{"title":"Central adiposity indices and inflammatory markers mediate the association between life's crucial 9 and periodontitis in US adults.","authors":"Jia-Jie Guo, Qi-Qi Hang, Ting Xu, Wei-Xuan Liang, Jia-Kun Gao, Hong-Biao Ou, Fu-Zhen Jiang, Xi-Chen-Hui Qiu, Zu-Zhang Tian, Yu-Zhong Zhang, Jing Zhang","doi":"10.1186/s12944-025-02619-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited.</p><p><strong>Methods: </strong>We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using weighted logistic regression, restricted cubic spline (RCS), subgroup and WQS analyses. Mediation analysis assessed the roles of central adiposity (ABSI, WWI) and systemic inflammation (SII, SIRI).</p><p><strong>Results: </strong>Higher LC9 scores were associated with lower periodontitis prevalence (29.4% in highest vs. 52.1% in lowest quartile; P < 0.001), with a 15.5% risk reduction per 10-unit increase (OR = 0.845; 95% CI: 0.795-0.897). WQS analysis identified nicotine exposure, sleep health, blood glucose, blood pressure, and depressive symptoms as key contributors. Mediation analysis showed partial effects through WWI (21.617%), ABSI (10.869%), SIRI (7.120%), and SII (5.351%). LC9 did not significantly outperform LE8 in prediction.</p><p><strong>Conclusions: </strong>Higher LC9 score is linked to reduced periodontitis prevalence and severity, with central adiposity and systemic inflammation partially mediating this relationship. These findings emphasize comprehensive cardiovascular health management may help reduce periodontal disease risk.</p>","PeriodicalId":18073,"journal":{"name":"Lipids in Health and Disease","volume":"24 1","pages":"199"},"PeriodicalIF":3.9000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lipids in Health and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12944-025-02619-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited.
Methods: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using weighted logistic regression, restricted cubic spline (RCS), subgroup and WQS analyses. Mediation analysis assessed the roles of central adiposity (ABSI, WWI) and systemic inflammation (SII, SIRI).
Results: Higher LC9 scores were associated with lower periodontitis prevalence (29.4% in highest vs. 52.1% in lowest quartile; P < 0.001), with a 15.5% risk reduction per 10-unit increase (OR = 0.845; 95% CI: 0.795-0.897). WQS analysis identified nicotine exposure, sleep health, blood glucose, blood pressure, and depressive symptoms as key contributors. Mediation analysis showed partial effects through WWI (21.617%), ABSI (10.869%), SIRI (7.120%), and SII (5.351%). LC9 did not significantly outperform LE8 in prediction.
Conclusions: Higher LC9 score is linked to reduced periodontitis prevalence and severity, with central adiposity and systemic inflammation partially mediating this relationship. These findings emphasize comprehensive cardiovascular health management may help reduce periodontal disease risk.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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