Lipids in Health and Disease最新文献

{"title":"Association between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy.","authors":"Yayu Wang, Yue Chang, Pei Zhang, Zhuoyin Zheng, Xiuyi Ai, Shu Zhang, Shiwen Wu","doi":"10.1186/s12944-025-02628-0","DOIUrl":"10.1186/s12944-025-02628-0","url":null,"abstract":"<p><strong>Background: </strong>Duchenne muscular dystrophy (DMD) is a serious, progressive neuromuscular condition that predominantly impacts male individuals, marked by progressive muscle weakness resulting from mutations in the dystrophin gene (DMD) encoding dystrophin. DMD is a primary muscle disorder that often presents with secondary abnormalities in lipid metabolism and decreased bone mineral density. Although disturbances in circulating lipid profiles and skeletal health have been observed in individuals with DMD, their relationship remains underexplored.This study aimed to investigate the potential association between lipid metabolic disturbances and spinal bone mineral density in patients with DMD by combining clinical lipid levels and bone density with transcriptomic pathway analysis of DMD muscle tissue.</p><p><strong>Methods: </strong>Retrospective analysis was performed on 219 genetically confirmed DMD patients and 99 age-matched healthy controls. Healthy controls with a family history of genetic disorders were excluded. Clinical data included lipid profiles (triglycerides [TGs], remnant cholesterol [RC]); bone mineral density of the lumbar spine was evaluated using Dual-energy X-ray absorptiometry (DXA); and corticosteroid use, including treatment status, dose, and duration. Patients were stratified by corticosteroid exposure. Restricted cubic splines and multivariable regression models were applied to explore potential relationships between lipid parameters and bone mineral density. Bioinformatic analyses were performed on RNA sequencing data from muscle biopsy samples from patients with DMD (GSE38417 dataset) and an independent validation cohort (GSE6011 dataset), focusing on pathways related to lipid metabolism and osteoclast differentiation.</p><p><strong>Results: </strong>Patients with DMD had higher TG, RC, and apolipoprotein B (ApoB) levels and lower high-density lipoprotein cholesterol (HDL-C) levels than healthy controls (P < 0.05). Elevated TG and RC levels were associated with reduced spine bone mineral density, independent of corticosteroid use. The bioinformatic analyses identified key pathways, including sphingolipid metabolism and osteoclast differentiation, as well as hub genes such as FCGR2B, C1QA, which are involved in lipid regulation and bone remodeling.</p><p><strong>Conclusions: </strong>Lipid abnormalities, particularly elevated TG and RC levels, were significantly associated with lower bone mineral density in patients with DMD. These findings suggest that lipid abnormalities are involved in bone health impairment in DMD, warranting further studies to confirm the association.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"209"},"PeriodicalIF":3.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between relative fat mass and psoriasis risk: insights from the NHANES data.","authors":"Zeru Chen, Haiwei Chen, Xiaotong Chen, Yuling Chen, Jintong Wang, Yuhua Ou","doi":"10.1186/s12944-025-02615-5","DOIUrl":"10.1186/s12944-025-02615-5","url":null,"abstract":"<p><strong>Background: </strong>Patients' quality of life is greatly impacted by psoriasis, a prevalent chronic inflammatory skin condition that is frequently linked to a number of systemic disorders. Recent research shows that obesity is a major risk factor for psoriasis. Since Relative Fat Mass (RFM), an innovative way to measure obesity, offers a more precise estimate of body fat percentage, this study aims to investigate the connection between RFM and psoriasis and its potential as a disease predictor.</p><p><strong>Methods: </strong>The analysis included 6,006 people the National Health and Nutrition Examination Survey (NHANES) conducted between 2003 and 2006, 151 of whom had psoriasis. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and interaction tests were employed to assess the link between RFM and psoriasis. ROC curves were used to compare RFM with conventional measures of obesity (WWI, BRI). Furthermore, LASSO regression and multivariable regression based on AIC were used to create a psoriasis risk prediction model that included RFM and additional clinical factors.</p><p><strong>Results: </strong>RFM and psoriasis risk were revealed to be significantly positively correlated. The chance of developing psoriasis increased by 7% for every unit rise in RFM (95% CI: 1.03 to 1.12). RFM showed better predictive ability than conventional markers including BMI, WWI, and BRI (AUC = 0.573). The RFM-psoriasis relationship and diabetes status significantly interacted, with the association being weaker in diabetic individuals, according to subgroup analysis and interaction tests. Promising results were obtained from the created psoriasis risk prediction model that included RFM, age, total dietary sugar, education level, history of heart disease, and hypertension.</p><p><strong>Conclusion: </strong>This research demonstrates that RFM outperforms traditional anthropometric methods in predicting risk. It also presents the initial evidence establishing a positive link between RFM and the likelihood of developing psoriasis.The psoriasis risk prediction model underscores RFM's effectiveness as a valuable approach in both clinical and public health domains, aiming to alleviate the impact of psoriasis-related issues by offering a practical instrument for early risk assessment and personalized clinical strategies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"210"},"PeriodicalIF":3.9,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol is associated with poor prognosis in patients with hepatitis B-related acute-on-chronic liver failure: a Chinese population-based study.","authors":"Juan Liu, Yuna Wang, Songsong Yuan, Jiwei Fu, Wentao Zhu","doi":"10.1186/s12944-025-02621-7","DOIUrl":"10.1186/s12944-025-02621-7","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) patients possess adverse lipid homeostatic alterations, subsequently affecting their treatment regimens and prognoses. However, the precise association between one lipid homeostasis indicator, remnant cholesterol (RC), and HBV-ACLF prognoses have not been fully elucidated. In this retrospective study, the relationship between RC with 28- and 90-day HBV-ACLF prognoses was delineated.</p><p><strong>Methods: </strong>595 HBV-ACLF patients were recruited, and data collected for laboratory parameters at admission, as well as whether poor 28- and 90-day prognoses occurred during the follow-up period, in the form of mortality, or liver transplantation. Patients were divided into 3 groups, based on RC tertiles (Q1-3), and 4 multivariate Cox regression analyses were conducted to identify the associations between RC levels and ACLF prognoses; these analyses excluded different confounding factors, based on the Strengthening the Reporting of Observational Studies in Epidemiology statement. Stratified analysis was conducted to investigate the association between RC and ACLF risk among different subgroups, based on age, sex as well as complications and artificial liver treatment. RC accuracy versus that of other lipid indicators to predict 28- and 90-day ACLF survival was evaluated by restricted cubic spline and receiver operating characteristic (ROC) curve analyses, while Kaplan-Meier curves measured cumulative 28- and 90-day mortality risks.</p><p><strong>Results: </strong>For all 4 regression models, higher RC were associated with worse liver function, coagulation, and HBV-ACLF prognoses. Restricted cubic spline analysis identified a non-linear relationship between RC and HBV-ACLF prognoses, in which the Q3 RC tertile had the lowest 28-day and 90-day HBV-ACLF survival rates; this was further confirmed by Kaplan-Meier analysis. Additionally, subgroup analysis found that higher RC correlated to worse ACLF prognoses among hypoproteinemia patients. Moreover, RC, compared to total cholesterol, triglycerides, high- and low-density lipoprotein cholesterol, as well as non-high density lipoprotein, was the most accurate in predicting poor 28- and 90-day ACLF prognoses.</p><p><strong>Conclusions: </strong>Elevated RC was significantly associated with poorer 28- and 90-day HBV-ACLF prognoses, even after accounting for all other traditional risk factors. Therefore, monitoring RC, along with interventions to reduce their levels, could aid in improving ACLF patient outcomes.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"207"},"PeriodicalIF":3.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The health status and the prevalence of metabolic disorders of adult endemic cretinism-An epidemiological study in China.","authors":"Yanhong He, Yun Chen, Haiyan Gao, Zheng Zhou, Bingxuan Ren, Jianshuang Li, Jinjin Liu, Lingbo Wang, Mengxue Du, Baoxiang Li, Lixiang Liu, Hongmei Shen","doi":"10.1186/s12944-025-02598-3","DOIUrl":"10.1186/s12944-025-02598-3","url":null,"abstract":"<p><strong>Background and aims: </strong>The cross-sectional survey aimed to characterize the health status of adult endemic cretinism patients in a severely iodine-deficient region, focusing on the prevalence of dyslipidemia, hyperglycemia, and hypertension. The study also sought to provide new epidemiological evidence for the association between endemic cretinism and lipid metabolism disorders, particularly hypercholesterolemia and hypertriglyceridemia.</p><p><strong>Methods and results: </strong>All surviving endemic cretinism patients (n = 31) and matched controls (n = 97) were investigated in December 2020. iodine concentration in urinary and serum, thyroid function parameters, lipid profile [total cholesterol (TC), triglyceride (TRIG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], fasting blood glucose (FBG), and blood pressure measurements [systolic blood pressure (SBP), diastolic blood pressure (DBP)] were assessed. Endemic cretinism patients exhibited significantly elevated thyroid-stimulating hormone (TSH) levels and a higher prevalence of hypothyroidism compared to controls. Serum TC and TRIG concentrations were markedly higher in endemic cretinism patients than in controls (5.27 mmol/L vs. 4.73 mmol/L, P = 0.009; and 1.65 mmol/L vs. 1.04 mmol/L, P < 0.001, respectively). The prevalence of hypercholesterolemia and hypertriglyceridemia was significantly higher in endemic cretinism patients (P = 0.001 and P < 0.001, respectively). Multivariate analysis revealed that endemic cretinism was an independent risk factor for both hypercholesterolemia [adjusted odds ratio (AOR) = 2.870, 95% confidence interval (CI): 1.129-7.298] and hypertriglyceridemia (AOR = 5.912, 95% CI: 2.261-15.455).</p><p><strong>Conclusion: </strong>Adult endemic cretinism patients demonstrate significantly elevated serum lipid levels and are more susceptible to hypercholesterolemia and hypertriglyceridemia, conditions closely associated with their underlying hypothyroidism. These findings highlight the importance of monitoring and managing metabolic parameters in adult endemic cretinism patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"208"},"PeriodicalIF":3.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between dyslipidaemia and gastric cancer: pathogenesis to prevention and treatment strategies.","authors":"Tao Wu, Lingna Zhang, Jiao Tian, Yuyuan Lu, Yan Yang, Xin Yang, Penghui Jin, Yuanhui Gu, Xiaoke Wang, Lin Yi","doi":"10.1186/s12944-025-02625-3","DOIUrl":"10.1186/s12944-025-02625-3","url":null,"abstract":"<p><p>As the sixth most common cancer in the world, the development of gastric cancer (GC) is influenced by many factors. Recent studies have revealed a strong association between dyslipidaemia and GC. In this paper, the relationships between dyslipidaemia and GC are discussed in depth. We review the development of GC through the mechanisms of the inflammatory response, signalling pathways, and apolipoprotein function, and the intersecting targets of atherosclerosis and GC are explored. The synergistic effects of Helicobacter pylori infection and dyslipidaemia on the development of GC are also analysed, and the potential value of statins in the prevention and treatment of GC is discussed. In this review, we systematically investigated the relationship between dyslipidaemia and GC to provide new ideas for GC prevention and treatment.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"204"},"PeriodicalIF":3.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific and metabolic subgroup heterogeneity in high-density lipoprotein cholesterol associations with diabetic kidney disease risk: a retrospective cohort study.","authors":"Huabin Wang, Xuanlin Jin, Fenfang Lin, Guangming Chen, Meili Lin, Yongjun Ma","doi":"10.1186/s12944-025-02632-4","DOIUrl":"10.1186/s12944-025-02632-4","url":null,"abstract":"<p><strong>Background: </strong>The role of high-density lipoprotein cholesterol (HDL-C) in diabetic kidney disease (DKD) remains controversial. This study aimed to delineate the subgroup-specific relationships between the two by exploring cumulative and threshold effects.</p><p><strong>Methods: </strong>3,040 patients with type 2 diabetes and no baseline evidence of DKD were included. Cox proportional hazards regression models were performed to investigate the potential relationship between HDL-C level and DKD risk. To address subgroup heterogeneity, sex-stratified restricted cubic splines (RCS) were employed to model nonlinear relationships. The optimal threshold was identified through the maximum selected statistics and validated via 1,000 bootstrap iterations. Subgroup analyses stratified by sex, diabetes duration, and metabolic status were performed to evaluate heterogeneity. Survival analysis using Kaplan-Meier curves further validated these threshold effects.</p><p><strong>Results: </strong>During a median follow-up of 3.13 years, 665 subjects (21.9%) progressed to DKD. Overall, each 1 mmol/L increase in HDL-C level independently reduced DKD risk by 43%. RCS analysis demonstrated an inverse correlation between HDL-C and DKD risk (P for overall = 0.025, P for nonlinear = 0.317), with increased risk reduction at lower concentrations, plateauing at higher levels. A robust threshold of 0.93 mmol/L was identified, showing significantly stronger protection against DKD progression (hazard ratio (HR) = 0.69, P < 0.001) compared to the traditional cutoff (HR = 0.86, P = 0.109). Females showed continuous protection (HR = 0.41, P = 0.009) without threshold dependency. The male and diabetes duration < 10 years subgroups exhibited threshold effects at > 0.93 mmol/L without continuous protection. The metabolically unstable (hypertension, poorly controlled glycemia, body mass index (BMI) > 28 kg/m²) and BMI < 24 kg/m² subgroups displayed dual effects (P < 0.05). Survival analysis confirmed lower cumulative DKD incidence with HDL-C > 0.93 mmol/L (P = 0.007).</p><p><strong>Conclusions: </strong>This study reveals sex- and metabolic context-dependent heterogeneity in HDL-C-DKD associations: males and short-duration diabetes exhibited threshold effects (0.93 mmol/L), females showed continuous protection, and subgroups with hypertension, poorly controlled glycemia, or obesity (BMI > 28 kg/m²) exhibited both continuous protection and threshold effects. These findings may inform individualized risk stratification in specific populations.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"205"},"PeriodicalIF":3.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between healthy lifestyle score and atherogenic indices in a general population of Iranian adults.","authors":"Reza Amani-Beni, Bahar Darouei, Noushin Mohammadifard, Awat Feizi, Motahare Bateni, Fahimeh Haghighatdoost, Maryam Boshtam, Narges Grau, Nizal Sarrafzadegan","doi":"10.1186/s12944-025-02631-5","DOIUrl":"10.1186/s12944-025-02631-5","url":null,"abstract":"<p><strong>Background: </strong>Atherogenic indices outperform traditional lipid markers; however, the combined association of lifestyle habits with these indices remains unclear. This study, which is based on population data, explored the link between the Healthy Lifestyle Score (HLS) and various atherogenic indices.</p><p><strong>Methods: </strong>In this cross-sectional analysis of the 2013 Isfahan Cohort Study 2 (participants aged ≥ 35 years), HLS was derived from four factors: smoking status, body mass index (18.5-24.9 kg/m²), physical activity (≥ 1350 MET minutes/week), and diet quality (top two quintiles of the Alternate Healthy Eating Index-2010). Each factor was scored as 1 for adherence and zero otherwise, yielding a score of 0-4. The atherogenic indices included the Atherogenic Coefficient (AC), Atherogenic Index of Plasma (AIP), Atherogenic Combined Index (ACI), Castelli Risk Indices I and II (CRI-I/II), non-high-density Lipoprotein Cholesterol (NHC), Lipoprotein Combined Index (LCI), Remnant Lipoprotein Cholesterol (RLPC), and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio. Logistic and linear regression analyses were conducted to examine these associations after adjusting for confounders.</p><p><strong>Results: </strong>Among 2,256 participants (49.7% men), the overall mean age was 58.15 ± 9.89 years. Across the population, a higher HLS was strongly linked to a decreased likelihood of elevated levels of individual atherogenic indices. Compared to individuals with HLS 0-1, those with HLS 3-4 had notably reduced odds of high AIP (odds ratio (OR): 0.42; 95% CI: 0.30-0.59), ACI (OR: 0.60; 95% CI: 0.47-0.77), and other indices (all P for trend < 0.05). Sex-stratified analyses revealed distinct patterns: in men, HLS was strongly associated with lower TG/HDL-C, AIP, and ACI, whereas in women, stronger associations were observed with cholesterol-driven markers (AC, NHC, RLPC, CRI-I, and CRI-II). Linear regression analysis confirmed that each unit increase in HLS corresponded to lower continuous values of these indices in the total population. AIP emerged as the most sensitive marker in both sexes.</p><p><strong>Conclusions: </strong>Adherence to a healthier lifestyle, as measured by the HLS, was significantly associated with lower atherogenic indices, highlighting its role in reducing cardiovascular risk. These results support integrating lifestyle interventions with cardiovascular prevention. Future studies should assess the causal impact of lifestyle modifications on atherogenic profiles.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"206"},"PeriodicalIF":3.9,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the atherogenic index of plasma with 28-day in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study from the eICU.","authors":"Yan Wang, Hong-Fei Zhang","doi":"10.1186/s12944-025-02630-6","DOIUrl":"10.1186/s12944-025-02630-6","url":null,"abstract":"<p><strong>Background: </strong>Despite substantial advancements in treatment strategies, acute myocardial infarction (AMI) continues to exhibit high mortality. Recent research has identified the atherogenic index of plasma (AIP) as a significant measure of cardiovascular outcomes. However, the relationship between the AIP and 28-day mortality during hospitalization in AMI patients remains to be further clarified.</p><p><strong>Methods: </strong>A retrospective analysis was conducted based on data sourced from the eICU Collaborative Research Database, encompassing records of 2,517 AMI patients treated in 208 critical care facilities across the U.S. from 2014 to 2015. AIP measurements were derived via log10 (triglyceride/high-density lipoprotein cholesterol) calculations. The primary endpoint was 28-day in-hospital mortality. The analysis utilized adjusted multivariable logistic models with restricted cubic splines for nonlinear associations. Subgroup analyses were performed to evaluate the relationships between AIP and mortality across various demographic and clinical subgroups. These subgroups included age, sex, body mass index (BMI), congestive heart failure, intubation status, mechanical ventilation, pneumonia, diabetes mellitus, antihyperlipidaemic agents, and AMI types.</p><p><strong>Results: </strong>Among the 2,517 patients enrolled in the cohort (median age: 64.42 years), 138 (5.48%) died within 28 days. The analysis revealed a nonlinear association between the AIP and mortality, presenting a J-curve shape with a threshold of 0.60 (P for nonlinearity = 0.028). Each 0.1-unit elevation above 0.60 corresponded to a 22% increased mortality risk (adjusted OR = 1.22, 95% CI: 1.09-1.36; P = 0.0004). The highest AIP quartile had a 112% greater mortality risk than the lowest quartile (adjusted OR = 2.12, 95% CI: 1.15-3.88; P = 0.0154). Subgroup analyses revealed consistent patterns across the strata.</p><p><strong>Conclusion: </strong>The relationship between the AIP and 28-day hospital mortality in AMI patients may be characterized by a J-shaped curve, where elevated AIP values are associated with increased mortality risk.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"202"},"PeriodicalIF":3.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal Dysosmobacter spp. concentration is linked to plasma lipidome in insulin-resistant individuals with overweight, obesity and metabolic syndrome.","authors":"Camille Petitfils, Clara Depommier, Nathalie M Delzenne, Amandine Everard, Matthias Van Hul, Patrice D Cani","doi":"10.1186/s12944-025-02629-z","DOIUrl":"10.1186/s12944-025-02629-z","url":null,"abstract":"<p><strong>Background: </strong>Obesity is reaching epidemic proportions worldwide. This excessive increase of adipose tissue is a risk factor for the development of multiple diseases and premature death. Amongst associated diseases, metabolic syndrome is one of the main comorbidities of obesity. In this context, the gut microbiota has been recognized as both shaping and responding to host energy metabolism. Recently metabolomics has emerged as a powerful tool to capture a snapshot of the metabolites present in a specific tissue, providing new insights into host-microbiota interactions. Integrating metabolomics with gut microbiota studies could help us better understand how specific species impact on host metabolomic profile. Dysosmobacter welbionis has been identified as a promising next generation beneficial bacteria with potential effects on fat mass and glucose metabolism in mice, and fecal Dysosmobacter spp. concentration was inversely correlated to body mass index fasting glucose and plasmatic HbA1c in humans.</p><p><strong>Methods: </strong>Concentration of Dysosmobacter spp. was quantified by qPCR in the stools of insulin resistant overweight/obese participants with a metabolic syndrome and plasma metabolites were analyzed using untargeted metabolomics. Correlations between Dysosmobacter spp. fecal abundance and the 1169 identified plasma metabolites were uncovered using Spearman correlations followed by a false discovery rate correction.</p><p><strong>Results: </strong>Interestingly, among the detected metabolites, Dysosmobacter spp. was exclusively associated with lipid molecules. Fecal concentration of Dysosmobacter spp. was positively associated with plasmatic levels of five phosphatidylcholines, arachidonate, two monoacylglycerols, twelve diacylglycerols, three lysophosphatidylethanolamines, one phosphatidylinositol and three lysophosphatidylinositols, as well as glycerophosphoethanolamines, glycerophosphatidylcholine and PC(P-16:0). The correlation was particularly interesting with acylcholine and lysophosphatidylcholine metabolites as, respectively, 6/8 and 8/10 detected molecules were positively associated with Dysosmobacter spp.</p><p><strong>Conclusion: </strong>These results suggest that Dysosmobacter spp. plays a specific role in host lipid metabolism. This finding aligns with previous in vivo studies highlighting lipid profile alterations in multiple tissues of mice treated with this bacterium. Further studies are needed to elucidate the underlying mechanisms and assess its potential therapeutic applications.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"203"},"PeriodicalIF":3.9,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-fat yogurt compared with non-fat yogurt reduces blood triacylglycerol concentrations and lowers the triacylglycerol content in specific lipoprotein subclasses in adults with prediabetes: an exploratory analysis of a randomized-controlled trial.","authors":"Victoria M Taormina, Simonne Eisenhardt, Matthew P Gilbert, Matthew E Poynter, C Lawrence Kien, Jana Kraft","doi":"10.1186/s12944-025-02616-4","DOIUrl":"10.1186/s12944-025-02616-4","url":null,"abstract":"<p><strong>Background: </strong>Low- and non-fat dairy foods have long been recommended over full-fat dairy foods due to the negative effect of saturated fatty acids on blood lipids. Recent research, however, suggests saturated fatty acids from dairy foods may not impart these negative health effects. Our objective was to evaluate changes in blood lipids following a diet with full-fat (3.25%) yogurt compared with a diet with non-fat yogurt.</p><p><strong>Methods: </strong>A randomized, double-masked crossover controlled-feeding trial was performed. Participants with prediabetes (n = 13, 7 female and 6 male participants) consumed three daily servings of full-fat or non-fat yogurt for the three weeks of each experimental diet. A one-week run-in diet preceded each experimental diet period. After each experimental diet period and the first run-in diet period, fasting blood and blood drawn at four post-prandial time points during a mixed meal tolerance test were analyzed for lipoprotein concentrations and contents (i.e., the lipid fractions within the lipoproteins). Statistical analyses were performed using linear mixed models, with values from the first run-in diet as the covariate.</p><p><strong>Results: </strong>Fasting blood triacylglycerol concentrations were 10% lower in response to the full-fat yogurt diet, compared with the non-fat yogurt diet (P < 0.01). While no diet-induced differences were observed in lipoprotein subclass concentrations, the triacylglycerol contents of smaller very low-density, intermediate-density, and low-density lipoproteins were lower in response to the full-fat yogurt diet (P ≤ 0.01). Trends indicated potentially greater high-density lipoprotein cholesterol concentrations and high-density lipoprotein size following the full-fat yogurt diet (P ≤ 0.05). The ratio of triacylglycerols: high-density lipoprotein cholesterol concentrations was 17% lower following the full-fat yogurt diet (P < 0.01).</p><p><strong>Conclusions: </strong>This exploratory analysis demonstrates that short-term full-fat yogurt consumption elicits beneficial effects on the blood lipid profile in individuals with prediabetes and highlights the need for further evaluation of the contribution of dairy fat in yogurt and other dairy food matrices in lipid homeostasis and metabolic health.</p><p><strong>Trial registration: </strong>This trial is registered at clinicaltrials.gov (NCT03577119).</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"201"},"PeriodicalIF":3.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12139295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}