{"title":"美国成年人内脏脂质积累指标与保存率受损肺活量测定之间的关系：2007 - 2012年一项基于人群的研究","authors":"Zhehao Xu, Jia Ding, Ruiyun Liang, Xiwei Huang, Shuangfeng Xie","doi":"10.1186/s12944-025-02730-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Preserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted value. Recent studies suggest that visceral lipid accumulation may play a role in respiratory health, but the relationship between visceral fat indices and PRISm remains under explored. To investigate the relationship between indicators of visceral lipid accumulation and PRISm in US adults using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Data from three consecutive cycles of NHANES (2007-2012) were analyzed. Logistic regression and generalized additive models (GAM) were used to assess the relationship between various indices of visceral lipid accumulation and PRISm. The data was randomly divided into training (70%) and validation (30%) sets. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key factors for a nomogram model, which was evaluated using receiver operating characteristic(ROC) curves.</p><p><strong>Results: </strong>A significant positive association was found between visceral fat indices and PRISm risk (P < 0.05). GAM analysis revealed a nonlinear relationship, with PRISm risk initially plateauing or slightly decreasing at lower levels of visceral fat indices before rising above a certain threshold (P for non-linearity < 0.05). The nomogram model demonstrated fair discriminative ability, with the area under the ROC curve (AUC) of 0.785 (95%CI: 0.771-0.800) in the training set and 0.769 (95%CI: 0.747-0.791) in the validation set.</p><p><strong>Conclusions: </strong>This study establishes a robust association between visceral fat indicators and PRISm, highlighting the significance of lipid indices in evaluating respiratory health. Clinical screening for visceral fat indicators could be essential for more precise clinical interventions.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"292"},"PeriodicalIF":3.9000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481954/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between visceral lipid accumulation indicator and preserved ratio impaired spirometry in US adults: a population-based study from 2007 to 2012.\",\"authors\":\"Zhehao Xu, Jia Ding, Ruiyun Liang, Xiwei Huang, Shuangfeng Xie\",\"doi\":\"10.1186/s12944-025-02730-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Preserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted value. Recent studies suggest that visceral lipid accumulation may play a role in respiratory health, but the relationship between visceral fat indices and PRISm remains under explored. To investigate the relationship between indicators of visceral lipid accumulation and PRISm in US adults using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Data from three consecutive cycles of NHANES (2007-2012) were analyzed. Logistic regression and generalized additive models (GAM) were used to assess the relationship between various indices of visceral lipid accumulation and PRISm. The data was randomly divided into training (70%) and validation (30%) sets. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key factors for a nomogram model, which was evaluated using receiver operating characteristic(ROC) curves.</p><p><strong>Results: </strong>A significant positive association was found between visceral fat indices and PRISm risk (P < 0.05). GAM analysis revealed a nonlinear relationship, with PRISm risk initially plateauing or slightly decreasing at lower levels of visceral fat indices before rising above a certain threshold (P for non-linearity < 0.05). The nomogram model demonstrated fair discriminative ability, with the area under the ROC curve (AUC) of 0.785 (95%CI: 0.771-0.800) in the training set and 0.769 (95%CI: 0.747-0.791) in the validation set.</p><p><strong>Conclusions: </strong>This study establishes a robust association between visceral fat indicators and PRISm, highlighting the significance of lipid indices in evaluating respiratory health. Clinical screening for visceral fat indicators could be essential for more precise clinical interventions.</p>\",\"PeriodicalId\":18073,\"journal\":{\"name\":\"Lipids in Health and Disease\",\"volume\":\"24 1\",\"pages\":\"292\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481954/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lipids in Health and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s12944-025-02730-3\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02730-3","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Association between visceral lipid accumulation indicator and preserved ratio impaired spirometry in US adults: a population-based study from 2007 to 2012.
Background: Preserved Ratio Impaired Spirometry (PRISm) is a condition characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) ratio ≥ 0.70, yet FEV1 is below 80% of the predicted value. Recent studies suggest that visceral lipid accumulation may play a role in respiratory health, but the relationship between visceral fat indices and PRISm remains under explored. To investigate the relationship between indicators of visceral lipid accumulation and PRISm in US adults using data from the National Health and Nutrition Examination Survey (NHANES).
Methods: Data from three consecutive cycles of NHANES (2007-2012) were analyzed. Logistic regression and generalized additive models (GAM) were used to assess the relationship between various indices of visceral lipid accumulation and PRISm. The data was randomly divided into training (70%) and validation (30%) sets. Least Absolute Shrinkage and Selection Operator (LASSO) regression identified key factors for a nomogram model, which was evaluated using receiver operating characteristic(ROC) curves.
Results: A significant positive association was found between visceral fat indices and PRISm risk (P < 0.05). GAM analysis revealed a nonlinear relationship, with PRISm risk initially plateauing or slightly decreasing at lower levels of visceral fat indices before rising above a certain threshold (P for non-linearity < 0.05). The nomogram model demonstrated fair discriminative ability, with the area under the ROC curve (AUC) of 0.785 (95%CI: 0.771-0.800) in the training set and 0.769 (95%CI: 0.747-0.791) in the validation set.
Conclusions: This study establishes a robust association between visceral fat indicators and PRISm, highlighting the significance of lipid indices in evaluating respiratory health. Clinical screening for visceral fat indicators could be essential for more precise clinical interventions.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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