Standardized extract of Ginkgo biloba treatment and novelty on the weak encoding of spatial recognition memory in rats.

IF 1.8 4区医学 Q4 NEUROSCIENCES

Learning & memory Pub Date : 2023-04-18 Print Date: 2023-04-01 DOI:10.1101/lm.053755.123

Carla Vitor de Andrade, Andressa Gabriela Soliani, Suzete Maria Cerutti

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引用次数: 0

Abstract

Long-term memory (LTM) formation is dependent on neurochemical changes that guarantee that a recently formed memory (short-term memory [STM]) remains in the specific neural circuitry via the consolidation process. The persistence of recognition memory has been evidenced by using behavioral tagging in young adult rats, but it has not been effective on aging. Here, we investigated the effects of treatment with a standardized extract of Ginkgo biloba (EGb) associated with novelty on the consolidation of object location memory (OLM) and its persistence after weak training of spatial object preference in young adult and aged rats. The object location task used in this study included two habituation sessions, training sessions associated or not associated with EGb treatment and contextual novelty, and short-term or long-term retention testing sessions. Altogether, our data showed that treatment with EGb associated with novelty close to the time of encoding resulted in STM that lasted for 1 h and persisted for 24 h for both young adult and aged rats. In aged rats, the cooperative mechanisms induced robust long-term OLM. Our findings support and extend our knowledge about recognition memory in aged rats and the modulating effects of EGb treatment and contextual novelty on the persistence of memory.

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银杏叶标准化提取物治疗和新奇感对大鼠空间识别记忆弱编码的影响

长期记忆（LTM）的形成依赖于神经化学变化，这种变化保证了最近形成的记忆（短期记忆 [STM]）通过巩固过程留在特定的神经回路中。识别记忆的持久性已通过对年轻成年大鼠的行为标记得到证明，但对衰老却没有效果。在此，我们研究了与新奇感相关的银杏叶标准化提取物（EGb）治疗对年轻成年大鼠和老年大鼠的物体位置记忆（OLM）巩固及其在空间物体偏好弱训练后的持续性的影响。本研究中使用的物体定位任务包括两次习惯性训练、与 EGb 治疗和情境新奇性相关或不相关的训练以及短期或长期保持测试。总之，我们的数据表明，在接近编码时间时使用与新奇事物相关的EGb会导致年轻成年大鼠和老年大鼠的STM持续1小时并持续24小时。在老年大鼠中，合作机制诱导了强有力的长期 OLM。我们的研究结果支持并扩展了我们对老年大鼠识别记忆以及 EGb 处理和情境新奇性对记忆持续性的调节作用的认识。

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来源期刊

Learning & memory 医学-神经科学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The neurobiology of learning and memory is entering a new interdisciplinary era. Advances in neuropsychology have identified regions of brain tissue that are critical for certain types of function. Electrophysiological techniques have revealed behavioral correlates of neuronal activity. Studies of synaptic plasticity suggest that some mechanisms of memory formation may resemble those of neural development. And molecular approaches have identified genes with patterns of expression that influence behavior. It is clear that future progress depends on interdisciplinary investigations. The current literature of learning and memory is large but fragmented. Until now, there has been no single journal devoted to this area of study and no dominant journal that demands attention by serious workers in the area, regardless of specialty. Learning & Memory provides a forum for these investigations in the form of research papers and review articles.