Lipids in Health and Disease最新文献

{"title":"Atherogenic index of plasma as a novel predictor for acute kidney injury and disease severity in acute pancreatitis: a retrospective cohort study.","authors":"Wen Wu, Yiming Li, Yupei Zhang, Xing Chen, Chunzhen Zhang, Xingguang Qu, Zhaohui Zhang, Rong Zhang, Zhiyong Peng","doi":"10.1186/s12944-025-02520-x","DOIUrl":"10.1186/s12944-025-02520-x","url":null,"abstract":"<p><strong>Background: </strong>The atherogenic index of plasma (AIP) can be used to reveal atherosclerosis. This study evaluated the AIP's efficacy in predicting the prognosis of acute kidney injury (AKI) and severity of acute pancreatitis (AP).</p><p><strong>Methods: </strong>This retrospective cohort study recruited AP cases from the First College of Clinical Medical Science of China Three Gorges University between January 2019 and October 2023, including 1470 patients. AIP was computed using the formula: log10 [serum triglyceride (mmol/L)/serum high-density lipoprotein cholesterol (mmol/L)]. The AIP relationships with AKI occurrence and AP severity were validated using multivariable logistic regression models, subgroup and sensitivity analyses, and curve fitting.</p><p><strong>Results: </strong>Among the 1470 patients with AP, 250 (17%) developed AKI and 166 (11.3%) with severe AP. AIP was positively correlated with AKI and the severity of AP. Potential confounders were adjusted, consequently, AIP was positively linearly related to AKI (P for non-linearity: 0.731, OR 2.5, 95% CI 1.31-4.77,) and the severity of AP (P for non-linearity: 0.145, OR 3.1, 95% CI 1.53-6.27), respectively. The strength of the association between AIP and AKI, along with the severity of AP, was demonstrated through stratified analyses. Significant interactions were not observed in sex, age, hypertension, BMI, diabetes mellitus, SOFA score, BISAP score, and etiology of AP (all P for interaction > 0.05). The areas under the curves for AIP in predicting the incidence of AKI and severity of AP were 0.64 and 0.65, respectively.</p><p><strong>Conclusions: </strong>This is the first study to suggest that the AIP is critical for the assessment of AKI risk, recommending early screening of severity among AP cases. Due to the observational nature of the study, the potential for residual confounding, and the need for external validation in larger, independent cohorts.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"111"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of antisense oligonucleotides on triglyceride, apolipoprotein C-III, and other lipid parameters levels in hypertriglyceridemia; a network meta-analysis of randomized controlled trials.","authors":"Abdelrahman Mahmoud, Kerollos Abdelsayed, Ahmed Almahdy Mohamed, Qasi Najah, Anas Abdulkader, Karim Ali, Shehroze Tabassum, Mohamed Riad Abouzid, Basel Abdelazeem, James D Mills","doi":"10.1186/s12944-024-02389-2","DOIUrl":"10.1186/s12944-024-02389-2","url":null,"abstract":"<p><strong>Background: </strong>Hypertriglyceridemia is an independent risk factor for cardiovascular diseases. In previous trials, apolipoprotein C-III (APOC3) inhibition through the antisense oligonucleotides volanesorsen, olezarsen, and plozasiran reduced triglyceride levels. However, the three medications' safety and efficacy have yet to be compared.</p><p><strong>Methods: </strong>A network meta-analysis was performed to compare multiple doses of the three medications to each other through the placebo. Randomized controlled trials (RCTs) were retrieved by searching PubMed, EMBASE, Web of Science, SCOPUS, and Cochrane until November 22nd, 2024. The mean difference (MD) and 95% confidence interval (CI) were used for continuous outcomes. The risk ratio (RR) and 95% CI were used for dichotomous outcomes.</p><p><strong>Results: </strong>Ten RCTs with a total of 1,129 patients were included. volanesorsen 300 mg once weekly showed the most significant percent reduction in triglyceride levels (MD = -91.0%, 95% CI: (-109.2%; -72.8%); P < 0.01). Only plozasiran once monthly, regardless of the dose, showed a non-significant percent reduction in triglycerides. This finding should be taken cautiously as the data were derived from a phase 1 trial with a small sample size. All the regimens significantly reduced APOC3 levels compared to placebo, with plozasiran 100 mg monthly and volanesorsen 300 mg once weekly showing the most significant reduction (MD range: -92.8% to -88.5%; P < 0.01). None of the treatments showed a statistically significant difference in overall adverse events rate compared to the placebo.</p><p><strong>Conclusion: </strong>APOC3 antisense oligonucleotide inhibitors effectively reduced triglyceride and APOC3 levels in hypertriglyceridemia with an acceptable safety profile. However, the results should be interpreted cautiously due to the small sample size. Further research is needed to confirm the beneficial effects of APOC3 inhibitors and show strong evidence of the impact of each regimen.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"109"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyslipidaemia among children and adolescents in Pakistan: a five-year retrospective cohort study based on laboratory data.","authors":"Quratul Ain, Amjad Nawaz, Madeeha Khan, Jaka Sikonja, Hijab Batool, Rabia Zaheer, Mohammad Iqbal Khan, Muhammad Ajmal, Fouzia Sadiq, Urh Groselj","doi":"10.1186/s12944-025-02529-2","DOIUrl":"10.1186/s12944-025-02529-2","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidaemia is a significant risk factor for cardiovascular diseases, which can manifest early in life. Despite its importance, the prevalence of dyslipidaemia in the paediatric population of Pakistan remains poorly understood. This study uses laboratory data to determine the prevalence of dyslipidaemia and lipid testing practices among Pakistani children and adolescents.</p><p><strong>Methods: </strong>This retrospective cohort study analysed the laboratory data from children and adolescents, aged up to 19 years, who underwent lipid testing. The data was obtained from two centres with collection points all over Pakistan for five years (March 2019-March 2024). Logistic regression models were used to assess relationships between demographic factors (age, sex and regions/provinces) and lipid profile parameters.</p><p><strong>Results: </strong>Over five years, 9,787 children and adolescents with a mean age of 13.8 ± 5.1 years underwent lipid testing. Boys accounted for 59.7% of those tested compared to 40.3% of girls (p = 0.09). Most tests were conducted in Punjab (81.2%), with minimal representation from Balochistan (0.5%) and Gilgit Baltistan (0.3%). Among tested children and adolescents, 33.3% had elevated total cholesterol, 25.4% high low-density lipoprotein cholesterol, 46.6% low high-density lipoprotein cholesterol, 48.0% abnormal non- high-density lipoprotein cholesterol and 41.7% hypertriglyceridemia. Compared to boys, girls had significantly lower odds of abnormal high-density lipoprotein cholesterol (Odds Ratio 0.556, 95% CI 0.511-0.607, p < 0.001) and triglyceride levels (Odds Ratio 0.702, 95% CI 0.642-0.767, p < 0.001).</p><p><strong>Conclusion: </strong>This study highlights a high prevalence of dyslipidaemia among Pakistani children, with boys more affected than girls. The study also highlights a gender-based inequality in lipid testing where girls appear to be less frequently tested compared to boys.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"110"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LESS IS MORE: classified management of hypertriglyceridemia-induced acute pancreatitis on the basis of a propensity score matching cohort study.","authors":"Pan Tan, Shasha Lu, Qingxia Chen, Huijian Ma, Wei Kong, Xiawei Huang, Chaohui Yu, Meng Jin","doi":"10.1186/s12944-025-02511-y","DOIUrl":"10.1186/s12944-025-02511-y","url":null,"abstract":"<p><strong>Background: </strong>Effective management of hypertriglyceridemia is crucial in the treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP). The prognosis of HTG-AP may vary with different serum triglyceride levels, suggesting the need for stratified treatment approaches. In this study, we investigated hypertriglyceridemia management in HTG-AP patients and the optimal strategy.</p><p><strong>Methods: </strong>Patients with HTG-AP from October 2020 to October 2022 were included in the study. Propensity score matching was used to balance the bias and confounding variables. A mixed-effects model was used to analyse the decreasing tendency of triglycerides.</p><p><strong>Results: </strong>A total of 171 patients who were diagnosed with HTG-AP were enrolled in this cohort. Patients with very severe serum triglycerides (> 22.6mmol/L) had a higher proportion of severe acute pancreatitis (p < 0.05) than patients with severe hypertriglyceridemia (11.3-22.6 mmol/L). For the very severe hypertriglyceridemia group, no significant differences in prognosis were noted between the insulin and heparin group and the plasma exchange group. The cost of the insulin and heparin group was significantly lower than that of the plasma exchange group (p < 0.01). In patients with severe hypertriglyceridemia, no significant differences in prognosis were noted between the nothing-by-mouth (NPO) group and the insulin and heparin group. Compared with the insulin and heparin group, the NPO group had lower hospital costs (p < 0.05).</p><p><strong>Conclusion: </strong>HTG-AP patients with very severe hypertriglyceridemia may be treated safely and effectively with insulin and heparin, potentially offering a more cost-effective treatment approach. Similarly, patients with severe hypertriglyceridemia might benefit from treatment involving NPO, which may be associated with lower costs. Further studies are needed to validate these findings in diverse populations and through long-term follow-up.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"108"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients.","authors":"Zebin Wang, Sibing Huang, Na Tian, Qingdong Xu, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Ning Su, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Jianbo Liang, Jiao Li, Yueqiang Wen","doi":"10.1186/s12944-025-02522-9","DOIUrl":"10.1186/s12944-025-02522-9","url":null,"abstract":"<p><strong>Background: </strong>In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein cholesterol (HDL-C) levels significantly influence clinical outcomes. Current clinical practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) and all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD and all-cause mortality rates among individuals receiving CAPD treatment.</p><p><strong>Methods: </strong>Between January 1, 2005 and December 31, 2016, a multi-center retrospective analysis of 2006 CAPD patients from five peritoneal dialysis hospitals in China was conducted. Participants were split into two subgroups in accordance with the baseline serum RC/HDL-C ratio restricted cubic spline cutoff value. The correlations between mortality and RC/HDL-C ratio were examined through case-specific hazard modeling.</p><p><strong>Results: </strong>The observation period documented 549 all-cause fatalities, with cardiovascular deaths accounting for 269 cases. The Kaplan-Meier analysis revealed statistically significant divergence in both all-cause mortality (log rank test P < 0.001) and CVD mortality (log rank test P = 0.003). Elevated RC/HDL-C ratios showed increased hazard ratios (HR) for all-cause mortality (1.335, 95% CI, 1.112-1.603, P = 0.002) and CVD mortality (1.319, 95% CI, 1.013-1.717, P = 0.040) compared to lower ratio counterparts. Nevertheless, no statistically meaningful association was found between CVD mortality and either RC (HR: 1.296, 95% CI, 0.992-1.691, P = 0.057) or HDL-C (HR: 0.887, 95% CI, 0.680-1.157, P = 0.376).</p><p><strong>Conclusion: </strong>The RC/HDL-C ratio independently predicts mortality in CAPD patients, persisting as a significant prognostic marker after multivariable adjustment.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"107"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different profiles of fatty acids between leukocytes and whole blood in children with idiopathic nephrotic syndrome.","authors":"S Turolo, A Edefonti, M L Syren, W Morello, E A de Marco, A Berrettini, C Agostoni, G Montini","doi":"10.1186/s12944-025-02523-8","DOIUrl":"10.1186/s12944-025-02523-8","url":null,"abstract":"<p><p>Idiopathic nephrotic syndrome (INS) is the most common pediatric glomerular disease, characterized by proteinuria, hypoalbuminemia and edema and caused by an immune dysregulation of T and B cells. Fatty acids (FA) are involved in immune response, with omega-6 prevailing in pro-inflammatory states and omega-3 promoting anti-inflammatory effects. While previous studies of INS assessed FA profile in blood or serum, which may be influenced by many systemic and dietary factors, the intracellular FA metabolism in white blood cells of children with INS, critical to immune cell activation, remains still unexplored. This pilot study compares the FA profile within leukocytes (endo-leukocyte, EL) and whole blood in 35 children with INS and 34 matched controls. INS patients were stratified by steroid sensitivity vs. steroid resistance and by remission vs. proteinuric state. EL FA profiles were analyzed via gas chromatography and dietary habits were evaluated by the Kid Med questionnaire. While blood FA profile of patients demonstrated both elevated omega-6 and omega-3 levels (P-value < 0.005), EL show an inflammatory dominance, with increased omega-6 (P-value < 0.005), but similar omega-3 levels, compared to controls. Furthermore, EL profiles showed reduced saturated FA and palmitic acid but elevated oleic acid levels (P-value < 0.005), possibly indicating a compensatory anti-inflammatory response. This study suggests that EL FA profile may provide unique insights into intracellular mechanisms of inflammation in INS, complementing data arising from blood FA analysis. Despite some limitations, including the small sample size, the study of FA inside the cellular population directly involved in INS underscores its potential in increasing diagnostic precision of FA anomalies in the course of nephrotic syndrome. This new approach may also represent the prerequisite for a clearcut evaluation of the effectiveness of pharmacologic and dietary therapies, like the supplementation with omega 3 metabolites and a diet rich in omega-3.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"106"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women.","authors":"Zihong Bao, Yanmei Zhang, Ju Zhou, Zhikun Dai","doi":"10.1186/s12944-025-02532-7","DOIUrl":"10.1186/s12944-025-02532-7","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"104"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study.","authors":"Hongming Yin, Yongjin Wang, Yujia Chen, Qayyum Shehzad, Feng Xiao","doi":"10.1186/s12944-025-02531-8","DOIUrl":"10.1186/s12944-025-02531-8","url":null,"abstract":"<p><strong>Background: </strong>& aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.</p><p><strong>Methods: </strong>The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.</p><p><strong>Results: </strong>Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR_T3-T1 = 0.22 (0.12-0.41), OR_T3-T1 = 0.29 (0.15-0.54), OR_T3-T1 = 0.49 (0.27-0.88), and OR_T3-T1 = 0.19 (0.09-0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [OR_T1-T3 = 2.02 (1.11-3.70), OR_T1-T3 = 2.10 (1.15-3.87), OR_T1-T3 = 2.82 (1.53-5.30), and OR_T1-T3 = 2.07 (1.12-3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.</p><p><strong>Conclusion: </strong>The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"101"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients.","authors":"Bowen Wang, Liping Zuo, Jinlei Fan, Wei Zhao, Yueming An, Wangshu Cai, Deixin Yu","doi":"10.1186/s12944-025-02530-9","DOIUrl":"10.1186/s12944-025-02530-9","url":null,"abstract":"<p><strong>Background: </strong>Hypertension and obesity are common in systemic lupus erythematosus (SLE) patients, with obesity-related changes potentially driving hypertension. However, the specific adiposity measures associated with hypertension in SLE patients remain unclear. This study assessed the association between myosteatosis and sarcopenia detected on abdominal CT and hypertension in SLE patients. Mediators of the association between myosteatosis and hypertension were also investigated.</p><p><strong>Methods: </strong>This was a retrospective study involving SLE patients enrolled from January 2017 to August 2023 and who underwent abdominal CT at the L3 level to track myosteatosis and sarcopenia based on the skeletal muscle mean radiodensity (SMD) and skeletal muscle index considered as binary and continuous variables. The association between these body composition measures and hypertension was tested using logistic regression analyses, while mediation modeling was used to assess the mediators.</p><p><strong>Results: </strong>A total of 279 adult SLE patients (median age, 41.00 [30.00, 51.00] years; 245 women) were included in this study. Hypertension was associated with myosteatosis (adjusted OR: 3.54; 95% CI: 1.18-10.61 for the binary variable and 1.31; 95% CI: 1.02-1.68 for the continuous variable). No statistically significant association was observed between hypertension and sarcopenia (adjusted OR: 0.48; 95%CI: 0.23-1.01 for the binary variable and 0.95; 95%CI: 0.78-1.16 for the continuous variable). Mediation analyses revealed eGFR could mediate the association between myosteatosis (considered as a continuous variable) and hypertension in SLE patients when taken alone (95% CI: 0.0177-0.2765) or in combination with the TyG index (95% CI: 0.0032-0.0614).</p><p><strong>Conclusions: </strong>Myosteatosis was associated with hypertension in SLE patients. eGFR alone or in combination with the TyG index may mediate this association.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"105"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study.","authors":"Chunxia Zhang, Yuchen Ying, Yuanhui Ru, Ziliang Wu, Yumeng Tian, Pingping Shen, Shiyuan Cao, Jing Zhang, Ri Liu","doi":"10.1186/s12944-025-02516-7","DOIUrl":"10.1186/s12944-025-02516-7","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an elevated risk of cardiovascular conditions, such as lower extremity arterial disease (LEAD). The Fibrosis-4 (FIB-4) index, a non-invasive marker of liver fibrosis, may have predictive value for LEAD in patients with MASLD. This study aimed to explore the association between FIB-4 and LEAD in a cohort of patients with MASLD.</p><p><strong>Methods: </strong>This cross-sectional study included 481 participants with MASLD, selected from a comprehensive health check-up database. Participants were categorized into three groups based on their FIB-4 index (< 1.3, 1.3-2.66, > 2.66) and underwent duplex ultrasonography to diagnose LEAD. Logistic regression models were employed to evaluate the association between FIB-4 and LEAD, adjusting for demographic, metabolic, and lipid-related factors. Subgroup analyses were performed by sex, age, diabetes mellitus status, hypertension, dyslipidemia, smoking status.</p><p><strong>Results: </strong>The prevalence of LEAD increased with FIB-4 levels, from 51.3% in the low FIB-4 group to 86.5% in the high FIB-4 group (p < 0.001). In fully adjusted models, higher FIB-4 levels were significantly associated with LEAD (adjusted odds ratio [OR]: 3.54, 95% confidence interval [CI]: 1.39-9.01) in the high FIB-4 group compared to the low group. As a continuous variable, each unit increase in FIB-4 was associated with a 66% higher likelihood of LEAD (adjusted OR: 1.66, 95% CI: 1.12-2.26, P < 0.001). Subgroup analyses did not reveal significant interactions (P for interaction > 0.05).</p><p><strong>Conclusions: </strong>Higher FIB-4 levels are independently associated with the prevalence of LEAD in MASLD patients, although subgroup analyses did not reveal significant interactions. This suggests that further studies with larger sample sizes are needed to explore these relationships more comprehensively.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"103"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}