Lipids in Health and Disease最新文献

{"title":"The role of caveolin-1 in atherosclerosis and its molecular mechanism.","authors":"Xuan Liu, Zian Wang, Bohan Liu, Jiancheng Wang, Qinghai Meng, Yu Li","doi":"10.1186/s12944-026-02965-8","DOIUrl":"https://doi.org/10.1186/s12944-026-02965-8","url":null,"abstract":"<p><p>Atherosclerosis (AS), the fundamental pathological basis of most cardiovascular diseases, is a chronic and progressive inflammatory disorder characterized by lipid deposition and plaque formation within the arterial wall. Despite significant advances in pharmacological and interventional therapies, the global burden of AS remains substantial, emphasizing the need to identify novel molecular regulators and therapeutic targets. Caveolin-1 (Cav-1), a key scaffolding protein of plasma membrane caveolae, has emerged as a context-dependent modulator of lipid handling and vascular homeostasis in AS. Evidence from experimental and clinical studies indicates that Cav-1 participates in endothelial low-density lipoprotein (LDL) transcytosis and barrier function in endothelial cells (ECs), regulates cholesterol efflux and inflammatory signaling in macrophages (MΦs), and influences phenotypic plasticity in vascular smooth muscle cells (VSMCs). These coordinated actions position Cav-1 at the intersection of lipid metabolism and vascular inflammation. Notably, while global Cav-1 deficiency markedly attenuates atherosclerotic lesion formation in animal models, the cell type-specific and stage-dependent mechanisms underlying these effects remain incompletely understood. Cav-1 activity is further modulated by post-translational modifications (PTMs), particularly tyrosine-14 phosphorylation, which can influence its membrane localization, stability, and protein-protein interactions. In addition, emerging evidence suggests dynamic interplay between Cav-1 and autophagy-related pathways, highlighting its role in maintaining lipid and cellular homeostasis under metabolic stress. In this review, we systematically summarize current evidence regarding Cav-1 and caveolae across vascular cell types, delineate existing controversies and knowledge gaps, and evaluate the translational potential of targeting Cav-1-associated lipid regulatory pathways in AS.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fiber intake and mortality among adults with hyperlipidemia : a retrospective cohort analysis from NHANES 1999-2018.","authors":"Zhenpeng Ye, Mengfei Wei, Zhiruo Wang, Yingfei Zhang, Shea Michaela James, Chenchen Jiang, Chaoming Wu, Xiaomin Shi","doi":"10.1186/s12944-026-02961-y","DOIUrl":"https://doi.org/10.1186/s12944-026-02961-y","url":null,"abstract":"<p><strong>Background: </strong>According to the reports of previous studies, dietary fiber has a beneficial effect on controlling serum lipid indices. However, it still remains unclear whether dietary fiber has an influence on mortality among individuals with hyperlipidemia.</p><p><strong>Methods: </strong>Our cohort study assessed the association between the daily intake of dietary fiber and both all-cause mortality and cardiovascular disease mortality among adults with hyperlipidemia on the basis of the data of the National Health and Nutrition Examination (1999-2018) participants over 18 years old. For both of the continuous dietary fiber variable and the categorical dietary fiber variable, the Weighted Cox proportional hazards regression models as well as the restricted cubic splines were used to assess this association after categorizing the participants into three groups based on the tertile of the daily intake of dietary fiber.</p><p><strong>Results: </strong>For every 10 g/day increase in the daily intake of dietary fiber, after multivariable adjustments, the hazard ratio for all-cause mortality was 0.791 (95% confidence interval 0.704-0.890), while the hazard ratio for cardiovascular disease mortality was 0.768 (95% confidence interval 0.609-0.968). Moreover, compared with participants with daily intake of dietary fiber below 11.4 g, the hazard ratios for participants with daily intake of dietary fiber above 18.15 g were 0.694 (95% confidence interval 0.560-0.860) for all-cause mortality and 0.607 (95% confidence interval 0.399-0.924) for cardiovascular disease mortality. Additionally, the association between the intake of dietary fiber and all-cause mortality remained consistent among most subgroups of adults with hyperlipidemia, such as the subgroup consisting of participants with a TC level ≥ 200 mg/dL, the subgroup composed of participants with a TG level ≥ 150 mg/dL, the subgroup made up of participants with a LDL-C level ≥ 130 mg/dL as well as the subgroup formed by females with a HDL-C level ≤ 50 mg/dL and males with a HDL-C level ≤ 40 mg/dL.</p><p><strong>Conclusions: </strong>For adults with hyperlipidemia, high daily intake of dietary fiber could reduce the risk of both of all-cause mortality and cardiovascular disease mortality.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood nutrition-related biomarkers for central nervous system injury rehabilitation prognosis: a retrospective study.","authors":"Guiqing Cheng, Kun Zhao, Xinge Yu, Wenhui Ding, Huilin Liu, Fen Ju, Wei Sun, Fei Tian, Feng Feng, Xinyu Liu, Tao Han, Yixing Lu, Xiaolong Sun, Hua Yuan","doi":"10.1186/s12944-026-02957-8","DOIUrl":"https://doi.org/10.1186/s12944-026-02957-8","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TyHGB as a predictive marker for preeclampsia: association with increased risk in pregnant women with normal glucose tolerance.","authors":"Yongying Bai, Ya Xi, Jiamin Huang, Kaiqi Wu, Binbin Yin, Jinghua Zhang","doi":"10.1186/s12944-026-02962-x","DOIUrl":"https://doi.org/10.1186/s12944-026-02962-x","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic index of plasma in early pregnancy: associations with gestational diabetes mellitus and preeclampsia and its mediating role.","authors":"Ning Zhang, Biying Wu, Jiangxia Li, Xiaoqin Wang, Rui Zhang, Jun Liu, Min Yang","doi":"10.1186/s12944-026-02955-w","DOIUrl":"https://doi.org/10.1186/s12944-026-02955-w","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regular exercise modifies the effects of 12 LDL-C SNPs on cardiovascular disease risk: KoGES.","authors":"Yon Chul Park, Ahhyun Cho, Yong-Sang Kim, Yonghwan Kim, Jae-Min Park, Kunhee Han, Bomtaeck Kim, Kwangyoon Kim, Junghwa Shin, Yu-Jin Kwon, Ja-Eun Choi, Kyung-Won Hong","doi":"10.1186/s12944-026-02963-w","DOIUrl":"https://doi.org/10.1186/s12944-026-02963-w","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) concentration, kringle IV-2 repeat copy number, and myocardial infarction risk in Chinese populations: insights from the INTERHEART China study.","authors":"Jinsong Jiang, Xiaonan Ma, Ying Wei, Binong Su, Xin Liu, Yanyan Xiao, Yan Gu, Ziyu Wang, Dong Luo, Huafang Gao, Xingyu Wang, Aihua Hu","doi":"10.1186/s12944-026-02929-y","DOIUrl":"https://doi.org/10.1186/s12944-026-02929-y","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased HDL-C in hidradenitis suppurativa: association with systemic inflammatory phenotype and implications for risk stratification.","authors":"Chao Wu, Yong-Jun Wang, Tie-Jun Liu, Hong-Zhong Jin","doi":"10.1186/s12944-026-02959-6","DOIUrl":"https://doi.org/10.1186/s12944-026-02959-6","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted plasma lipidomic profiling associated with pediatric metabolic dysfunction-associated steatohepatitis (MASH).","authors":"Gahyun Lim, Helaina E Huneault, Chih-Yu Chen, Grey Won, Cristian Sanchez-Torres, Kristal Maner-Smith, Miriam B Vos","doi":"10.1186/s12944-026-02937-y","DOIUrl":"https://doi.org/10.1186/s12944-026-02937-y","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the triglyceride-high-density lipoprotein-glucose-body index and new-onset stroke risk: a prospective cohort study.","authors":"AoMen Lu, Qian Xu","doi":"10.1186/s12944-026-02953-y","DOIUrl":"https://doi.org/10.1186/s12944-026-02953-y","url":null,"abstract":"","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147723191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}