Novel Insights into the Association of ZJU index with Periodontitis in US participants: a cross-sectional study.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-07-17 DOI:10.1186/s12944-025-02655-x

Wei Liu, Jie An, Cheng Jiao, Jun Guo, Lipu Zhang, Zichuan Zhang, Guangchao Liu, Yao Zhang

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引用次数: 0

Abstract

Background: To investigate the association between the Zhejiang University (ZJU) Index, a comprehensive metabolic indicator, and the prevalence of periodontitis in a large-scale population-based study using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: This cross-sectional study analyzed data from NHANES (2009-2014) and included 7,547 participants after applying strict inclusion and exclusion criteria. The ZJU Index was used as the exposure variable, and periodontitis was diagnosed based on clinical attachment loss and probing pocket depth. Weighted multivariable logistic regression analysis was performed to assess the relationship between the ZJU Index and periodontitis, adjusting for potential confounders. Subgroup and sensitivity analyses were conducted to evaluate the robustness of the findings.

Results: A significant positive association was found between the ZJU Index and the prevalence of periodontitis, presenting a J-shaped, non-linear relationship (P for nonlinearity = 0.026). When the ZJU Index was ≥ 45, the likelihood of periodontitis increased significantly, and the dose-response curve became steeper. An increase of 5 units in the ZJU Index was associated with an OR of 1.19 for periodontitis (95% CI: 1.02-1.40, P = 0.028). Subgroup analyses showed no significant interactions among different subgroups. Sensitivity analyses confirmed the robustness of the results, with the E-value indicating that the association was robust unless the OR of an unmeasured confounder exceeded 2.17.

Conclusions: This study confirmed the significant association between the ZJU Index and periodontitis, reinforcing the link between metabolic syndrome and oral health. The ZJU Index may serve as a potential biomarker for early screening assessment of periodontitis. Future research should focus on longitudinal studies to establish causality and evaluate the impact of targeted metabolic interventions on periodontal health.

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美国参与者ZJU指数与牙周炎关联的新见解：一项横断面研究。

背景：利用全国健康与营养调查（NHANES）的数据，开展了一项大规模人群研究，探讨综合代谢指标浙江大学指数（ZJU）与牙周炎患病率之间的关系。方法：本横断面研究分析了NHANES（2009-2014）的数据，采用严格的纳入和排除标准，纳入了7547名参与者。以ZJU指数作为暴露变量，根据临床附着缺失和探诊袋深度诊断牙周炎。采用加权多变量logistic回归分析评估ZJU指数与牙周炎之间的关系，并对潜在混杂因素进行调整。进行亚组分析和敏感性分析以评估研究结果的稳健性。结果：ZJU指数与牙周炎患病率呈显著正相关，呈j型非线性关系（非线性P = 0.026）。当ZJU指数≥45时，患牙周炎的可能性显著增加，剂量-反应曲线更陡峭。ZJU指数增加5个单位与牙周炎的OR为1.19相关（95% CI: 1.02-1.40, P = 0.028）。亚组分析显示，不同亚组之间无显著的相互作用。敏感性分析证实了结果的稳健性，e值表明除非未测量混杂因素的OR超过2.17，否则该关联是稳健性的。结论：本研究证实了ZJU指数与牙周炎之间的显著相关性，强化了代谢综合征与口腔健康之间的联系。ZJU指数可作为牙周炎早期筛查评估的潜在生物标志物。未来的研究应侧重于纵向研究，以建立因果关系，并评估有针对性的代谢干预对牙周健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.