Lipids in Health and Disease最新文献

{"title":"Baseline self-reported supplement category use and two-visit difference in lipoprotein(a): an observational analysis in UK Biobank.","authors":"Ying Sun, Yuefeng Yu, Lingli Cai, Kun Zhang, Xiao Tan, Yingli Lu, Yuying Wang, Ningjian Wang","doi":"10.1186/s12944-026-03010-4","DOIUrl":"10.1186/s12944-026-03010-4","url":null,"abstract":"<p><strong>Background: </strong>Circulating Lp(a) is largely genetically determined, but repeated measurements indicate that Lp(a) concentrations may differ within individuals over time. It remains unclear whether self-reported use of common supplement categories is associated with differences between repeated Lp(a) measurements. We aimed to investigate associations between baseline self-reported supplement-category use and two-visit difference in Lp(a), and to explore whether these associations differed by Lp(a) genetic risk.</p><p><strong>Methods: </strong>We included 12,109 UK Biobank participants with Lp(a) measured at baseline and at the first repeat assessment. Self-reported use of common supplement categories (vitamins A, B, C, D, E, folate, and multi-vitamins) was assessed by questionnaire. The primary outcome was the continuous two-visit difference in log10[Lp(a)], defined as log10[repeat-assessment Lp(a)] minus log10[baseline Lp(a)]. The primary analysis used core behavioral/sociodemographic-adjusted multivariable linear regression. Threshold-category and genetic-risk analyses were secondary and exploratory.</p><p><strong>Results: </strong>Among 12,109 participants with repeated Lp(a) measurements over a median 4.4 years, estimates in the primary core behavioral/sociodemographic-adjusted continuous log-scale model were small and centered near the null, ranging from β = -0.014 to 0.005 log10 units, corresponding to approximately - 3.18% to 1.22% relative difference in the conditional repeat-to-baseline Lp(a) ratio. None met the Bonferroni-corrected threshold. Expanded clinical/genetic adjustment and secondary descriptive screens did not alter the null interpretation.</p><p><strong>Conclusions: </strong>In this selected repeat-assessment sample, baseline self-reported use of common supplement categories was not associated with two-visit difference in log10[Lp(a)]. Because supplement use was measured only as broad baseline self-reported categories, these findings should not be interpreted as evidence about dose-specific, sustained, or biological effects of vitamin supplementation on Lp(a).</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of hypertension and remnant cholesterol on arterial stiffness in Chinese middle-aged and elderly populations.","authors":"Fuliang Yi, Xuena Zou, Wenzhu Song, Xin Liu, Yujuan Ying, Qiaojin Xie, Yang Gao","doi":"10.1186/s12944-026-03006-0","DOIUrl":"10.1186/s12944-026-03006-0","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Arterial stiffness (AS) is a critical pathological basis for major cardiovascular diseases (CVD), with its progression closely associated with modifiable risk factors such as hypertension and dyslipidemia. Remnant cholesterol (RC), a key dyslipidemia indicator, is increasingly recognized for its cardiovascular risk predictive value independent of low-density lipoprotein cholesterol (LDL-C). This study explored the independent and additive interactive associations of hypertension and RC with AS in a Chinese middle-aged and elderly population, so as to provide evidence-based support for the prevention and management of cardiovascular diseases in this high-risk population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted on 6,886 middle-aged and elderly participants (≥ 45 years) who underwent health examinations at the Health Management Center of Zigong Fourth People's Hospital from January to December 2023. All participants completed measurements of brachial-ankle pulse wave velocity (baPWV) for AS assessment, blood pressure, blood lipids, and other biochemical indicators. Participants were stratified into the AS group (baPWV ≥ 1800 cm/s) and normal group (baPWV &lt; 1800 cm/s). Multiple analytical approaches were used to analyze the relationship between hypertension, RC and AS: multivariable logistic regression models (adjusted for age, gender, BMI, smoking history, drinking history, diabetes, and other confounding factors) were applied to evaluate their independent and joint effcets with AS; participants were further divided into four subgroups (low RC without hypertension, high RC without hypertension, low RC with hypertension, high RC with hypertension) to assess the interaction of the two factors on AS risk; additive interaction models were constructed to quantify their additive interaction; restricted cubic spline (RCS) models were used to explore the non-linear relationship between blood pressure and AS risk and to identify apparent inflection points within the study population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 6,886 participants, 4,702 (68.3%) were identified with AS. Both hypertension and elevated RC were independently associated with an increased odds of AS (P &lt; 0.001). Participants with both hypertension and high RC exhibited the highest risk of AS (OR = 3.50, 95% CI: 2.66-4.61) compared to the low RC without hypertension. A additive interaction between hypertension and elevated RC on AS was observed, with the relative excess risk due to interaction (RERI) = 1.21 (95% CI: 0.13-2.23). The RCS model identified apparent inflection points around 127 mmHg for systolic blood pressure (SBP) and 84 mmHg for diastolic blood pressure (DBP), where the risk of AS appeared to increase more rapidly within the study population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This study identified an additive interaction between hypertension and elevated RC in relation to AS among middle-aged and elderly Ch","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint effects of depression, lipid metabolic dysfunction, and their trajectories on incident cardiometabolic multimorbidity: a prospective multi-cohort analysis from two national cohorts.","authors":"Yupeng Zeng, Qiuqiu Wang, Hui He, Weiqing Wu, Qingshan Geng","doi":"10.1186/s12944-026-03008-y","DOIUrl":"10.1186/s12944-026-03008-y","url":null,"abstract":"<p><strong>Background: </strong>Cardiometabolic multimorbidity (CMM) imposes a growing public health burden on middle-aged and older adults. Depression and lipid metabolic dysfunction are modifiable risk factors for CMM, yet their joint effects and dynamic co-trajectories on CMM risk across diverse ageing populations remain poorly understood.</p><p><strong>Methods: </strong>This prospective multicohort study used individual-level data from the China Health and Retirement Longitudinal Study (CHARLS) and the English Longitudinal Study of Ageing (ELSA). Two analytical risk sets were defined to support static and dynamic analyses. Metabolic status was assessed using the atherogenic index of plasma (AIP) and remnant cholesterol (RC); depressive symptoms were measured by the Centre for Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards regression, counterfactual population attributable fractions (PAF), interaction analyses, and trajectory analyses were applied to examine associations between depression, metabolic status, and incident CMM. Multiple sensitivity analyses confirmed robustness.</p><p><strong>Results: </strong>Depression and metabolic dysfunction each independently increased CMM risk, and their co-occurrence conferred the highest risk (AIP, fully adjusted: CHARLS HR = 1.71, 95% CI 1.45-2.01; ELSA HR = 1.55, 95% CI 1.26-1.89), with consistent findings for RC. In the dynamic analysis, persistent co-exposure to elevated metabolic burden and depression was associated with the greatest CMM risk in CHARLS (HR = 2.78, 95% CI 1.73-4.45), with a consistent directional pattern in ELSA.</p><p><strong>Conclusions: </strong>Depression and lipid metabolic dysfunction independently and jointly increase incident CMM risk across two nationally representative ageing cohorts. Integrating mental health screening and metabolic assessment into CMM primary prevention may offer meaningful reductions in disease burden across diverse ageing populations.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of altered HDL2b/HDL3 ratio on the function of innate immune cells in sepsis.","authors":"Shubi Zhao, Yichun Jiang, Puqiao Lian, Chaoguang Ji, Zewei Huang, Xueyan Liu","doi":"10.1186/s12944-026-03005-1","DOIUrl":"10.1186/s12944-026-03005-1","url":null,"abstract":"<p><strong>Background: </strong>Sepsis is characterized by dysregulated immunologic reactions to infectious insults, representing a main cause of death for seriously ill patients. Studies have demonstrated correlations between rapidly declined high-density lipoprotein (HDL) levels during initial sepsis phases with increased mortality and adverse clinical outcomes. Furthermore, HDL subcomponents, specifically HDL2b and HDL3, undergo significant alterations in composition in sepsis patients. This article was aimed at investigating the effects of alterations in the ratio of HDL2b to HDL3 (HDL2b/3) on the function of human umbilical vein endothelial cells (HUVECs) and monocyte-macrophages (THP-1 and RAW264.7 cells).</p><p><strong>Methods: </strong>Plasma samples were collected from 10 sepsis patients and 10 healthy controls. High-density lipoprotein (HDL) subclasses (HDL2b and HDL3) were separated and quantified using fast protein liquid chromatography (FPLC) and ELISA. Human monocytic leukemia cells (THP-1) and human umbilical vein endothelial cells (HUVECs) were co-incubated with different reconstituted ratios of HDL2b/3 under lipopolysaccharide (LPS) stimulation to evaluate cell viability, inflammatory cytokine expression, angiogenesis, and cell migration.</p><p><strong>Results: </strong>Our results showcase evidently reduced HDL2b/3 ratios for the sepsis group compared with their non-sepsis counterparts. Notably, HDL2b/3 from both groups attenuated the gene expression of lipopolysaccharide-stimulated inflammatory factors (interleukin-1β and tumor necrosis factor-α) within THP-1 cells, RAW264.7 cells, and HUVECs. Additionally, HDL2b/3 mitigated the detrimental effects of LPS on THP-1 and RAW264.7 cells.</p><p><strong>Conclusion: </strong>This research highlights that altered HDL subcomponent ratios can potentially modulate inflammation and cellular responses during sepsis.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of three metabolic biomarkers with the risk of cardiometabolic multimorbidity: a national prospective study.","authors":"Yan Jiang, Mengdie Liu, Hua Chen, Fengpei Zhang, Si Liu, Xin Li, Ting Guo, Zhiteng Xiong, Qihui Shen, Xiaoyun Xiong","doi":"10.1186/s12944-026-02986-3","DOIUrl":"10.1186/s12944-026-02986-3","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction is a key contributor to cardiometabolic diseases (CMD); however, its role in the development of cardiometabolic multimorbidity (CMM) remains insufficiently understood. Using data from the China Health and Retirement Longitudinal Study (CHARLS), this study examined the associations between three metabolic indices and the risk of developing CMM among Chinese adults, namely the triglyceride glucose index (TyG), the cholesterol-high-density lipoprotein-glucose index (CHG), and the C-reactive protein triglyceride glucose index (CTI).</p><p><strong>Methods: </strong>A total of 5,666 participants were included in this study. The associations between the three metabolic indices and incident CMM were estimated using Cox proportional hazards regression models with adjustment for relevant confounders. Restricted cubic spline analyses were performed to evaluate potential nonlinear associations. The discriminative performance of the metabolic indices was assessed using receiver operating characteristic (ROC) curves and the area under the curve (AUC). Subgroup analyses were conducted according to age and sex.</p><p><strong>Results: </strong>Incident CMM occurred in 473 of 5,666 participants (8.3%). Cox regression analyses showed that higher values of the TyG, CHG, and CTI indices were associated with an increased risk of CMM. Compared with participants in the lowest quartile, those in the highest quartiles of TyG and CTI had substantially higher risks of CMM, with HRs (95% CIs) of 2.10 (1.50-2.94) for TyG Q4 versus Q1 and 2.55 (1.82-3.57) for CTI Q4 versus Q1. In contrast, participants in CHG Q4 did not have a significantly higher risk of CMM than those in Q1, with an HR (95% CI) of 1.12 (0.85-1.48). No significant effect modification by age or sex was observed. ROC analyses indicated that CTI and composite indices incorporating CTI showed relatively better discriminative performance, with AUC values of 0.670 for CTI and 0.671 for the TyG-CTI index.</p><p><strong>Conclusions: </strong>The three metabolic indices were independently associated with an elevated risk of CMM, with composite indices incorporating CTI showing the strongest discriminative performance. These findings support the use of metabolic indices for early risk stratification and targeted interventions, thereby potentially contributing to healthier aging and reducing the societal burden of CMM.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declines in ovarian reserve associated with ambient ozone exposure: mediating role of lipid profile.","authors":"Yina Hu, Chenxi Zhao, Yanqing Deng, Abigail Solomon, Sydney Bell, Leizhen Xia, Lifeng Tian, Yan Zhao, Xiaoyan Ai, Haisheng Wu, Jialyu Huang","doi":"10.1186/s12944-026-03003-3","DOIUrl":"10.1186/s12944-026-03003-3","url":null,"abstract":"<p><strong>Background: </strong>Ambient ozone pollution represents a growing threat to public health. However, evidence regarding its association with ovarian reserve and the mediating mechanisms remains limited and inconsistent.</p><p><strong>Methods: </strong>This cross-sectional study included 8,233 women aged 20-45 who attended the Center for Reproductive Medicine at Jiangxi Maternal and Child Health Hospital between 2021 and 2023. Based on data from the Tracking Air Pollution in China project, ozone exposure was determined by assigning 10-km-resolution daily maximum 8-hour average ozone concentration to each participant's residential address. Serum anti-Müllerian hormone (AMH) levels were measured to evaluate ovarian reserve, with six distinct exposure periods defined according to the stages of female follicular development. Participants' lipid profiles were characterized by total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol and triglycerides. The ozone-AMH relationship was assessed using multivariable linear regression models, supplemented by stratified, mediation, and sensitivity analyses.</p><p><strong>Results: </strong>Each interquartile range increase in ozone concentration was linked to an 8.14% (95% confidence intervals [CI]: 3.09% to 12.93%) decrease in AMH levels during period 4. Compared with women aged 20-29 years, this ozone-related decline was less pronounced among women over 35 (P for interaction = 0.004). Among the four lipid indicators, TC mediated 11.415% of the association between ozone and AMH levels, while LDL-C accounted for 7.38%. Similar findings were observed for period 6, while no significant linear associations were identified across the other periods.</p><p><strong>Conclusion: </strong>Higher ambient ozone exposure is significantly linked to diminished ovarian reserve. This association is particularly evident during the developmental window from primary and secondary follicles to small antral follicle stage, with younger women showing greater susceptibility. To the best of current knowledge, this study provides the first evidence that alterations in lipid profiles may partially mediate this relationship, offering novel insights for protecting female reproductive health and informing environmental health interventions.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148330573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between glycolipid metabolism 7 factors (GLM7) and sarcopenia: insights from NHANES and CHARLS.","authors":"Yan Chen, Yujie Zhang, Wenyu Fan, Jing Gao, Xiaodong Feng","doi":"10.1186/s12944-026-03000-6","DOIUrl":"https://doi.org/10.1186/s12944-026-03000-6","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia is an age-related condition associated with metabolic dysfunction. The composite Glycolipid Metabolism 7 (GLM7) index may help quantify this association.</p><p><strong>Aim: </strong>To investigate association between the GLM7 and sarcopenia risk among middle-aged and older adults, and the predictive capability of GLM7.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from the US National Health and Nutrition Examination Survey (NHANES 2011-2018, n = 1,563). Survey-weighted multivariable logistic regression models were employed to assess the association, and restricted cubic splines (RCS) analysis was conducted to examine the dose-response relationship between GLM7 and the risk of sarcopenia. Sensitivity analyses included subgroup analysis, further medication adjustment and complete-case analysis. Predictive performance of GLM7 was evaluated using area under the receiver operating characteristic curve (AUC), and was validated in the China Health and Retirement Longitudinal Study (CHARLS, n = 7,387).</p><p><strong>Results: </strong>In NHANES, increase in GLM7 level was associated with higher odds of sarcopenia (fully-adjusted OR = 2.119, 95% CI: 1.319-3.406). A significant positive trend was observed across GLM7 quartiles (P for trend < 0.001). The association remained robust in sensitivity analyses and was significantly modified by sex (P for interaction < 0.001). The GLM7 index showed moderate predictive value in NHANES (test AUC = 0.756) and excellent performance in CHARLS (test AUC = 0.841).</p><p><strong>Conclusion: </strong>The GLM7 index is significantly associated with sarcopenia risk and demonstrates consistent predictive ability across diverse populations, suggesting its potential utility for risk screening.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factor analysis of early-onset dyslipidemia-a cross-sectional study of 3.7 million population.","authors":"Fen Liu, Liting Cai, Qian Zhao, Jing Tao, Yaoguo Wang, Juan Wang, Deyang Li, Junqing Xie, Xiaomei Li, Yining Yang","doi":"10.1186/s12944-026-03002-4","DOIUrl":"10.1186/s12944-026-03002-4","url":null,"abstract":"<p><strong>Background: </strong>China has a large population, and the prevalence of dyslipidemia varies across regions. The prevalence of dyslipidemia is closely associated with the increasing burden of cardiovascular disease. Currently, there is a lack of high-quality data on early-onset dyslipidemia in Northwest China. This study aims to comprehensively assess the prevalence and risk factors of early-onset dyslipidemia among adults in this region, providing epidemiological evidence for disease prevention and health promotion.</p><p><strong>Methods: </strong>This is a cross-sectional study based on the universal health check-up program conducted in northwestern China from January to December 2019. Adults (aged 18 to 65 years old) living in both rural and urban areas were included. Participants received a questionnaire survey, physical examination, and laboratory tests, including liver and kidney function, complete blood count, fasting blood glucose, and lipid profile.</p><p><strong>Result: </strong>This study included a total of 3,559,141 participants (43.2% male and 56.8% female). The prevalence of early-onset dyslipidemia was 25.7%, with hypercholesterolemia accounting for 3.6%, hypertriglyceridemia for 10.6%, elevated low-density lipoprotein cholesterol for 2.7%, and reduced high-density lipoprotein cholesterol for 14.5%. Abnormalities in a single lipid parameter were observed in 20.5% of participants, while abnormalities in two, three, and four lipid parameters were observed in 4.6%, 0.6%, and 0.1% of participants, respectively. Male sex, age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity were all significant risk factors for early-onset dyslipidemia.</p><p><strong>Conclusion: </strong>The age-standardized prevalence of early-onset dyslipidemia and its subtypes in Northwest China remains lower than the national level. Existing evidence consistently indicates that males, advancing age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity are independent risk factors for early-onset dyslipidemia. Therefore, systematic screening should be initiated for this population (< 40 years old), with stratified management involving enhanced lifestyle interventions combined with evidence-based lipid-lowering medications.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential associations of lipid profile and genetic susceptibility with sleep duration.","authors":"Zihao Zhang, Yuanyuan Zhang, Ziyi Peng, Yirong Yang, Kuan Ning, Yijia Chen, Yuhe Wu, Xuerui Yao, Hailun Wu, Yifan Wang, Hancun Yi, Dandan Tan, Tanxiu Chen, Daojun Hong, Wen-Quan Zou","doi":"10.1186/s12944-026-02998-z","DOIUrl":"10.1186/s12944-026-02998-z","url":null,"abstract":"<p><strong>Background: </strong>Lipid metabolism is influenced by multiple factors, and its association with sleep duration may vary across lipid fractions. Lipid levels and their genetic susceptibility have been associated with sleep duration; however, these associations are heterogeneous, and it remains unclear whether specific lipid components exhibit more consistent associations with sleep duration.</p><p><strong>Methods: </strong>This study included 410,493 participants from the UK Biobank. Multivariable linear regression (MLR) was used to assess the associations of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) with sleep duration. Polygenic risk scores (PRSs) were incorporated to evaluate genetic susceptibility. Interaction terms between lipid levels and PRSs were included in multivariable models. Cox proportional hazards models were used to examine the associations of lipid levels and PRSs with sleep disorders. Joint exposure analyses of lipid levels and PRSs were performed, and interaction effects were assessed. Restricted cubic spline models were further applied to evaluate potential non-linear associations. Proteomic analyses were conducted to explore proteomic features associated with both lipid profile and sleep duration.</p><p><strong>Results: </strong>MLR analyses showed that TG levels were positively associated with sleep duration (β = 0.027, P < 0.001), whereas TC levels were inversely associated with sleep duration (β = -0.005, P = 0.005). No significant association was observed for LDL. In contrast, PRSs for TG, TC, and LDL were consistently inversely associated with sleep duration. A significant interaction was observed between TG and their PRS (β = -0.009, p < 0.001). TG and PRS-TG were associated with higher risks of sleep disorders (6.9% and 3.2% per unit increase), with a significant interaction (p = 0.014). Elevated risks were observed in high TG groups, while TC and LDL were not significant. Both lipid traits and sleep duration were mainly enriched in immune and inflammatory pathways.</p><p><strong>Conclusions: </strong>Triglycerides showed the most consistent associations with sleep duration, and TG-related genetic susceptibility may influence TG levels and their associations with sleep duration and sleep disorders.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yearly attained adherence to Mediterranean diet, estimated trajectories of lipid profile from 60 to 80 years, and onset of clinical dyslipidemias in older adults at high cardiovascular risk.","authors":"Álvaro Hernáez, Camille Lassale, Viviana Sandoval, Emilio Ros, Emilio Ortega, Xavier Pintó, Olga Castañer, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Ramón Estruch, Juan Timiraos, José Lapetra, Miquel Fiol, Enrique Gómez-Gracia, Lluis Serra-Majem, Karla Alejandra Pérez-Vega, Estefanía Toledo, José V Sorlí, Nancy Babio, Montserrat Fitó","doi":"10.1186/s12944-026-02999-y","DOIUrl":"10.1186/s12944-026-02999-y","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association between yearly attained adherence to a Mediterranean diet (MedDiet) and trajectories of triglycerides, high-density lipoprotein cholesterol (HDL-C), and the low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio, as well as the risk of clinically relevant dyslipidemias, in adults aged 60-80 at high cardiovascular risk.</p><p><strong>Methods: </strong>In 4,954 participants (68.1 ± 5.5 years, 62% women, median follow-up: 4 years) from the Prevención con Dieta Mediterránea trial, trajectories of triglycerides, HDL-C, and LDL-C/HDL-C were compared between participants with high or low cumulative adherence to the MedDiet (≥ 10 vs. <10 points) over time. The association between high MedDiet adherence and the risk of five dyslipidemias (triglycerides ≥ 150 or ≥ 200 mg/dL; low HDL-C; LDL-C ≥ 130 or ≥ 160 mg/dL) was examined using multivariable Cox regressions.</p><p><strong>Results: </strong>Compared with low adherence to the MedDiet, high adherence was associated with lower triglycerides (differences in the range: -6 to -12 mg/dL), particularly among individuals using triglyceride-lowering medications (-17 to -41 mg/dL). High adherence was also associated with higher HDL-C (+ 0.8 to + 2.3 mg/dL) and lower LDL-C/HDL-C ratio. High adherence to the MedDiet was associated with a lower risk of all dyslipidemias (range: -21% to -45%). One-point increases in adherence were associated with a 48-91% lower dyslipidemia risk among individuals with low adherence (< 8 points).</p><p><strong>Conclusion: </strong>In adults aged 60-80 at high cardiovascular risk, greater long-term adherence to a MedDiet was associated with a better lipid profile and a lower risk of clinically relevant dyslipidemias.</p><p><strong>Trial registration number: </strong>ISRCTN35739639 (registration date: Oct 5, 2005).</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13505054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}