keying Wu, Meng Chen, Dongmei Zhang","doi":"10.1186/s12944-025-02508-7","DOIUrl":"10.1186/s12944-025-02508-7","url":null,"abstract":"<p><strong>Background: </strong>The cardiometabolic index (CMI) serves as a significant marker of diabetes mellitus (DM) and may predict the potential for cardiovascular disease development. Nevertheless, the correlation between CMI and atherosclerotic cardiovascular disease (ASCVD) among individuals exhibiting varying glucose metabolism statuses (GMS) continues to be unclear.</p><p><strong>Methods: </strong>Overall, 24,006 individuals aged 20 and above were enrolled in the research, drawn from the National Health and Nutrition Examination Survey (NHANES) database. Individuals in the study was classified into three distinct categories according to the level of fasting plasma glucose or glycated haemoglobin: normal glucose regulation, prediabetes, and DM. Multivariate logistic regression models and smoothed curve-fitting techniques were applied to investigate the correlation between CMI and ASCVD risk across varying GMS. Additionally, subgroup analyses stratified by relevant factors were performed to identify potential effect modifiers in this relationship.</p><p><strong>Results: </strong>Overall, 2352 participants (9.8%) with ASCVD were included. An increasing trend in ASCVD risk was observed for each successive CMI tertile. After adjusting for all related covariates, a significantly positive association was observed between CMI and ASCVD (P = 0.0004). Participants with DM in the highest CMI tertile had a 114% higher ASCVD risk compared to those in the lowest tertile (OR = 2.14; 95% CI = 1.30-3.53). Smoothed curve-fitting consistently confirmed the correlation between CMI and ASCVD across diverse GMS. Subgroup analyses and interaction tests highlighted statistically significant differences within the drinking status subgroup (P-interaction = 0.0479) and GMS subgroups (P-interaction = 0.0397).</p><p><strong>Conclusion: </strong>This research suggests a positive association between ASCVD and CMI in adults in the United States, particularly among individuals with DM.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"93"},"PeriodicalIF":3.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.","authors":"Amirhossein Yadegar, Fatemeh Mohammadi, Kiana Seifouri, Kiavash Mokhtarpour, Sepideh Yadegar, Ehsan Bahrami Hazaveh, Seyed Arsalan Seyedi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani","doi":"10.1186/s12944-025-02526-5","DOIUrl":"10.1186/s12944-025-02526-5","url":null,"abstract":"<p><strong>Background: </strong>Surrogate insulin resistance (IR) indices are simpler and more practical alternatives to insulin-based IR indicators for clinical use. This study explored the association between surrogate IR indices, including triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist to height ratio (TyG-WHtR), metabolic score for insulin resistance (METS-IR), and the triglycerides/high-density lipoprotein cholesterol (TG/HDL-C) ratio, and coronary artery disease (CAD) in patients with type 2 diabetes (T2D).</p><p><strong>Methods: </strong>Patients with T2D were enrolled in this study and divided into two groups, matched for age and diabetes duration: those with CAD and those without CAD. The association between surrogate IR indices and CAD was evaluated using restricted cubic spline (RCS) and multivariable logistic regression and their discriminative ability was assessed via Receiver operating characteristic (ROC) curve analysis. Additionally, machine learning models, including Logistic Regression, Random Forest, eXtreme Gradient Boosting (XGBoost), Light Gradient Boosting Machine (LightGBM), and Support Vector Machine (SVM), were employed to predict CAD presence using multiple surrogate IR indices and their components.</p><p><strong>Results: </strong>All surrogate IR indices exhibited non-linear associations with CAD. TyG demonstrated a U-shaped relationship, where both extremely low and high levels were associated with higher odds of CAD compared to intermediate levels. The surrogate IR indices showed a relatively strong discriminative ability for CAD, with AUC values exceeding 0.708 across all indices. The TG/HDL-C ratio displayed the highest AUC (0.721), accuracy (68%), and sensitivity (71%), whereas TyG-WC showed the highest specificity (78%). Machine learning algorithms (except logistic regression) demonstrated greater discriminative power than individual IR indices. Random forest and XGBoost revealed the best performance when using either multiple surrogate IR indices or their components.</p><p><strong>Conclusions: </strong>Surrogate IR indices could be used as valuable tools for evaluating cardiometabolic risk in patients with T2D, who are at high risk for CAD. Integrating machine learning models further improved CAD prediction, underscoring their potential for better risk stratification. The observed association between these indices and CAD in T2D may help clarify the complex pathophysiology of CAD and offer insights for future research.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"96"},"PeriodicalIF":3.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Relative fat mass as a predictor of gallstones: insights from national health and nutrition examination survey data.","authors":"Xiaochun Lin, Hao Lin, Jing Xu, Shouxing Yang, Lei Miao","doi":"10.1186/s12944-025-02519-4","DOIUrl":"10.1186/s12944-025-02519-4","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"95"},"PeriodicalIF":3.9,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the atherogenic index of plasma and all-cause mortality in patients undergoing peritoneal dialysis: a multicenter cohort study.","authors":"Yaohua Hu, Liming Yang, Zhanshan Sun, Xiaoxuan Zhang, Xueyan Zhu, Jian Li, Xinyang Li, Mengyuan Yu, Wenpeng Cui","doi":"10.1186/s12944-025-02510-z","DOIUrl":"10.1186/s12944-025-02510-z","url":null,"abstract":"<p><strong>Background: </strong>The Atherogenic Index of Plasma (AIP) has been reported as a strong predictor of all-cause mortality in the overall population. However, the lipid profile changes in individuals with end-stage kidney disease (ESKD) undergoing peritoneal dialysis (PD) may affect the prognostic utility of AIP for all-cause mortality. The connection between them remains unclear.</p><p><strong>Methods: </strong>This study included patients receiving PD at five hospitals in China from January 1, 2013, to December 31, 2019, with follow-up until June 30, 2020. The primary exposure variable in this investigation was the logarithm of the triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, which was used to compute the AIP, and the outcome variable was all-cause mortality. A Cox proportional hazards regression model was employed to analyze the association between AIP and all-cause mortality. Moreover, stratified analyses were performed to investigate this association further. Kaplan-Meier curves were employed for survival analysis, assessing the prognostic implications of varying AIP levels. Nonlinear associations were examined using smooth curve fitting techniques.</p><p><strong>Results: </strong>A total of 869 patients were included in this study, of whom 153 died during the follow-up period. An inverse association was observed between AIP and all-cause mortality risk in the highest tertile compared to the lowest tertile (HR: 0.56, 95% CI: 0.37-0.84) after correcting for potential confounding variables. Moreover, a nonlinear association was observed between the rates of all-cause mortality and AIP. A segmented Cox regression model identified an inflection point at an AIP value of 0.63 (P = 0.014 for the log-likelihood ratio test). More specifically, it was negatively associated with the all-cause mortality risk (HR: 0.42, 95% CI: 0.25-0.73, P = 0.002) when AIP was ≤ 0.63. On the other hand, AIP showed a positive association with the risk of all-cause mortality when it was more than 0.63 (HR: 8.94, 95% CI: 1.66-48.10, P = 0.011).</p><p><strong>Conclusion: </strong>The present study identified a non-linear association between AIP and all-cause mortality in patients receiving peritoneal dialysis.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"91"},"PeriodicalIF":3.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}