Lipids in Health and Disease最新文献

{"title":"The effects of estimated glucose disposal rate and high sensitivity C-reactive protein on risk of incident cardiovascular diseases in middle-aged and elderly Chinese adults: a nationwide prospective cohort study.","authors":"Linghao Xu, Jiangping Ma, Yong Xu","doi":"10.1186/s12944-025-02653-z","DOIUrl":"10.1186/s12944-025-02653-z","url":null,"abstract":"<p><strong>Aim: </strong>Cardiovascular diseases (CVD) remain the predominant contributor to global mortality and morbidity, necessitating enhanced strategies for primary prevention and early detection. This investigation sought to characterize the associations between estimated glucose disposal rate (eGDR), high sensitivity C-reactive protein (hsCRP), and incident CVD.</p><p><strong>Methods: </strong>The research used data from China Health and Retirement Longitudinal Study (CHARLS). The primary exposures included eGDR and hsCRP. Incident CVD served as the primary study endpoint. All statistical analyses were performed utilizing SPSS software (version 25.0) and R software (version 4.4.4).</p><p><strong>Results: </strong>The analysis of 7,742 participants revealed incident CVD in 1,981 cases (25.6%), with Kaplan-Meier curves demonstrating significantly elevated cumulative incidence among individuals exhibiting both reduced eGDR and elevated hsCRP levels. Significant interactions were observed between these biomarkers, including an additive effect (relative excess risk due to interaction = 0.09, 95% confidence interval [CI]: 0.03-0.14) and a multiplicative effect (hazard ratio = 1.02, 95% CI: 1.01-1.03). Mediation analyses indicated bidirectional relationships, with eGDR accounting for 5.81% (95% CI: 2.13-9.49%) of the hsCRP-CVD association and hsCRP mediating 8.52% (95% CI: 3.87-13.17%) of the eGDR-CVD relationship. Notably, in individuals with diabetes, the combined predictive capacity of eGDR and hsCRP (area under the curve: 0.645) demonstrated superior discriminative performance compared to either biomarker alone (AUC: 0.645).</p><p><strong>Conclusion: </strong>eGDR and hsCRP exert significant joint, interactive and mediating effects on incident CVD in middle-aged and elderly Chinese population. Using eGDR (10.52 mg/kg/min) and hsCRP (1 mg/L) thresholds can be an affordable screening tool in primary care, especially where advanced diagnostics are lacking. Incorporating these assessments into regular check-ups may lower long-term CVD complications and reduce economic burdens.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"234"},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of dyslipidemia and its association with blood pressure control in Iranian hypertensive patients: insights from STEPS 2021.","authors":"Shervin Mossavarali, Yosra Azizpour, Ali Golestani, Nazila Rezaei, Sepehr Khosravi, Mina Mirzad, Pouria Khashayar, Ozra Tabatabaei-Malazy","doi":"10.1186/s12944-025-02660-0","DOIUrl":"10.1186/s12944-025-02660-0","url":null,"abstract":"<p><strong>Background: </strong>Given the association between dyslipidemia and hypertension and their significant impact on cardiovascular diseases (CVDs) in Middle Eastern countries, coordinated monitoring of these risk factors across the region is essential. This study aimed to assess the prevalence of dyslipidemia among hypertensive Iranians and explore its association with hypertension control.</p><p><strong>Methods: </strong>Data from the Iranian STEPwise Approach to Non-communicable Disease (NCD) Risk Factor Surveillance (STEPS) 2021 survey, including questionnaires, physical measurements, laboratory tests, from a total of 5,997 participants, were analyzed. Hypertension was defined as the current use of antihypertensive medication or blood pressure ≥ 140/90 mmHg. Lipid markers, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), Non-HDL-C, and triglycerides (TG), were evaluated using the National Cholesterol Education Program Adult Treatment Panel III 2004 criteria. Associations between lipid markers and uncontrolled hypertension were assessed using a multivariable modified Poisson regression model, with results presented as adjusted prevalence ratio (APR) and 95% confidence interval (CI). All analyses were conducted utilizing STATA software version 14.2.</p><p><strong>Results: </strong>The prevalence of dyslipidemia among hypertensive Iranian adults was 86.4% [95% CI: 85.0, 87.6], with the most common abnormalities being low HDL-C 71.3% [95% CI: 69.6, 72.9], followed by hypertriglyceridemia 48.4% [95% CI: 46.5, 50.2], hypercholesterolemia 24.9% [95% CI: 23.3, 26.6], and high LDL-C 18.8% [95% CI: 17.3, 20.3]. In the multivariable model, TC, LDL-C, Non-HDL-C, TC/HDL-C, and LDL-C/HDL-C were significantly associated with uncontrolled hypertension in both males and females. Each 1 mmol/L increase in LDL-C was associated with a higher prevalence of uncontrolled hypertension by 1.07 [95% CI: 1.04, 1.09] in males and 1.05 [95% CI: 1.03, 1.07] in females; Non-HDL-C by 1.06 [95% CI: 1.04, 1.08] in males and 1.05 [95% CI: 1.03, 1.07] in females; TC by 1.06 [95% CI: 1.04, 1.08] in males and 1.05 [95% CI: 1.03, 1.07] in females; and TG by 1.02 [95% CI: 1.00, 1.03] in males.</p><p><strong>Conclusions: </strong>Dyslipidemia is highly prevalent among hypertensive Iranian adults and may be associated with poor blood pressure control. In particular, low HDL-C emerged as the most frequent lipid abnormality and should be carefully assessed and managed as part of integrated, preventive hypertension care.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"232"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001-2010.","authors":"Yike Wang, Zeyu Liu, Haoyu Wu, Chunsheng Wang","doi":"10.1186/s12944-025-02603-9","DOIUrl":"10.1186/s12944-025-02603-9","url":null,"abstract":"<p><strong>Background: </strong>Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP.</p><p><strong>Methods: </strong>Participants from NHANES 2001-2010 were enrolled. CMI was computed based on anthropometric and biochemical indexes, covering height, waist circumference, triglyceride, and high-density lipoprotein cholesterol. OA diagnosis data were derived from the Medical Conditions questionnaires. Multivariate logistic regressions, restricted cubic spline (RCS) analysis, subgroup analyses, and interaction tests were implemented to investigate the association. A mediation analysis was employed to verify the mediating role of CRP.</p><p><strong>Results: </strong>After controlling for all covariates, CMI was significantly linked with OA (OR: 1.07, 95% CI (1.01, 1.13), P = 0.038). RCS analyses elicited a non-linear link between CMI and OA (P - non - linear = 0.0012). The inflection point was 0.54. Threshold effect analysis was conducted through two-segment linear regression, including the left side ( < = 0.54) (OR: 2.06, 95% CI: 1.03, 6.58) and the right side of the inflection point (> 0.54) (OR: 0.40, 95% CI: 0.15, 1.03). CRP partially mediated the link between CMI and OA, around 7.59% of the total effect.</p><p><strong>Conclusion: </strong>CMI is positively linked with OA, with CRP mediating the link. This paper unveils novel perspectives on the mechanism that links CMI to OA. Managing CMI and monitoring CRP levels may alleviate OA.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"231"},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPP2CB aggravates atherosclerosis-related dyslipidemia via LOX-1/MAPK/ERK signaling pathway.","authors":"He An, Dong-Liang Cheng, Xian-Ru Xia, Xian-Dong Li, Zhi-Hua Ruan, Chun-Yan Peng","doi":"10.1186/s12944-025-02647-x","DOIUrl":"10.1186/s12944-025-02647-x","url":null,"abstract":"<p><strong>Background: </strong>Dyslipidemia has been extensively documented as a key driver of cardiovascular pathology. Regulating lipid homeostasis holds promise for treating atherosclerosis (AS). Although the protein phosphatase 2 catalytic subunit beta (PPP2CB) is involved in post-transcriptional gene regulation, its role in AS-associated dyslipidemia is not well understood.</p><p><strong>Methods: </strong>The study included both human participants and animal models. The following techniques were employed: cell culture, extraction of exosomes, preparation of pooled hyperlipidemic serum (HS), transfection, western blotting, immunofluorescence staining, quantitative reverse transcription polymerase chain reaction (qRT-PCR), co-immunoprecipitation, low-density lipoprotein cholesterol (LDL-C) uptake assay, biochemical assays, assessment of aortic atherosclerotic lesions, as well as statistical analysis.</p><p><strong>Results: </strong>This study identified a marked upregulation of PPP2CB expression in peripheral blood leukocytes of AS patients, artery plaque of ApoE^-/- mice given a high-fat diet, and hepatic cells exposed to hyperlipidemic stimuli. Overexpression of PPP2CB in hepatic cells exacerbated lipid accumulation and low-density lipoprotein uptake, whereas silencing PPP2CB mitigated this effect. Immunofluorescence co-localization and co-immunoprecipitation analysis confirmed a direct interaction between PPP2CB and lectin-like oxidized LDL receptor-1 (LOX-1). Notably, PPP2CB manipulation disrupted hyperlipidemia-induced LOX-1 expression. Additionally, PPP2CB-mediated lipid dysregulation was linked to the activation of the LOX-1/ mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling cascade.</p><p><strong>Conclusions: </strong>These results unveil PPP2CB as a novel lipid regulator in the progression of pathological AS and highlight its involvement in signaling regulation during abnormal lipid metabolism. PPP2CB could be considered a promising candidate for biomarker development and therapeutic intervention in AS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"229"},"PeriodicalIF":3.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12224689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of triglyceride-glucose index-related indices in evaluating migraine: perspectives from multi-centre cross-sectional studies and machine learning models.","authors":"Zixuan Yan, Lincheng Duan, Hong Yin, Muchen Wang, Jingwen Li, Chenghua Li, Xiao Wang, Dingjun Cai, Fanrong Liang, Wenchuan Qi","doi":"10.1186/s12944-025-02648-w","DOIUrl":"10.1186/s12944-025-02648-w","url":null,"abstract":"<p><strong>Background: </strong>This study employed representative data from the U.S. and China to delve into the correlation among migraine prevalence, the triglyceride‒glucose index, a marker of insulin resistance, and the composite indicator of obesity.</p><p><strong>Methods: </strong>Cross-sectional data were acquired from the National Health and Nutrition Examination Survey conducted between 1999 and 2004, as well as from the China Longitudinal Study of Health and Retirement (CHARLS) performed from 2011 to 2012. Weighted logistic regression analysis, subgroup analysis, smooth curve fitting and threshold effect analysis were used to ascertain the intricate relationships among triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-waist height ratio (TyG-WHtR) and migraine. Boruta's algorithm and nine machine learning models were applied. SHapley Additive Explanations (SHAP) values were used to analyze leading models, highlighting influential features.</p><p><strong>Results: </strong>The analysis included 6,204 U.S. participants and 9,401 Chinese participants. TyG-BMI as well as TyG-WHtR were shown to be strongly correlated with the incidence of migraine among U.S. adults (TyG-BMI: OR = 1.28, 95% CI 1.14-1.44, P < 0.001; TyG-WHtR: OR = 1.17, 95% CI 1.09-1.26, P < 0.001). However, this correlation was not detected in Chinese adults. TyG-BMI indicated a strong positive association beyond the threshold of 206, while TyG-WHtR demonstrated a significant positive link below the cutoff of 7.4. In addition, age was an important interaction factor between TyG-BMI and TyG-WHtR and migraine. The XGBoost model showed excellent performance, with higher AUC values for TyG-BMI than for TyG-WHtR (0.929/0.926).</p><p><strong>Conclusions: </strong>The TyG-BMI, relative to the TyG-WHtR, may provide clinicians with information about patients' insulin sensitivity, thus helping to develop individualized treatment strategies. These findings contribute to population-level health interventions aimed at mitigating metabolic and neurological disease burdens, ensuring healthy lives and promoting well-being.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"230"},"PeriodicalIF":3.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol inflammatory index, calculated from residual cholesterol to C-reactive protein ratio, and stroke outcomes: a retrospective study using the National institutes of health stroke scale and modified Rankin scale.","authors":"Yanmei Yu, Yiming Zhang, Chunyan Zhu, Tingting Duan, Zichen Rao","doi":"10.1186/s12944-025-02650-2","DOIUrl":"10.1186/s12944-025-02650-2","url":null,"abstract":"<p><strong>Background: </strong>Globally, acute ischemic stroke (AIS) persists as a significant driver of both mortality and prolonged disability. Reliable biomarkers for predicting stroke outcomes must be identified to improve clinical decision-making. Residual cholesterol (RC) and RC inflammatory index (RCII) have been proposed as potential biomarkers, although their precise prognostic significance in stroke remains unclear. This research sought to examine the predictive value of RCII and RC in estimating extent of neurological impairment, assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional recovery, evaluated using the three-month modified Rankin Scale (mRS), among individuals diagnosed with AIS.</p><p><strong>Methods: </strong>The study enrolled 775 individuals diagnosed with AIS. RC and RCII were derived and subsequently grouped into quartiles for analysis. The associations between RCII, RC, NIHSS, and the three-month mRS were investigated using multivariable logistic regression analysis. Subpopulation analysis, inflection point analysis, generalized additive models (GAM), and receiver operating curve (ROC) analyses were utilized to evaluate the ability of these biomarkers to predict outcomes and to identify their optimal cutoff points.</p><p><strong>Results: </strong>RCII demonstrated a significant relationship with unfavorable functional prognosis, with participants belonging to the top quartile of RCII levels having almost double the risk of poor outcomes compared to those in the lowest quartile. (odds ratio [OR] = 1.98, 95% confidence interval [CI]; 1.20-3.26, P = 0.0071). RC showed no significant association with the NIHSS or three-month mRS (P > 0.05). ROC analysis demonstrated that the RCII exhibited moderate discriminatory power in predicting poor three-month outcomes (AUC = 0.641, 95% CI; 0.595-0.688), whereas RC demonstrated modest predictive performance (AUC = 0.519, 95% CI; 0.475-0.564, P = 0.0018). GAM analysis revealed a J-shaped relationship for RCII, with optimal thresholds of 2.47 for NIHSS and 0.45 for three-month mRS, indicating significant associations above these cutoffs. The subgroup analysis showed stronger associations for RCII in men, smokers, and individuals with hypertension, but no significant associations were found for RC in any subgroup.</p><p><strong>Conclusion: </strong>The RCII serves as an independent predictor of unfavorable three-month prognoses among individuals diagnosed with AIS. As a composite biomarker combining lipid and inflammatory factors, the RCII can enhance early risk stratification and guide personalized prognostic prediction in Acute stroke management.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"228"},"PeriodicalIF":3.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral immune cell profiling reveals modulations in immune cell response to repetitive inhaled organic dust exposure in a high omega-3 fatty acid mouse model.","authors":"Logan S Dean, Maëlis Wahl, Alissa N Threatt, Morgan Pauly, Melea Barahona, Emmanuel O Oyewole, Tara M Nordgren","doi":"10.1186/s12944-025-02651-1","DOIUrl":"10.1186/s12944-025-02651-1","url":null,"abstract":"<p><p>Exposure of the lungs to particulate matter (i.e. dust, wildfire smoke, air pollution) places individuals at an increased risk for developing chronic respiratory disease. Recent work has demonstrated the efficacy of omega-3 fatty acids and their metabolites in promoting the resolution of prolonged inflammation, however a comprehensive understanding of how omega-3 fatty acid balance impacts immune cell populations and crosstalk remains undescribed. We developed a 17-marker, 14-color spectral flow cytometry method to characterize the immunophenotypic changes in the bronchoalveolar space and lung tissue following 14 days of repetitive organic dust exposure or PBS vehicle. The populations of immune cells were compared in C57BL/6 (WT) and a transgenic model of increased omega-3 fatty acid (Fat-1) mice. Histopathologic examination revealed no difference between WT and Fat-1 mice at baseline or following organic dust exposure. Immune cell makeup within the bronchoalveolar space and lung tissue differed between WT and Fat-1 mice, with and without organic dust exposure. Fat-1 mice demonstrated a monocyte-dominant response compared to WT in both the airway and the lung tissue. Intriguingly, this monocyte-dominance was more prominent in female Fat-1 mice in the lung tissue and male Fat-1 mice in the airway. This suggests that monocyte populations are preferentially loaded following organic dust exposure in the lung and airways as a result omega-3 fatty acid metabolite-linked resolution processes, and that sex-dependent factors in this immune response are pivotal to consider in therapeutic strategies aimed at mitigating disease.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"227"},"PeriodicalIF":3.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12219126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The non-linear relationship between atherogenic index of plasma and stroke: a study among middle-aged and elderly Chinese adults with depression.","authors":"Lu Chen, Yanan Zhao, Pengjia Wang, Xuanzhi Feng, Jiawei Han, Qianyu Yang, Xuesen Su, Yan Liu, Shouyuan Tian","doi":"10.1186/s12944-025-02641-3","DOIUrl":"10.1186/s12944-025-02641-3","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"224"},"PeriodicalIF":3.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ceramide signaling in immunity: a molecular perspective.","authors":"Himani Thakkar, Vinnyfred Vincent, Bhagirath Chaurasia","doi":"10.1186/s12944-025-02642-2","DOIUrl":"10.1186/s12944-025-02642-2","url":null,"abstract":"<p><p>Ceramides are bioactive lipids that play a crucial role in cellular signaling and structural integrity (Nat Rev Mol Cell Biol 19:175-191, 2018). As members of the sphingolipid family, ceramides consist of a sphingoid base attached to a fatty acid (Annu Rev Biophys 47:633-654, 2018). Their unique structure confers both hydrophobic and amphipathic properties, enabling them to organize into membrane microdomains that influence cellular dynamics (Annu Rev Biophys 47:633-654, 2018). In recent years, ceramides have garnered attention for their role in modulating a range of cellular and organismal functions. Unlike other lipids that primarily serve structural roles, ceramides act as bioactive lipids in key signaling pathways, mediating stress responses such as inflammation, oxidative stress, growth inhibition, metabolism, autophagy, and apoptosis (J Lipid Res 60:913-918, 2019). Their regulatory effects are particularly important in immune cells, where ceramides can influence cell fate, modulate cellular metabolism, affect cytokine production, and dictate responses to external stimuli (Nature 510:58-67, 2014). Since ceramides maintain a dynamic equilibrium with other sphingolipids within a cell, understanding their role in immune cells in isolation provides only a partial perspective. Nevertheless, as a bioactive lipid and the central precursor of other sphingolipids, ceramides play a pivotal role in immune cells, deserving focused attention.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"225"},"PeriodicalIF":3.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of weight-adjusted waist index with all-cause and cardiovascular disease mortality among rheumatoid arthritis population: a cohort study from the NHANES 1999-2018.","authors":"Song Liu, Siyuan Chen, Yifeng Huang, Qizhang Man, Ying Yang, Jinfeng Wen, Hao Xie, Lei Fan","doi":"10.1186/s12944-025-02594-7","DOIUrl":"10.1186/s12944-025-02594-7","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) represents a pressing global health challenge. While obesity is a controllable risk factor for RA patients, traditional body measurements like body mass index (BMI) have shown limitations in assessing risk. The weight-adjusted waist index (WWI), a new measurement method, provides better insight into belly fat distribution patterns. This research seeks to understand how WWI relates to both all-cause mortality and cardiovascular disease (CVD) mortality in people with RA.</p><p><strong>Methods: </strong>Researchers conducted a longitudinal analysis examining participants diagnosed with RA using data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2018. The study introduced a novel anthropometric measure, WWI, by dividing the waist circumference (WC) measurement by the body weight's square root. The main outcomes of this study were all-cause mortality and cardiovascular mortality. The research team employed several statistical approaches: multivariable Cox proportional hazards models, restricted cubic spline (RCS) analysis, and survival assessment through Kaplan-Meier (KM) analysis. The investigation accounted for confounding factors and incorporated both subgroup and sensitivity analyses to ensure result reliability. To evaluate the effectiveness of different indicators in predicting mortality, we conducted receiver operating characteristic (ROC) analyses.</p><p><strong>Results: </strong>This investigation encompassed 2,564 qualified participants with 102 months as the median follow-up duration. Analysis using a fully adjusted statistical model demonstrated that mortality risk exhibited a progressive increase corresponding to elevated WWI values. RCS analysis revealed two distinct patterns: the relationship between WWI and all-cause mortality followed an inverted-U configuration, whereas cardiovascular mortality demonstrated a linear association with WWI. Survival analysis indicated that RA patients with lower WWI measurements demonstrated markedly improved survival outcomes. Further statistical testing through both sensitivity and subgroup analyses confirmed that these relationships remained robust across different population demographics. ROC curve analysis demonstrated that WWI surpasses both BMI and WC in predicting mortality among RA patients.</p><p><strong>Conclusions: </strong>The study revealed that elevated WWI levels corresponded with increased all-cause and CVD mortality, suggesting its utility as a prognostic indicator in this population.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"223"},"PeriodicalIF":3.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}