Learning & memory最新文献

Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory. 成年大鼠的多重情境歧视：性别变异和厌恶性记忆时间依赖泛化的动态。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-06-16 Print Date: 2025-05-01 DOI: 10.1101/lm.054081.124

Fernanda Nogueira Lotz, Kétlyn Talise Knak Guerra, Ana Paula Crestani, Jorge Alberto Quillfeldt

{"title":"Multiple context discrimination in adult rats: sex variability and dynamics of time-dependent generalization of an aversive memory.","authors":"Fernanda Nogueira Lotz, Kétlyn Talise Knak Guerra, Ana Paula Crestani, Jorge Alberto Quillfeldt","doi":"10.1101/lm.054081.124","DOIUrl":"10.1101/lm.054081.124","url":null,"abstract":"Memory generalization involves the transfer of conditioned fear responses to novel contexts, a phenomenon observed in systems consolidation, whereby a time-dependent reduction in discrimination precision occurs due to the reorganization of brain regions supporting memory retrieval. To understand the fine temporal structure of this process across sexes, young adult female and male rats were trained in contextual fear conditioning and tested in the same or one of three distinct novel contexts at 2, 28, or 45 days post-training. Neutral contexts were designed to allow graded levels of fear expression relative to the training context, and sex differences were evident at the recent memory test. This pattern, however, disappeared over time due to partial generalization, with fear converging into similar, higher values, grouped into two levels for both sexes. In all experiments, females were better discriminators and displayed lower fear responses than males, apparently prioritizing different sensory modalities, with multivariate analysis suggesting that chamber size was salient for females and floor texture for males. This study is the first to compare fear responses between adult female and male rats across multiple neutral contexts and time points revealing several dimorphic findings.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 5-6","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust renewal after extinction of remotely acquired Pavlovian conditioning. 远得性巴甫洛夫条件反射消失后的强更新。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-06-09 Print Date: 2025-05-01 DOI: 10.1101/lm.054103.125

Joseph W Charles, Samantha K Moriarty, Danielle I Fournier, Neil E Winterbauer, Emily A Cooper, Travis P Todd

引用次数: 0

Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation. PDE4B和PDE4D亚家族在预防睡眠剥夺引起的物体定位记忆障碍中的个体贡献

IF 1.8 4区医学

Learning & memory Pub Date : 2025-06-09 Print Date: 2025-05-01 DOI: 10.1101/lm.054101.125

Hongyu Zhao, Arjan Blokland, Jos Prickaerts, Robbert Havekes, Elroy L Meijer, Pim R A Heckman

引用次数: 0

Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder. 使用社交富集环境测试来评估不同治疗方法对社交焦虑障碍小鼠模型社交行为的影响。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-05-02 Print Date: 2025-04-01 DOI: 10.1101/lm.054041.124

Zineb Boudjafad, Chaima Ihsan, Ilias Chaibi, Fatima-Zahra Lamghari Moubarrad, Mohamed Bennis, René Garcia, Saadia Ba-M'hamed

{"title":"Using a socially enriched environment test to evaluate the effects of different therapeutic approaches on social behavior in a mouse model of social anxiety disorder.","authors":"Zineb Boudjafad, Chaima Ihsan, Ilias Chaibi, Fatima-Zahra Lamghari Moubarrad, Mohamed Bennis, René Garcia, Saadia Ba-M'hamed","doi":"10.1101/lm.054041.124","DOIUrl":"10.1101/lm.054041.124","url":null,"abstract":"Social anxiety disorder (SAD) stands as a prevalent psychiatric condition characterized by the apprehension of scrutiny and embarrassment in social settings, leading to anxiety symptoms, avoidance behaviors, and impaired social and occupational functioning. Despite the efficacy of various evidence-based treatments, a substantial portion of patients remain unresponsive. In this study, we used the socially enriched environment test (SEE, developed in our laboratory) to assess behaviors associated with social anxiety disorder after intervention, using various therapeutic strategies. We tested, in male mice, the effects of acute oxytocin injection, behavioral extinction, and high-frequency stimulation of the infralimbic (IL) cortex on social anxiety induced by a social fear conditioning paradigm. The SEE test revealed three behavioral changes, including reduced social interaction, reduced collective object exploration, and increased freezing behavior. Oxytocin and high-frequency stimulation of the IL cortex affected all these behavioral changes, while extinction training affected two (social interaction and freezing behavior). In conclusion, the SEE test is a reliable tool for exploring social anxiety behaviors in mice. Moreover, it can be used to evaluate different therapeutic approaches, providing valuable information on innovative therapeutic strategies for the effective treatment of SAD.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the parahippocampal cortex in memory consolidation for scenes. 海马旁皮层在情景记忆巩固中的作用。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-05-02 Print Date: 2025-04-01 DOI: 10.1101/lm.054053.124

Weizhen Xie, Susan G Wardle, Jenna Langbein, Oceane Fruchet, Molly Baumhauer, Audrey Phan, Ai Phuong Tong, Shruti Japee, Sara K Inati, Chris I Baker, Kareem A Zaghloul

{"title":"The role of the parahippocampal cortex in memory consolidation for scenes.","authors":"Weizhen Xie, Susan G Wardle, Jenna Langbein, Oceane Fruchet, Molly Baumhauer, Audrey Phan, Ai Phuong Tong, Shruti Japee, Sara K Inati, Chris I Baker, Kareem A Zaghloul","doi":"10.1101/lm.054053.124","DOIUrl":"10.1101/lm.054053.124","url":null,"abstract":"Classic models propose that forming lasting visual memories involves coordinated interactions between visually selective neocortical structures and the hippocampus during memory consolidation. However, the precise role of visually selective neocortical structures in memory consolidation remains elusive, given their potential contributions spanning from initial perceptual encoding to subsequent memory reactivation. We capitalized on a unique opportunity, involving direct recording from the posterior parahippocampus and its subsequent resection in a neurological patient, to investigate the impact of scene-selective neocortical lesions on visual memory consolidation. First, with intracranial EEG, we confirmed the functional relevance of the patient's resected tissues in representing a specific visual category, in this case, scene images. Subsequently, we identified disruption of memory for scenes relative to faces and objects during the participant's postoperative visit. This finding prompted a comprehensive analysis of visual memory across different visual categories in this participant, as well as an examination of similar functions in other neurological patients with intact parahippocampi and a cohort of online participants. Through these within- and between-participant comparisons, we identified greater time-dependent reduction in visual memory for scene images following the resection of the posterior parahippocampus. Importantly, these changes in memory retention could not be attributed to a general reduction in initial memory encoding following neocortical lesions. Our findings, therefore, suggest that reactivating scene-selective neocortical areas is essential for converting transient visual perceptual experiences into lasting long-term scene memories.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medial septal theta stimulation enhances spatial working memory performance in rats. 内隔刺激提高大鼠空间工作记忆能力。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-04-10 Print Date: 2025-04-01 DOI: 10.1101/lm.054075.124

Zachary M Gemzik, Amy L Griffin

引用次数: 0

Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation. 杏仁核中H2A单泛素化的减少抑制了恐惧记忆的形成。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-03-18 Print Date: 2025-03-01 DOI: 10.1101/lm.054092.125

Yeeun Bae, Harshini Venkat, Natalie Preveza, Meagan Turner, Timothy J Jarome

引用次数: 0

Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning. 行为微观分析细化了符号跟踪表征，揭示了遗漏和消失学习过程中不同的反应动力学。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-03-07 Print Date: 2025-03-01 DOI: 10.1101/lm.054065.124

Erica S Townsend, Kyle S Smith

{"title":"Behavioral microanalyses refine sign-tracking characterization and uncover different response dynamics during omission and extinction learning.","authors":"Erica S Townsend, Kyle S Smith","doi":"10.1101/lm.054065.124","DOIUrl":"10.1101/lm.054065.124","url":null,"abstract":"Sign-tracking, a conditioned response in which animals engage with reward-predictive cues, is a powerful behavioral tool for assessing Pavlovian motivation. In rodents, it is most frequently studied via automatic readouts, such as deflections of levers that act as reward cues. These readouts have been immensely helpful, but they may not be ideal for some tasks and paradigms. For example, animals can show a range of sign-tracking responses to a lever cue that do not result in lever deflection, and a reduction in deflections when animals are exposed to an omission contingency (i.e., when lever deflection cancels reward) hides the fact that the animals are still sign-tracking in other ways. Here, we analyzed the behavior of sign-tracking animals through both video monitoring and automatic task readouts in Pavlovian conditioning. This analysis aided in the classification of sign-tracking animals and revealed that lever deflections do not result from any identifiable pattern of sign-tracking. We then used omission and extinction procedures to unmask detailed behavior changes that can only be detected with video data. Automated readouts showed similar reductions of lever deflection in both task conditions. However, detailed behavioral analysis revealed quite distinct behavioral adaptations to these conditions with sign-tracking decreasing entirely during extinction while many sign-tracking behaviors (biting, sniffing, etc.) seemed to remain persistent during omission despite the decrease in deflections. Detailed behavioral analysis was thus critical for capturing sign-tracking maintenance, persistence, and loss.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 3","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overexpression of the Apoe gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior. 小鼠额叶皮层中Apoe基因的过度表达会导致学习、注意力和焦虑样行为的性别依赖性变化。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-03-07 Print Date: 2025-03-01 DOI: 10.1101/lm.054064.124

Lizbeth Ramos, Abigail E Harr, Finian L Zakas, Samuel R Essig, Griffen J Kempskie, Nelly A Fadil, Makayla G Schmid, Madison D Pompy, Michael C Curley, Lisa A Gabel, Henry L Hallock

{"title":"Overexpression of the Apoe gene in the frontal cortex of mice causes sex-dependent changes in learning, attention, and anxiety-like behavior.","authors":"Lizbeth Ramos, Abigail E Harr, Finian L Zakas, Samuel R Essig, Griffen J Kempskie, Nelly A Fadil, Makayla G Schmid, Madison D Pompy, Michael C Curley, Lisa A Gabel, Henry L Hallock","doi":"10.1101/lm.054064.124","DOIUrl":"10.1101/lm.054064.124","url":null,"abstract":"Apolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. APOE gene variants are associated with Alzheimer's disease, as well as attentional function in healthy humans. Previous research has shown that Apoe transcription is increased following stimulation of the pathway between the locus coeruleus (LC) and frontal cortex (FC) in mice. This result suggests that Apoe may affect attentional function by virtue of its expression in circuits that control attention. Does Apoe causally regulate attention, or is its expression simply a byproduct of neuronal activity in the LC and FC? To answer this question, we synthetically induced Apoe transcription in the FC of male and female mice, and subsequently tested their ability to learn a touchscreen-based rodent version of the continuous performance test of sustained attention (the rCPT). We found that increased Apoe transcription impaired performance when attentional demand was increased in male mice, while in female mice, increased Apoe transcription significantly accelerated rCPT learning. We further found that this increase in Apoe transcription affected one metric of the open field test, as well as cellular activity in the FC in a sex-dependent manner. The results of this study provide insight into how Apoe causally regulates translationally relevant behaviors in rodent models.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 3","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large-scale study of human memory for meaningful narratives. 大规模研究人类对有意义叙述的记忆。

IF 1.8 4区医学

Learning & memory Pub Date : 2025-02-21 Print Date: 2025-02-01 DOI: 10.1101/lm.054043.124

Antonios Georgiou, Tankut Can, Mikhail Katkov, Misha Tsodyks

{"title":"Large-scale study of human memory for meaningful narratives.","authors":"Antonios Georgiou, Tankut Can, Mikhail Katkov, Misha Tsodyks","doi":"10.1101/lm.054043.124","DOIUrl":"10.1101/lm.054043.124","url":null,"abstract":"The statistical study of human memory requires large-scale experiments, involving many stimulus conditions and test subjects. While this approach has proven to be quite fruitful for meaningless material such as random lists of words, naturalistic stimuli, like narratives, have until now resisted such a large-scale study, due to the quantity of manual labor required to design and analyze such experiments. In this work, we develop a pipeline that uses large language models (LLMs) both to design naturalistic narrative stimuli for large-scale recall and recognition memory experiments, as well as to analyze the results. We performed online memory experiments with a large number of participants and collected recognition and recall data for narratives of different sizes. We found that both recall and recognition performance scale linearly with narrative length; however, for longer narratives, people tend to summarize the content rather than recalling precise details. To investigate the role of narrative comprehension in memory, we repeated these experiments using scrambled versions of the narratives. Although recall performance declined significantly, recognition remained largely unaffected. Recalls in this condition seem to follow the original narrative order rather than the actual scrambled presentation, pointing to a contextual reconstruction of the story in memory. Finally, using LLM text embeddings, we construct a simple measure for each clause based on semantic similarity to the whole narrative, that shows a strong correlation with recall probability. Overall, our work demonstrates the power of LLMs in accessing new regimes in the study of human memory, as well as suggesting novel psychologically informed benchmarks for LLM performance.","PeriodicalId":18003,"journal":{"name":"Learning & memory","volume":"32 2","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0