Lipids in Health and Disease最新文献

{"title":"Retraction Note: The effect of probiotics supplementation on blood pressure: a systemic review and meta-analysis.","authors":"Dan Qi, Xiao-Lu Nie, Jian-Jun Zhang","doi":"10.1186/s12944-024-02418-0","DOIUrl":"10.1186/s12944-024-02418-0","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"418"},"PeriodicalIF":3.9,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of triglyceride-glucose index and diabesity: evidence from a national longitudinal study.","authors":"Fan Zhang, Yan Sun, Yan Bai, Rong Wu, Hua Yang","doi":"10.1186/s12944-024-02403-7","DOIUrl":"10.1186/s12944-024-02403-7","url":null,"abstract":"<p><strong>Background: </strong>Diabesity, a co-occurrence of diabetes and obesity, is a growing public health concern globally. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with various metabolic disorders. This study aimed to investigate the association between TyG index and new-onset diabesity in a national longitudinal study.</p><p><strong>Methods: </strong>We utilized data from the China Health and Retirement Longitudinal Study (CHARLS). Baseline data from the first wave (2011) and follow-up data from the third wave (2015) were analyzed. A Competing risks model based on Fine and Gray's subdistribution hazard approach was employed to examine the association between the TyG index and developing of three mutually exclusive outcomes: remaining free of diabetes and obesity, diabetes alone, and new-onset diabesity (co-occurrence of diabetes and obesity).</p><p><strong>Results: </strong>A total of 6,976 participants were included in the analysis. During a mean follow-up period of 4.0 years, a total of 557 diabetes and 155 diabesity were recorded, respectively. After adjusting for socio-demographic information, lifestyle and comorbidities, compared with participants in the lowest quartile of TyG, the corresponding adjusted subdistribution hazard ratios (HRs) with 95% confidence intervals (95% CIs) for participants in the second, third, and fourth quartiles were 2.112 (95% CI: 1.047-4.259; P-value = 0.037), 2.911 (95% CI: 1.481-5.722, P-value = 0.002), and 4.305 (95% CI: 2.220-8.346, P-value < 0.001). The association between TyG and diabetes alone was equally significant when diabesity treated as the competing risk. Sensitivity analyses proved the robustness of results.</p><p><strong>Conclusion: </strong>This national longitudinal study in China provides evidence that a higher TyG index is associated with an increased risk of developing diabesity.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"412"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002-2022).","authors":"Ioanna Kechagia, Fotios Barkas, Evangelos Liberopoulos, Christina Chrysohoou, Petros P Sfikakis, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos","doi":"10.1186/s12944-024-02383-8","DOIUrl":"10.1186/s12944-024-02383-8","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the association between simple, combined lipid biomarkers, and 20-year cumulative incidence of new type 2 diabetes mellitus (T2DM) among adults participating in the ATTICA cohort study (2002-2022).</p><p><strong>Methods: </strong>The present analysis included data from 2000 individuals free of T2DM at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations; combined lipid markers were evaluated.</p><p><strong>Results: </strong>The 20-year cumulative incidence of T2DM was 26.3% (95%CI 24.4, 28.3%). All, simple and combined lipid markers were independently associated with new T2DM onset. The accuracy of simple and combined markers was approximately 75%, without any significant differences between simple and combined indices. The additive correct classification gain of lipid markers to glucose metabolism indices on 20-year new T2DM cumulative incidence varied between 0.9% for cardiometabolic index to 10.6% for LDL-cholesterol.</p><p><strong>Conclusions: </strong>Lipid profile is associated with the long-term onset of T2DM. Evaluated through simple or combined markers, lipid profiles can be utilized for identifying and improving risk stratification in individuals at high risk for T2DM, while also enhancing the effectiveness of primary prevention measures and public health strategies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"413"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between all-cause mortality and triglyceride glucose body mass index among critically ill patients with sepsis: a retrospective cohort investigation.","authors":"Huijun Jin, Xuefeng Xu, Chun Ma, Xinghai Hao, Jinglan Zhang","doi":"10.1186/s12944-024-02390-9","DOIUrl":"10.1186/s12944-024-02390-9","url":null,"abstract":"<p><strong>Background: </strong>We determined utilizing a sepsis participant cohort whether there is a significant association between TyG-BMI (triglyceride glucose body mass index) and mortality rates at any stage.</p><p><strong>Methods: </strong>Herein, a historical cohort investigation approach was adopted, using information provided by the Medical Information Mart for Intensive Care-IV (MIMIC-IV). We categorized the included individuals in accordance with their TyG-BMI data quartiles, and the primary outcomes were mortality during the hospital stay and death rate due to any reason at postadmission day 28, 90, and 365. To evaluate TyG-BMI mortality's relationship with sepsis-induced mortality risk, we employed restricted cubic spline regression (RCS) and Cox regression models. Additionally, we confirmed TyG-BMI's significant predictive value for mortality via machine learning methods. Furthermore, we performed subgroup analyses to investigate possible differences among various patient groups.</p><p><strong>Results: </strong>The cohort included 4759 individuals, aged 63.9 ± 15.0 years, involving 2885 males (60.6%). The rates of death that took place during hospital stay and at 28, 90 and 365 days postadmission were respectively 19.60%, 24.70%, 28.80%, and 35.20%. As reflected by Cox models, TyG-BMI was negatively associated with mortality risk at various intervals: in-hospital [hazard ratio (HR) 0.47 (0.39-0.56), P = 0.003], 28 days postadmission [HR 0.42 (0.35-0.49), P < 0.001], 90 days postadmission [HR 0.41 (0.35-0.48), P < 0.001], and 365 days postadmission [HR 0.41 (0.35-0.47), P < 0.001]. Additionally, the relationship between TyG-BMI and death rates was L-shaped, as reflected by the RCS, with a TyG-BMI of 249 being the turning point.</p><p><strong>Conclusions: </strong>Among sepsis patients in critical care, TyG-BMI is negatively correlated with mortality possibility at various intervals: during hospital stay and 28 days, 90 days, and one year postadmission. TyG-BMI is a beneficial parameter for categorizing risk levels among sepsis patients and for predicting their mortality risk within one year.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"414"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between life's simple 7 (LS7) and arthritis: the mediating role of body fat percentage (BFP).","authors":"Huan Chen, Zhao Wang, Ning Du, Jinseok Oh, Jing Xu, Rongcan Liu, Junlong Song, Junsheng Zhang, Chan Kang","doi":"10.1186/s12944-024-02392-7","DOIUrl":"10.1186/s12944-024-02392-7","url":null,"abstract":"<p><strong>Background: </strong>Life's Simple 7 (LS7), developed by the American Heart Association, addresses seven key health behaviors and relationship factors. Although LS7 has been studied in relation to various chronic diseases, its association with arthritis remains unclear. This study seeks to investigate the association between LS7 and arthritis, with particular emphasis on the mediating role of body fat percentage (BFP).</p><p><strong>Methods: </strong>Data from the 2011-2018 National Health and Nutrition Examination Survey (NHANES), including 16,332 adult participants, were analyzed. The connection between LS7 and arthritis was evaluated using multivariable logistic regression, smooth curve fitting, and subgroup analysis. Mediation analysis assessed the role of BFP in this relationship. Additionally, ROC curve analysis was used to assess the predictive performance of the model, and the Boruta algorithm identified the influential factors associated with arthritis.</p><p><strong>Results: </strong>After adjusting for relevant covariables, each standard deviation increase in LS7 was linked to a 13% lower likelihood of arthritis [OR = 0.87, 95% CI: 0.84, 0.89]. Participants in the highest LS7 tertile (T3) exhibited a 50% reduced likelihood of developing arthritis compared to those in the lowest tertile (T1) [OR = 0.50, 95% CI: 0.43, 0.60]. Mediation analysis confirmed that BFP significantly mediated the LS7-arthritis relationship. Furthermore, the Boruta algorithm identified LS7 and BFP as key variables associated with arthritis.</p><p><strong>Conclusion: </strong>Elevated LS7 scores were associated with a lower likelihood of arthritis, with BFP serving as a mediating factor. Improving LS7 scores and managing body fat may help prevent arthritis. Due to the study's cross-sectional design, causality cannot be confirmed. Future research should use longitudinal studies to verify these findings and target high-risk groups.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"415"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Probucol on plasma amyloid-β transport in patients with hyperlipidemia: a 12-week randomized, double-blind, placebo-controlled trial.","authors":"Liangjun Dang, Shan Wei, Yi Zhao, Rong Zhou, Suhang Shang, Fan Gao, Jingyi Wang, Jin Wang, Qiumin Qu","doi":"10.1186/s12944-024-02398-1","DOIUrl":"10.1186/s12944-024-02398-1","url":null,"abstract":"<p><strong>Background: </strong>Although dyslipidemia has been acknowledged as a risk factor for Alzheimer's disease (AD), the effects of lipid-lowering drugs on AD have not been determined. The primary pathophysiological hallmark of AD is the deposition of amyloid-β (Aβ) plaques in the brain. Plasma Aβ levels are influenced by the transport of Aβ from the central nervous system to the peripheral blood. This study investigates the effects of Probucol, a lipid-lowering and antioxidant drug, on plasma Aβ transport.</p><p><strong>Methods: </strong>A total of 120 hyperlipidemic patients with normal cognition were randomly assigned (1:1 ratio) to receive either Probucol (1000 mg daily for 12 weeks) or a placebo. Plasma Aβ, soluble receptor of advanced glycation end products (sRAGE), and fasting lipid profiles were measured at baseline and every 6 weeks.</p><p><strong>Results: </strong>A total of 108 participants completed the study, with 55 in the Probucol group. The cohort consisted of 58 (53.7%) women, with a mean age of 58.4 ± 8.0 (range, 45-80) years. After 12 weeks of treatment, the changes in plasma Aβ₄₂ and sRAGE levels significantly differed between the Probucol and placebo groups (ΔAβ₄₂: β = 6.827, P = 0.030; ΔsRAGE: β = 98.668, P = 0.004). Furthermore, ΔsRAGE was positively correlated with the change in Aβ₄₂ (β = 0.018, P = 0.048). When adjusted for ΔsRAGE, the effect of Probucol on plasma Aβ₄₂ levels was attenuated (β = 5.065, P = 0.116). In the Probucol group only, ΔsRAGE was significantly correlated with oxidized low-density lipoproteins (β = 4.27, P = 0.011), total cholesterol (β = 67.50, P = 0.046), and low-density lipoproteins (β = - 91.01, P = 0.011).</p><p><strong>Conclusions: </strong>Daily oral administration of Probucol (1000 mg) for 12 weeks significantly increased plasma Aβ₄₂ levels, likely through modulation of sRAGE. This effect may be attributed to the antioxidant and lipid-lowering properties of Probucol. These findings suggest that Probucol could potentially serve as a protective agent against the pathological processes of AD.</p><p><strong>Trial registration: </strong>This study was registered on the Chinese Clinical Trial Registry platform in June 2019 (Trial registration number: ChiCTR-1900023542).</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"410"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating role of triglyceride-glucose index and its derivatives in the relationship between central obesity and Hashimoto thyroiditis in type 2 diabetes.","authors":"Ya-Jie Zhai, Chen-Ying Lin, Jing-Bo Li, Hui-Na Qiu, Fan Wu, Yu-Lun Wang, Jing-Na Lin","doi":"10.1186/s12944-024-02402-8","DOIUrl":"10.1186/s12944-024-02402-8","url":null,"abstract":"<p><strong>Background: </strong>Obesity and insulin resistance (IR) may be risk factors for thyroid disease, but there is no clinical-based consensus on this topic. Therefore, this study aims to evaluate the associations between the triglyceride-glucose index (TyG) and its derivatives and Hashimoto thyroiditis (HT) in type 2 diabetes mellitus (T2DM) patients, and explore the relationships between the central obesity indicators and HT risk to provide a reliable basis for the early prevention of HT.</p><p><strong>Methods: </strong>A total of 1071 T2DM patients aged ≥ 20 years were selected from a tertiary hospital in Tianjin, all of them had normal thyroid function (including free triiodothyronine, free thyroxine, total triiodothyronine, total thyroxine, and thyroid-stimulating hormone). HT was assessed via thyroid-associated antibodies and thyroid colour Doppler ultrasound. TyG and its derivatives were measured via IR. Restricted cubic spline (RCS) models, multivariable logistic regression, and receiver operating characteristic (ROC) curve analysis were used to explore the correlations and predict HT. Mediation analysis explored the mediating role of TyG and its derivatives in the associations between the central obesity indicators and HT.</p><p><strong>Results: </strong>RCS models revealed that increases in waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), TyG-WC, TyG-WHR, and TyG-WHtR were associated with increased HT risk. Logistic regression revealed that participants in the fourth quartile of TyG-WC, TyG-WHR, and TyG-WHtR had approximately 3.38 times greater HT risk (odds ratio range: 2.807 to 3.375). ROC analysis revealed that WC, WHtR, WHR, TyG-WC, TyG-WHtR and TyG-WHtR could distinguish the presence of HT. In females, the WHR had the highest predictive power, with an area under the ROC curve of 0.651 (95% confidence interval 0.611-0.691, P < 0.001). Mediation analysis revealed that high IR, as assessed by the TyG-body mass index (TyG-BMI), significantly mediated the effects of WC, WHtR, and WHR on the risk of HT. Among them, the TyG-BMI had the highest proportion of mediating effect of WC on HT risk, reaching 74.08%.</p><p><strong>Conclusion: </strong>IR significantly mediates the increased risk of HT associated with central obesity. In clinical practice, WC, WHtR, WHR, TyG-WC, TyG-WHR, and TyG-WHtR serve as sensitive indicators for predicting HT risk in adult T2DM patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"411"},"PeriodicalIF":3.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11657283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats.","authors":"Baishuo Cheng, Jinchan Du, Shuai Tian, Zixiong Zhang, Wei Chen, Yang Liu","doi":"10.1186/s12944-024-02397-2","DOIUrl":"10.1186/s12944-024-02397-2","url":null,"abstract":"<p><strong>Background: </strong>High-intensity interval training (HIT) does not burn fat during exercise. However, it significantly reduces visceral adipose after long-term training. The underlying mechanism may be related to the elevation of fat consumption during the post-exercise recovery period, which is regulated by the hypothalamus-adipose axis. Lactate is a hallmark metabolite of high-intensity exercise, which could mediate significant neuroplasticity through the brain-derived neurotrophic factor (BDNF) pathway. However, whether HIT could enhance hypothalamus activity and adipose catabolism in the recovery period remains to be elucidated. Also, it is worth exploring whether adding lactate administration to prolonged, continuous submaximal aerobic training (AT) could simulate HIT-induced neuroplastic effects and fat loss.</p><p><strong>Methods: </strong>First, we compared the influence of 4-week HIT and aerobic training (AT) on the electrophysiology of the ventromedial hypothalamus (VMH), which is deeply involved in the regulation of lipolysis, as well as the 24-hour excess post-exercise oxygen consumption (EPOC), the fat oxidation rate and lipolysis. To further confirm whether excess lactate during AT could reproduce the effect of HIT, we also observed the effects of lactate infusion during AT (AT + Lac) on neuroplasticity and metabolism.</p><p><strong>Results: </strong>Four-week HIT induced higher BDNF expression and a higher neuronal spike firing rate in VMH than AT, accompanied by elevated EPOC, fat oxidation and visceral fat lipolysis. AT + Lac and HITT could induce similar hypothalamic and metabolic changes. However, power spectral density analysis of local field potentials (LFPs) showed that the AT + Lac group was affected in fewer frequency bands than the HIT group.</p><p><strong>Conclusion: </strong>HIT-induced reduction of visceral fat was accompanied by increased VMH activity. Adding lactate administration to AT could partially reproduce hypothalamic plasticity and the metabolic effects of HIT. However, different band changes of LFPs implied that the neuronal subpopulations or pathways influenced by these two methods were not entirely consistent.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"405"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEC14L2 regulates the transport of cholesterol in non-small cell lung cancer through SCARB1.","authors":"Qianhui Zhou, Dianwu Li, Yanchao Liang, Yunzhu Long, Yi Liu","doi":"10.1186/s12944-024-02401-9","DOIUrl":"10.1186/s12944-024-02401-9","url":null,"abstract":"<p><strong>Background: </strong>Inhibiting cholesterol metabolism has shown great potential in non-small cell lung cancer (NSCLC). However, the regulatory mechanism of the lipid metabolism key factor Sect. 14-like lipid binding 2 (SEC14L2) in NSCLC remains unclear. This study investigates the effects of differentially expressed genes related to cholesterol metabolism on the development of NSCLC.</p><p><strong>Methods: </strong>Cox regression and survival analysis were performed to screen cholesterol metabolism-related genes and predict survival prognosis in NSCLC patients. The proliferation and migration of NSCLC cells were assessed by CCK-8, EdU, colony formation and wound-healing assay. Cholesterol depletion and rescue trials were used to evaluate the effect of SEC14L2 on cholesterol transport in NSCLC cells. IF and Co-IP were used to analyze the targeting relationship between SEC14L2 and scavenger receptor class B member 1 (SCARB1).</p><p><strong>Results: </strong>SEC14L2 was a key gene related to prognosis in NSCLC patients and was highly expressed in A549 and Calu-1 cells. Subsequent studies demonstrated that knockdown of SEC14L2 significantly reduced the proliferation and migration of NSCLC cells, resulting in inhibited tumor growth. Furthermore, both in vitro and in vivo experiments indicated that SEC14L2 regulated cholesterol uptake. Silencing SEC14L2 partially counteracted the promotion of cholesterol content by MβCD-chol in A549 and Calu-1 cells. We then verified that there was a protein interaction between SEC14L2 and SCARB1.</p><p><strong>Conclusion: </strong>SEC14L2 promoted cholesterol uptake in NSCLC cells by up-regulating SCARB1 expression, thereby promoting NSCLC development.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"407"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease.","authors":"Clément J F Heymann, Anne Linde Mak, Adriaan G Holleboom, Joanne Verheij, Ronit Shiri-Sverdlov, Saskia W C van Mil, Maarten E Tushuizen, Ger H Koek, Aldo Grefhorst","doi":"10.1186/s12944-024-02380-x","DOIUrl":"10.1186/s12944-024-02380-x","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with many aspects of disturbed metabolic health. MASLD encompasses a wide spectrum of liver diseases, ranging from isolated steatosis to metabolic dysfunction-associated steatohepatitis (MASH), up to fibrosis, cirrhosis, and ultimately hepatocellular carcinoma. Limited noninvasive diagnostic tools are currently available to distinguish the various stages of MASLD and as such liver biopsy remains the gold standard for MASLD diagnostics. We aimed to explore whether the plasma lipidome and its variations can serve as a biomarker for MASLD stages.</p><p><strong>Methods: </strong>We investigated the plasma lipidome of 7 MASLD-free subjects and 32 individuals with MASLD, of whom 11 had MASH based on biopsy scoring.</p><p><strong>Results: </strong>Compared with the MASLD-free subjects, individuals with MASLD had higher plasma concentrations of sphingolipids, glycerolipids, and glycerophospholipids. Only plasma concentrations of ceramide-1-phosphate C1P(d45:1) and phosphatidylcholine PC(O-36:3), PC(O-38:3), and PC(36:2) differed significantly between presence of MASH in individuals with MASLD. Of these lipids, the first three have a very low relative plasma abundance, thus only PC(36:2) might serve as a biomarker with higher plasma concentrations in MASLD individuals without MASH compared to those with MASH.</p><p><strong>Conclusions: </strong>Plasma lipids hold promise as biomarkers of MASLD stages, whereas plasma PC(36:2) concentrations would be able to distinguish individuals with MASH from those with MASLD without MASH.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"23 1","pages":"402"},"PeriodicalIF":3.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}