The relationship between the triglyceride to high-density lipoprotein cholesterol ratio and positive blood or pus cultures in patients with pyogenic liver abscess.
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引用次数: 0
Abstract
Background/aims: High triglyceride (TG) levels, low high-density lipoprotein cholesterol (HDL-C), and an elevated TG/HDL-C ratio are linked to increased systemic inflammation and impaired immune function. However, the clinical significance of the TG/HDL-C ratio in pyogenic liver abscess (PLA) remains poorly defined.
Methods: In this multicenter, cross-sectional study of 2,201 cases of PLA, logistic regression, smoothed curve fitting, and comprehensive sensitivity analyses were employed to assess the relationship between the baseline TG/HDL-C ratio and positive blood or pus cultures. Subgroup analyses and interaction tests were performed to evaluate the robustness of the findings.
Results: Logistic regression showed that the TG/HDL-C ratio was positively associated with blood or pus culture positivity in PLA [odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02-1.06, P < 0.001. Smoothed curve fitting revealed a nonlinear dose-response relationship, with an inflection point at 9.2. Below this threshold, the TG/HDL-C ratio remained significantly associated with culture positivity (OR = 1.1, 95% CI: 1.1-1.2, P < 0.001). Sensitivity analyses and interaction tests confirmed these results.
Conclusions: The TG/HDL-C ratio demonstrates a nonlinear relationship with the risk of positive blood or pus cultures in patients with PLA, with a pivotal threshold value identified at 9.2. This readily obtainable ratio may help clinicians individualize management strategies and facilitate timely interventions for PLA patients in this at-risk group, leading to improved health outcomes for this vulnerable population.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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