Lipids in Health and Disease最新文献

{"title":"Lipid droplet dynamics in type 2 diabetes and its complications: pathophysiological insights and therapeutic options.","authors":"Caiyi Long, Zihan Li, Liangliang Jiang, Xinyu Yang, Siyu Deng, Yayi Jiang, Boxun Zhang, Rensong Yue","doi":"10.1186/s12944-025-02747-8","DOIUrl":"10.1186/s12944-025-02747-8","url":null,"abstract":"<p><p>Patients with type 2 diabetes mellitus (T2DM) often exhibit dysregulated lipid metabolism, which contributes to the development and progression of complications, such as cardiomyopathy and nephropathy. Lipid droplet (LD) dynamics involve several processes, such as synthesis, lipolysis, and lipophagy. They also interact with organelles, such as the endoplasmic reticulum, mitochondria, and Golgi apparatus. These dynamic behaviors are essential for the maintenance of cellular energy homeostasis. Under physiological conditions, LDs in pancreatic β-cells are involved in lipid metabolism that regulates insulin secretion, while also isolating harmful lipids to protect β-cells from damage due to nutrient excess. In the adipose tissue, LDs respond to nutrient fluctuations by modulating lipolysis and releasing free fatty acids (FFAs) and glycerol. Glycerol can enter the liver for gluconeogenesis and changes in FFA levels affect systemic insulin sensitivity, thereby influencing glucose uptake by skeletal muscles and contributing to whole-body glucose homeostasis. Under pathological conditions, abnormal LD accumulation can lead to ectopic lipid deposition and lipotoxicity, exacerbating T2DM and its complications in target organs, such as the heart, kidneys, retina, and brain. Lifestyle interventions, such as diet and exercise, influence LD homeostasis in tissues affected by T2DM. Pharmacological agents, including certain antidiabetic and lipid-lowering drugs as well as bioactive natural products, have demonstrated tissue-specific regulatory effects on LD dynamics. Emerging therapeutic strategies targeting LDs, such as photodynamic therapy, gene editing, and gut microbiota modulation, are also being investigated. In summary, a deeper understanding of the physiological and pathological roles of LDs in different organs may offer targeted and integrated treatment options for T2DM and its associated complications.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"284"},"PeriodicalIF":3.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between atherogenic index of plasma and tinnitus: evidence from NHANES and the mediating role of hypertension.","authors":"Wenjie Miao, Chuntao Wu, Dongjie Yuan, Yanfeng Li, Tong Wu","doi":"10.1186/s12944-025-02716-1","DOIUrl":"10.1186/s12944-025-02716-1","url":null,"abstract":"<p><strong>Background: </strong>Tinnitus is a prevalent auditory disorder that significantly affects quality of life, with emerging evidence suggesting a connection between metabolic dysregulation and tinnitus pathogenesis. The Atherogenic Index of Plasma (AIP), a marker of atherogenic lipid metabolism, has been associated with cardiovascular disease risk but remains underexplored in the context of tinnitus.</p><p><strong>Objective: </strong>This study aimed to investigate the relationship between AIP and tinnitus prevalence in U.S. adults, and to further examine whether hypertension mediates this association.</p><p><strong>Methods: </strong>We analyzed data from 2,464 participants in the National Health and Nutrition Examination Survey (NHANES, 2005-2012). Tinnitus status was determined by self-report, and AIP was calculated as log10(triglycerides/HDL-C). Multivariable logistic regression models were used to assess the association between AIP and tinnitus. Stratified analyses and mediation analysis were conducted to explore effect modification and the mediating role of hypertension. Hypertension was defined as a self-reported physician diagnosis or use of antihypertensive medication.</p><p><strong>Results: </strong>Elevated AIP was significantly associated with an increased risk of tinnitus in a dose-response manner (fully adjusted OR = 1.73, 95% CI: 1.19-2.52, P = 0.01). Stronger associations were observed in younger participants, females, non-Hispanic Whites, and smokers. Mediation analysis showed that hypertension partially mediated the association between AIP and Tinnitus, accounting for 17.53% of the total effect.</p><p><strong>Conclusions: </strong>Higher AIP is associated with greater tinnitus prevalence, with hypertension serving as a partial mediator. These findings highlight the potential value of AIP as a metabolic biomarker for tinnitus risk stratification and emphasize the importance of managing metabolic dysregulation in tinnitus prevention.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"283"},"PeriodicalIF":3.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver fat mediates hippocampal-orbitofrontal reward circuit disruption and cognitive-emotional impairments in MASLD.","authors":"Liqiang Wu, Ruoyu Tang, Yidan Liang, Yihan Jin, Kuanghui Xu, Xiaofei Chen, Junping Shi, Jie Li","doi":"10.1186/s12944-025-02728-x","DOIUrl":"10.1186/s12944-025-02728-x","url":null,"abstract":"<p><strong>Background: </strong>As a major chronic liver condition, metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to numerous extrahepatic manifestations, including cognitive and emotional dysfunction. However, its neuroanatomical and functional brain correlates remain unclear. This study investigates cerebral alterations in MASLD by examining structural differences via voxel-based morphometry (VBM), along with functional features using resting-state functional connectivity (FC).</p><p><strong>Methods and patients: </strong>Seventy-four MASLD patients and sixty-two demographically matched healthy controls (HC) underwent structural MRI and resting-state fMRI. Group differences in gray matter volume (GMV) and FC were analyzed using VBM and seed-based FC methods. Correlations and mediation analyses were further used to assess the relationships among abnormal GMV, altered resting-state FC and clinical indicators in MASLD individuals.</p><p><strong>Results: </strong>Patients with MASLD exhibited reduced GMV in the bilateral hippocampus, left parahippocampal gyrus, left middle temporal gyrus, right fusiform gyrus, right supplementary motor area (SMA), and right cerebellum. Importantly, liver fat content fully mediated the effects of hippocampal atrophy on cognitive-emotional symptoms. Seed-based FC analysis further revealed decreased connectivity between the right hippocampus and the right orbitofrontal cortex. This reduction in connectivity was also associated with worse cognitive function and a higher waist-to-hip ratio.</p><p><strong>Conclusion: </strong>MASLD-related brain atrophy and functional disruption are linked to visceral adiposity and neuropsychiatric deficits. The mediating role of liver fat highlights the importance of dual-pathway interventions that target both metabolic health and neural protection, potentially reducing long-term neurocognitive disability burdens and enabling accessible risk stratification in practice.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"282"},"PeriodicalIF":3.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-stratified and ascorbic acid intake-modified associations between body roundness index and biological aging: a NHANES-based study on interactions and mediation.","authors":"Xinxing Wang, Xiaoxiao Qu, Guosong Jiang","doi":"10.1186/s12944-025-02708-1","DOIUrl":"10.1186/s12944-025-02708-1","url":null,"abstract":"<p><strong>Background: </strong>Biological aging, defined as the biological age (BA) or phenotypic age (PA) exceeding the chronological age (CA), is a key indicator of premature aging. Obesity accelerates aging; however, the effect of Body Roundness Index (BRI), an indicator of abdominal obesity, combined with sex or Ascorbic acid (Asc), on biological aging remains unclear. This study examined the association between BRI and biological aging, its interaction with sex and Asc intake, and its mediating mechanisms.</p><p><strong>Methods: </strong>Data from the 1999-2018 U.S. National Health and Nutrition Examination Survey (NHANES) formed the basis of this study. Biological aging is characterized by BA or PA surpassing CA. Association between the BRI and biological aging was evaluated using multivariable-adjusted weighted regression. To assess for nonlinearity, restricted cubic splines were utilized, while interactions were investigated through both additive and multiplicative analyses. The bootstrap method was used to examine the potential mediating effects of biomarkers of metabolic dysfunction, oxidative stress, and protective pathways.</p><p><strong>Results: </strong>The final analysis included 14,337 U.S. adults (mean age 47.5 years; 50.27% women). A total of 49.32% of the participants showed signs of biological aging, with BRI being positively associated with biological aging in a nonlinear manner, including a threshold effect. The increase in the risk per BRI unit was more significant in women, and high doses of Asc reduced the risk of biological aging associated with increased BRI. Mediation analysis indicated that the association between BRI and accelerated aging was partly mediated by metabolic dysfunction (mediated by the triglyceride-glucose index [18.73%] and by triglycerides [9.21%], oxidative stress mediated by uric acid [17.92%] and by white blood cell count [5.80%], and depletion of protective factors mediated by vitamin D [- 3.85%] and by high-density lipoprotein [- 4.24%]). A sensitivity analysis confirmed the reliability of the findings.</p><p><strong>Conclusions: </strong>A higher BRI showed a nonlinear positive association with accelerated biological aging, a relationship that appears to be modified by female sex and Asc intake. Clinical approaches targeting metabolic dysfunction, oxidative stress, and antioxidant and vasoprotective reserves may help combat obesity-related aging. BRI thresholds enable early identification of individuals at high risk for personalized interventions.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"281"},"PeriodicalIF":3.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated metabolic-inflammatory risk assessment: HbA1c/HDL-c and hsCRP-to-albumin ratios synergistically predict major adverse cardiovascular events in post-PCI STEMI patients.","authors":"Jinyong Huang, Junyi Zhang, Zhonghui Xie, Linjie Li, Meiyan Chen, Yongle Li, Xiangdong Yu, Shaozhuang Dong, Qing Wang, Jun Chen, Qing Yang, Shaopeng Xu","doi":"10.1186/s12944-025-02707-2","DOIUrl":"10.1186/s12944-025-02707-2","url":null,"abstract":"<p><strong>Background: </strong>This study looked into how predictive in ST-segment elevation myocardial infarction (STEMI) is the high-sensitivity C-reactive protein-to-albumin ratio (hsCAR) as well as glycated hemoglobin to high-density lipoprotein cholesterol (HbA1c/HDL-c) ratio.</p><p><strong>Methods: </strong>This retrospective cohort research was carried out on 1,177 patients having STEMI who were given percutaneous coronary intervention (PCI). For major adverse cardiovascular events (MACE), the independent and combined predictive values of the HbA1c/HDL-c ratio (threshold ≥ 6.61) and hsCAR (threshold ≥ 0.18) were assessed. MACE was an amalgamation of death from all causes, ischemia-induced revascularization, myocardial infarction not leading to death, heart failure hospitalization, and cerebrovascular events. The team used Cox regression models, causal mediation examination, and receiver operating characteristic curves to assess prognostic performance and mechanistic pathways, and compared them with the Global Registry of Acute Coronary Events (GRACE) risk score.</p><p><strong>Results: </strong>The interquartile range for follow-up was 79 to 672 days, with 461 median days. A raised HbA1c/HDL-c ratio (≥ 6.61) and hsCAR (≥ 0.18) independently predicted MACE, with 1.51 (95% confidence interval [CI]: 1.26-1.81; P < 0.001) as well as 1.84 (95% CI: 1.53-2.21; P = 0.005) hazard ratios (HRs), respectively. Combined use enhanced risk stratification, with the high HbA1c/HDL-c-high hsCAR group showing the highest risk (adjusted HR 2.19, 95% CI: 1.67-2.87; P < 0.001). Causal mediation examination revealed that coronary lesion complexity partially mediated these associations; the SYNergy between PCI with TAXUS and Cardiac Surgery (SYNTAX) and the residual SYNTAX scores were responsible for accounting for 24.2%/17.7% of the hsCAR effect and 16.8%/25.2% of the HbA1c/HDL-c ratio effect, respectively. Compared with the individual markers or the GRACE risk score, the combined biomarker model demonstrated superior discriminatory capacity (area under the curve = 0.63, 95% CI = 0.60-0.66; P < 0.001), with significant improvement in integrated discrimination.</p><p><strong>Conclusion: </strong>The integration of HbA1c/HDL-c and hsCAR can significantly improve risk stratification in patients with STEMI, outperforming traditional scoring systems and assisting in the precise management of individuals at risk.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"280"},"PeriodicalIF":3.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific association of novel complex inflammatory markers with colorectal polyps: mediating effects of triglyceride-glucose and non-high-density lipoprotein cholesterol.","authors":"Min Li, Yujing Wan, Na Wang, Ziyue Wei, Jieru Zhou, Wenjing Gui, Chunwu Zhang, Weihong Lin","doi":"10.1186/s12944-025-02679-3","DOIUrl":"10.1186/s12944-025-02679-3","url":null,"abstract":"<p><strong>Background: </strong>The CRP-albumin-lymphocyte (CALLY) index has potential clinical value as a novel marker integrating inflammatory, nutritional and immune status in the development of colorectal polyps. This study examined whether gender factors influence the association between CALLY and colorectal polyps; in addition to elucidating whether metabolic pathways mediate this relationship.</p><p><strong>Methods: </strong>This is a cross-sectional study including 5409 adult health screening participants who completed colonoscopy. Logistic regression analysis, correlation analysis, linear regression analysis and restricted cubic spline modeling, and mediation analysis were employed to investigate the intricate associations between CALLY index, inflammatory biomarkers, metabolic factors and colorectal polyps.</p><p><strong>Results: </strong>A total of 2201 subjects were diagnosed with colorectal polyps. Logistic regression analysis showed that higher CALLY index quartiles were inversely correlated with colorectal polyp prevalence (OR = 0.83,95% CI = 0.70-0.98, P = 0.025), and that this association was more pronounced in the female population (OR = 0.67,95% CI = 0.50-0.91, P = 0.011), while no significant association was observed in males (P > 0.05). Mediation analyses showed partial mediation of TyG (mediated effect: 15.14%, P < 0.01) and Non-HDL-C (mediated effect: 8.20%, P < 0.01) between CALLY index and colorectal polyps, whereas females showed stronger mediation of TyG (mediated effect: 15.49%, P = 0.020).</p><p><strong>Conclusions: </strong>There were sex differences in the negative association of CALLY index with colorectal polyps, with a stronger association in women; the glucose metabolism (TyG) and lipid metabolism (Non-HDL-C) pathways partially mediated the association, and the mediating effect of TyG was more significant in women.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"276"},"PeriodicalIF":3.9,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body muscle mass versus fat mass: gender-specific associations with NAFLD and liver fibrosis.","authors":"Konstantinos Volaklis, Dennis Freuer, Christa Meisinger, Jakob Linseisen","doi":"10.1186/s12944-025-02694-4","DOIUrl":"10.1186/s12944-025-02694-4","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the gender-specific associations of skeletal muscle mass and fat mass with non-alcoholic fatty liver disease (NAFLD) and NAFLD-related liver fibrosis in two population-based studies.</p><p><strong>Methods: </strong>Analyses were based on data from the MEGA (n = 238) and the MEIA study (n = 594) conducted between 2018 and 2023 in Augsburg, Germany. Bioelectrical impedance analysis was used to evaluate relative skeletal muscle mass (rSM) and SM index (SMI) as well as relative fat mass (rFM) and FM index (FMI); furthermore, the fat-to-muscle ratio was built. The fatty liver index (FLI) was calculated to identify NAFLD. To estimate the degree of liver fibrosis, liver stiffness was assessed in the MEGA study using ultrasound elastography. Multivariable gamma regression models with log-link were used to analyze the respective associations.</p><p><strong>Results: </strong>After adjusting for confounders, FMI and rFM (p < 0.001) as well as SMI (p < 0.001) were significantly positive associated with FLI. The associations were non-linear, and effect modification by gender (p_{gender-interaction} < 0.001) existed in all models except for SMI, while age modified the rSM and SMI results. The effect estimates for FMI and rFMI were higher in men than in women but approached each other at the high FMI range. Increasing rSM was inversely associated with FMI. The fat-to-muscle ratio was positively associated with FLI in men and women. However, no associations were found between the exposure variables and liver fibrosis.</p><p><strong>Conclusions: </strong>This population-based study demonstrated gender-specific positive associations between fat mass parameters and FLI, and an inverse association with rSM. Furthermore, for rSM effect modification by age was observed. Neither in men nor in women associations between body composition and liver fibrosis could be identified.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"278"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram for hypertriglyceridemic severe acute pancreatitis that includes metabolic indexes.","authors":"Zhiguo Wang, Yongshuai Liu, Xin Zhang, Chunfei Wang, Jin Tian, Hanqing Zhao, Qiang Tian, Hongmei Qu","doi":"10.1186/s12944-025-02702-7","DOIUrl":"10.1186/s12944-025-02702-7","url":null,"abstract":"<p><strong>Background: </strong>Current scoring systems for hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) severity are few and lack reliability. The present work focused on screening predicting factors for HTG-SAP, then constructing and validating the visualization model of HTG-AP severity by combining relevant metabolic indexes.</p><p><strong>Methods: </strong>Between January 2020 and December 2024, retrospective clinical information for HTG-AP inpatients from Weifang People's Hospital was examined. CT scans of included patients were evaluated for muscle and fat parameters. To identify independent predictors of HTG-SAP, univariate regression, least absolute contraction and selection operator (LASSO) regression, and multivariable logistic regression were conducted. Meanwhile, the nomogram was created for model visualization, and the model was verified for accuracy, consistency, stability, and utility by calibration, clinical decision curve (DCA), as well as receiver operating characteristic (ROC) analyses.</p><p><strong>Results: </strong>Altogether 244 HTG-AP patients were enrolled, and they were categorized as a severe group (N = 44) or a non-severe group (N = 200) in line with Atlanta classification criteria. The analysis showed that lactate dehydrogenase (LDH), serum creatinine(Scr), visceral adipose tissue index (VATI), serum albumin(ALB), and triglyceride and glucose (TyG) index independently predicted the HTG-AP severity prediction model, and a nomogram was constructed for visualization, with an internally validated Harrell's consistency index (c-index) of 0.966 (95% CI, 0.943-0.989), besides, calibration curves, ROC, and DCA all revealed that the nomogram had good predictive ability.</p><p><strong>Conclusion: </strong>LDH, Scr, VATI, ALB, and TyG independently predict HTG-SAP, and our constructed prediction model has high sensitivity and specificity, which can early identify HTG-AP severity, with a view to giving appropriate interventions to the patients in time, delaying the progression of the patients' conditions, and reducing the complications.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"279"},"PeriodicalIF":3.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.","authors":"Jing Tian, Yiming Huang, Zhun Xiao, Shuaipeng Yuan, Suping Ma, Xiaonuo Zhao, Yang Liu","doi":"10.1186/s12944-025-02715-2","DOIUrl":"10.1186/s12944-025-02715-2","url":null,"abstract":"<p><strong>Background: </strong>Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition. This study systematically investigates the association between the UHR index and obesity in postmenopausal women and evaluates its predictive value.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of 7,811 postmenopausal women from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models, adjusted for sociodemographic characteristics, behavioral patterns, and clinical covariates, were employed to examine the UHR index's association with three obesity indices: body mass index (BMI), waist-to-height ratio (WHtR), and weight-adjusted waist index (WWI). Robustness was assessed through stratified subgroup analyses, interaction tests, restricted cubic spline (RCS) modeling, receiver operating characteristic (ROC) curves, and sensitivity analyses to evaluate nonlinear relationships and predictive performance.</p><p><strong>Results: </strong>The weighted obesity prevalence was 44.05%. After full adjustment, the highest UHR quartile (Q4) showed significantly elevated obesity risks versus the lowest quartile (Q1): BMI-defined obesity (adjusted OR = 8.08, 95% CI: 6.49-10.09), WHtR-defined obesity (adjusted OR = 29.95, 95% CI: 17.08-52.51), and WWI-defined obesity (adjusted OR = 4.58, 95% CI: 3.70-5.67). Subgroup analyses revealed significant effect modifications by diabetes, cardiovascular disease, and chronic kidney disease status (P for interaction < 0.05 for all three obesity indices). The RCS analysis demonstrated a nonlinear dose-response relationship. ROC analysis indicated superior predictive performance for WHtR-defined abdominal obesity (AUC = 0.795, 95% CI: 0.778-0.813), with sensitivity analyses corroborating the primary findings.</p><p><strong>Conclusion: </strong>The UHR index exhibits a strong, dose-dependent association with obesity risk in postmenopausal women, persisting after comprehensive covariate adjustment. As a metabolic indicator, the UHR index provides clinically meaningful supplementation to conventional obesity assessments, particularly in capturing metabolically driven obesity risk.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"277"},"PeriodicalIF":3.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From guidelines to practice: LDL-C achievement in very high cardiovascular risk patients - analysis of the EDHIPO MARCA registry.","authors":"Brayan Daniel Cordoba-Melo, Sebastián Seni-Molina, Juan Pablo Arango-Ibanez, Milton René Ayala, José Fidel Tatis-Méndez, Viviana Quintero Yepez, Luz Aída Mejía Cadavid, José D Cruz-Cuevas, Nicolás Ariza-Ordóñez, Andrés Buitrago, Jose Patricio Lopez-Lopez, Alfredo Hinestrosa, Jorge Sabogal, Cristian Reyes-Vargas, Álvaro Herrera-Escandon, Juan Sebastián Hurtado, Juan Fernando Velásquez Osorio, Sergio Londoño, Carlos Salamanca, Liliana Vallecilla, Hoover Leon-Giraldo, Alvaro J Ruiz, Dora Inés Molina, Juan Esteban Gomez-Mesa","doi":"10.1186/s12944-025-02657-9","DOIUrl":"10.1186/s12944-025-02657-9","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with dyslipidemia playing a key role in its progression. Despite advances in lipid-lowering therapy (LLT), LDL-C (Low-Density Lipoprotein Cholesterol) goal achievement remains suboptimal. This study evaluated LDL-C goal attainment in Colombian patients with very high cardiovascular risk (CVR) due to coronary artery disease (CAD) following ESC/EAS guidelines updates.</p><p><strong>Methods: </strong>EDHIPO MARCA (Evaluación De adherencia a la terapia HIPOlipemiante en pacientes de Muy Alto Riesgo CArdiovascular) is a retrospective, multicenter study assessing LDL-C goal achievement in patients with CAD. Data were collected from previous coronary angiogram reports and medical records across 11 Colombian healthcare institutions with certified interventional cardiology services. Patients with CAD who had at least one follow-up LDL-C measurement and an LLT prescription within 12 months post-angiogram were included. LDL-C goal attainment was assessed across three periods-2011-2012, 2016-2017, and 2021-2022-corresponding to the updates of ESC/EAS guidelines (2011, 2016, and 2019, respectively). The LDL-C goals were <70 mg/dL for the first two periods and <55 mg/dL for the most recent one. LDL-C was measured or estimated using the Friedewald equation. Descriptive analyses were performed.</p><p><strong>Results: </strong>A total of 1,788 patients were included, with a median age of 66 years (IQR: 59-74), and 70.7% were male. Hypertension (67.5%) and overweight (40.8%) were the most common comorbidities. At discharge, statins were prescribed in 84.1% (95% CI: 82.4-85.8%) of patients, increasing to 99.1% (95% CI: 98.6-99.5%) at the end of follow-up (median 6.8 months); PCSK9 inhibitors were prescribed in 1.5%, exclusively in 2019. At the end of follow-up, 36.6% (95% CI: 34.3%, 38.8%) achieved LDL-C goals. By guideline period, goal attainment was 12.1% (95% CI: 5.4%, 18.8%) in 2011, 42.3% (95% CI: 37.9%, 46.8%) in 2016, and 36.2% (95% CI: 33.5%, 38.9%) in 2019. By number of follow-ups, LDL-C goal achievement increased from 32.9% (1 follow-up) to 44.0% (4 follow-ups).</p><p><strong>Conclusions: </strong>Despite widespread LLT use, LDL-C target achievement remains suboptimal. Frequent follow-up and greater use of combination therapy beyond statins may be essential to improve lipid control in very high CVR patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"275"},"PeriodicalIF":3.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144959085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}