Lipids in Health and Disease最新文献

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Relationship between Ikigai and longitudinal changes in serum HDL cholesterol levels: the Circulatory Risk in Communities Study (CIRCS). Ikigai 与血清高密度脂蛋白胆固醇水平纵向变化之间的关系:社区循环风险研究 (CIRCS)。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-28 DOI: 10.1186/s12944-024-02256-0
Shiori Ikeda, Ai Ikeda, Kazumasa Yamagishi, Isao Muraki, Takumi Matsumura, Tomomi Kihara, Tomoko Sankai, Midori Takada, Takeo Okada, Masahiko Kiyama, Hironori Imano, Hiroyasu Iso, Takeshi Tanigawa
{"title":"Relationship between Ikigai and longitudinal changes in serum HDL cholesterol levels: the Circulatory Risk in Communities Study (CIRCS).","authors":"Shiori Ikeda, Ai Ikeda, Kazumasa Yamagishi, Isao Muraki, Takumi Matsumura, Tomomi Kihara, Tomoko Sankai, Midori Takada, Takeo Okada, Masahiko Kiyama, Hironori Imano, Hiroyasu Iso, Takeshi Tanigawa","doi":"10.1186/s12944-024-02256-0","DOIUrl":"10.1186/s12944-024-02256-0","url":null,"abstract":"<p><strong>Background: </strong>Having positive psychological well-being has been associated with serum high-density lipoprotein cholesterol (HDLC), but no longitudinal study to date has examined the association between Ikigai and serum HDLC. Therefore, we examined the association between Ikigai and change in serum HDLC over time using a cohort dataset spanning 2010-2018.</p><p><strong>Methods: </strong>The study included 471 men and 776 women aged 40-74 years who underwent a cardiovascular examination in 2010 and were asked their levels of Ikigai. We combined \"definitely yes\" and \"yes\" as \"with Ikigai\" and recorded \"a little\" as \"with a little Ikigai\" and \"no\" as \"without Ikigai\". We measured serum HDLC using direct methods. The association between Ikigai and serum HDLC levels at baseline, and changes in this relationship during an eight-year period, were analyzed using linear mixed-effect models.</p><p><strong>Results: </strong>At the baseline, relative to those without Ikigai, women with Ikigai had higher serum HDLC (baseline difference in those with a little Ikigai = 7.52 mg/dl, 95% confidence interval [CI]: 1.12 to 13.9 and in those with Ikigai = 8.11 mg/dl, 95% CI: 1.54 to 14.7). The difference in serum HDLC between women with and without Ikigai remained over the eight-year follow-up period. There were no similar Ikigai-associated differences in the serum HDLC of men.</p><p><strong>Conclusions: </strong>Women with Ikigai showed differences in serum HDLC that were observed at baseline and persisted over time.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome-wide association study for metabolic syndrome reveals APOA5 single nucleotide polymorphisms with multilayered effects in Koreans. 代谢综合征全基因组关联研究揭示了韩国人具有多层影响的 APOA5 单核苷酸多态性。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-28 DOI: 10.1186/s12944-024-02248-0
Young Jun Park, Sungji Moon, Jaeyong Choi, Juhyun Kim, Hyun-Jin Kim, Ho-Young Son, Sun-Wha Im, Jong-Il Kim
{"title":"Genome-wide association study for metabolic syndrome reveals APOA5 single nucleotide polymorphisms with multilayered effects in Koreans.","authors":"Young Jun Park, Sungji Moon, Jaeyong Choi, Juhyun Kim, Hyun-Jin Kim, Ho-Young Son, Sun-Wha Im, Jong-Il Kim","doi":"10.1186/s12944-024-02248-0","DOIUrl":"10.1186/s12944-024-02248-0","url":null,"abstract":"<p><strong>Background and purpose: </strong>Genome-wide association studies (GWAS) of metabolic syndrome (MetS) have predominantly focused on non-Asian populations, with limited representation from East Asian cohorts. Moreover, previous GWAS analyses have primarily emphasized the significance of top single nucleotide polymorphisms (SNPs), poorly explaining other SNP signals in linkage disequilibrium. This study aimed to reveal the interaction between rs651821 and rs2266788, the principal variants of apolipoprotein A5 (APOA5), within the most significant loci identified through GWAS on MetS.</p><p><strong>Methods: </strong>GWAS on MetS and its components was conducted using the data from the Korean Genome and Epidemiology Study (KoGES) city cohort comprising 58,600 individuals with available biochemical, demographic, lifestyle factors, and the most significant APOA5 locus was analyzed further in depth.</p><p><strong>Results: </strong>According to GWAS of MetS and its diagnostic components, a significant association between the APOA5 SNPs rs651821/rs2266788 and MetS/triglycerides/high-density lipoprotein phenotypes was revealed. However, a conditional analysis employing rs651821 unveiled a reversal in the odds ratio for rs2266788. Therefore, rs651821 and rs2266788 emerged as independent and opposing signals in the extended GWAS analysis, i.e., the multilayered effects. Further gene-environment interaction analyses regarding lifestyle factors such as smoking, alcohol consumption, and physical activity underscored these multilayered effects.</p><p><strong>Conclusion: </strong>This study unveils the intricate interplay between rs651821 and rs2266788 derived from MetS GWAS. Removing the influence of lead SNP reveals an independent protective signal associated with rs2266788, suggesting a multilayered effect between these SNPs. These findings underline the need for novel perspectives in future MetS GWAS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20-59: a population-based study in the United States. 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率 (NHHR) 与 20-59 岁成年人肌肉质量低之间的关系:一项基于美国人口的研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-28 DOI: 10.1186/s12944-024-02243-5
Jia-Qi Hao, Zi-Xuan Zhuang, Shu-Yue Hu, Yu-Jie Zhang, Jia-Wan Zhang, Feng-Jun He, Rui Wang, Wen Zhuang, Mo-Jin Wang
{"title":"The association between non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) and low muscle mass in adults aged 20-59: a population-based study in the United States.","authors":"Jia-Qi Hao, Zi-Xuan Zhuang, Shu-Yue Hu, Yu-Jie Zhang, Jia-Wan Zhang, Feng-Jun He, Rui Wang, Wen Zhuang, Mo-Jin Wang","doi":"10.1186/s12944-024-02243-5","DOIUrl":"10.1186/s12944-024-02243-5","url":null,"abstract":"<p><strong>Background: </strong>The ratio between non-high-density lipoprotein cholesterol and high-density lipoprotein cholesterol (NHHR) is a reliable marker for assessing the risk linked to lipid metabolism disorders. Sarcopenia, characterized by age-related loss of muscle mass and strength/function, includes the assessment of muscle mass, muscle strength, and muscle-specific strength. However, research into NHHR's relationship with low muscle mass risk remains unexplored.</p><p><strong>Methods: </strong>Our study utilized a cross-sectional approach, examining data derived from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. Through multivariable linear and logistic regression, we investigated the relationships of the NHHR with muscle mass and low muscle mass. We visualized the results using smoothing curves and assessed threshold effects. We also performed various subgroup and sensitivity analyses.</p><p><strong>Results: </strong>This research encompassed 9,012 participants and demonstrated significant nonlinear associations between NHHR and ALM<sub>BMI</sub> or low muscle mass risk in a generalized additive model (GAM), pinpointing critical NHHR values (3.328 and 3.367) where changes in NHHR significantly impacted ALM<sub>BMI</sub> and low muscle mass risk.</p><p><strong>Conclusions: </strong>The NHHR demonstrates a significant association with an increased risk of low muscle mass among middle-aged Americans. This ratio has potential as a predictive marker for low muscle mass. Further exploration of NHHR is expected to aid in advancing preventive and therapeutic measures for this condition.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hyperuricemia in cancer patients: evidence from NHANES 2007-2018. 癌症患者非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与高尿酸血症之间的非线性关系:来自 2007-2018 年 NHANES 的证据。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-26 DOI: 10.1186/s12944-024-02261-3
Ran He, Qilei Zhu, Youjun Ye, Shuaihang Chen, Changsheng Xie
{"title":"Nonlinear association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hyperuricemia in cancer patients: evidence from NHANES 2007-2018.","authors":"Ran He, Qilei Zhu, Youjun Ye, Shuaihang Chen, Changsheng Xie","doi":"10.1186/s12944-024-02261-3","DOIUrl":"10.1186/s12944-024-02261-3","url":null,"abstract":"<p><strong>Background: </strong>Evidence shows that cancer patients are more likely to have hyperuricemia (HUA) compared to the general population, with lipid metabolism playing a significant role. However, it is still unclear whether there is a non-linear relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and HUA in these patients. This study aims to explore the association between NHHR and HUA in cancer patients.</p><p><strong>Methods: </strong>This study included participants from the NHANES database from 2007 to 2018. We used multivariable logistic regression, restricted cubic splines (RCS) analysis, and subgroup analysis to examine the association between NHHR and HUA and gout in cancer patients, as well as to investigate differences in this association among specific subgroups.</p><p><strong>Results: </strong>A total of 2826 participants were included, with a HUA prevalence of 24.30%. Weighted multivariable logistic regression showed that for each unit increase in NHHR, the odds of HUA in cancer patients increased by 16% (95% confidence interval [CI]: 1.06, 1.29, P = 0.002). When NHHR was divided into tertiles, those in the highest tertile (Q3) had a 1.84 times higher odds of developing HUA compared to those in the lowest tertile (Q1) (95% CI: 1.32, 2.58, P < 0.001). However, there was no significant association with gout. RCS analysis further revealed a significant non-linear positive association, particularly among males. Subgroup analysis and interaction tests indicated a stronger association in cancer patients who did not have a history of stroke.</p><p><strong>Conclusion: </strong>There is a non-linear association between NHHR and HUA in cancer patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening and molecular docking verification of feature genes related to phospholipid metabolism in hepatocarcinoma caused by hepatitis B. 乙型肝炎肝癌磷脂代谢相关特征基因的筛选与分子对接验证
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-24 DOI: 10.1186/s12944-024-02253-3
Jian Zhang, Fengmei Zhang, Lei Zhang, Meiling Zhang, Shuye Liu, Ying Ma
{"title":"Screening and molecular docking verification of feature genes related to phospholipid metabolism in hepatocarcinoma caused by hepatitis B.","authors":"Jian Zhang, Fengmei Zhang, Lei Zhang, Meiling Zhang, Shuye Liu, Ying Ma","doi":"10.1186/s12944-024-02253-3","DOIUrl":"10.1186/s12944-024-02253-3","url":null,"abstract":"<p><strong>Background: </strong>The progression of tumours is related to abnormal phospholipid metabolism. This study is anticipated to present a fresh perspective for disease therapy targets of hepatocarcinoma caused by hepatitis B virus in the future by screening feature genes related to phospholipid metabolism.</p><p><strong>Methods: </strong>This study analysed GSE121248 to pinpoint differentially expressed genes (DEGs). By examining the overlap between the metabolism-related genes and DEGs, the research focused on the genes involved in phospholipid metabolism. To find feature genes, functional enrichment studies were carried out and a network diagram was proposed. These findings were validated via data base of The Cancer Genome Atlas (TCGA). Further analyses included immune infiltration studies and metabolomics. Finally, the relationships between differentially abundant metabolites and feature genes were confirmed by molecular docking, providing a thorough comprehension of the molecular mechanisms.</p><p><strong>Results: </strong>The seven genes with the highest degree of connection (PTGS2, IGF1, SPP1, BCHE, NR1I2, NAMPT, and FABP1) were identified as feature genes. In the TCGA database, the seven feature genes also had certain diagnostic efficiency. Immune infiltration analysis revealed that feature genes regulate the infiltration of various immune cells. Metabolomics successfully identified the different metabolites of the phospholipid metabolism pathway between patients and normal individuals. The docking study indicated that different metabolites may play essential roles in causing disease by targeting feature genes.</p><p><strong>Conclusions: </strong>In this study, for the first time, it reveals the possible involvement of genes linked to phospholipid metabolism-related genes using bioinformatics analysis. Identifying genes and probable therapeutic targets could provide clues for the further treatment of disease.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model. 基于机器学习识别潜在特征基因,预测非酒精性脂肪性肝炎动物模型的药物疗效。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-24 DOI: 10.1186/s12944-024-02231-9
Marwa Matboli, Ibrahim Abdelbaky, Abdelrahman Khaled, Radwa Khaled, Shaimaa Hamady, Laila M Farid, Mariam B Abouelkhair, Noha E El-Attar, Mohamed Farag Fathallah, Manal S Abd El Hamid, Gena M Elmakromy, Marwa Ali
{"title":"Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model.","authors":"Marwa Matboli, Ibrahim Abdelbaky, Abdelrahman Khaled, Radwa Khaled, Shaimaa Hamady, Laila M Farid, Mariam B Abouelkhair, Noha E El-Attar, Mohamed Farag Fathallah, Manal S Abd El Hamid, Gena M Elmakromy, Marwa Ali","doi":"10.1186/s12944-024-02231-9","DOIUrl":"10.1186/s12944-024-02231-9","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic Steatohepatitis (NASH) results from complex liver conditions involving metabolic, inflammatory, and fibrogenic processes. Despite its burden, there has been a lack of any approved food-and-drug administration therapy up till now.</p><p><strong>Purpose: </strong>Utilizing machine learning (ML) algorithms, the study aims to identify reliable potential genes to accurately predict the treatment response in the NASH animal model using biochemical and molecular markers retrieved using bioinformatics techniques.</p><p><strong>Methods: </strong>The NASH-induced rat models were administered various microbiome-targeted therapies and herbal drugs for 12 weeks, these drugs resulted in reducing hepatic lipid accumulation, liver inflammation, and histopathological changes. The ML model was trained and tested based on the Histopathological NASH score (HPS); while (0-4) HPS considered Improved NASH and (5-8) considered non-improved, confirmed through rats' liver histopathological examination, incorporates 34 features comprising 20 molecular markers (mRNAs-microRNAs-Long non-coding-RNAs) and 14 biochemical markers that are highly enriched in NASH pathogenesis. Six different ML models were used in the proposed model for the prediction of NASH improvement, with Gradient Boosting demonstrating the highest accuracy of 98% in predicting NASH drug response.</p><p><strong>Findings: </strong>Following a gradual reduction in features, the outcomes demonstrated superior performance when employing the Random Forest classifier, yielding an accuracy of 98.4%. The principal selected molecular features included YAP1, LATS1, NF2, SRD5A3-AS1, FOXA2, TEAD2, miR-650, MMP14, ITGB1, and miR-6881-5P, while the biochemical markers comprised triglycerides (TG), ALT, ALP, total bilirubin (T. Bilirubin), alpha-fetoprotein (AFP), and low-density lipoprotein cholesterol (LDL-C).</p><p><strong>Conclusion: </strong>This study introduced an ML model incorporating 16 noninvasive features, including molecular and biochemical signatures, which achieved high performance and accuracy in detecting NASH improvement. This model could potentially be used as diagnostic tools and to identify target therapies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
J-shaped relationship between Chinese visceral adiposity index and hyperuricemia: a cross-sectional study. 中国人内脏脂肪指数与高尿酸血症之间的 J 型关系:一项横断面研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-24 DOI: 10.1186/s12944-024-02247-1
Yuntong Liu, Lan Luo, Zhengnan Gao
{"title":"J-shaped relationship between Chinese visceral adiposity index and hyperuricemia: a cross-sectional study.","authors":"Yuntong Liu, Lan Luo, Zhengnan Gao","doi":"10.1186/s12944-024-02247-1","DOIUrl":"10.1186/s12944-024-02247-1","url":null,"abstract":"<p><strong>Background: </strong>Recent years have seen the emergence of numerous novel indicators for visceral obesity. This study investigates the potential correlation between the Chinese visceral adiposity index (CVAI) and hyperuricemia (HUA).</p><p><strong>Methods: </strong>This research, derived from a 2011 cross-sectional analysis in Dalian, China, employed restricted cubic spline (RCS) plots to identify inflection points. Subsequently, one-way and multifactorial logistic regression models were utilized, with HUA as the outcome variable. Additionally, subgroup analyses and interaction tests were conducted. Eventually, receiver operating characteristic (ROC) curves were calculated to assess the effectiveness of CVAI and other body composition indices in predicting HUA.</p><p><strong>Results: </strong>The study included 10,061 individuals, with a HUA prevalence of 14.25%. Significant relationships with HUA were observed for CVAI. RCS analysis revealed a J-shaped relationship between CVAI and HUA. Compared to those in the low CVAI category, HUA was notably associated with individuals in the high CVAI category in multifactorial logistic regression (OR = 2.661, 95% CI: 2.323, 3.047). Subgroup analyses demonstrated stronger relationships in women, participants without hypertension, and participants without diabetes. Additional modeling via ROC curves suggested that the CVAI may offer effective predictive value for HUA.</p><p><strong>Conclusion: </strong>This study confirmed that an elevated CVAI elevates the risk of HUA in middle-aged and elderly populations in the Dalian community. The findings advance obesity prevention strategies that mitigate HUA risk and support healthcare initiatives for China's aging population.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: The predictive value of nontraditional lipid parameters for intracranial and extracranial atherosclerotic stenosis: a hospital‑based observational study in China. 更正:非传统血脂参数对颅内和颅外动脉粥样硬化性狭窄的预测价值:一项基于中国医院的观察研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-22 DOI: 10.1186/s12944-024-02250-6
Shun Yu, Lihong Yan, Junwei Yan, Xiaozhi Sun, Meixia Fan, Huanhuan Liu, Yongxin Li, Mingjin Guo
{"title":"Correction: The predictive value of nontraditional lipid parameters for intracranial and extracranial atherosclerotic stenosis: a hospital‑based observational study in China.","authors":"Shun Yu, Lihong Yan, Junwei Yan, Xiaozhi Sun, Meixia Fan, Huanhuan Liu, Yongxin Li, Mingjin Guo","doi":"10.1186/s12944-024-02250-6","DOIUrl":"10.1186/s12944-024-02250-6","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and gallstones among US adults aged ≤ 50 years: a cross-sectional study from NHANES 2017-2020. 非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值(NHHR)与美国 50 岁以下成年人胆结石的关系:一项来自 2017-2020 年 NHANES 的横断面研究。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-22 DOI: 10.1186/s12944-024-02262-2
Quankai Cheng, Ziming Wang, Haicheng Zhong, Sheng Zhou, Chang Liu, Jingjing Sun, Sihai Zhao, Jie Deng
{"title":"Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and gallstones among US adults aged ≤ 50 years: a cross-sectional study from NHANES 2017-2020.","authors":"Quankai Cheng, Ziming Wang, Haicheng Zhong, Sheng Zhou, Chang Liu, Jingjing Sun, Sihai Zhao, Jie Deng","doi":"10.1186/s12944-024-02262-2","DOIUrl":"10.1186/s12944-024-02262-2","url":null,"abstract":"<p><strong>Background: </strong>The chronic digestive condition gallstones is quite common around the world, the development of which is closely related to oxidative stress, inflammatory response and abnormalities of lipid metabolism. In the last few years, as a novel biomarker of lipid metabolism, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has garnered significant interest. However, its relationship with gallstones has not been studied yet.</p><p><strong>Methods: </strong>3,772 people, all under 50, were included in this study, and their full data came from the National Health and Nutrition Examination Survey (NHANES) database for the years 2017-2020. Information on gallstones was obtained through self-reported questionnaires. Smoothed curve fitting multifactorial logistic regression was utilized to evaluate the connection of NHHR with gallstone formation incidence. Subsequently, subgroup analysis and interaction tests were applied. Finally, to create a prediction model, logistic regression and feature screening by last absolute shrinkage and selection operator (LASSO) were used. The resulting model was displayed using a nomogram.</p><p><strong>Results: </strong>In multivariate logistic regression that accounted for all factors, there was a 77% increase in the likelihood of gallstones for every unit rise in lnNHHR (OR 1.77 [CI 1.11-2.83]). Following NHHR stratification, the Q4 NHHR level was substantially more linked to the risk of gallstones than the Q1 level (OR 1.86 [CI 1.04-3.32]). This correlation was stronger in women, people under 35, smokers, abstainers from alcohol, non-Hispanic White people, those with excessively high cholesterol, people with COPD, and people without diabetes. After feature screening, a predictive model and visualized nomogram for gallstones were constructed with an AUC of 0.785 (CI 0.745-0.819), which was assessed by DCA to be clinically important.</p><p><strong>Conclusion: </strong>In the group of people ≤ 50 years of age, elevated NHHR levels were substantially linked to a higher incidence of gallstones. This correlation was stronger in several specific groups such as females, under 35 years of age, smokers, and so on. Predictive models constructed using the NHHR have potential clinical value in assessing gallstone formation.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluctuations in serum lipid levels during neoadjuvant treatment as novel predictive and prognostic biomarkers for locally advanced breast cancer: a retrospective analysis based on a prospective cohort. 新辅助治疗期间血清脂质水平的波动作为局部晚期乳腺癌的新型预测和预后生物标志物:基于前瞻性队列的回顾性分析。
IF 3.9 2区 医学
Lipids in Health and Disease Pub Date : 2024-08-22 DOI: 10.1186/s12944-024-02140-x
Xinru Chen, Yingying Zhao, Yaohui Wang, Yumei Ye, Shuguang Xu, Liheng Zhou, Yanping Lin, Jingsong Lu, Wenjin Yin
{"title":"Fluctuations in serum lipid levels during neoadjuvant treatment as novel predictive and prognostic biomarkers for locally advanced breast cancer: a retrospective analysis based on a prospective cohort.","authors":"Xinru Chen, Yingying Zhao, Yaohui Wang, Yumei Ye, Shuguang Xu, Liheng Zhou, Yanping Lin, Jingsong Lu, Wenjin Yin","doi":"10.1186/s12944-024-02140-x","DOIUrl":"10.1186/s12944-024-02140-x","url":null,"abstract":"<p><strong>Background: </strong>With increasing attention given to host-specific lipid metabolism status, it is of urgent need to identify lipid metabolism indices with predictive or prognostic value in locally advanced breast cancer patients treated with neoadjuvant chemotherapy (NAC), and to evaluate the performance improvement by incorporating them into the existing Neo-Bioscore staging system.</p><p><strong>Methods: </strong>Patients from a prospectively maintained database of locally advanced breast cancer patients who received radical surgery after NAC between January 2014 to December 2020 were enrolled in this study. The enrolled patients were randomly divided into a training set and a test set at a ratio of 6:4. The random forest algorithm was applied to rank the importance of prognostic factors, top-ranked lipid metabolism indices of which were then incorporated into Neo-Bioscore to construct an updated prognostic model. The performances of these two models were compared in both training set and test set from multiple perspectives. Study outcomes included disease-free survival (DFS), relapse-free survival (RFS), distance-recurrence-free survival (DRFS), locoregional-recurrence-free survival (LRFS) and overall survival (OS).</p><p><strong>Results: </strong>A total of 200 eligible patients were included in this study. After a median follow-up of 4.73 years, it was demonstrated that the relative increase in total cholesterol (TC; DFS: HR = 4.782, 95%CI 1.410 ~ 16.217, P = 0.012) and low-density lipoprotein (LDL; DFS: HR = 4.622, 95%CI 1.517 ~ 14.088, P = 0.007) during NAC led to poorer survival outcomes. Patients with either a higher body mass index (BMI) or elevated LDL during NAC had a worse prognosis (DFS: HR = 6.351, 95%CI 1.938 ~ 20.809, P = 0.002; OS, HR = 6.919, 95%CI 1.296 ~ 36.932, P = 0.024). Incorporating BMI and LDL fluctuations during NAC into Neo-Bioscore improved the prognostic stratification, especially in terms of LRFS (P = 0.046 vs. P = 0.65) and OS (P = 0.013 vs. P = 0.61). Multidimensional evaluation confirmed the improvement in model fit and clinical use for the updated model in both training set and test set.</p><p><strong>Conclusions: </strong>This is the first study to illustrate the relative elevation of LDL and TC levels during NAC as independent prognosticators for locally advanced breast cancer. This is also the first attempt to incorporate lipid metabolism indices into the original Neo-Bioscore staging system, which further improves the prognostic stratification of patients receiving NAC.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11340160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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