Lipids in Health and Disease最新文献

{"title":"Low-density lipoprotein cholesterol is inversely associated with left atrial low-voltage areas in patients with persistent atrial fibrillation: a retrospective cohort study.","authors":"Jiahe Hu, Beining E, Jiawei Lu, Wenxing Guo, Binli Xu, Xinpeng You, Ling Yang, Qi Jiang","doi":"10.1186/s12944-026-03020-2","DOIUrl":"https://doi.org/10.1186/s12944-026-03020-2","url":null,"abstract":"<p><strong>Background: </strong>Left atrial low-voltage areas (LVAs) reflect advanced atrial remodeling and are associated with postablation recurrence in patients with persistent atrial fibrillation (PerAF). However, the relationship between routinely measured metabolic parameters and LVAs remains insufficiently characterized. This study aimed to identify clinical factors associated with LVAs in patients with PerAF, with particular emphasis on metabolic parameters.</p><p><strong>Methods: </strong>This retrospective single-center cohort included consecutive PerAF patients who underwent initial catheter ablation between January 2021 and August 2024. LVA status was analyzed as a binary outcome based on the results of the intraprocedural substrate assessment. Logistic regression was used to assess associations with LVAs, while mediation, restricted cubic spline, and quartile-based analyses were conducted as secondary analyses; the quartile-based analyses were descriptive. Postablation recurrence was assessed by Kaplan-Meier and Cox analyses.</p><p><strong>Results: </strong>Among 404 patients, 232 (57.4%) had LVAs. Age, female sex, fibrillatory wave amplitude, left atrial diameter (LAD), and LDL-C levels were associated with the presence of LVAs. Higher LDL-C levels were associated with lower odds of LVAs (odds ratio [OR] 0.72 per mmol/L, 95% confidence interval [CI] 0.53-0.97). LAD may partly account for this association (15%-18%). Quartile-based analyses revealed heterogeneity in LVA prevalence and recurrence across LDL-C categories, but these results were descriptive.</p><p><strong>Conclusion: </strong>In patients with PerAF, higher LDL-C levels were independently associated with a lower likelihood of LVAs. Lower LDL-C levels may help identify patients with a higher likelihood of advanced atrial remodeling before ablation.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"25 1","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13471465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) and adverse cardiovascular outcomes in dialysis patients: a systematic review and meta-analysis.","authors":"Ioannis Bellos, Smaragdi Marinaki, Vassiliki Benetou","doi":"10.1186/s12944-026-03018-w","DOIUrl":"https://doi.org/10.1186/s12944-026-03018-w","url":null,"abstract":"<p><strong>Background: </strong>Patients receiving maintenance dialysis experience exceptionally high cardiovascular morbidity and mortality. Lipoprotein(a) [Lp(a)] is an established cardiovascular risk factor in the general population; however, its prognostic significance in dialysis populations remains uncertain.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of observational cohort studies evaluating circulating Lp(a) levels and adverse cardiovascular outcomes in maintenance dialysis patients were conducted. MEDLINE, Scopus, Web of Science, and CENTRAL were searched from inception through May 5, 2026. The outcomes included all-cause mortality, cardiovascular mortality, and MACEs. Random-effects meta-analysis was performed when at least two studies reported comparable adjusted hazard ratios; pooled analyses based on very few studies were considered exploratory.</p><p><strong>Results: </strong>Fifteen reports representing 14 unique cohorts and 6380 dialysis patients were included. Nine studies evaluated hemodialysis populations exclusively, three evaluated peritoneal dialysis populations, and two evaluated mixed dialysis cohorts. Exploratory meta-analyses revealed associations between elevated Lp(a) levels and all-cause mortality (HR: 1.58; 95% CI: 1.24-2.02), cardiovascular mortality (HR: 2.07; 95% CI: 1.22-3.50), and MACE (HR: 1.56; 95% CI: 1.28-1.90). Certainty was low for MACE and very low for mortality outcomes.</p><p><strong>Conclusions: </strong>Available evidence suggests an association between high Lp(a) concentrations and mortality and adverse cardiovascular events in maintenance dialysis patients. However, routine clinical use for cardiovascular risk stratification cannot yet be recommended because thresholds, assay standardization, incremental predictive value, and treatment implications remain unresolved.</p><p><strong>Trial registration: </strong>https://dx.doi.org/10.17504/protocols.io.dm6gp7491gzp/v1 .</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"25 1","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health-related quality of life is associated with sustained lipid-lowering therapy adherence after acute coronary syndrome.","authors":"Asem H Ali, Katherine A Tak, Elisa M Taylor-Yeremeeva, Cassie R Shao, Carrie R Shao, Nico Fandino-Rubio, Maritza Jerome, Darleen Lessard, Catarina I Kiefe, David D McManus, Khanh-Van Tran","doi":"10.1186/s12944-026-03017-x","DOIUrl":"10.1186/s12944-026-03017-x","url":null,"abstract":"<p><strong>Background: </strong>Acute coronary syndrome (ACS) is a critical manifestation of cardiovascular disease, which necessitates rigorous secondary prevention to reduce recurrent events and mortality. While lipid-lowering therapy (LLT) is integral to post-ACS secondary prevention, long-term adherence remains a significant clinical challenge. This study evaluated psychological, socioeconomic, and clinical factors associated with LLT adherence in patients after ACS, with a specific focus on mental health components and chronic comorbidities.</p><p><strong>Methods: </strong>ACS survivors were included from the Transitions, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education cohort (TRACE-CORE). Baseline demographic, medical history and mental health data - including the 36-Item Short Form Survey (SF-36) Mental Component (MCS) and Physical Component Scores (PCS) and the Patient Health Questionnaire-9 (PHQ-9)- were collected during hospitalization. Adherence to LLT was assessed up to twelve-months post-discharge. We performed a comparative analysis between patients with complete versus incomplete follow-up and utilized binary logistic regression to identify factors associated with adherence to LLT.</p><p><strong>Results: </strong>Of the cohort, 51% completed the 12-month follow-up. Completers were significantly older, had higher education, better mental health metrics (higher MCS, lower PHQ-9), and higher prevalence of chronic conditions including diabetes, hypertension, and hyperlipidemia. Participants in the adherent group were more likely to be males and White and had higher MCS and PCS scores. Lower income (<$35,000) was associated with adherence in unadjusted analyses but did not remain independently associated after multivariable adjustment. In the regression, each 10-point increase in MCS (OR 1.24; 95% CI 1.07-1.44), hyperlipidemia (OR 1.42;1.05-1.92), male sex (OR 1.36;1.02-1.81) and white race (1.47;1.02-2.13) were associated with increased odds of adherence.  CONCLUSIONS: Mental health-related quality of life, as measured by MCS, along with hyperlipidemia, male sex, and White race, was associated with LLT adherence after ACS. These findings suggest that post-ACS secondary prevention may benefit from incorporating patient-reported mental health assessment to identify individuals at increased risk for nonadherence.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the cholesterol-high-density lipoprotein-glucose index and new-onset stroke in middle-aged and older adults with depressive symptoms: a longitudinal cohort analysis.","authors":"Yishu Wen, Wei Zhang, Lanxiang Wu, Jiaqi Zhu, Yingxue Yu, Xinping Yu, Sheng Tian, Qi Zuo, Runyu Zhou, Mingxu Liu, Wei Wu, Heqing Zheng","doi":"10.1186/s12944-026-03001-5","DOIUrl":"https://doi.org/10.1186/s12944-026-03001-5","url":null,"abstract":"<p><strong>Background: </strong>Depression is a global disease that significantly increases the risk of stroke. The cholesterol, high-density lipoprotein, and glucose index (CHG index) as an emerging composite metabolic marker has shown value in cardiovascular diseases and diabetes, but its predictive role in new-onset stroke among depressed individuals remains unclear.</p><p><strong>Methods: </strong>This study is based on the data from the Chinese Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. A total of 5,138 participants aged 45 and above, who had depressive symptoms (CES-D score ≥ 10) at the baseline and had no history of stroke, were included. Sequential Cox proportional hazards regression models were used as the main analysis to evaluate the association between the CHG index and new-onset stroke, and multivariable logistic regression was used as a secondary analysis to verify the consistency of the direction. Multiple imputation (20 datasets) was used to handle missing values of covariates. Restricted cubic splines and two-stage Cox regression models were used to explore potential nonlinear relationships and threshold effects.</p><p><strong>Results: </strong>During a total follow-up period of 35,554 person-years (with a median follow-up of 7 years), a total of 421 new-onset stroke events occurred. In the fully adjusted Cox model, for every 1-unit increase in the CHG index, the risk of new-onset stroke increased by 48% (HR = 1.48, 95% CI: 1.15-1.90, P = 0.003). However, the restricted cubic spline analysis revealed a significant non-linear relationship (D1 test P = 0.005), with the inflection point occurring at a CHG index of 5.59. When the CHG index was below 5.59, for every 1-unit increase, the risk of stroke increased by 117% (HR = 2.17, 95% CI: 1.37-3.44, P = 0.001); above this inflection point, no statistically significant association was observed (HR = 1.00, 95% CI: 0.62-1.62, P = 0.996). Multivariable logistic regression yielded a consistent significant association (OR = 1.53, 95% CI: 1.16-2.03, P = 0.003). Subgroup analysis and multiple sensitivity analyses (quartile analysis, exclusion of early stroke events, median binary classification analysis) all supported the robustness of the main findings.</p><p><strong>Conclusion: </strong>Among middle‑aged and older Chinese adults with depressive symptoms, the CHG index shows a significant non-linear positive association with the risk of new-onset stroke, and the risk increases sharply when the index is below 5.59. The CHG index may serve as a potential indicator for the early risk of stroke in this high-risk population.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipidomic profiling reveals time-resolved oxylipin responses to severe burn injury.","authors":"Revati S Dewal, Lisa A Baer, Shinsuke Nirengi, Nickolai P Seculov, Diego Hernandez-Saavedra, Kendra Madaris, Valerie Bussberg, Michael A Kiebish, Charles E Wade, Kristin I Stanford","doi":"10.1186/s12944-026-03016-y","DOIUrl":"10.1186/s12944-026-03016-y","url":null,"abstract":"<p><strong>Background: </strong>Severe burn injuries affecting more than 40% of the total body surface area (TBSA) are associated with a high risk of mortality. Clinically, burn injury is accompanied by increased systemic inflammation, adipose tissue lipolysis, and skeletal muscle catabolism that can contribute to muscle wasting. Despite the well-established role of inflammation in mediating these processes, the role of circulating oxylipins, released from various tissues and potentially linked to the inflammatory response, remains poorly understood.</p><p><strong>Methods: </strong>In this study, we investigated the temporal dynamics of plasma oxylipins in male and female patients with severe burn injuries (n = 7, mean TBSA 61 ± 6%) over a 33-day period post-injury, using high-resolution lipidomic profiling. A total of 114 lipid species were quantified, revealing distinct time-dependent alterations in both pro-inflammatory and anti-inflammatory lipid mediators. In addition, selected oxylipins were evaluated in C2C12 myotubes to test whether they engage atrophy-related and inflammatory transcriptional programs.</p><p><strong>Results: </strong>Specifically, levels of the pro-inflammatory oxylipins 15-hydroxyeicosatetraenoic acid (15-HETE) and its downstream metabolite 15-oxo-eicosatetraenoic acid (15-oxoETE) were elevated immediately after injury, whereas the anti-inflammatory oxylipin resolvin D1 (RvD1) peaked during the later phase of recovery. C2C12 myotubes incubated with 15-oxoETE increased expression of genes involved in muscle protein catabolism and inflammation, while co-incubation with RvD1 attenuated this transcriptional response.</p><p><strong>Conclusion: </strong>These findings define dynamic changes in the plasma lipidome following severe burn injury and identify selected burn-regulated oxylipins that can modulate skeletal muscle stress- and catabolism-related transcriptional programs in vitro.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-pregnancy glucose-lipid signatures and metabolic heterogeneity of gestational diabetes with extension to hypertensive comorbidity in singleton and twin pregnancies: a multicenter cohort study.","authors":"Minhuan Lin, Zhaoran Meng, Yiqing Chen, Shuting Xia, Yingnan Ye, Ting Ye, Jian Cai, Linhuan Huang, Li Wen, Yanmin Luo","doi":"10.1186/s12944-026-03009-x","DOIUrl":"10.1186/s12944-026-03009-x","url":null,"abstract":"<p><strong>Background: </strong>Early pregnancy is a critical window for metabolic adaptation, marked by coordinated regulation of glucose and lipid metabolism. Disruption of this balance may contribute to gestational diabetes mellitus (GDM), a condition increasingly recognized as metabolically heterogeneous. Whether early-pregnancy glucose-lipid indices capture this heterogeneity and extend to hypertensive disorders of pregnancy (HDP) remains unclear.</p><p><strong>Methods: </strong>This retrospective multicenter cohort included 13,419 pregnancies (11,765 singleton and 1,654 twin pregnancies). Fasting glucose and lipid measurements obtained at 5-16 weeks of gestation were used to derive eight composite indices, including the triglyceride-glucose (TyG) index, TyG-BMI, METS-IR, SPISE, AIP, CHG, NHHR, and lnRC. Multinomial logistic regression evaluated associations with GDM subtypes (post-load, isolated fasting, and combined GDM), using normoglycemia as the reference. Extension analyses assessed GDM-HDP phenotypes (GDM-only, HDP-only, and combined GDM-HDP) relative to normoglycemic-normotensive pregnancies. Restricted cubic spline models examined dose-response relationships, and receiver operating characteristic analyses assessed discriminative performance.</p><p><strong>Results: </strong>Early-pregnancy glucose-lipid indices showed a clear gradient across GDM subtypes, with progressively stronger associations from post-load GDM to isolated fasting GDM and combined GDM; adjusted odds ratios (ORs) per unit increase in TyG index were 2.54, 6.21, and 8.91, respectively. When analyses were extended to hypertensive outcomes, the strongest association was observed for combined GDM-HDP (adjusted OR, 4.81; 95% confidence interval, 3.35-6.89). Significant interaction with prepregnancy overweight status was observed for TyG-BMI, with more pronounced heterogeneity across HDP-related phenotypes, whereas associations were directionally similar across singleton and twin pregnancies after accounting for center composition. For the highest-risk phenotypes, area under the curve (AUC) values were 0.786 for combined GDM (TyG index and TyG-BMI) and 0.811 for combined GDM-HDP (TyG-BMI). A significant interaction between fasting glucose and high-density lipoprotein cholesterol was detected for both combined GDM (interaction OR 3.61) and combined GDM-HDP (interaction OR 3.79).</p><p><strong>Conclusions: </strong>Early-pregnancy glucose-lipid indices are associated with a graded pattern of metabolic heterogeneity across GDM subtypes, and a similar pattern is observed for hypertensive comorbidity. These findings are consistent with shared metabolic perturbations underlying glycemic and vascular complications during pregnancy and may inform future approaches to early-pregnancy risk assessment.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) and atherosclerosis risk across estimated glucose disposal rate strata: evaluating synergistic predictive utility.","authors":"Yihui Li, Nahua Xu, Lei Yan, Pingting Yang, Jiangang Wang","doi":"10.1186/s12944-026-03014-0","DOIUrl":"10.1186/s12944-026-03014-0","url":null,"abstract":"<p><strong>Background: </strong>High lipoprotein(a) [Lp(a)] levels and insulin resistance (IR) are both established risk factors for atherosclerosis. Nevertheless, the interrelationship between these two factors and their combined effects on atherosclerosis remain poorly understood. This research aimed to explore the distribution characteristics of Lp(a) across individuals at varying IR degrees and to evaluate the combined ability of Lp(a) levels and the IR surrogate marker, estimated glucose disposal rate (eGDR), in predicting atherosclerosis.</p><p><strong>Methods: </strong>This retrospective study involved data from 10,753 participants who received health examinations at the Third Xiangya Hospital (2017-2025). Carotid ultrasound was employed to diagnose atherosclerotic plaques. Logistic regression and restricted cubic spline (RCS) analysis were used across eGDR quartiles to examine the relationship between Lp(a) and plaque risk. The incremental benefits of incorporating both Lp(a) and eGDR in predicting atherosclerosis were further assessed via machine learning-based analyses.</p><p><strong>Results: </strong>In this study, the median Lp(a) concentration of the participants was 12.4 mg/dL, with 14.4% exhibiting values greater than 30 mg/dL. RCS analysis identified a significant nonlinear (U-shaped) relationship of Lp(a) with eGDR, whereas peak Lp(a) levels were observed within the uppermost eGDR quartile (Q4). Lp(a) levels demonstrated an independent positive link to atherosclerotic plaque risk; notably, this association remained significant in both the lowest and highest eGDR quartiles. Furthermore, machine learning analyses indicated that the incorporation of Lp(a) and eGDR conferred a modest gain in the model's discriminative capacity when forecasting atherosclerotic plaque, with the AUROC value increasing slightly from 0.7810 to 0.7820.</p><p><strong>Conclusions: </strong>Lp(a) levels exhibited a positive linear association with atherosclerotic plaques in the overall population, which varied across eGDR strata. Furthermore, the interaction between Lp(a) and eGDR was significantly relevant for the prediction of this condition. The integration of Lp(a) levels and the eGDR into machine learning models modestly improved the identification of high-risk individuals. This strategy supports more precise clinical interventions, ultimately contributing to improved cardiovascular health outcomes.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148422130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between glycolipid metabolism 7 factors (GLM7) and pregnancy loss in women aged 18-35 years: evidence from NHANES 2009-2018.","authors":"Zhoujun Zhu, Reweiguli Aihaiti, Lan Xia, Zhihong Niu","doi":"10.1186/s12944-026-02991-6","DOIUrl":"10.1186/s12944-026-02991-6","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence suggests that metabolic disturbances underlie pregnancy losses, imposing a substantial public health burden among young women of reproductive age. Glycolipid metabolism 7 factors (GLM7) is a composite glycolipid metabolism index derived from routinely measured metabolic indicators; however, its relevance to pregnancy loss in young women remains unexamined.</p><p><strong>Methods: </strong>The present study analyzed publicly available data from the 2009-2018 National Health and Nutrition Examination Survey (NHANES) cycles. Participants were categorized as having no pregnancy loss, single pregnancy loss, or recurrent pregnancy loss (≥ 2 losses). GLM7 was calculated as the logarithm of the product of age, body mass index, fasting blood glucose, fasting insulin, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol levels. The association between GLM7 and pregnancy loss categories was evaluated, potential dose-response patterns were explored, and effect modification by selected sociodemographic and behavioral factors was assessed.</p><p><strong>Results: </strong>Of the 736 women included in the analysis, 300 (37%) reported a history of pregnancy loss. In binary analyses, higher GLM7 was initially associated with pregnancy loss (OR = 1.21, 95% CI: 1.03-1.44); however, the association was attenuated after adjustment for the number of pregnancies (OR = 1.19, 95% CI: 0.99-1.44). In multinomial analyses, higher GLM7 levels were not significantly associated with single pregnancy loss. In contrast, higher GLM7 remained independently associated with recurrent pregnancy loss after adjustment for all covariates (OR = 1.17, 95% CI: 1.02-1.42; P = 0.046). Women in the second to fourth quartiles had significantly higher odds of recurrent pregnancy loss than those in the lowest quartile. No significant nonlinearity was observed in the association between GLM7 and recurrent pregnancy loss (P for nonlinearity = 0.265). No statistically significant interaction was observed across the subgroups.</p><p><strong>Conclusions: </strong>In this nationally representative sample of U.S. women aged 18-35 years, higher GLM7 levels were more robustly associated with recurrent rather than isolated pregnancy loss. The findings suggested that cumulative glycolipid metabolic burden may be particularly relevant to repeated reproductive failures and serve as indicators to improved strategies for early reproductive risk identification and preventive healthcare for women.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational lipid profile partially mediates adverse obstetric outcomes associated with polycystic ovary syndrome: a multicentre cohort study in China.","authors":"Fangfang Wang, Leyi Fu, Tianyi Zhou, Feng Yun, Ying Li, Xinyin Hu, Lifang You, Tianjing Wang, Xi Xi, Yimin Zhou, Jinghua Zhang, Zhengqiang Jiang, Danqing Chen, Paul J Hardiman, Jae Youl Cho, Dawei Xie, Fan Qu","doi":"10.1186/s12944-026-03013-1","DOIUrl":"10.1186/s12944-026-03013-1","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovary syndrome (PCOS) is associated with dyslipidaemia and adverse obstetric outcomes. Even among nonobese women, triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) levels differ between those with and without PCOS. This study aimed to elucidate the role of gestational lipid profiles in the association of PCOS with obstetric outcomes.</p><p><strong>Methods: </strong>This multicentre retrospective cohort study enrolled 2,515 pregnant women from 2016 to 2021 at 3 hospitals (1 provincial and 2 municipal) to assess the associations between maternal PCOS (exposure), obstetric outcomes (cesarean delivery, gestational complications, foetal ultrasonographic biometric measurements and neonatal unit admission), and lipid profile markers (mediators) using multivariate linear and logistic regression models and mediation analyses.</p><p><strong>Results: </strong>Pregnant women with PCOS were more likely to have a cesarean delivery (OR = 1.28, 95% CI 1.08, 1.52) than those without PCOS were. The levels of maternal lipid profile markers were associated with cesarean delivery [triglyceride (log TG): OR = 1.62, 95% CI 1.29, 2.03; high-density lipoprotein-cholesterol (HDL-C): OR = 0.67, 95% CI 0.53, 0.85]. These associations were independent of maternal age, educational attainment, the rate of total gestational weight gain (GWG), gravidity, parity, and neonatal sex. In terms of the association between maternal PCOS and cesarean delivery, the mediation effect of TG was 0.010 (95% CI 0.005, 0.016), and that of HDL-C was 0.007 (95% CI 0.002, 0.013). With respect to the secondary outcomes, both TG and HDL-C partially mediated the link between maternal PCOS and pregnancy hypertensive disorders and biparietal diameter in late pregnancy, whereas only TG partially mediated the effect of maternal PCOS on gestational diabetes mellitus and preterm delivery. HDL-C partially mediated the effect of maternal PCOS on admission to neonatal units.</p><p><strong>Conclusions: </strong>Gestational lipid profile markers partially mediated the link between maternal PCOS and adverse obstetric outcomes, including cesarean delivery, gestational complications, foetal ultrasonographic biometric measurements and neonatal unit admission, across different conception modes, independent of maternal age, educational attainment, the rate of total GWG, gravidity, parity and neonatal sex.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial anchoring of lipid metabolism shapes immune fate in the tumor microenvironment.","authors":"Shi Zheng, Zhonghua Tan, Yuxi Bao, Xuankai Gong, Xiaolin Zhong","doi":"10.1186/s12944-026-03011-3","DOIUrl":"10.1186/s12944-026-03011-3","url":null,"abstract":"<p><p>Cancer metabolic reprogramming has typically been regarded as a cell-autonomous process; however, this perspective fails to fully capture the intricacies of immunosuppression and treatment resistance within the heterogeneous and spatially organized tumor microenvironment (TME). While the metabolism of all major nutrients is subject to spatial constraints, lipid metabolism exhibits a unique and pronounced sensitivity due to the hydrophobic nature of lipids, which necessitates a specialized network of carrier proteins and organelles for their transport, storage, and signaling. We propose a model of spatio-specific lipid-immune regulatory programs that connects the intrinsic metabolic drivers of cancer cells with the spatial architecture of the TME, While grounded in existing literature, several of the mechanistic connections we describe represent a conceptual framework and working hypotheses that require direct experimental testing in the tumor microenvironment. Our investigation focuses on how three distinct spatial niches, the hypoxic core, invasive margin, and perivascular area, shape diverse lipid metabolic profiles through their unique physicochemical conditions and cellular compositions. Metabolic states specific to location determine the destiny and role of infiltrating immune cells, shaping an immune network significantly impacted by spatial positioning. Additionally, we investigate the potential of this spatial framework in identifying niche-specific biomarkers and developing novel combination therapies.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}