Exploring the association between healthy lifestyle score and atherogenic indices in a general population of Iranian adults.

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Lipids in Health and Disease Pub Date : 2025-06-07 DOI:10.1186/s12944-025-02631-5

Reza Amani-Beni, Bahar Darouei, Noushin Mohammadifard, Awat Feizi, Motahare Bateni, Fahimeh Haghighatdoost, Maryam Boshtam, Narges Grau, Nizal Sarrafzadegan

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引用次数: 0

Abstract

Background: Atherogenic indices outperform traditional lipid markers; however, the combined association of lifestyle habits with these indices remains unclear. This study, which is based on population data, explored the link between the Healthy Lifestyle Score (HLS) and various atherogenic indices.

Methods: In this cross-sectional analysis of the 2013 Isfahan Cohort Study 2 (participants aged ≥ 35 years), HLS was derived from four factors: smoking status, body mass index (18.5-24.9 kg/m²), physical activity (≥ 1350 MET minutes/week), and diet quality (top two quintiles of the Alternate Healthy Eating Index-2010). Each factor was scored as 1 for adherence and zero otherwise, yielding a score of 0-4. The atherogenic indices included the Atherogenic Coefficient (AC), Atherogenic Index of Plasma (AIP), Atherogenic Combined Index (ACI), Castelli Risk Indices I and II (CRI-I/II), non-high-density Lipoprotein Cholesterol (NHC), Lipoprotein Combined Index (LCI), Remnant Lipoprotein Cholesterol (RLPC), and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio. Logistic and linear regression analyses were conducted to examine these associations after adjusting for confounders.

Results: Among 2,256 participants (49.7% men), the overall mean age was 58.15 ± 9.89 years. Across the population, a higher HLS was strongly linked to a decreased likelihood of elevated levels of individual atherogenic indices. Compared to individuals with HLS 0-1, those with HLS 3-4 had notably reduced odds of high AIP (odds ratio (OR): 0.42; 95% CI: 0.30-0.59), ACI (OR: 0.60; 95% CI: 0.47-0.77), and other indices (all P for trend < 0.05). Sex-stratified analyses revealed distinct patterns: in men, HLS was strongly associated with lower TG/HDL-C, AIP, and ACI, whereas in women, stronger associations were observed with cholesterol-driven markers (AC, NHC, RLPC, CRI-I, and CRI-II). Linear regression analysis confirmed that each unit increase in HLS corresponded to lower continuous values of these indices in the total population. AIP emerged as the most sensitive marker in both sexes.

Conclusions: Adherence to a healthier lifestyle, as measured by the HLS, was significantly associated with lower atherogenic indices, highlighting its role in reducing cardiovascular risk. These results support integrating lifestyle interventions with cardiovascular prevention. Future studies should assess the causal impact of lifestyle modifications on atherogenic profiles.

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探讨伊朗成年人健康生活方式评分与动脉粥样硬化指数之间的关系。

背景：动脉粥样硬化指标优于传统的脂质标志物；然而，生活习惯与这些指数的综合关系尚不清楚。本研究以人口数据为基础，探讨了健康生活方式评分（HLS）与各种动脉粥样硬化指数之间的联系。方法：在2013年伊斯法罕队列研究2（参与者年龄≥35岁）的横断面分析中，HLS来源于四个因素：吸烟状况、体重指数（18.5-24.9 kg/m²）、身体活动（≥1350 MET分钟/周）和饮食质量（替代健康饮食指数-2010的前两个五分之一）。每个因素在依从性方面得分为1，在其他方面得分为0，得分为0-4。致动脉粥样硬化指标包括：致动脉粥样硬化系数（AC）、血浆致动脉粥样硬化指数（AIP）、致动脉粥样硬化综合指数（ACI）、Castelli风险指数I和II （CRI-I/II）、非高密度脂蛋白胆固醇（NHC）、脂蛋白综合指数（LCI）、残余脂蛋白胆固醇（RLPC）、甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）比值。在调整混杂因素后，进行了逻辑和线性回归分析来检验这些关联。结果：2256名参与者（男性49.7%），总平均年龄为58.15±9.89岁。在整个人群中，较高的HLS与个体动脉粥样硬化指数升高的可能性降低密切相关。与HLS 0-1的个体相比，HLS 3-4的个体发生高AIP的几率显著降低(比值比（OR）： 0.42；95% ci: 0.30-0.59), aci (or: 0.60；95% CI: 0.47-0.77)和其他指数（均P为趋势）结论：HLS测量的坚持更健康的生活方式与较低的动脉粥样硬化指数显著相关，突出了其在降低心血管风险方面的作用。这些结果支持将生活方式干预与心血管预防相结合。未来的研究应该评估生活方式改变对动脉粥样硬化的因果影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.