Lipids in Health and Disease最新文献

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Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients. 腹膜透析患者残余胆固醇与高密度脂蛋白胆固醇比率与死亡率的关系。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-21 DOI: 10.1186/s12944-025-02522-9
Zebin Wang, Sibing Huang, Na Tian, Qingdong Xu, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Ning Su, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Jianbo Liang, Jiao Li, Yueqiang Wen
{"title":"Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients.","authors":"Zebin Wang, Sibing Huang, Na Tian, Qingdong Xu, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Ning Su, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Jianbo Liang, Jiao Li, Yueqiang Wen","doi":"10.1186/s12944-025-02522-9","DOIUrl":"10.1186/s12944-025-02522-9","url":null,"abstract":"<p><strong>Background: </strong>In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein cholesterol (HDL-C) levels significantly influence clinical outcomes. Current clinical practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) and all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD and all-cause mortality rates among individuals receiving CAPD treatment.</p><p><strong>Methods: </strong>Between January 1, 2005 and December 31, 2016, a multi-center retrospective analysis of 2006 CAPD patients from five peritoneal dialysis hospitals in China was conducted. Participants were split into two subgroups in accordance with the baseline serum RC/HDL-C ratio restricted cubic spline cutoff value. The correlations between mortality and RC/HDL-C ratio were examined through case-specific hazard modeling.</p><p><strong>Results: </strong>The observation period documented 549 all-cause fatalities, with cardiovascular deaths accounting for 269 cases. The Kaplan-Meier analysis revealed statistically significant divergence in both all-cause mortality (log rank test P < 0.001) and CVD mortality (log rank test P = 0.003). Elevated RC/HDL-C ratios showed increased hazard ratios (HR) for all-cause mortality (1.335, 95% CI, 1.112-1.603, P = 0.002) and CVD mortality (1.319, 95% CI, 1.013-1.717, P = 0.040) compared to lower ratio counterparts. Nevertheless, no statistically meaningful association was found between CVD mortality and either RC (HR: 1.296, 95% CI, 0.992-1.691, P = 0.057) or HDL-C (HR: 0.887, 95% CI, 0.680-1.157, P = 0.376).</p><p><strong>Conclusion: </strong>The RC/HDL-C ratio independently predicts mortality in CAPD patients, persisting as a significant prognostic marker after multivariable adjustment.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"107"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Different profiles of fatty acids between leukocytes and whole blood in children with idiopathic nephrotic syndrome.
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02523-8
S Turolo, A Edefonti, M L Syren, W Morello, E A de Marco, A Berrettini, C Agostoni, G Montini
{"title":"Different profiles of fatty acids between leukocytes and whole blood in children with idiopathic nephrotic syndrome.","authors":"S Turolo, A Edefonti, M L Syren, W Morello, E A de Marco, A Berrettini, C Agostoni, G Montini","doi":"10.1186/s12944-025-02523-8","DOIUrl":"10.1186/s12944-025-02523-8","url":null,"abstract":"<p><p>Idiopathic nephrotic syndrome (INS) is the most common pediatric glomerular disease, characterized by proteinuria, hypoalbuminemia and edema and caused by an immune dysregulation of T and B cells. Fatty acids (FA) are involved in immune response, with omega-6 prevailing in pro-inflammatory states and omega-3 promoting anti-inflammatory effects. While previous studies of INS assessed FA profile in blood or serum, which may be influenced by many systemic and dietary factors, the intracellular FA metabolism in white blood cells of children with INS, critical to immune cell activation, remains still unexplored. This pilot study compares the FA profile within leukocytes (endo-leukocyte, EL) and whole blood in 35 children with INS and 34 matched controls. INS patients were stratified by steroid sensitivity vs. steroid resistance and by remission vs. proteinuric state. EL FA profiles were analyzed via gas chromatography and dietary habits were evaluated by the Kid Med questionnaire. While blood FA profile of patients demonstrated both elevated omega-6 and omega-3 levels (P-value < 0.005), EL show an inflammatory dominance, with increased omega-6 (P-value < 0.005), but similar omega-3 levels, compared to controls. Furthermore, EL profiles showed reduced saturated FA and palmitic acid but elevated oleic acid levels (P-value < 0.005), possibly indicating a compensatory anti-inflammatory response. This study suggests that EL FA profile may provide unique insights into intracellular mechanisms of inflammation in INS, complementing data arising from blood FA analysis. Despite some limitations, including the small sample size, the study of FA inside the cellular population directly involved in INS underscores its potential in increasing diagnostic precision of FA anomalies in the course of nephrotic syndrome. This new approach may also represent the prerequisite for a clearcut evaluation of the effectiveness of pharmacologic and dietary therapies, like the supplementation with omega 3 metabolites and a diet rich in omega-3.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"106"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women. 更正:血浆致动脉粥样硬化指数与不孕症之间的关系:一项基于美国女性的横断面研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02532-7
Zihong Bao, Yanmei Zhang, Ju Zhou, Zhikun Dai
{"title":"Correction: Association between atherogenic index of plasma and infertility: a cross-sectional study based on U.S. women.","authors":"Zihong Bao, Yanmei Zhang, Ju Zhou, Zhikun Dai","doi":"10.1186/s12944-025-02532-7","DOIUrl":"10.1186/s12944-025-02532-7","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"104"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study. 红细胞脂肪酸组成与食管癌风险之间的关系:一项基于医院的病例对照研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02531-8
Hongming Yin, Yongjin Wang, Yujia Chen, Qayyum Shehzad, Feng Xiao
{"title":"Association between red blood cell fatty acids composition and risk of esophageal cancer: a hospital-based case-control study.","authors":"Hongming Yin, Yongjin Wang, Yujia Chen, Qayyum Shehzad, Feng Xiao","doi":"10.1186/s12944-025-02531-8","DOIUrl":"10.1186/s12944-025-02531-8","url":null,"abstract":"<p><strong>Background: </strong>& aims: Esophageal cancer (EC) is a tumor type with high invasiveness and poor prognosis, attracting scientists' attention to its pathogenesis and etiology. Given the limited evidence and conflicting findings regarding the association between EC risk and RBC fatty acids, we aimed to evaluate this association.</p><p><strong>Methods: </strong>The study utilized gas chromatography to analyze RBC fatty acids in 158 EC patients and 224 controls. Multivariable conditional logistic regression and restricted cubic spline analysis were employed to assess the association between EC risk and RBC fatty acids, as well as to determine the odds ratio with a 95% confidence interval (OR, 95% CI) for this association.</p><p><strong>Results: </strong>Higher levels of total n-3 polyunsaturated fatty acids (n-3 PUFA), docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 index were associated with lower odds of being an EC case [OR<sub>T3-T1</sub> = 0.22 (0.12-0.41), OR<sub>T3-T1</sub> = 0.29 (0.15-0.54), OR<sub>T3-T1</sub> = 0.49 (0.27-0.88), and OR<sub>T3-T1</sub> = 0.19 (0.09-0.35), respectively]. Total saturated fatty acids (SFA), particularly palmitic acid (C16:0), stearic acid (C18:0), and arachidonic acid (C20:4n-6) in high concentrations, were associated with higher odds of being an EC case [OR<sub>T1-T3</sub> = 2.02 (1.11-3.70), OR<sub>T1-T3</sub> = 2.10 (1.15-3.87), OR<sub>T1-T3</sub> = 2.82 (1.53-5.30), and OR<sub>T1-T3</sub> = 2.07 (1.12-3.86), respectively]. Total monounsaturated fatty acids (MUFA) and total trans fatty acids (TFA) showed no significant association with EC case status.</p><p><strong>Conclusion: </strong>The different types of RBC fatty acids may significantly influence susceptibility to EC. Higher levels of total n-3 PUFA in RBC, specifically DHA and EPA, were associated with lower odds of being an EC case, while higher levels of C20:4n-6, C18:0, and C16:0 were associated with higher odds.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"101"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients.
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02530-9
Bowen Wang, Liping Zuo, Jinlei Fan, Wei Zhao, Yueming An, Wangshu Cai, Deixin Yu
{"title":"Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients.","authors":"Bowen Wang, Liping Zuo, Jinlei Fan, Wei Zhao, Yueming An, Wangshu Cai, Deixin Yu","doi":"10.1186/s12944-025-02530-9","DOIUrl":"10.1186/s12944-025-02530-9","url":null,"abstract":"<p><strong>Background: </strong>Hypertension and obesity are common in systemic lupus erythematosus (SLE) patients, with obesity-related changes potentially driving hypertension. However, the specific adiposity measures associated with hypertension in SLE patients remain unclear. This study assessed the association between myosteatosis and sarcopenia detected on abdominal CT and hypertension in SLE patients. Mediators of the association between myosteatosis and hypertension were also investigated.</p><p><strong>Methods: </strong>This was a retrospective study involving SLE patients enrolled from January 2017 to August 2023 and who underwent abdominal CT at the L3 level to track myosteatosis and sarcopenia based on the skeletal muscle mean radiodensity (SMD) and skeletal muscle index considered as binary and continuous variables. The association between these body composition measures and hypertension was tested using logistic regression analyses, while mediation modeling was used to assess the mediators.</p><p><strong>Results: </strong>A total of 279 adult SLE patients (median age, 41.00 [30.00, 51.00] years; 245 women) were included in this study. Hypertension was associated with myosteatosis (adjusted OR: 3.54; 95% CI: 1.18-10.61 for the binary variable and 1.31; 95% CI: 1.02-1.68 for the continuous variable). No statistically significant association was observed between hypertension and sarcopenia (adjusted OR: 0.48; 95%CI: 0.23-1.01 for the binary variable and 0.95; 95%CI: 0.78-1.16 for the continuous variable). Mediation analyses revealed eGFR could mediate the association between myosteatosis (considered as a continuous variable) and hypertension in SLE patients when taken alone (95% CI: 0.0177-0.2765) or in combination with the TyG index (95% CI: 0.0032-0.0614).</p><p><strong>Conclusions: </strong>Myosteatosis was associated with hypertension in SLE patients. eGFR alone or in combination with the TyG index may mediate this association.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"105"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study. MASLD 患者的 FIB-4 指数与下肢动脉疾病之间的关系:一项横断面研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02516-7
Chunxia Zhang, Yuchen Ying, Yuanhui Ru, Ziliang Wu, Yumeng Tian, Pingping Shen, Shiyuan Cao, Jing Zhang, Ri Liu
{"title":"Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study.","authors":"Chunxia Zhang, Yuchen Ying, Yuanhui Ru, Ziliang Wu, Yumeng Tian, Pingping Shen, Shiyuan Cao, Jing Zhang, Ri Liu","doi":"10.1186/s12944-025-02516-7","DOIUrl":"10.1186/s12944-025-02516-7","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an elevated risk of cardiovascular conditions, such as lower extremity arterial disease (LEAD). The Fibrosis-4 (FIB-4) index, a non-invasive marker of liver fibrosis, may have predictive value for LEAD in patients with MASLD. This study aimed to explore the association between FIB-4 and LEAD in a cohort of patients with MASLD.</p><p><strong>Methods: </strong>This cross-sectional study included 481 participants with MASLD, selected from a comprehensive health check-up database. Participants were categorized into three groups based on their FIB-4 index (< 1.3, 1.3-2.66, > 2.66) and underwent duplex ultrasonography to diagnose LEAD. Logistic regression models were employed to evaluate the association between FIB-4 and LEAD, adjusting for demographic, metabolic, and lipid-related factors. Subgroup analyses were performed by sex, age, diabetes mellitus status, hypertension, dyslipidemia, smoking status.</p><p><strong>Results: </strong>The prevalence of LEAD increased with FIB-4 levels, from 51.3% in the low FIB-4 group to 86.5% in the high FIB-4 group (p < 0.001). In fully adjusted models, higher FIB-4 levels were significantly associated with LEAD (adjusted odds ratio [OR]: 3.54, 95% confidence interval [CI]: 1.39-9.01) in the high FIB-4 group compared to the low group. As a continuous variable, each unit increase in FIB-4 was associated with a 66% higher likelihood of LEAD (adjusted OR: 1.66, 95% CI: 1.12-2.26, P < 0.001). Subgroup analyses did not reveal significant interactions (P for interaction > 0.05).</p><p><strong>Conclusions: </strong>Higher FIB-4 levels are independently associated with the prevalence of LEAD in MASLD patients, although subgroup analyses did not reveal significant interactions. This suggests that further studies with larger sample sizes are needed to explore these relationships more comprehensively.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"103"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-20 DOI: 10.1186/s12944-025-02513-w
Alessandro Medoro, Francesca Graziano, Gaetano Cardinale, Serena Voccola, Tiziana Zotti, Mariano Intrieri, Giovanni Scapagnini, Sergio Davinelli
{"title":"The influence of FADS1 and ELOVL2 genetic polymorphisms on polyunsaturated fatty acid composition in response to fish oil supplementation.","authors":"Alessandro Medoro, Francesca Graziano, Gaetano Cardinale, Serena Voccola, Tiziana Zotti, Mariano Intrieri, Giovanni Scapagnini, Sergio Davinelli","doi":"10.1186/s12944-025-02513-w","DOIUrl":"10.1186/s12944-025-02513-w","url":null,"abstract":"<p><strong>Background: </strong>Unhealthy dietary habits have been recognized as key contributors to the increasing incidence of non-communicable diseases. Among the healthy nutrients studied, omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have received considerable attention for their benefits in cardiovascular health and inflammation management. Their synthesis is regulated by enzymes encoded by FADS1 and ELOVL2 genes. Single nucleotide polymorphisms (SNPs) within these genes can modify the efficiency of fatty acid conversion, thereby influencing the Omega-3 Index, which reflects omega-3 status, particularly EPA and DHA. This study aimed to assess the impact of FADS1 (rs174537) and ELOVL2 (rs953413) polymorphisms on the effects on fatty acids profiles of fish oil supplementation in healthy individuals.</p><p><strong>Methods: </strong>Eighty-six healthy adults aged 20-70 participated in a quasi-experimental intervention involving a 4-week fish oil supplementation rich in EPA and DHA. Dried-blood spots (DBS) were collected before and after the intervention to evaluate lipid profiles. Genotyping for FADS1 and ELOVL2 SNPs was performed using high-resolution melting analysis.</p><p><strong>Results: </strong>Post-supplementation, the percentage of EPA and DHA increased significantly (p < 0.001), leading to an improved Omega-3 Index. Baseline omega-3 percentages did not differ significantly between FADS1 and ELOVL2 genotypes. However, individuals with the ELOVL2 minor allele (GA + AA) genotype benefited more from the fish oil supplementation with increased EPA and DBS Omega-3 Index, indicating a more favorable metabolic response.</p><p><strong>Conclusions: </strong>Genetic variability may influence the metabolic response to fish oil supplementation. These findings underscore the importance of personalized nutrition strategies to optimize health outcomes and prevent non-communicable diseases.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"102"},"PeriodicalIF":3.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum.
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-19 DOI: 10.1186/s12944-024-02420-6
Silmara de Melo Carmona, Daniele Pereira Jardim, Maria Aparecida Dalboni, Renata Nakamichi, Mariana Kuniyoshi, Mauro Marrocos, Beata Marie Redublo Quinto, Marcelo Costa Batista
{"title":"Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum.","authors":"Silmara de Melo Carmona, Daniele Pereira Jardim, Maria Aparecida Dalboni, Renata Nakamichi, Mariana Kuniyoshi, Mauro Marrocos, Beata Marie Redublo Quinto, Marcelo Costa Batista","doi":"10.1186/s12944-024-02420-6","DOIUrl":"10.1186/s12944-024-02420-6","url":null,"abstract":"<p><p>The high incidence of cardiovascular events in chronic kidney disease (CKD) exhibits an epidemic character, affecting patients in predialysis, hemodialysis, and post-transplant stages, accounting for approximately 50% of deaths, with a mortality rate around 9% per year. Statins are primarily used in the treatment of dyslipidemia and possess pleiotropic effects that are not yet fully understood. Moreover, there is insufficient evidence to support their use in attenuating cardiovascular outcomes or their potential role in modulating the ABCA-1 transporter in CKD. Thus, the aim of this study was to investigate the effect of statins on ABCA-1 modulation in cultures of human umbilical vein endothelial cells (HUVEC) incubated with uremic serum from CKD patients. The results demonstrate that statins influence the inflammatory response of HUVEC exposed to a uremic environment by reducing TNF-α secretion compared to baseline levels. Furthermore, the uremic environment was found to decrease the expression of LxR-β and RxR-α, leading to a consequent reduction in ABCA-1 expression in HUVEC. Cells pre-treated with simvastatin exhibited increased expression of ABCA-1, LxR-β, and RxR-α, along with a significant increase in the transcription of ABCA-1, LXR-β, and RxR-α, indicating that statins may exert a positive modulation on LxR-β and RxR-α receptors, activating ABCA-1 transcription.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"100"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding metabolic connections: the role of salivary amylase activity in modulating visceral fat and triglyceride glucose index.
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-18 DOI: 10.1186/s12944-025-02524-7
Gita Erta, Gita Gersone, Antra Jurka, Peteris Tretjakovs
{"title":"Decoding metabolic connections: the role of salivary amylase activity in modulating visceral fat and triglyceride glucose index.","authors":"Gita Erta, Gita Gersone, Antra Jurka, Peteris Tretjakovs","doi":"10.1186/s12944-025-02524-7","DOIUrl":"10.1186/s12944-025-02524-7","url":null,"abstract":"<p><strong>Background: </strong>Salivary amylase activity (SAA) is recognized as a potential biomarker for metabolic health. Previous studies suggest an association between SAA and insulin sensitivity, but the mechanisms remain unclear. This study investigates the relationship between SAA, visceral fat (VF), and the triglyceride-glucose (TyG) index to clarify the pathways linking SAA to metabolic risk factors.</p><p><strong>Methods: </strong>This cross-sectional study analysed data from women of reproductive age who were classified as overweight. Linear regression models were used to assess associations between salivary amylase activity (SAA), visceral fat (VF) and the triglyceride-glucose (TyG) index, while adjusting for confounding variables such as age, body mass index (BMI), physical activity and dietary patterns. Mediation analysis was conducted to determine whether VF mediates the relationship between SAA and the TyG index.</p><p><strong>Results: </strong>Higher SAA was inversely associated with VF (β = -0.45, 95% CI: -0.65 to -0.25, p < 0.001). No direct association was observed between SAA and TyG index (β = -0.10, 95% CI: -0.25 to 0.05, p = 0.18) after adjustment for covariates. Mediation analysis revealed that visceral fat significantly mediated the relationship between SAA and the TyG index. The indirect effect of SAA on the TyG index through VF (A × B) was statistically significant (β = -0.16, 95% CI: -0.26 to -0.08), accounting for 45% of the total effect.</p><p><strong>Conclusions: </strong>These findings suggest that higher SAA may confer metabolic benefits by reducing VF, thereby indirectly influencing the TyG index. This highlights the critical role of VF in mediating the protective effects of SAA on metabolic health and provides insights into potential pathways for intervention.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"98"},"PeriodicalIF":3.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep duration as a mediator in the association between dietary intake of live microbes and insulin resistance: a cross-sectional study. 睡眠时间是膳食中活微生物摄入量与胰岛素抵抗之间关系的调解因素:一项横断面研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2025-03-18 DOI: 10.1186/s12944-025-02507-8
Lei Peng, Yanmei Liu, Yujun Deng, Jianan Jing, Gaohuang Chen, Yang Liu, Maofeng Wu, Jinduan Lin, Weiguo Yin
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