PDE4B和PDE4D亚家族在预防睡眠剥夺引起的物体定位记忆障碍中的个体贡献

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2025-06-09 Print Date: 2025-05-01 DOI:10.1101/lm.054101.125

Hongyu Zhao, Arjan Blokland, Jos Prickaerts, Robbert Havekes, Elroy L Meijer, Pim R A Heckman

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引用次数: 0

摘要

睡眠不足会破坏海马体中的cAMP信号通路，对海马体依赖性记忆产生负面影响。在本研究中，我们探讨了选择性PDE4B或选择性PDE4D抑制是否可以改善睡眠剥夺（SD）小鼠在物体定位测试（OLT）中的海马依赖空间记忆。结果表明，SD损害了OLT的表现，而A-33和zatolmilast在SD期开始和中期给药时都可以防止SD的负面影响。这些发现表明PDE4B和PDE4D亚家族都有助于PDE4抑制sd诱导的记忆巩固损伤。

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Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation.

Insufficient sleep compromises the cAMP signaling pathway in the hippocampus, negatively impacting hippocampus-dependent memory. In the current study, we explored whether selective PDE4B or selective PDE4D inhibition can improve hippocampus-dependent spatial memory in the object location test (OLT) in mice after sleep deprivation (SD). The results demonstrated that SD impaired the OLT performance, and both A-33 and zatolmilast protected against the negative consequences of SD when administered at the start and middle of the SD period. These findings suggest that both PDE4B and PDE4D subfamilies contribute to the beneficial effect of PDE4 inhibition against SD-induced memory consolidation impairment.

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.