C-reactive protein as a mediator in the link between cardiometabolic index and osteoarthritis: insights from NHANES 2001-2010.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-07-07 DOI:10.1186/s12944-025-02603-9

Yike Wang, Zeyu Liu, Haoyu Wu, Chunsheng Wang

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Abstract

Background: Evidence has noted associations of osteoarthritis (OA) with obesity and C-reactive protein (CRP). However, little is clarified about the link between cardiometabolic index (CMI) and OA and the mediating role of CRP.

Methods: Participants from NHANES 2001-2010 were enrolled. CMI was computed based on anthropometric and biochemical indexes, covering height, waist circumference, triglyceride, and high-density lipoprotein cholesterol. OA diagnosis data were derived from the Medical Conditions questionnaires. Multivariate logistic regressions, restricted cubic spline (RCS) analysis, subgroup analyses, and interaction tests were implemented to investigate the association. A mediation analysis was employed to verify the mediating role of CRP.

Results: After controlling for all covariates, CMI was significantly linked with OA (OR: 1.07, 95% CI (1.01, 1.13), P = 0.038). RCS analyses elicited a non-linear link between CMI and OA (P - non - linear = 0.0012). The inflection point was 0.54. Threshold effect analysis was conducted through two-segment linear regression, including the left side ( < = 0.54) (OR: 2.06, 95% CI: 1.03, 6.58) and the right side of the inflection point (> 0.54) (OR: 0.40, 95% CI: 0.15, 1.03). CRP partially mediated the link between CMI and OA, around 7.59% of the total effect.

Conclusion: CMI is positively linked with OA, with CRP mediating the link. This paper unveils novel perspectives on the mechanism that links CMI to OA. Managing CMI and monitoring CRP levels may alleviate OA.

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c反应蛋白在心脏代谢指数和骨关节炎之间的中介作用：来自NHANES 2001-2010的见解。

背景：有证据表明骨关节炎（OA）与肥胖和c反应蛋白（CRP）有关。然而，关于心脏代谢指数（CMI）与OA之间的联系以及CRP的介导作用，目前尚不清楚。方法：纳入2001-2010年NHANES的参与者。CMI是根据人体测量和生化指标计算的，包括身高、腰围、甘油三酯和高密度脂蛋白胆固醇。OA诊断数据来源于医疗状况问卷。采用多变量logistic回归、限制性三次样条（RCS）分析、亚组分析和相互作用检验来调查相关性。采用中介分析验证CRP的中介作用。结果：在控制所有协变量后，CMI与OA显著相关（OR: 1.07, 95% CI (1.01, 1.13), P = 0.038）。RCS分析显示CMI与OA之间存在非线性关系（P -非线性= 0.0012）。拐点为0.54。采用双段线性回归进行阈值效应分析，包括左侧（0.54）（OR: 0.40, 95% CI: 0.15, 1.03）。CRP部分介导CMI和OA之间的联系，约占总效应的7.59%。结论：CMI与OA呈正相关，CRP在其中起中介作用。本文揭示了将CMI与OA联系起来的机制的新观点。控制CMI和监测CRP水平可以缓解OA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.