Lipids in Health and Disease最新文献

{"title":"Lipoprotein trajectories from prediabetes to type 2 diabetes with complications: a Chinese population-specific formula for sdLDL-C estimation.","authors":"Bin Feng, Yi Wang, Jingjie Xu, Liang Sang, Yanhua Zhao, Wei Gan","doi":"10.1186/s12944-025-02636-0","DOIUrl":"10.1186/s12944-025-02636-0","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"226"},"PeriodicalIF":3.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Association between triglycerides and remnant cholesterol levels and spine bone mineral density in Duchenne muscular dystrophy.","authors":"Yayu Wang, Yue Chang, Pei Zhang, Zhuoyin Zheng, Xiuyi Ai, Shu Zhang, Shiwen Wu","doi":"10.1186/s12944-025-02646-y","DOIUrl":"10.1186/s12944-025-02646-y","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"222"},"PeriodicalIF":3.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond LDL-C: discordant small dense LDL cholesterol stratifies hypertension risk in a Chinese longitudinal cohort.","authors":"Xiaofei Wu, Chunfang Ma, Weihai Chen, Shan Liu, Hao Shen, Xiangxiang Li","doi":"10.1186/s12944-025-02637-z","DOIUrl":"10.1186/s12944-025-02637-z","url":null,"abstract":"<p><strong>Background: </strong>This longitudinal study investigated small dense low-density lipoprotein cholesterol (sdLDL-C) and its discordance with ‌low-density lipoprotein cholesterol (LDL-C) as predictors of hypertension (HTN) incidence in a Chinese population.</p><p><strong>Methods: </strong>Sampson's equation was used to calculate sdLDL-C‌. Using data from 4,574 adults aged ≥ 45 from the ‌China Health and Retirement Longitudinal Study (CHARLS)‌, participants were stratified into three groups by sdLDL-C‌/LDL-C‌ percentile divergence (≥ 10%): discordantly low sdLDL-C, concordant, and discordantly high sdLDL-C. Cox regression analyses were performed to examine the relationship between sdLDL-C and HTN, adjusting for potential confounders. Additionally, we compared the LDL-C values derived from the Sampson equation with those measured by the homogeneous assay employed in this study.</p><p><strong>Results: </strong>Over 9 years, 1,826 (39.9%) developed HTN‌. Cox regression adjusted for confounders showed baseline log-transformed sdLDL-C independently predicted HTN risk (hazard ratio [HR]‌ = 1.36, 95% confidence interval [CI]‌:1.17-1.57). The discordantly high sdLDL-C group had 24% higher HTN risk versus the discordantly low group (‌HR‌ = 1.28, 95% ‌CI‌:1.13-1.45). Stratification by three LDL-C clinical thresholds and median values revealed individuals with low LDL-C but high sdLDL-C had the highest HTN risk (vs. low LDL-C/low sdLDL-C reference group in fully adjusted models). Despite strong correlation (Spearman's r = 0.956), systematic biases between direct LDL-C and Sampson methods may limit clinical interchangeability.</p><p><strong>Conclusion: </strong>sdLDL-C, particularly its discordance with LDL-C, is independently associated with incident HTN risk in Chinese adults. These findings underscore sdLDL-C's potential to refine cardiovascular risk stratification and enhance precision prevention strategies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"221"},"PeriodicalIF":3.9,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical management of lipid metabolism abnormalities induced by antipsychotics in closed psychiatric settings: challenges and integrated strategies.","authors":"Jiakuan Tu, Yu Qiu, Yueting Zhang, Yang Yang, Yi Huang","doi":"10.1186/s12944-025-02644-0","DOIUrl":"10.1186/s12944-025-02644-0","url":null,"abstract":"<p><p>In closed psychiatric settings, antipsychotic-induced lipid metabolism abnormalities pose significant clinical challenges. Constrained by limited patient mobility, fluctuating treatment adherence, and monotonous diets, traditional management struggles to adequately balance drug side effects with patient health needs. This study presents an integrated framework involving surveillance, intervention, and interdisciplinary collaboration. It includes a comprehensive \"admission-to-intervention\" monitoring system, low-glycemic diet combined with portion control, symptom-specific exercise programs, and strategies to improve treatment adherence. We establish quality metrics, including 100% baseline lipid testing for new admissions and ≥ 95% timely intervention rate for abnormalities. The patient-centered model reduces cardiovascular risks, improves patient outcomes, and offers a scalable approach for metabolic health management in resource-limited environments.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"220"},"PeriodicalIF":3.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between serum pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) levels and hypertension: a cross-sectional analysis of NHANES data.","authors":"Tanping Chen, Jing Luo, Shuai Li, Xinyan Li, Wenhao Wang, Wenlong Lu, Yandong He, Xiaolin Xu","doi":"10.1186/s12944-025-02640-4","DOIUrl":"10.1186/s12944-025-02640-4","url":null,"abstract":"<p><strong>Background: </strong>Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) are considered to have protective effects on cardiovascular health. However, research on the relationship between C15:0 and C17:0 levels and hypertension remains limited. This cross-sectional study aims to investigate the association between serum levels of odd-chain fatty acids (C15:0 and C17:0) and prevalent hypertension.</p><p><strong>Methods: </strong>Data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) were used for this study. Multiple logistic regression models, restricted cubic spline (RCS) analysis, saturation threshold effect analysis, and interaction effect tests were employed to analyze the relationship between serum C15:0 and C17:0 levels and prevalent hypertension.</p><p><strong>Results: </strong>A total of 4,775 participants (C15:0 analysis group) and 4,718 participants (C17:0 analysis group) were included in this study. The prevalence of hypertension in the two groups is 46.99% and 46.82%, respectively. To improve the distribution and comparability of the data, the primary analysis used the per mille of total fatty acids (C15:0‰ and C17:0‰). After adjusting for multiple confounders, both C15:0‰ and C17:0‰ levels were significantly inversely associated with the odds of prevalent hypertension. In the fully adjusted model, an increase in C15:0‰ and C17:0‰ levels was associated with a lower odds of prevalent hypertension (C15:0‰: OR = 0.78, 95% CI: 0.66-0.93, P = 0.0063; C17:0‰: OR = 0.77, 95% CI: 0.64-0.93, P = 0.0074). Further restricted cubic splines analysis showed a significant nonlinear relationship between C15:0‰ level and prevalent hypertension. Saturation threshold effect analysis revealed that when C15:0‰ level was below 1.5‰, the inverse association with the odds of prevalent hypertension was stronger (OR = 0.42, 95% CI: 0.23-0.77, P = 0.0052), while the relationship weakened when C15:0‰ level was above 1.5‰ (OR = 0.89, 95% CI: 0.74-1.07, P = 0.2158). Interaction effect tests indicated that, in the subgroup with C15:0‰ level ≥ 1.5‰, age modified the relationship between C15:0‰ level and prevalent hypertension. In the population aged ≥ 65 years, C15:0‰ level was inversely associated with the odds of prevalent hypertension (OR = 0.54, 95% CI: 0.36-0.79, P = 0.0384), while no significant association was observed in the population aged < 65 years (OR = 0.83, 95% CI: 0.68-1.02, P = 0.1032).</p><p><strong>Conclusions: </strong>Serum C15:0 and C17:0 levels are significantly inversely associated with the odds of prevalent hypertension, suggesting that serum C15:0 and C17:0 levels may serve as potential biomarkers for hypertension monitoring.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"219"},"PeriodicalIF":3.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of anthropometric measurements for identifying obesity in high-altitude pediatric populations: evidence from tibet via bioelectrical impedance analysis.","authors":"Ming-Jian Nie, Rui-Zhe Sun, Chao-Qun Fan, Jing-Jing Wang, Xi Fei, Zi-Kang Hu, Hong-Juan Li","doi":"10.1186/s12944-025-02623-5","DOIUrl":"10.1186/s12944-025-02623-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The diagnostic accuracy of anthropometric measurements for obesity screening in high-altitude pediatric populations remains understudied, particularly since existing measurements have been validated predominantly in lowland populations. This study evaluated the effectiveness of 19 anthropometric measurements for obesity screening among youth residing in the Tibetan Plateau region, aiming to identify the most reliable measurement approach for this distinct demographic.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study included 1,650 Tibetan and Han Chinese students aged 8-18 years from six schools in Lhasa's Chengguan District (altitude 3,650 m). Anthropometric measurements comprised both basic anthropometric parameters and computed indices. The basic anthropometric parameters included height, weight, waist circumference, mid-upper arm circumference as well as skinfold thickness measured at three sites, such as abdominal skinfold thickness (AST). The computed indices consisted of Body Mass Index (BMI), the tri-ponderal mass index (TMI), the sum of skinfold thickness from two or three (SuST&lt;sub&gt;3&lt;/sub&gt;) sites, the waist-to-height ratio, the mid-upper arm-to-height ratio, the conicity index (C-index), the relative fat mass, the body roundness index, two variants of a body shape index (ABSI&lt;sub&gt;OR&lt;/sub&gt; and ABSI&lt;sub&gt;CN&lt;/sub&gt;), and two percentage body fat values derived from two skinfold thickness equations (such as Y-PBF). Bioelectrical impedance analysis-derived percentage of body fat (PBF&lt;sub&gt;BIA&lt;/sub&gt;) was used as the reference method to construct Receiver Operating Characteristic (ROC) curves for the 19 anthropometric measurements, and the Area Under the Curve (AUC) was calculated to evaluate the performance of each measurement in obesity screening.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Statistical analysis revealed that TMI, SuST&lt;sub&gt;3&lt;/sub&gt;, AST, and BMI consistently demonstrated robust correlations with PBF&lt;sub&gt;BIA&lt;/sub&gt; across all demographic subgroups (p &lt; 0.001, r &gt; 0.7) and exhibited strong diagnostic capabilities (AUC &gt; 0.800). Among all anthropometric measurements, the TMI, SuST&lt;sub&gt;3&lt;/sub&gt;, AST, Y-PBF, and BMI had the highest subgroup mean rankings according to the AUC (top 5), and the ABSI&lt;sub&gt;OR&lt;/sub&gt;, C-index, and ABSI&lt;sub&gt;CN&lt;/sub&gt; were the worst (bottom 3). DeLong's test confirmed these measurements as optimal measures in the majority of population subgroups (&gt; 10 out of 19 subgroups), with the TMI showing the most comprehensive applicability (valid for the total sample and 17 subgroups). Notably, the TMI also demonstrated the highest stability in cutoff values (SD = 0.49, range = 1.89) and superior diagnostic performance (accuracy = 0.84, precision = 0.70, recall = 0.83, F score = 0.75).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our findings indicate that the TMI is the best anthropometric indices for screening for obesity in children and adolescents on the Tibetan Plateau, with a wide range of applicability to populat","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"216"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of mesenchymal stem cell-derived extracellular vesicle in nonalcoholic fatty liver disease: a systematic review and meta-analysis of preclinical evidence.","authors":"Qiangqiang Dai, Di Zhu, Xiaoming Du, Hao Tan, Qiu Chen","doi":"10.1186/s12944-025-02635-1","DOIUrl":"10.1186/s12944-025-02635-1","url":null,"abstract":"<p><strong>Objective: </strong>Nonalcoholic fatty liver disease (NAFLD) is a global chronic health challenge, demanding the development of innovative therapeutic strategies. Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have emerged as a promising therapeutic approach for NAFLD; however, current evidence is limited to preclinical studies. This systematic review and meta-analysis assessed the therapeutic efficacy of MSC-EVs in rodent models of NAFLD and its progressive form, nonalcoholic steatohepatitis (NASH). By synthesizing preclinical data, we aim to establish a robust evidence base that can guide future clinical trials and optimize MSC-EV-based therapies.</p><p><strong>Methods: </strong>Comprehensive searches of the PubMed, Web of Science, Embase, CNKI, Wanfang, and VIP databases identified eligible animal studies. Methodological quality was assessed via the SYRCLE risk-of-bias tool. The meta-analyses were conducted following Cochrane Handbook guidelines via Stata 18.0.</p><p><strong>Results: </strong>MSC-EVs led to significant reductions in key metabolic parameters, including AST (SMD = -2.79, 95% CI [-3.64, -1.94], p< 0.01), ALT (SMD = -2.47, 95% CI [-3.44, -1.50], p < 0.01), TG (SMD = -1.86, 95% CI [-2.98, -0.73], P < 0.01), liver TG (SMD = -4.02, 95% CI [-5.84, -2.20], p < 0.01), TC (SMD = -2.52, 95% CI [-3.56, -1.48], p < 0.01), liver TC (SMD = -5.28, 95% CI [-7.71, -2.84], p < 0.01), NAS score(SMD = -3.56, 95% CI [-5.04, -2.09], P < 0.01), FBG SMD = -1.89, 95% CI [-2.94, -0.83], p < 0.01), and body weight (SMD = -2.34, 95% CI [-3.94, -0.74], p < 0.01). Additionally, MSC-EVs improved the level of inflammatory cytokines (TNF-α and IL-6) and oxidative stress markers (SOD and MDA). These effects surpass those reported in previous MSC-EVs studies targeting liver disease, particularly regarding unassessed lipid parameters and oxidative stress indicators.</p><p><strong>Conclusion: </strong>MSC-EVs show promising potential for treating NAFLD/NASH, with substantial evidence supporting their therapeutic and reparative effects. Our findings directly inform clinical trial design by identifying optimal parameters-such as human-derived EVs, treatment durations longer than four weeks, and exosome preparations obtained via differential ultracentrifugation-to maximize therapeutic efficacy. These findings warrant further clinical investigation to facilitate the clinical translation of MSC-EVs as a therapeutic option for NAFLD/NASH.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"217"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index and its related factors may be predictors for cardiovascular disease among Chinese postmenopausal women: a 12-year cohort study.","authors":"Weiyan Tu, Rongdi Xu, Dan Wang, Na Luo, Meijing Wu, Yong Zhou, Jing Ning","doi":"10.1186/s12944-025-02643-1","DOIUrl":"10.1186/s12944-025-02643-1","url":null,"abstract":"<p><strong>Background: </strong>This study investigated and compared the abilities of the triglyceride glucose index (TyG) and its correlated factors involving TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), and TyG-waist circumference (TyG-WC) to predict cardiovascular disease (CVD) among Chinese postmenopausal women. This topic has not been adequately explored in the existing literature.</p><p><strong>Methods: </strong>This prospective study included 1110 Chinese postmenopausal women, stratified into the CVD group and the non-CVD group. The TyG index and its correlated components (TyG, TyG-BMI, TyG-WHtR, and TyG-WC) were calculated. The primary endpoint was CVD.</p><p><strong>Results: </strong>Across a 12-year follow-up period, 76 (6.84%) CVDs were documented. The TyG index, in collaboration with various indicators of obesity, demonstrated a robust positive correlation with the risk of CVD. In comparison to other TyG indices, TyG-WC was the strongest predictor for CVD (HR: 2.61, 95%CI:1.64-4.14; P < 0.001), and the TyG-WHtR index exhibited the strongest diagnostic value in identifying CVD (AUC: 0.632, 95%CI: 0.603-0.660; P < 0.001). Incorporating TyG-WHtR into the base model significantly enhanced incremental risk stratification for CVD (NRI: 0.115, 95%CI: 0.040-0.190, P < 0.05; AIC: 996; BIC: 1041; Harrell's C-index: 0.73). Decision curve analysis (DCA) suggested that TyG, TyG-WHtR, and TyG-WC can provide significant clinical benefits for Chinese postmenopausal women. The sensitivity analyses have demonstrated the robustness of these results.</p><p><strong>Conclusions: </strong>The TyG index and its correlated factors can effectively predict CVD in Chinese postmenopausal women. TyG-WHtR has the most potent ability to predict CVD among postmenopausal women.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"218"},"PeriodicalIF":3.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid droplet accumulation in microglia and their potential roles.","authors":"Yunxia Li, Qi Zhao, Yan Wang, Wenyi Du, Riyun Yang, Jian Wu, Yi Li","doi":"10.1186/s12944-025-02633-3","DOIUrl":"10.1186/s12944-025-02633-3","url":null,"abstract":"<p><p>Microglia are the resident immune cells of the central nervous system (CNS), where lipid metabolism is critical for maintaining homeostasis. In response to various external stimuli, they demonstrate a range of phenotypic expressions and lipid metabolic reprogramming. Lipid droplets (LDs) are dynamic organelles that function beyond energy storage, actively participating in neuropathological progress. Recent investigations have identified a subset of microglia characterized by the accumulation of LDs, referred to as \"lipid-droplet-accumulating microglia\" (LDAM). This review aims to investigate the processes involved in LD formation and degradation, the factors that modulate them, focusing particularly on the function of LDAM and their implications for CNS disorders. By synthesizing current evidence, we clarify the biological significance of LDs in these cells and their therapeutic targeting potential, providing new directions for future research.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"215"},"PeriodicalIF":3.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of interleukins 38 and 1 Beta gene expression by N-(4-benzoylphenyl)-5-nitrofuran-2-carboxamide in Triton WR-1339 induced hyperlipidemic rats.","authors":"Mohammad Alwahsh, Lama Hamadneh, Suhair Hikmat, Yasmeen Zaid Al-Kilani, Aya Hasan, Sameer Al-Kouz, Rahaf Alejel, Yusuf Al-Hiari, Arwa R Althaher, Basmah Al-Jammal, Buthaina Hussein, Tariq Al-Qirim","doi":"10.1186/s12944-025-02624-4","DOIUrl":"10.1186/s12944-025-02624-4","url":null,"abstract":"<p><strong>Background: </strong>Atherosclerosis (AS) is characterized by a gradual plaque buildup within the arteries, resulting in hardened and narrowed arteries. Thus, it leads to blood flow limitation and increased risk of critical diseases. Hyperlipidemia is correlated with inflammation, as seen with increased expression of different inflammatory markers including tumor-necrosis factor-alpha (TNF-α), C-reactive protein (CRP), chemokines and interleukins. This current study explores the relationship between novel anti-hyperlipidemic compounds and the expression of specific inflammatory markers in acute hyperlipidemic rats induced by Triton WR-1339.</p><p><strong>Methods: </strong>Male Wistar rats were separated into six different groups including a normal control group, a hyperlipidemic control group, four hyperlipidemic groups administrated with fenofibrate, N-(4-benzoylphenyl)-5-nitrofuran-2-carboxamide (NF4BP), N-(3-benzoylphenyl)-5-nitrofuran-2-carboxamide (NF3BP) and N-(4-acetylphenyl)-5-nitrofuran-2-carboxamide (NF4AP). The rats were sacrificed after 20 h of treatment; RT-PCR was employed to assess the specific inflammatory markers expression levels and protein-protein network was predicted using STRING 11.5 database.</p><p><strong>Results: </strong>This study demonstrated that the novel compounds significantly reduced total triglyceride levels when compared to the hyperlipidemic group. Two-fold changes in CRP, TNF-α, interleukin-1 beta (IL-1β), interleukin-38 (IL-38), interleukin-6 (IL-6), intercellular adhesion molecule (ICAM-1), chemokine-16 (CXCL-16), and vascular cell adhesion molecule (VCAM-1) were evaluated in comparison to the hyperlipidemic group revealed a significant downregulation of CRP (~ 3 folds), IL-1β (~ 7 folds), IL-6 (~ 5 folds), and TNF-α (~ 4 folds) after administration of NF4AP; the findings also showed a significant downregulation of TNF-α (~ 4 folds), and IL-1β (~ 6 folds) after administration of NF3BP; and there was also a significant downregulation of IL-1β (~ 6 folds). TNF-α (~ 2 folds), and IL-6 (~ 3 folds), expression after administration of NF4BP, suggesting a substantial suppression of pro-inflammatory signaling. It is noteworthy that anti-inflammatory IL-38 was significantly overexpressed after administration of NF4BP (~ 42 folds). STRING 11.5 database predicted that IL-1β down regulation plays an important role among the inflammatory markers tested.</p><p><strong>Conclusion: </strong>In conclusion, all novel compounds and fenofibrate demonstrated significant antihyperlipidemic properties. Among the three compounds, NF4BP showed the highest elevation in the expression levels of anti-inflammatory marker IL-38 accompanied by down regulation of proinflammatory markers. Understanding the impact of these compounds on inflammatory markers' expression is critical for developing effective therapeutic strategies for managing hyperlipidemia-associated complications. Hence, targeting these inflammatory pathways by th","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"214"},"PeriodicalIF":3.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}