Lipids in Health and Disease最新文献

{"title":"Combined effect of fasting blood glucose and serum uric acid on nonalcoholic fatty liver disease.","authors":"Yifan Hao, Xuerui Li, Yiting Zhang, Jun Zheng, Yuyang Miao, Jin Tan, Qiang Zhang","doi":"10.1186/s12944-025-02538-1","DOIUrl":"https://doi.org/10.1186/s12944-025-02538-1","url":null,"abstract":"<p><strong>Background: </strong>This study sought to investigate the independent and synergistic impacts of fasting blood glucose (FBG) and serum uric acid (SUA) levels on non-alcoholic fatty liver disease (NAFLD) in participants with and without type 2 diabetes mellitus (T2DM).</p><p><strong>Method: </strong>A total of 12,430 participants (mean age: 54.34 ± 15.23, 34.34% female) were enrolled through the Health Screening Center of Tianjin Medical University General Hospital. FBG was classified as < 6 mmol/L, 6-7 mmol/L, and ≥ 7 mmol/L. SUA was classified into two categories: normal SUA and hyperuricemia (SUA level ≥ 420 µmol/L for men, ≥ 360 µmol/L for women). T2DM was ascertained through self-reported data. The diagnosis of NAFLD is established via abdominal ultrasound imaging. Logistic regression models and interaction effect models are used for data analysis.</p><p><strong>Result: </strong>Of the 12,430 participants, 4846 (38.99%) were diagnosed with NAFLD. In comparison to individuals with FBG < 6 mmol/L and no self-reported T2DM, those with FBG ≥ 7 mmol/L and no self-reported T2DM exhibited the highest prevalence of NAFLD (odds ratio [OR] 2.91, 95% CI 2.16-3.93) following multi-adjusted analysis. In the joint effect analysis of FBG and SUA, FBG ≥ 7 mmol/L and hyperuricemia were linked to a greater prevalence of NAFLD compared to FBG < 6 mmol/L and normal SUA, both in individuals with self-reported T2DM (OR 2.92, 95% CI 1.68-5.05) and those without self-reported T2DM (OR 7.87, 95% CI 3.57-17.34). An additive interaction existed between FBG and SUA regarding NAFLD in individuals without self-reported T2DM (AP 0.488, 95% CI: 0.068-0.909, P = 0.02).</p><p><strong>Conclusion: </strong>Elevated FBG levels are associated with NAFLD irrespective of self-reported T2DM status. The concomitant elevation of FBG and SUA levels exhibits a significant correlation with NAFLD, particularly in individuals lacking self-reported T2DM.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"168"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol improved atherosclerosis by increasing LDLR levels via the EGFR-ERK1/2 signaling pathway.","authors":"Dandan Hu, Litian Wang, Lin Qi, Xiangxuan Yang, Yamin Jin, Huailiu Yin, Yewei Huang, Jun Sheng, Xuanjun Wang","doi":"10.1186/s12944-025-02585-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02585-8","url":null,"abstract":"<p><strong>Background and aims: </strong>Atherosclerosis (AS) is a complex and chronic vascular disease and elevated low-density lipoprotein cholesterol (LDL-C) level is one of its primary causative factors. As a key surface receptor, low-density lipoprotein receptor (LDLR) plays an essential role in LDL-C clearance. Resveratrol (RSV) has emerged as a promising compound for investigating potential therapeutic targets for AS due to its ability to lower cholesterol, reduce endothelial anti-inflammatory and suppress vascular smooth muscle cell proliferation. This study explored the effects of RSV on AS through upregulating LDLR and analyzed the mechanism through a combination of in vivo and vitro experiments.</p><p><strong>Methods: </strong>HepG2 cells were exposed to varying concentrations of RSV. The effects of RSV on LDLR expression and cholesterol uptake were analyzed by western blot, RT-qPCR and DiI-LDL uptake assay. In vivo, C57BL/6J ApoE^-/- mice were used and the experimental groups were treated with RSV, Lovastatin and Gefitinib. Plaque formation in the arteries and aortic roots was assessed by Oil Red O staining and plaque stability was evaluated using Hematoxylin-Eosin (H&E) and Elastic Van Gieson (EVG) staining. Western blot, RT-qPCR and immunohistochemical staining were employed to analyze the expression of LDLR in the livers of mice.</p><p><strong>Results: </strong>RSV significantly enhanced the stability of LDLR mRNA and promoted LDLR protein expression. The inhibition experiments of EGFR signaling pathway (Cetuximab and Gefitinib) demonstrated that the efficacy of RSV was markedly weakened when this signaling pathway was inhibited. It indicated that RSV modulated LDLR gene expression by activating EGFR-ERK1/2 pathway. In ApoE^-/- mice, RSV notably reduced arterial plaque formation, improved plaque stability and increased hepatic LDLR expression.</p><p><strong>Conclusion: </strong>This study elucidated the mechanism by which RSV upregulates LDLR gene expression through activating EGFR-ERK1/2 signaling pathway. In vivo experiments demonstrated its efficacy in reducing arterial plaque formation and stabilizing existing plaques. These results further indicated that RSV held potential therapeutic value for ameliorating atherosclerosis and cardiovascular diseases. Collectively, these findings provided novel theoretical support for RSV's potential role in cardiovascular therapy.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"167"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between relative fat mass and cognitive function among US older men: NHANES 2011-2014.","authors":"Linlin Liu, Anshi Wu, Shengnan Yang","doi":"10.1186/s12944-025-02593-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02593-8","url":null,"abstract":"<p><strong>Background: </strong>Relative fat mass (RFM) is a new metric developed to assess the entire body fat proportion in adults. The objective of this study was to examine the correlation between cognitive performance and RFM in older American males.</p><p><strong>Methods: </strong>A total of 1,321 individuals were selected from the National Health and Nutrition Examination Survey (NHANES) that was carried out between the years 2011 and 2014. Specifically, the Consortium to Establish a Registry for Alzheimer's Disease Word Learning Test (CERAD-WL), the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST) were used in order to achieve the objective of assessing cognitive function. The standardized scores of the three previously mentioned tests were averaged to create the Z-scores, a composite, generalized metric. RFM was ascertained by measuring waist circumference (WC) and height. The relationships that exist between RFM and cognitive performance were investigated using a variety of statistical methods, including multivariate linear regression, threshold effect analyses, smooth curve fitting, and subgroup analyses.</p><p><strong>Results: </strong>The study included 1,321 male volunteers aged 60 years or older, and comprehensive data was provided for each individual. Fully adjusted models indicated a negative correlation between RFM and CERAD-WL scores[-0.17, (-0.32,-0.01)], DSST scores[-0.83, (-1.16,-0.50)] and Z-scores[-0.03, (-0.05, -0.01)]. It was observed that the negative correlation that exists between RFM and Z-scores became more pronounced when RFM exceeded 35.78. Furthermore, subgroup analyses showed that the association between RFM and cognitive function was significantly impacted by education level, poverty-income ratio (PIR), smoking status, and drinking status.</p><p><strong>Conclusions: </strong>A higher RFM was linked to lower cognitive function in older men, suggesting that management of RFM may prove advantageous in mitigating cognitive decline among older male populations.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"166"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the intake of polyunsaturated fatty acids and chronic constipation and diarrhea: NHANES 2005-2010.","authors":"Ping Lin, Wei Wang, Yun Zhou, Yong Yang, Ping Liu","doi":"10.1186/s12944-025-02570-1","DOIUrl":"https://doi.org/10.1186/s12944-025-02570-1","url":null,"abstract":"<p><strong>Background: </strong>Polyunsaturated fatty acids (PUFAs) have shown notable protective effects in various diseases. This study aims to investigate the associations between PUFAs intake and both chronic constipation (CC) and chronic diarrhea (CD).</p><p><strong>Methods: </strong>Data from three survey cycles (2005-2006, 2007-2008, and 2009-2010) of the National Health and Nutrition Examination Survey (NHANES) were used for analysis. 24-hour dietary recall interviews were employed to evaluate PUFAs intake. The associations between PUFAs intake and both CC and CD were analyzed via multivariable weighted logistic regression (WLR). Furthermore, stratified analysis and restricted cubic splines analysis were carried out.</p><p><strong>Results: </strong>7723 participants were included, among whom 545 (8.35%) were CC patients and 579 (7.50%) were CD patients. According to the results of multivariable MLR, a nonlinear association between PUFAs intake and CC was found (P for nonlinear < 0.05), where the increased daily intake was related to a declined prevalence of CC [OR = 0.976 (0.959, 0.993), P = 0.007] in the fully adjusted model. However, there was no significant evidence of an association between PUFAs intake and CD (P > 0.05).</p><p><strong>Conclusion: </strong>PUFAs intake was negatively associated with CC and was not strongly associated with CD. It suggested that adjusting daily PUFAs intake may alleviate CC symptoms.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"164"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body roundness index trajectories in Chinese bariatric surgery patients: a retrospective longitudinal study.","authors":"Kang Zhao, Wenbing Shi, Xinyi Xu, Ningli Yang, Hui Liang, Qin Xu","doi":"10.1186/s12944-025-02583-w","DOIUrl":"https://doi.org/10.1186/s12944-025-02583-w","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the body roundness index (BRI) trajectory categories 12 months post-bariatric surgery and to explore the association between BRI and metabolic abnormalities.</p><p><strong>Design and methods: </strong>Subject data were pooled from a tertiary hospital at baseline, 3 and 12 months post-surgery. Anthropometric measurements included the BRI and body mass index (BMI). Metabolic biomarkers comprised triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glucose (GLU), and uric acid (UA). The BRI level was categorized using growth mixture model, and a multilevel logistic regression model was employed to explore the relationship between BRI and metabolic risk.</p><p><strong>Results: </strong>A total of 669 patients were included in this study, comprising 286 males (42.8%) and 383 females (57.2%), with an average age of 31.70 ± 9.53 years (range of 18 to 65 years). Patients were classified into three BRI trajectory categories. Compared to the Low-gradual decline group, the High-rapid decline group had an increased risk of abnormal HDL-C (OR = 2.84 [95% CI, 1.73 ~ 4.67]), and had the highest proportion of sleeve gastrectomy plus jejunojejunal bypass (SG + JJB) and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) (P < 0.001); while the High-gradual decline group had increased risk of abnormal TG (OR = 3.28 [95%CI,1.67-6.42]), HDL-C (OR = 4.30 [95%CI, 2.31 ~ 8.00]), LDL-C (OR = 2.10 [95%CI, 1.12 ~ 3.93]), and UA (OR = 2.33 [95%CI, 1.33 ~ 4.10]). After adjusting for demographics, lifestyle factors, and surgical procedures, the distribution of risk outcomes remained primarily consistent.</p><p><strong>Conclusions: </strong>Sleeve gastrectomy (SG) plus procedures could potentially be associated with improvements in abdominal obesity and metabolic status in patients with high BRI. The post-bariatric trajectories based on BRI may offer insights into the metabolic risk levels of Chinese bariatric patients, but further research is needed to confirm these findings.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"165"},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of body roundness index with uterine fibroids in women of childbearing age: a cross-sectional analysis of NHANES 1999-2006.","authors":"Feng Zhang, Min Liu, Shanshan Hu, Ningying Zhou, Danni Wu, Yuqing Zan, Fei Sun","doi":"10.1186/s12944-025-02568-9","DOIUrl":"https://doi.org/10.1186/s12944-025-02568-9","url":null,"abstract":"<p><strong>Background and aim: </strong>Previous studies have shown an association between obesity and uterine fibroids (UF). Body roundness index (BRI) is an anthropometric measure associated with obesity. However, the association with UF has not been thoroughly elucidated, and further investigation is required to explore the possible link. Our study investigated the possible link between BRI and UF in women aged 20 to 44 years, with a view to providing effective scientific evidence for health management and disease prevention in this population.</p><p><strong>Methods: </strong>This cross-sectional study analysis included data from 4043 women of childbearing age from the National Health and Nutrition Examination Survey (NHANES) database 1999-2006.We applied multiple regression analysis to study the association between BRI and UF, subgroup analysis was used to ensure broad applicability and representativeness of conclusions, and finally linear correlation between BRI and UF was explored by smooth curve fitting.</p><p><strong>Results: </strong>This study involved 4,043 female participants aged 20-44 years, of whom 331 (8.19%) had fibroids. After controlling for all potential confounders, each additional unit of BRI increased the prevalence of UF by 7% (OR = 1.07,95% CI: 1.01,1.12), Sensitivity analysis by dividing BRI into four groups found a 54% increase in the prevalence of UF within the fourth quartile (Q4) of BRI compared with the first quartile (Q1) of BRI (OR = 1.54, 95% CI: 1.08, 2.20).The link between BRI and UF maintained in subgroup analyses. Furthermore, the study showed a linear positive correlation between BRI and the probability of UF prevalence.</p><p><strong>Conclusions: </strong>Higher levels of BRI may be linked to a higher prevalence of UF, according to studies conducted on American women of childbearing age. The study's conclusions highlight how important BRI is for managing and preventing UF.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"163"},"PeriodicalIF":3.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis.","authors":"Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun","doi":"10.1186/s12944-025-02562-1","DOIUrl":"https://doi.org/10.1186/s12944-025-02562-1","url":null,"abstract":"<p><strong>Background and objective: </strong>This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with their value for distinguishing individuals with a notable aICAS burden.</p><p><strong>Methods: </strong>This study enrolled 2000 participants (aged ≥ 40 years) based on the Rose asymptomatic IntraCranial Artery Stenosis study. Transcranial Doppler ultrasound combined with magnetic resonance angiography was utilized to confirm aICAS. Logistic regression was applied to assess the associations between TyG or TyG-related indices (TyG-body mass index, TyG-waist circumference [TyG-WC], TyG-waist-to-hip ratio [TyG-WHR], or TyG-waist-to-height ratio [TyG-WHtR]) and aICAS. The diagnostic potential of them was investigated using receiver operating characteristic (ROC) analysis.</p><p><strong>Results: </strong>Among the 2000 participants, 146 (7.3%) had a diagnosis of aICAS. TyG-WC, TyG-WHR, or TyG-WHtR were independently related to the prevalence of aICAS (TyG-WC: OR 1.26, 95%CI 1.03-1.54; TyG-WHR: OR 1.29, 95%CI 1.07-1.55; TyG-WHtR: OR 1.25, 95%CI 1.04-1.51). ROC analysis disclosed that TyG-WHtR had significant superior performance in identifying aICAS compared with other parameters (all P < 0.05). Subgroup analysis revealed that higher TyG-WHtR values showed a positive association with a heightened prevalence of aICAS observed in elderly participants aged ≥ 65 years (OR 1.69, 95%CI 1.20-2.38), and hypertensive patients (OR 1.30, 95%CI 1.06-1.59).</p><p><strong>Conclusion: </strong>The association of TyG-WHtR with aICAS showed that TyG-WHtR might be a more effective indicator for identifying populations with early-stage aICAS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"161"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of machine learning models for predicting low muscle mass in patients with obesity and diabetes.","authors":"Jiaying Ge, Siqi Sun, Jiangping Zeng, Yujie Jing, Huihui Ma, Chunhua Qian, Ran Cui, Shen Qu, Hui Sheng","doi":"10.1186/s12944-025-02577-8","DOIUrl":"https://doi.org/10.1186/s12944-025-02577-8","url":null,"abstract":"<p><strong>Background and aims: </strong>Low muscle mass (LMM) is a critical complication in patients with obesity and diabetes, exacerbating metabolic and cardiovascular risks. Novel obesity indices, such as the body roundness index (BRI), conicity index, and relative fat mass, have shown promise for assessing body composition. This study aimed to investigate the associations of these indices with LMM and to develop machine learning models for accurate and accessible LMM prediction.</p><p><strong>Method: </strong>Data from NHANES 2011-2018 (n = 2,176) were analyzed. Obesity was defined by body fat percentage, and LMM was determined using skeletal muscle mass index thresholds adjusted for BMI. Predictive models were developed using logistic regression, random forest, and other algorithms, with feature selection via LASSO regression. Validation included NHANES 2005-2006 data (n = 310). Model performance was evaluated using AUROC, Brier scores, and SHapley Additive exPlanations (SHAP) for feature importance.</p><p><strong>Results: </strong>BRI was independently associated with LMM (odds ratio 1.39, 95% confidence interval 1.22-1.58; P < 0.001). Eight features were included in the random forest model, which achieved excellent discrimination (AUROC = 0.721 in the validation set) and calibration (Brier score = 0.184). Feature importance analysis highlighted BRI, creatinine, race, age, and HbA1c as key contributors to the model's predictive performance. SHAP analysis emphasized BRI's role in predicting LMM. An online prediction tool was developed.</p><p><strong>Conclusions: </strong>BRI is a significant predictor of LMM in patients with obesity and diabetes. The random forest model demonstrated strong performance and offers a practical tool for early LMM detection, supporting clinical decision-making and personalized interventions.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"162"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative approach to the detection of circulating tumor biomarkers: multi-dimensional application of liposome technology.","authors":"Weichu Tan, Yitong Zhu, Siting Chen","doi":"10.1186/s12944-025-02578-7","DOIUrl":"https://doi.org/10.1186/s12944-025-02578-7","url":null,"abstract":"<p><p>Malignant tumors represent a significant worldwide health challenge, with elevated morbidity and mortality rates necessitating enhanced early identification and individualized treatment. Liposomes, as biomimetic lipid-based nanovesicles, have developed as a multifaceted platform for detecting and treating malignant tumors due to their excellent biocompatibility, stability, and membrane fusion properties. Circulating tumor markers, such as circulating tumor cells (CTCs), extracellular vesicles (EVs), circulating tumor proteins (CTPs), and circulating tumor nucleic acids (ctNAs), play a key role in early cancer diagnosis, disease progression monitoring, and personalized therapy. Liposome-based platforms enable effective molecular recognition, targeted detection, and signal amplification by targeting circulating tumor biomarkers, significantly increasing the potential for early tumor diagnosis and treatment. This review systematically summarizes advancements in the study of liposomes concerning circulating tumor markers, including applications in targeted recognition, early detection, and disease diagnosis, while discussing present problems and prospective applications of existing technology.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"160"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the impact of cumulative insulin resistance surrogates exposure on stroke: optimizing prevention strategies.","authors":"Dezhi Hong, Xiaohui Li, Guotai Sheng, Hongyi Yang, Wei Wang, Yang Zou","doi":"10.1186/s12944-025-02579-6","DOIUrl":"https://doi.org/10.1186/s12944-025-02579-6","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) plays a major role in increasing the risk of stroke. The objective of this research is to systematically evaluate and compare the impact of cumulative exposure over time to four commonly used IR surrogates-triglyceride-glucose (CumTyG) index, metabolic score for IR (CumMetS-IR), estimated glucose disposal rate (CumeGDR) and triglyceride to high-density lipoprotein cholesterol (CumTG/HDL-C) ratio-on stroke risk, providing insights for optimizing monitoring strategies for primary stroke prevention.</p><p><strong>Methods: </strong>The study population was sourced from the China Health and Retirement Longitudinal Study (CHARLS2011-2018). Cumulative exposure to IR (CumIR) surrogates was calculated as the mean value of IR surrogates measured in the first and third waves of CHARLS, multiplied by the total exposure duration. The primary endpoint was incident stroke, determined through questionnaires in the third and fourth waves of CHARLS. Multivariable Cox regression models were applied to estimate and compare HRs and 95% CIs for stroke across quartiles of CumIR surrogates.</p><p><strong>Results: </strong>A total of 4,669 participants with no history of stroke at baseline were included. During a median follow-up of 6 years, 347 new stroke events (7.43%) were recorded. The incidence rates of stroke in the highest quartiles of CumTyG index, CumTG/HDL-C ratio, and CumMetS-IR, as well as the lowest quartile of CumeGDR, were 9.67%, 9.93%, 10.45%, and 13.02%, respectively. In terms of risk assessment, the multivariable Cox regression analysis showed that the highest quartiles of CumTyG index, CumTG/HDL-C ratio, and CumMetS-IR and the lowest quartile of CumeGDR were associated with stroke risk, with corresponding HR (95% CI) of 1.48(1.05-2.10), 1.61(1.15-2.24), 1.72(1.21-2.43), and 3.57(2.25-5.68), respectively. In terms of event prediction, receiver operating characteristic analysis revealed that CumeGDR had the highest predictive accuracy for incident stroke compared with other common IR surrogates.</p><p><strong>Conclusions: </strong>In assessing stroke risk and predicting events in middle-aged and elderly populations, cumulative exposure to eGDR demonstrates significant advantages over other common IR surrogates. Incorporating eGDR as an IR monitoring marker is recommended for primary stroke prevention.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"158"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}