Lipids in Health and Disease最新文献

{"title":"Relationship between serum lipids and the risk of hemorrhagic stroke: a meta-analysis of 50 million participants from prospective cohort studies.","authors":"Xuefan Yao, Houlin Lai, Kehui Ma, Benke Zhao, Aini He, Wei Sun, Yuan Wang, Haiqing Song","doi":"10.1186/s12944-025-02698-0","DOIUrl":"10.1186/s12944-025-02698-0","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"303"},"PeriodicalIF":3.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between visceral lipid accumulation indicator and preserved ratio impaired spirometry in US adults: a population-based study from 2007 to 2012.","authors":"Zhehao Xu, Jia Ding, Ruiyun Liang, Xiwei Huang, Shuangfeng Xie","doi":"10.1186/s12944-025-02730-3","DOIUrl":"10.1186/s12944-025-02730-3","url":null,"abstract":"<p><strong>Background: </strong>Preserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted value. Recent studies suggest that visceral lipid accumulation may play a role in respiratory health, but the relationship between visceral fat indices and PRISm remains under explored. To investigate the relationship between indicators of visceral lipid accumulation and PRISm in US adults using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Data from three consecutive cycles of NHANES (2007-2012) were analyzed. Logistic regression and generalized additive models (GAM) were used to assess the relationship between various indices of visceral lipid accumulation and PRISm. The data was randomly divided into training (70%) and validation (30%) sets. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key factors for a nomogram model, which was evaluated using receiver operating characteristic(ROC) curves.</p><p><strong>Results: </strong>A significant positive association was found between visceral fat indices and PRISm risk (P < 0.05). GAM analysis revealed a nonlinear relationship, with PRISm risk initially plateauing or slightly decreasing at lower levels of visceral fat indices before rising above a certain threshold (P for non-linearity < 0.05). The nomogram model demonstrated fair discriminative ability, with the area under the ROC curve (AUC) of 0.785 (95%CI: 0.771-0.800) in the training set and 0.769 (95%CI: 0.747-0.791) in the validation set.</p><p><strong>Conclusions: </strong>This study establishes a robust association between visceral fat indicators and PRISm, highlighting the significance of lipid indices in evaluating respiratory health. Clinical screening for visceral fat indicators could be essential for more precise clinical interventions.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"292"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling.","authors":"Wen-Cheng Liu, Chih-Feng Lien, Yi-Jhen Huang, Pei-Yu Lien, Sy-Jou Chen, Chin-Sheng Lin, Rou-Ling Cho, Yi-Ping Chuang","doi":"10.1186/s12944-025-02720-5","DOIUrl":"10.1186/s12944-025-02720-5","url":null,"abstract":"<p><strong>Background: </strong>Metabolic associated fatty liver disease (MAFLD) has emerged as the most common chronic liver disease worldwide. However, effective pharmacological treatments remain limited. Dysregulated lipid metabolism and impaired bile acid synthesis are recognized as key contributors to the pathogenesis of MAFLD. This study aimed to investigate the therapeutic potential and underlying mechanisms of nitroxoline (Nit), an antimicrobial agent identified through drug repurposing, in ameliorating hepatic steatosis.</p><p><strong>Methods: </strong>Nit was administered to high-fat diet (HFD)-fed low-density lipoprotein receptor knockout (Ldlr^⁻/⁻) mice to assess hepatic steatosis, aortic atherosclerosis, serum lipid levels, and bile acid metabolism comprehensively. In vitro, Huh-7 cells were used to examine Nit-mediated regulation of lipid metabolism-related genes. RNA sequencing (RNA-seq) and pharmacologic inhibition studies were conducted to elucidate the underlying molecular mechanisms.</p><p><strong>Results: </strong>Nit treatment significantly reduced liver weight without affecting body weight in HFD-fed Ldlr⁻/⁻ mice. Serum total cholesterol, low-density lipoprotein (LDL)-cholesterol, and triglyceride levels were markedly decreased. Mechanistically, Nit enhanced the expression of ATP-binding cassette subfamily G5 (ABCG5) and G8 (ABCG8) transporters, along with cholesterol 7α-hydroxylase (CYP7A1), thereby promoting cholesterol efflux into bile and bile acid synthesis. In Huh-7 cells, Nit induced ABCG5, ABCG8 and CYP7A1 expression in a dose-dependent manner. Furthermore, RNA-Seq analysis revealed liver receptor homolog-1 (LRH-1) as a potential transcriptional regulator related to Nit. Notably, pretreatment with the LRH-1 inhibitor, ML-180 abolished Nit-induced upregulation of ABCG5, ABCG8 and CYP7A1, suggesting that Nit may alleviate hepatic lipid accumulation primarily through LRH-1 activation.</p><p><strong>Conclusions: </strong>This study identifies Nit as a promising pharmacological candidate for MAFLD by modulating cholesterol metabolism and bile acid synthesis through LRH-1-mediated activation. These findings not only advance the understanding of metabolic liver disease pathogenesis but also support the development of innovative and accessible therapeutic strategies by leveraging existing compounds to improve health outcomes.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"296"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity alters VLDL profile and remnant cholesterol differently in metabolically healthy men and women: a ¹H-NMR study.","authors":"Victoria Santisteban, Anallely López-Yerena, Natàlia Muñoz-Garcia, Gemma Vilahur, Lina Badimon, Teresa Padro","doi":"10.1186/s12944-025-02723-2","DOIUrl":"10.1186/s12944-025-02723-2","url":null,"abstract":"<p><strong>Background and aims: </strong>Lipoprotein particle (p) size and count beyond lipoprotein lipid content [triglycerides (tg) and cholesterol (c)] are critical for their atherogenicity. This study characterized lipoprotein profiles in metabolically healthy individuals with overweight or obesity and assessed the impact of sex, obesity, and lipid background.</p><p><strong>Methods: </strong>Proton-nuclear magnetic resonance (¹H-NMR) was used to assess the composition of very low-, low-, intermediate-, and high-density lipoproteins (VLDL, LDL, IDL, HDL), and particle number and size of VLDL, LDL, and HDL in 101 healthy subjects with overweight and obesity.</p><p><strong>Results: </strong>Men showed significantly higher VLDLc and VLDLtg levels, counts of VLDLp (all subfractions) and LDLp (total and small), and smaller LDLp size, compared to women. Men had lower HDLc and HDLp (total and medium). In Obesity (Ob) compared to overweight (Ov), VLDLp number, VLDLtg and remnant cholesterol (RC) levels were significantly increased [Fold changes (FC) Ob.vs.Ov: 1.45, 1.39, and 1.26, respectively]. When stratified by sex, obesity-related VLDL and IDL profile deterioration was evident only in women. Individuals with LDLc ≥ 130 mg/dL showed increased RC compared to those with LDLc < 130 mg/dL (FC:1.26). The median 10-year cardiovascular disease (CVD) risk REGICOR was low (2%), but higher in men and in obesity. Individuals with higher CVD risk showed increased VLDLc, VLDLtg, VLDLp, and RC levels.</p><p><strong>Conclusion: </strong>Men had a higher 10-year CVD risk and a less favorable triglyceride-rich lipoprotein and RC profile, while obesity aggravated these patterns, particularly in women. These findings support considering high-risk lipoprotein patterns in targeted CVD prevention for overweight and obese populations.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"301"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the U-shaped nonlinear relationship of CHG index with metabolic syndrome and mortality risks in metabolic syndrome patients.","authors":"Shouxin Wei, Sijia Yu, Chuan Qian, Zhengwen Xu, Yindong Jia, Bo Chen","doi":"10.1186/s12944-025-02714-3","DOIUrl":"10.1186/s12944-025-02714-3","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a worldwide condition that markedly elevates the risk of chronic conditions. The cholesterol, high-density lipoprotein, and glucose (CHG) indices simultaneously reflect various metabolic parameters, including lipid metabolism, cardiovascular function, and insulin sensitivity, providing considerable clinical value. This study aimed to investigate the association between the CHG index and MetS, along with their connections with all-cause death and cardiovascular disease (CVD) death in individuals with MetS.</p><p><strong>Methods: </strong>The NHANES dataset (2001-2018) was used to assess the relationship between the CHG index and MetS via cross-sectional research and weighted logistic regression analysis. Cohort studies and a weighted Cox proportional hazards model were employed to investigate the relationships of CHG with all-cause mortality and cardiovascular mortality in individuals with MetS. A possible nonlinear association between the CHG score and MetS, along with all-cause and CVD mortality in MetS patients, was assessed via general additive models and smooth fitting of curves. Kaplan‒Meier (K‒M) survival curves were generated to illustrate prognostic variations across CHG index quartiles. Subgroup analyses were performed to investigate discrepancies in these associations across different populations. Finally, the consistency and dependability of the outcomes were verified through repeated analysis via multiple imputation of the data and external validation with CHARLS.</p><p><strong>Results: </strong>After adjusting for relevant confounding factors, the CHG index was positively correlated with all-cause Mortality and CVD Mortality among individuals with MetS. Further analysis revealed a U-shaped nonlinear relationship for these associations, with inflection points at 46.12, 52.67, and 50.82, respectively. K‒M survival curve analysis indicated that the prognosis for the middle quartile of the CHG index was better than that for both the lower and upper quartiles. Subgroup analyses further highlighted differences in these associations across various populations. Ultimately, the sensitivity analysis demonstrated the robustness of the findings.</p><p><strong>Conclusion: </strong>The CHG index has a substantial U-shaped nonlinear association with the incidence of MetS and the risk of all-cause and cardiovascular death in patients with MetS. Previous interventions have focused primarily on high-risk extremes, but the findings of this study suggest that patients with low CHG levels should also be included in monitoring. Future prospective studies are needed to validate these findings and explore their potential clinical applications in managing MetS patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"294"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid profile and the variables associated with control of selected lipid parameters in patients of a large multi-specialist hospital in Poland - the Jurasz Lipid Study (JLS).","authors":"Marcin Ziółkowski, Jakub Ratajczak, Karolina Obońska, Piotr Adamski, Maciej Banach, Krzysztof Chlebus, Maciej Grymuza, Klaudyna Grzelakowska, Piotr Jankowski, Jacek Konarski, Ewa Laskowska, Piotr Niezgoda, Małgorzata Ostrowska, Elżbieta Ozorowska, Przemysław Podhajski, Jacek Przybylski, Grzegorz Skonieczny, Bożena Sosnowska, Łukasz Szarpak, Małgorzata Topolska, Julia Umińska, Magdalena Krintus, Jacek Kryś, Jacek Kubica","doi":"10.1186/s12944-025-02712-5","DOIUrl":"10.1186/s12944-025-02712-5","url":null,"abstract":"<p><strong>Background: </strong>Hyperlipidemia is the most prevalent cardiovascular (CV) risk factors. We aimed to analyze the distribution of lipid parameters and clinical variables associated with elevated and non-elevated selected lipid factors in a cohort of all consecutive patients whose lipid profile was assessed at a multi-specialist clinical center.</p><p><strong>Materials and methods: </strong>This cross-sectional study analyzed electronic medical records of consecutive patients treated between March and November 2024. Lipid parameters measured included: total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), apolipoprotein B (apoB), and lipoprotein (a) [Lp(a)]. Non-high-density lipoprotein cholesterol (non-HDL-C) was calculated as TC-HDL-C. We used multivariate analysis to identify factors associated with LDL-C, TG, and Lp(a) concentrations.</p><p><strong>Results: </strong>A total of 10,597 patients were included in the analysis. The median lipid concentrations (mg/dL) were: TC 162 (IQR 132-198), LDL-C 94 (IQR 69-129), non-HDL-C 112 (IQR 88-146), apoB 78 (IQR 63-99), and Lp(a) 11 (IQR 5-29). Elevated LDL-C > 100 mg/dL was observed in 45.7% of patients, non-HDL-C > 130 mg/dL in 35.1%, and apoB > 100 mg/dL in 23.2%. A discordance between LDL-C and apoB concentrations was present in 23.7% of patients (p < 0.001), while LDL-C/non-HDL-C and apoB/non-HDL-C discordance rates were 13% and 12.6%, respectively (p < 0.001). Patients at very high CV risk had lower TC, LDL-C, non-HDL-C, and apoB concentrations compared to those with low-to-moderate and high CV risk (p < 0.001) and showed the highest median Lp(a) concentration of 13 mg/dL (IQR 5-31; p = 0.01). Goal achievements of LDL-C < 100 mg/dL, TG < 150 mg/dL, and Lp(a) < 30 mg/dL were associated with lipid-lowering treatment [OR 1.32 (95% CI 1.12-1.52)], atrial fibrillation [OR 1.31 (95% CI 1.11-1.54)], chronic coronary syndromes [OR 1.27 (95% CI 1.05-1.52)], smoking [OR 0.78 (95% CI 0.65-0.95)], BMI [OR 0.98 (95% CI 0.96-0.99)], and age [OR 1.006 (95% CI 1.002-1.009)].</p><p><strong>Conclusion: </strong>The highest proportion of patients with results within the normal range was observed for apoB and the lowest for LDL-C. The highest discordance was observed between apoB/LDL-C, with similar discordance rates between LDL-C/non-HDL-C and apoB/non-HDL-C. Lipid profile control was associated with BMI, atrial fibrillation, age, chronic coronary syndrome, aortic stenosis, diabetes, male gender, lipid-lowering therapy, and smoking. These findings highlight the complexity of lipid management.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"300"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial.","authors":"Solmaz Vahedi, Masome Rahimi, Tayebeh Sargazi Shad, Yaser Khanchemehr, Khadije Jahangasht Ghoozlu, Somayeh Fallah, Mahboobeh Moradi","doi":"10.1186/s12944-025-02726-z","DOIUrl":"10.1186/s12944-025-02726-z","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic foot ulcers (DFUs) are a severe complication of diabetes, leading to infections, amputations, and reduced quality of life. Ozonated olive oil, combining ozone's antimicrobial properties with olive oil's biocompatibility, shows promise in chronic wound management. Limited evidence exists on its comprehensive effects in DFUs. This study evaluates its impact on wound healing, quality of life, glycemic control, lipid profiles, and inflammation.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted at a tertiary care center in Hormozgan Province (January-December 2024) with 123 adults (aged 18-75) with type-2 diabetes and Wagner grade 1-2 DFUs. Participants were randomized (1:1) to receive daily topical ozonated olive oil (50 g/m³, 5 mL) or standard care for 4 weeks. Outcomes included wound severity (Bates-Jensen Wound Assessment Tool [BWAT]), quality of life (Diabetes Quality of Life Questionnaire [DQOL]), glycemic control (Glycated Hemoglobin [HbA1c], Fasting Blood Glucose [FBG], Postprandial Glucose [PPG]), lipid profiles (Low-Density Lipoprotein [LDL], High-Density Lipoprotein [HDL], Triglycerides [TG], Total Cholesterol), and inflammatory markers (High-Sensitivity C-Reactive Protein [hs-CRP], Interleukin-6 [IL-6], Tumor Necrosis Factor-alpha [TNF-α]). Assessments occurred at baseline, post-intervention, and 4 weeks post-intervention. Linear Mixed Models (LMM) and Analysis of Covariance (ANCOVA) analyzed outcomes, adjusting for baseline values.</p><p><strong>Results: </strong>The intervention group (n = 62) showed significant improvements compared to controls (n = 61). Bates-Jensen scores decreased (22.3 ± 4.5 vs. 26.1 ± 4.9, p < 0.001, Cohen's d = 0.67) at 4 weeks post-intervention, indicating better wound healing. Quality of life scores improved (50.1 ± 9.5 vs. 57.8 ± 10.0, p < 0.001, Cohen's d = 0.72). HbA1c reduced (7.1 ± 1.0% vs. 7.7 ± 1.1%, p = 0.005, Cohen's d = 0.51), as did fasting (145.3 ± 22.5 vs. 158.7 ± 23.9 mg/dL, p = 0.015) and postprandial glucose (190.1 ± 31.5 vs. 210.2 ± 33.8 mg/dL, p = 0.009). Also, hs-CRP levels dropped (2.9 ± 1.0 vs. 3.6 ± 1.1 mg/L, p = 0.006, Cohen's d = 0.50), but IL-6/TNF-α and lipid profiles showed no significant changes (p > 0.05).</p><p><strong>Conclusion: </strong>Topical ozonated olive oil significantly enhances wound healing, quality of life, glycemic control, and reduces inflammation in DFU patients. Its affordability and efficacy make it a promising adjunctive therapy. Further studies should explore long-term effects and mechanisms. It offers a scalable solution for DFU management.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"291"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulated serum lipid profiles in neovascular age-related macular degeneration revealed by UPLC‒MS/MS lipidomics.","authors":"Yuan Qu, Yujuan Liu, Junwei Fang, Chong Chen, Lu Cheng, Xiaoyin Xu, Jing Jin, Xia Chen, Tian Niu, Hanying Wang, Xindan Xing, Xin Shi, Yinchen Shen, Kun Liu","doi":"10.1186/s12944-025-02735-y","DOIUrl":"10.1186/s12944-025-02735-y","url":null,"abstract":"<p><strong>Purpose: </strong>Neovascular age-related macular degeneration (nAMD) is a major aetiology of vision loss characterized by lipid metabolism dysregulation. This study investigated the alterations in lipid profiles associated with wet AMD (wAMD) and its subtype, polypoidal choroidal vasculopathy (PCV).</p><p><strong>Methods: </strong>A cross-sectional lipidomic analysis was derived from a prospective longitudinal study in China (2017-2019). Serum samples from 195 wAMD patients, 130 PCV patients and 119 controls were analysed using ultra-performance liquid chromatography‒tandem mass spectrometry (UPLC‒MS/MS), focusing on acylcarnitines, glycerophospholipids and sphingolipids. Training and test sets were randomly generated after sample size matching. Orthogonal partial least squares-discriminant (OPLS-DA), univariate and multivariate analyses were performed. The selection criteria for differential lipids were a variable importance in projection (VIP) > 1.0, a fold change (FC) > 1.2 or < 0.83, and a false discovery rate (FDR) < 0.05. Key lipids were refined using the Boruta algorithm and evaluated through Firth regression and receiver operating characteristic (ROC) analysis. Spearman's rank correlation analysis was used to assess the relationships between the differential lipids and ocular indicators, including central retinal thickness (CRT), central retinal volume (CRV) and best-corrected visual acuity (BCVA).</p><p><strong>Results: </strong>No significant Lipid profile differences were detected between wAMD and PCV. Compared with the controls, wAMD patients had 53 differential lipids (52 upregulated, 1 downregulated), whereas PCV patients had 34 (31 upregulated, 3 downregulated). Upregulated PC ae C42:0 was consistently associated with ocular indicators in both groups. A 9-lipid panel for wAMD and a 6-lipid panel for PCV showed moderate diagnostic performance in the ROC models. Significant correlations with macular structure and BCVA were observed in PCV patients for 12 phosphatidylcholines, 3 sphingomyelins and 2 acylcarnitines and in wAMD patients for one phosphatidylcholine and one acylcarnitine. Downregulated lipids were negatively correlated with CRT or CRV, whereas upregulated lipids showed the opposite trend. Age-related lipid associations were found in wAMD but not in PCV patients.</p><p><strong>Conclusions: </strong>PCV and wAMD had shared and distinct lipidomic dysregulations, with stronger systemic-retinal associations in PCV, suggesting that subtype-specific metabolic reprogramming may affect nAMD pathology, offering new perspectives regarding early diagnosis and intervention strategies to mitigate disease burden.</p><p><strong>Trial registration: </strong>NCT03128463 ( www.</p><p><strong>Clinicaltrial: </strong>gov ) was registered on 9 March 2017.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"302"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity-depression-metabolism triad: amplification of cardiometabolic multimorbidity risk in Chinese adults (CHARLS 2011-2018).","authors":"Qinglin He, Wen Yu, Chubing Long, Dong Lin, Feng Lu, Maoling Zhong, Wei Lin, Shupeng Huang, Shuiying Hua, Fuzhou Hua, Xifeng Wang","doi":"10.1186/s12944-025-02724-1","DOIUrl":"10.1186/s12944-025-02724-1","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"295"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose index trajectories and in-hospital mortality in sepsis: a cohort study based on the MIMIC-IV database.","authors":"Fengwei Yao, Lei Liu, Xiaolan Chen, Zhijun He","doi":"10.1186/s12944-025-02743-y","DOIUrl":"10.1186/s12944-025-02743-y","url":null,"abstract":"<p><strong>Background: </strong>Sepsis remains a major challenge in critical care medicine, characterized by high incidence and mortality rates that severely threaten patient prognosis. Insulin resistance (IR) plays a pivotal role in the metabolic disturbances and adverse outcomes associated with sepsis. The triglyceride-glucose (TyG) index, as a readily attainable surrogate diagnostic for IR, has been frequently employed in clinical studies. The relationship between the TyG index's dynamic trajectories and clinical outcomes is yet unknown, though, as prior research has mostly assessed the index at a single time point.</p><p><strong>Methods: </strong>This retrospective study included ICU patients with sepsis, identified according to the Sepsis-3 criteria, from the MIMIC-IV database (2008-2019). Eligible participants were those aged ≥ 18 years, with first ICU admission, at least three venous blood glucose measurements, and at least one triglyceride measurement. The latent class mixed model (LCMM) was applied to classify dynamic trajectories of the TyG index within the first 72 h of ICU stay. LASSO and Boruta algorithms were jointly used for covariate selection. Subgroup and interaction analyses were conducted in addition to multivariable logistic regression to evaluate the relationship between various TyG trajectories and mortality.</p><p><strong>Results: </strong>A total of 3,555 sepsis patients were included. Trajectory analysis identified five distinct TyG dynamic patterns. Using the \"persistently low\" group as the reference, the fully adjusted model showed that the \"increase-then-decrease\" (OR = 2.61, 95% CI: 1.64-4.16), \"decrease-then-increase\" (OR = 1.46, 95% CI: 1.01-2.13), and \"stable moderate\" (OR = 1.23, 95% CI: 1.01-1.50) groups had significantly higher risks of in-hospital mortality. Subgroup analyses indicated that these associations were robust across most clinical strata.</p><p><strong>Conclusion: </strong>The TyG index exhibits substantial dynamic heterogeneity among ICU patients with sepsis. Certain abnormal trajectories (such as \"increase-then-decrease\", \"decrease-then-increase\", and \"stable moderate\") are associated with a markedly increased risk of in-hospital mortality. TyG trajectory analysis may provide a novel tool for risk stratification and individualized management in sepsis patients.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"297"},"PeriodicalIF":3.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}