Learning & memory最新文献_第10页

Self-reported encoding quality promotes lure rejections and false alarms. 自我报告的编码质量会导致诱饵被拒绝和误报。

IF 2 4区医学

Learning & memory Pub Date : 2023-05-04 Print Date: 2023-04-01 DOI: 10.1101/lm.053751.123

Christopher N Wahlheim, Sydney M Garlitch, Rawan M Mohamed, Blaire J Weidler

引用次数: 0

Corrigendum: Depotentiation depends on IP₃ receptor activation sustained by synaptic inputs after LTP induction. 勘误:减弱依赖于LTP诱导后突触输入维持的IP3受体激活。

IF 2 4区医学

Learning & memory Pub Date : 2023-05-01 DOI: 10.1101/lm.053796.123

Satoshi Fujii, Yoshihiko Yamazaki, Jun-Ichi Goto, Hiroki Fujiwara, Katsuhiko Mikoshiba

引用次数: 0

Standardized extract of Ginkgo biloba treatment and novelty on the weak encoding of spatial recognition memory in rats. 银杏叶标准化提取物治疗和新奇感对大鼠空间识别记忆弱编码的影响

IF 2 4区医学

Learning & memory Pub Date : 2023-04-18 Print Date: 2023-04-01 DOI: 10.1101/lm.053755.123

Carla Vitor de Andrade, Andressa Gabriela Soliani, Suzete Maria Cerutti

{"title":"Standardized extract of Ginkgo biloba treatment and novelty on the weak encoding of spatial recognition memory in rats.","authors":"Carla Vitor de Andrade, Andressa Gabriela Soliani, Suzete Maria Cerutti","doi":"10.1101/lm.053755.123","DOIUrl":"10.1101/lm.053755.123","url":null,"abstract":"Long-term memory (LTM) formation is dependent on neurochemical changes that guarantee that a recently formed memory (short-term memory [STM]) remains in the specific neural circuitry via the consolidation process. The persistence of recognition memory has been evidenced by using behavioral tagging in young adult rats, but it has not been effective on aging. Here, we investigated the effects of treatment with a standardized extract of Ginkgo biloba (EGb) associated with novelty on the consolidation of object location memory (OLM) and its persistence after weak training of spatial object preference in young adult and aged rats. The object location task used in this study included two habituation sessions, training sessions associated or not associated with EGb treatment and contextual novelty, and short-term or long-term retention testing sessions. Altogether, our data showed that treatment with EGb associated with novelty close to the time of encoding resulted in STM that lasted for 1 h and persisted for 24 h for both young adult and aged rats. In aged rats, the cooperative mechanisms induced robust long-term OLM. Our findings support and extend our knowledge about recognition memory in aged rats and the modulating effects of EGb treatment and contextual novelty on the persistence of memory.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"30 4","pages":"85-95"},"PeriodicalIF":2.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10165992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9494805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats. 听觉恐惧条件反射中的特定行为和杏仁核基底外侧AMPA受体的突触后表达预测雄性大鼠恐惧泛化的个体间差异。

IF 2 4区医学

Learning & memory Pub Date : 2023-04-01 DOI: 10.1101/lm.053612.122

Bruno José Moraes, Oliver Hardt

{"title":"Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats.","authors":"Bruno José Moraes, Oliver Hardt","doi":"10.1101/lm.053612.122","DOIUrl":"https://doi.org/10.1101/lm.053612.122","url":null,"abstract":"Auditory fear conditioning in rats is a widely used method to study learning, memory, and emotional responding. Despite procedural standardizations and optimizations, there is substantial interindividual variability in fear expression during test, notably in terms of fear expressed toward the testing context alone. To better understand which factors could explain this variation between subjects, we here explored whether behavior during training and expression of AMPA receptors (AMPARs) after long-term memory formation in the amygdala could predict freezing during test. We studied outbred male rats and found strong variation in fear generalization to a different context. Hierarchical clustering of these data identified two distinct groups of subjects that independently correlated with a specific pattern of behaviors expressed during initial training (i.e., rearing and freezing). The extent of fear generalization correlated positively with postsynaptic expression of GluA1-containing AMPA receptors in the basolateral nucleus of the amygdala. Our data thus identify candidate behavioral and molecular predictors of fear generalization that may inform our understanding of some anxiety-related disorders, such as posttraumatic stress disorder (PTSD), that are characterized by overgeneralized fear.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"30 4","pages":"74-84"},"PeriodicalIF":2.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/2a/LM053612Mor.PMC10165993.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9503484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differential effects of emotional valence on mnemonic performance with greater hippocampal maturity. 海马成熟度越高，情绪情感对记忆力表现的影响越不同

IF 2 4区医学

Learning & memory Pub Date : 2023-03-15 Print Date: 2023-03-01 DOI: 10.1101/lm.053628.122

Adam Kimbler, Dana L McMakin, Nicholas J Tustison, Aaron T Mattfeld

{"title":"Differential effects of emotional valence on mnemonic performance with greater hippocampal maturity.","authors":"Adam Kimbler, Dana L McMakin, Nicholas J Tustison, Aaron T Mattfeld","doi":"10.1101/lm.053628.122","DOIUrl":"10.1101/lm.053628.122","url":null,"abstract":"The hippocampal formation (HF) facilitates declarative memory, with subfields providing unique contributions to memory performance. Maturational differences across subfields facilitate a shift toward increased memory specificity, with peripuberty sitting at the inflection point. Peripuberty is also a sensitive period in the development of anxiety disorders. We believe HF development during puberty is critical to negative overgeneralization, a common feature of anxiety disorders. To investigate this claim, we examined the relationship between mnemonic generalization and a cross-sectional pubertal maturity index (PMI) derived from partial least squares correlation (PLSC) analyses of subfield volumes and structural connectivity from T1-weighted and diffusion-weighted scans, respectively. Participants aged 9-14 yr, from clinical and community sources, performed a recognition task with emotionally valent (positive, negative, and neutral) images. HF volumetric PMI was positively associated with generalization for negative images. Hippocampal-medial prefrontal cortex connectivity PMI evidenced a behavioral relationship similar to that of the HF volumetric approach. These findings reflect a novel developmentally related balance between generalization behavior supported by the hippocampus and its connections with other regions, with maturational differences in this balance potentially contributing to negative overgeneralization during peripuberty.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"30 3","pages":"55-62"},"PeriodicalIF":2.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9149369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep disruption by memory cues selectively weakens reactivated memories. 记忆线索对睡眠的干扰会选择性地削弱重新激活的记忆。

IF 1.8 4区医学

Learning & memory Pub Date : 2023-03-15 Print Date: 2023-03-01 DOI: 10.1101/lm.053615.122

Nathan W Whitmore, Ken A Paller

引用次数: 0

Neuronal and astrocytic protein degradation are critical for fear memory formation. 神经元和星形胶质细胞的蛋白质降解对恐惧记忆的形成至关重要。

IF 2 4区医学

Learning & memory Pub Date : 2023-03-15 Print Date: 2023-03-01 DOI: 10.1101/lm.053716.122

Kayla Farrell, Taylor McFadden, Timothy J Jarome

引用次数: 0

Aging impacts memory for perceptual, but not narrative, event details. 衰老会影响对感知事件细节的记忆，但不会影响对叙述事件细节的记忆。

IF 1.8 4区医学

Learning & memory Pub Date : 2023-03-02 Print Date: 2023-02-01 DOI: 10.1101/lm.053740.122

Angelique I Delarazan, Charan Ranganath, Zachariah M Reagh

{"title":"Aging impacts memory for perceptual, but not narrative, event details.","authors":"Angelique I Delarazan, Charan Ranganath, Zachariah M Reagh","doi":"10.1101/lm.053740.122","DOIUrl":"10.1101/lm.053740.122","url":null,"abstract":"Memory is well known to decline over the course of healthy aging. However, memory is not a monolith and draws from different kinds of representations. Historically, much of our understanding of age-related memory decline stems from recognition of isolated studied items. In contrast, real-life events are often remembered as narratives, and this kind of information is generally missed in typical recognition memory studies. Here, we designed a task to tax mnemonic discrimination of event details, directly contrasting perceptual and narrative memory. Older and younger adults watched an episode of a television show and later completed an old/new recognition test featuring targets, novel foils, and similar lures in narrative and perceptual domains. While we observed no age-related differences on basic recognition of repeated targets and novel foils, older adults showed a deficit in correctly rejecting perceptual, but not narrative, lures. These findings provide insight into the vulnerability of different memory domains in aging and may be useful in characterizing individuals at risk for pathological cognitive decline.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"30 2","pages":"48-54"},"PeriodicalIF":1.8,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forgetting dynamics for items of different categories. 不同类别物品的遗忘动态。

IF 1.8 4区医学

Learning & memory Pub Date : 2023-02-24 Print Date: 2023-02-01 DOI: 10.1101/lm.053713.122

Antonios Georgiou, Mikhail Katkov, Misha Tsodyks

引用次数: 0

Context matters: changes in memory over a period of sleep are driven by encoding context. 情境很重要：睡眠期间记忆的变化受编码情境的影响。

IF 2 4区医学

Learning & memory Pub Date : 2023-01-31 Print Date: 2023-02-01 DOI: 10.1101/lm.053634.122

Eitan Schechtman, Julia Heilberg, Ken A Paller

引用次数: 0