Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2025-03-18 Print Date: 2025-03-01 DOI:10.1101/lm.054092.125

Yeeun Bae, Harshini Venkat, Natalie Preveza, Meagan Turner, Timothy J Jarome

引用次数: 0

Abstract

Evidence suggests a role for monoubiquitination of histone H2B, a regulator of increased gene transcription, in memory formation. However, whether monoubiquitination of histone H2A (H2Aubi), a transcriptional repressor, is involved in memory formation has not been explored. We found global and gene-specific decreases in H2Aubi in the amygdala following fear conditioning. H2Aubi decreased at Pten, an inhibitor of PI3K-AKT-mTOR signaling, which occurred concurrently with increases in PTEN expression. CRISPR-dCas9 mediated upregulation of the H2Aubi ligase, Ring1b, in the amygdala enhanced contextual memory. These results suggest that decreases in transcriptionally repressive H2Aubi in the amygdala functions to constrain fear memory strength.

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.