Full-fat yogurt compared with non-fat yogurt reduces blood triacylglycerol concentrations and lowers the triacylglycerol content in specific lipoprotein subclasses in adults with prediabetes: an exploratory analysis of a randomized-controlled trial.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Victoria M Taormina, Simonne Eisenhardt, Matthew P Gilbert, Matthew E Poynter, C Lawrence Kien, Jana Kraft
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引用次数: 0

Abstract

Background: Low- and non-fat dairy foods have long been recommended over full-fat dairy foods due to the negative effect of saturated fatty acids on blood lipids. Recent research, however, suggests saturated fatty acids from dairy foods may not impart these negative health effects. Our objective was to evaluate changes in blood lipids following a diet with full-fat (3.25%) yogurt compared with a diet with non-fat yogurt.

Methods: A randomized, double-masked crossover controlled-feeding trial was performed. Participants with prediabetes (n = 13, 7 female and 6 male participants) consumed three daily servings of full-fat or non-fat yogurt for the three weeks of each experimental diet. A one-week run-in diet preceded each experimental diet period. After each experimental diet period and the first run-in diet period, fasting blood and blood drawn at four post-prandial time points during a mixed meal tolerance test were analyzed for lipoprotein concentrations and contents (i.e., the lipid fractions within the lipoproteins). Statistical analyses were performed using linear mixed models, with values from the first run-in diet as the covariate.

Results: Fasting blood triacylglycerol concentrations were 10% lower in response to the full-fat yogurt diet, compared with the non-fat yogurt diet (P < 0.01). While no diet-induced differences were observed in lipoprotein subclass concentrations, the triacylglycerol contents of smaller very low-density, intermediate-density, and low-density lipoproteins were lower in response to the full-fat yogurt diet (P ≤ 0.01). Trends indicated potentially greater high-density lipoprotein cholesterol concentrations and high-density lipoprotein size following the full-fat yogurt diet (P ≤ 0.05). The ratio of triacylglycerols: high-density lipoprotein cholesterol concentrations was 17% lower following the full-fat yogurt diet (P < 0.01).

Conclusions: This exploratory analysis demonstrates that short-term full-fat yogurt consumption elicits beneficial effects on the blood lipid profile in individuals with prediabetes and highlights the need for further evaluation of the contribution of dairy fat in yogurt and other dairy food matrices in lipid homeostasis and metabolic health.

Trial registration: This trial is registered at clinicaltrials.gov (NCT03577119).

与脱脂酸奶相比,全脂酸奶降低了糖尿病前期成人血液中甘油三酯的浓度,并降低了特定脂蛋白亚类中的甘油三酯含量:一项随机对照试验的探索性分析。
背景:长期以来,由于饱和脂肪酸对血脂的负面影响,低脂和脱脂乳制品比全脂乳制品更受推荐。然而,最近的研究表明,乳制品中的饱和脂肪酸可能不会对健康造成这些负面影响。我们的目的是评估全脂(3.25%)酸奶饮食与脱脂酸奶饮食后血脂的变化。方法:采用随机双盲交叉对照喂养试验。患有前驱糖尿病的参与者(n = 13,7名女性和6名男性参与者)在三周的实验饮食中每天食用三份全脂或脱脂酸奶。在每个实验饮食期之前,进行为期一周的磨合饮食。在每个实验饮食期和第一个磨合饮食期结束后,分析空腹血和混合膳食耐受性试验中四个餐后时间点的血中脂蛋白的浓度和含量(即脂蛋白中的脂质部分)。采用线性混合模型进行统计分析,以首次磨合饮食的值作为协变量。结论:这项探索性分析表明,短期食用全脂酸奶会对糖尿病前期患者的血脂状况产生有益的影响,并强调有必要进一步评估酸奶和其他乳制品基质中乳制品脂肪对脂质稳态和代谢健康的贡献。试验注册:本试验在clinicaltrials.gov注册(NCT03577119)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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