Light-Science & Applications最新文献

Dye-sensitized cascaded energy transfer for amplified 1525 nm luminescence in highly doped lanthanide nanoparticles 高掺杂镧系纳米颗粒中1525nm放大发光的染料敏化级联能量转移

Light-Science & Applications Pub Date : 2026-04-27 DOI: 10.1038/s41377-026-02302-9

Fei Long, Dechao Gan, Haoran Chen, Qiqing Li, Wang Wang, Zexuan Sui, Youlin Zhang, Dabing Li, Yulei Chang

{"title":"Dye-sensitized cascaded energy transfer for amplified 1525 nm luminescence in highly doped lanthanide nanoparticles","authors":"Fei Long, Dechao Gan, Haoran Chen, Qiqing Li, Wang Wang, Zexuan Sui, Youlin Zhang, Dabing Li, Yulei Chang","doi":"10.1038/s41377-026-02302-9","DOIUrl":"https://doi.org/10.1038/s41377-026-02302-9","url":null,"abstract":"Lanthanide-based probes for second near-infrared (NIR-II) luminescence imaging enable deep-tissue penetration with minimal autofluorescence. However, their broader application is hindered by intrinsic limitations such as low brightness and weak absorption. To address these, we developed a dye-sensitized construct, NaErF4@NaYF4:50%Yb@ICG. This design harnesses population dynamics in heavily doped Er3+ systems through a cascaded energy transfer process enabled by dual 808 nm excitation of both indocyanine green (ICG) and the Er3+-rich core—specifically, it harvests energy destined for nonradiative decay by inserting a Yb3+-mediated relay (ICG → Yb3+ → Er3+) into the original ICG → Er3+ pathway. This approach yields 1965-fold and 11-fold enhancements in 1525 nm downshifting emission compared to the corresponding core and counterpart, respectively. The resulting nanoprobe enables high-resolution NIR-IIb vascular imaging with a signal-to-background ratio of 3.09. These mechanistic insights and design principles inform the design of efficient NIR-II nanoprobes, demonstrating substantial potential for advancing vascular biology.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147751808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy 用于肿瘤闭环光热治疗的多功能光纤治疗探头

Light-Science & Applications Pub Date : 2026-04-27 DOI: 10.1038/s41377-026-02219-3

Zesen Li, Zhuoran Li, Zhongyuan Cheng, Claudia Borri, Ambra Giannetti, Ni Lan, Junqiu Long, Wenwei Chen, Xiangran Cai, Jingge Yang, Bai-Ou Guan, Francesco Chiavaioli, Yang Ran

{"title":"Multifunctional fiber-optic theranostic probe for closed-loop tumor photothermal therapy","authors":"Zesen Li, Zhuoran Li, Zhongyuan Cheng, Claudia Borri, Ambra Giannetti, Ni Lan, Junqiu Long, Wenwei Chen, Xiangran Cai, Jingge Yang, Bai-Ou Guan, Francesco Chiavaioli, Yang Ran","doi":"10.1038/s41377-026-02219-3","DOIUrl":"https://doi.org/10.1038/s41377-026-02219-3","url":null,"abstract":"The combination of optical fiber and phototheranostic agents has emerged as a promising strategy to address the challenges of limited light penetration depth and systemic toxicity of nanomaterials. However, the multiplexing potential of fiber-optic probes remains underrated, resulting in enlarged incisions, repeated invasive procedures, and a lack of real-time therapeutic feedback. Herein, we propose a scheme for single‑fiber multifunctional integration leveraging wavelength division multiplexing technology. As a proof-of-concept, by co-immobilizing pH indicator, temperature indicator, and photothermal agent with non-overlapped excitation bands onto tapered optical fiber surface, a fiber-optic theranostic probe enabling closed-loop tumor photothermal therapy was developed. Pre-treatment, the probe can achieve tumor edge identification through revealing the tumor pH gradient. Intra-treatment, the photothermal agent can convert optical energy into heat for photothermal therapy, while simultaneous temperature monitoring enables precise thermal dose control. Post-treatment, rapid efficacy assessment can be achieved via real-time monitoring of the reversal of acidic tumor microenvironment. Animal experiments validate the excellent therapeutic efficacy and biocompatibility of the probe. This research opens new avenues for multifunctional fiber-optic theranostic platforms, where modular wavelength assignment enables customizable minimally invasive interventions and feedback monitoring, holding significant promise for both clinical practice and mechanistic exploration.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147751809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hybrid-frequency programmable synthetic-dimension simulator with rich coupling on a single chip. 在单芯片上实现了一种多耦合的混合频率可编程综合尺寸模拟器。

Light-Science & Applications Pub Date : 2026-04-24 DOI: 10.1038/s41377-026-02309-2

Xiao-Dong Zeng,Zhao-An Wang,Jia-Ming Ren,Yi-Tao Wang,Chun Ao,Wei Liu,Nai-Jie Guo,Lin-Ke Xie,Jun-You Liu,Yu-Hang Ma,Ya-Qi Wu,Shuang Wang,Pei-Yun Li,Mu Yang,Jin-Shi Xu,Xi-Wang Luo,Jian-Shun Tang,Chuan-Feng Li,Guang-Can Guo

{"title":"A hybrid-frequency programmable synthetic-dimension simulator with rich coupling on a single chip.","authors":"Xiao-Dong Zeng,Zhao-An Wang,Jia-Ming Ren,Yi-Tao Wang,Chun Ao,Wei Liu,Nai-Jie Guo,Lin-Ke Xie,Jun-You Liu,Yu-Hang Ma,Ya-Qi Wu,Shuang Wang,Pei-Yun Li,Mu Yang,Jin-Shi Xu,Xi-Wang Luo,Jian-Shun Tang,Chuan-Feng Li,Guang-Can Guo","doi":"10.1038/s41377-026-02309-2","DOIUrl":"https://doi.org/10.1038/s41377-026-02309-2","url":null,"abstract":"High-performance photonic chips provide a powerful platform for analog computing, enabling the simulation of high-dimensional physical systems using low-dimensional devices with additional synthetic dimensions. The realization of large-scale complex simulations necessitates an architecture capable of rich coupling configurations (encompassing symmetric, asymmetric and long-range coupling schemes) which is also crucial for scaling up. Previous approaches rely on excessive physical components to introduce asymmetric coupling, however, are restricted in reconfiguring and scaling by the relatively complicated structures. Here, to solve this problem, we propose a hybrid-frequency synthetic-dimension simulator architecture that combines both intra-resonant and inter-resonant frequency-lattice sites, and experimentally demonstrate it using the thin-film lithium niobate (TFLN) photonic chip. Employing this hybrid programmable architecture, we are able to simulate both the regular and long-range coupled forms of diverse compound-lattice models, such as the Hall ladder, Creutz ladder (symmetric) and Su-Schrieffer-Heeger (SSH, asymmetric) model, on a single chip, simultaneously reducing the experimental requirements significantly. As results, the direct readout of the bandstructure of the SSH model is able to be achieved, to be distinguished from all previous works, and important phenomena such as spin-momentum locking, topological flat band and Aharonov-Bohm cage effect are also observed with lower experimental requirements. Furthermore, applications like piecewise-continuous optical frequency shifting can be enabled by cascading our devices. Our results offer promising insights for future large-scale complex on-chip simulators with rich couplings.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topological control of chirality and spin with structured light 结构光手性和自旋的拓扑控制

Light-Science & Applications Pub Date : 2026-04-24 DOI: 10.1038/s41377-026-02278-6

Light Mkhumbuza, Pedro Ornelas, Angela Dudley, Isaac Nape, Kayn A. Forbes

{"title":"Topological control of chirality and spin with structured light","authors":"Light Mkhumbuza, Pedro Ornelas, Angela Dudley, Isaac Nape, Kayn A. Forbes","doi":"10.1038/s41377-026-02278-6","DOIUrl":"https://doi.org/10.1038/s41377-026-02278-6","url":null,"abstract":"Structured light beams with engineered topological properties offer a powerful means to control spin angular momentum (SAM) and optical chirality, key quantities shaped by spin-orbit interaction (SOI) in light. Such effects are commonly associated with non-paraxial focusing or light-matter interfaces. Here, we demonstrate that higher-order Poincaré modes carrying a tunable Pancharatnam topological charge ℓp enable deterministic control of SOI entirely in free space and within the paraxial regime. We show that modulation of ℓp drives a measurable radial separation of circular polarization components - a free-space optical Hall effect arising from propagation-induced mechanisms alone. The effect originates from differential Gouy-phase evolution and radial divergence between the two circular components of an initially spin-balanced vector beam. This identifies ℓp as a single, tunable parameter linking Pancharatnam topology to paraxial spin-orbit coupling, establishing a simple and material-independent route to generate and control optical chirality and SAM. This approach provides new opportunities for tunable optical manipulation, chiral sensing, and high-dimensional photonic information processing.\u0000\u0000The alternative text for this image may have been generated using AI.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147751816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deformation engineering enables precise dispersion control in an optical microcavity. 变形工程使光学微腔中的精确色散控制成为可能。

Light-Science & Applications Pub Date : 2026-04-23 DOI: 10.1038/s41377-026-02297-3

Julius Kullig,Jan Wiersig

引用次数: 0

Editors at the frontier: exploring advanced optical engineering in the UK. 编辑在前沿：探索先进的光学工程在英国。

Light-Science & Applications Pub Date : 2026-04-20 DOI: 10.1038/s41377-026-02292-8

Siqiu Guo,Xiangqian Jiang

引用次数: 0

Space-time-coding metasurfaces for high-dimensional communications with OAM-, polarization-, and frequency-division multiplexing. 使用OAM、极化和频分复用的高维通信的空时编码元表面。

Light-Science & Applications Pub Date : 2026-04-20 DOI: 10.1038/s41377-026-02282-w

Lei Zhang,Tie Jun Cui

引用次数: 0

High-performance thermally-evaporated light-emitting diodes via one-step vapor purification. 通过一步蒸汽净化的高性能热蒸发发光二极管。

Light-Science & Applications Pub Date : 2026-04-20 DOI: 10.1038/s41377-026-02226-4

Xiang Zhang,Yuanwu Wu,Jianfeng Ou,Zixi Shen,Nian Liu,Thamraa Alshahrani,Abd Rashid Bin Mohd Yusoff,Jiang Tang,Jiajun Luo

{"title":"High-performance thermally-evaporated light-emitting diodes via one-step vapor purification.","authors":"Xiang Zhang,Yuanwu Wu,Jianfeng Ou,Zixi Shen,Nian Liu,Thamraa Alshahrani,Abd Rashid Bin Mohd Yusoff,Jiang Tang,Jiajun Luo","doi":"10.1038/s41377-026-02226-4","DOIUrl":"https://doi.org/10.1038/s41377-026-02226-4","url":null,"abstract":"Purity has been fundamental to the fabrication of high-performance semiconductors, spanning from precursors to reaction atmospheres. Emerging thermally evaporated perovskites involving precise control impose even stricter requirements on the purity of the vapor atmosphere. Compared to the purified solvent for the reaction atmosphere in the solution-based method, efficient and effective vapor purification remains unexplored. Here, we report one-step vapor purification for a pure atmosphere with less than one percent detrimental impurity. The in-situ residual gas analysis was employed to emphasize the complexity of the gas-phase composition and reveal the impurity reaction competition during the purification. The pre-control of the vapor atmosphere enabled a record external quantum efficiency over 20% for a thermally-evaporated perovskite light-emitting diode (PeLED) based on defect-suppressed FAxCs1-xPbBr3 films. Moreover, the PeLED display panels exhibit over 5-fold and 2-fold magnification in operational and storage stability. The stability extension in OLEDs by this strategy demonstrates its universal effectiveness and commercialization potential for other types of thermally evaporated optoelectronic devices.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"207 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional ligand engineering for pure-blue halide perovskite nanocrystal LEDs. 纯蓝色卤化物钙钛矿纳米晶体led的多功能配体工程。

Light-Science & Applications Pub Date : 2026-04-20 DOI: 10.1038/s41377-026-02288-4

Mark T Swihart

引用次数: 0

NIR-II-triggered plasmonic catalysis with tip-localized enhancement: a strategy for hypoxic biofilm eradication on orthopedic implants. nir - ii触发的等离子体催化与尖端局部增强：矫形植入物缺氧生物膜根除的策略。

Light-Science & Applications Pub Date : 2026-04-17 DOI: 10.1038/s41377-026-02279-5

Yu Sun,Fanglin Sheng,Yi Liang,Jinhui Meng,Ke Huang,Sanmao Liu,Yingfeng Qin,Maolin He,Jin-Wen Liu

{"title":"NIR-II-triggered plasmonic catalysis with tip-localized enhancement: a strategy for hypoxic biofilm eradication on orthopedic implants.","authors":"Yu Sun,Fanglin Sheng,Yi Liang,Jinhui Meng,Ke Huang,Sanmao Liu,Yingfeng Qin,Maolin He,Jin-Wen Liu","doi":"10.1038/s41377-026-02279-5","DOIUrl":"https://doi.org/10.1038/s41377-026-02279-5","url":null,"abstract":"The utilization of light as an external stimulus to promote the generation of hot electrons in plasmonic heterostructures and thus augment their catalytic efficacy presents significant potential for bacterial biofilm eradication. However, the inefficient harnessing of photoinduced hot electrons in conventional developed strategies greatly impede their therapeutic application in bone tissues. To overcome these challenges, we herein engineered a near-infrared II (NIR-II)-triggered plasmonic catalysis, which was fabricated through the integration of gold nanobipyramids (Au NBPs) with tip-deposited platinum nanoparticles (Pt NPs), for effective elimination of hypoxic bacterial biofilms on bone implants. The strategic deposition of Pt NPs at the tip of Au NBPs (ePt-Au NBPs) not only brought the redshift of the NIR absorption peak, but also accelerated charge separation and electromagnetic field localization, which endowed the ePt-Au NBPs plasmonic heterostructures with enhanced catalytic activity. Under NIR-II laser irradiation, the plasmonic catalysis with tip-localized enhancement enabled robust generation of hydroxyl radicals (•OH), thereby facilitating the cleavage of extracellular DNA (eDNA) within biofilms, disrupting biofilm integrity, and ultimately sensitizing bacteria to thermal ablation. These attributes collectively contribute to the effective elimination of hypoxic bacterial biofilms. Furthermore, surface functionalization with RGDC peptides conferred the implant with superior biocompatibility and osteogenic integration capabilities. This rationally designed plasmonic catalysis, combining the NIR-II-triggered simultaneous production of enhanced catalytic activity and localized hyperthermia, demonstrates significant potential for translational applications in light-responsive therapeutic strategies for implant-associated infections.","PeriodicalId":18069,"journal":{"name":"Light-Science & Applications","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0