Robust renewal after extinction of remotely acquired Pavlovian conditioning.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2025-06-09 Print Date: 2025-05-01 DOI:10.1101/lm.054103.125

Joseph W Charles, Samantha K Moriarty, Danielle I Fournier, Neil E Winterbauer, Emily A Cooper, Travis P Todd

引用次数: 0

Abstract

Extinguished responses are prone to renew outside the context where extinction occurred. Two experiments compared extinction and renewal following either a 1 day conditioning-to-extinction interval or a 27 day interval. Rats received tone-shock pairings in Context A, and extinction in Context B. Testing occurred in Context A (Experiment 1) or C (Experiment 2). Extinction occurred at a similar rate after both retention intervals. Robust renewal was also observed and was not affected by the conditioning-to-extinction retention interval. Results are discussed with respect to prior research on the timing of extinction, the neurobiology of recent and remote memory retrieval, and translational relevance.

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远得性巴甫洛夫条件反射消失后的强更新。

消失的反应在发生消失的环境之外容易更新。两个实验比较了在1天和27天的时间间隔后的消退和更新。大鼠在情境A中接受音调-电击配对，在情境b中接受消失实验。实验分别在情境A（实验1）和情境C（实验2）中进行。在两个保留间隔后，消失的速度相似。强健的更新也被观察到，并且不受条件反射到消失的保持间隔的影响。结果讨论了关于灭绝的时间，最近和远程记忆检索的神经生物学和翻译相关性先前的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.