High-density lipoprotein particles are associated with the risk of mortality from all-causes and cardiovascular diseases (CVDs) in patients with CVD: a systematic review and meta-analysis study.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-07-17 DOI:10.1186/s12944-025-02620-8

Elham Sharifi-Zahabi, Nooshin Nasiri, Fatemeh Hajizadeh-Sharafabad, Sobhan Mohammadi, Shaghayegh Shahbazi, Nahid Salehi

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引用次数: 0

Abstract

Background & aims: Increasing data indicate that the concentration of high-density lipoprotein particles (HDL-p) may be a strong indicator of cardiovascular disease. This study aimed to carry out a meta-analysis to examine the link between subclasses of HDL-p and the hazard of mortality in individuals suffering from cardiovascular diseases (CVDs).

Methods: A rigorous systematic search was executed through Scopus, PubMed, and Web of Science up to April 2025.

Results: Seven unique cohort studies were deemed eligible for incorporation in this meta-analysis. The overall hazard was derived by applying a random effects model. The results indicated a negative association of total HDL-p (RR: 0.74, 95% CI: 0.69-0.78, P < 0.001) and small HDL-p with all-cause mortality (RR: 0.69, 95% CI: 0.63-0.75, P < 0.001) for each 5 µmol/l increment. Similarly, each 5 µmol/l large HDL-p was directly related to all-cause mortality (RR: 1.71, 95% CI: 1.14- 2.56; P = 0.009). Moreover, each 5 µmol/l increase in small HDL-p was linked to a 33% reduction in CVD mortality (RR: 0.67, 95% CI: 0.50-0.91; P = 0.01).

Conclusion: This study revealed that small and total HDL-p were negatively correlated with all-cause mortality, whereas latge HDL-p was positively related to mortality from all causes. Additionally, small HDL-p had an inverse relationship with CVD mortality in patients with CVD.

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高密度脂蛋白颗粒与心血管疾病患者全因死亡风险和心血管疾病（CVD）相关：一项系统回顾和荟萃分析研究。

背景与目的：越来越多的数据表明，高密度脂蛋白颗粒（HDL-p）的浓度可能是心血管疾病的一个重要指标。本研究旨在开展一项荟萃分析，以检查HDL-p亚类与心血管疾病（cvd）患者死亡风险之间的联系。方法：截止到2025年4月，通过Scopus、PubMed和Web of Science进行严格的系统检索。结果：7项独特的队列研究被认为符合纳入本荟萃分析的条件。通过应用随机效应模型推导出总体危害。结果显示总HDL-p呈负相关（RR: 0.74, 95% CI: 0.69-0.78， P）。结论：本研究表明，总HDL-p和总HDL-p与全因死亡率呈负相关，而高HDL-p与全因死亡率呈正相关。此外，小HDL-p与CVD患者的CVD死亡率呈负相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.