Lasers in Medical Science最新文献_第2页

Computational modeling of combined laser-ultrasound hyperthermia therapy for breast cancer using gold nanoparticles: A simulation study. 使用金纳米粒子联合激光-超声热疗治疗乳腺癌的计算模型：一项模拟研究。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-13 DOI: 10.1007/s10103-025-04657-8

Helia Sadat Kazemi Siyanaki, Fatemeh Rezaei, Saeedeh Kabiri, Behnam Ashrafkhani

{"title":"Computational modeling of combined laser-ultrasound hyperthermia therapy for breast cancer using gold nanoparticles: A simulation study.","authors":"Helia Sadat Kazemi Siyanaki, Fatemeh Rezaei, Saeedeh Kabiri, Behnam Ashrafkhani","doi":"10.1007/s10103-025-04657-8","DOIUrl":"https://doi.org/10.1007/s10103-025-04657-8","url":null,"abstract":"Breast cancer is a disease in which cells in the breast grow out of control. After surgery, chemotherapy, and other invasive treatments, hyperthermia is a suitable choice with the minimal side effects. In this paper, the treatment of breast cancer using a combination of laser and ultrasound irradiation, in the presence of gold nanoparticles, is investigated. In the simulations, the breast tissue is represented as a multilayer structure and the tumor is supposed to consist of two parts: a superficial section and a deeper region. In the initial stage, the superficial parts of the tumor, which also contain gold nanoparticles, are exposed to a continuous laser for 50 s followed by a cooling period of 20 s. Then, for deeper sections, ultrasound irradiation is utilized. The results indicated that the tissue necrosis volume was enhanced by the application of nanoparticles. Furthermore, it was demonstrated that the combined application of both laser and ultrasound could eradicate both the superficial parts of the tumor and the deep parts.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"430"},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of 450 nm blue light on platelet multiomics and bacterial inactivation. 450nm蓝光对血小板多组学和细菌灭活的影响。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-11 DOI: 10.1007/s10103-025-04692-5

Xiaomin Su, Chaofeng Ma, Hanshi Gong, Hua Xu

{"title":"Impact of 450 nm blue light on platelet multiomics and bacterial inactivation.","authors":"Xiaomin Su, Chaofeng Ma, Hanshi Gong, Hua Xu","doi":"10.1007/s10103-025-04692-5","DOIUrl":"https://doi.org/10.1007/s10103-025-04692-5","url":null,"abstract":"To investigate the efficiency of 450 nm blue light irradiation on bacterial inactivation in apheresis platelets and the effects of irradiation on the quality of apheresis platelets. The toxicity of 450 nm blue light on the Staphylococcus aureus (S. aureus) (102 CFU/ml). The bacterial cells were incubated with different time of 29 mW/cm2 intensity 450 nm blue light (0, 0.5, 1, 2, 3, 4 h). Viable bacteria counts and platelet indices (platelet count, MPV, PDW, MA, PF) were measured pre- and post-irradiation. Proteomics and metabolomics analyses assessed changes in platelets and the impact of blue light. The numbers of viable bacteria in platelet decreased significantly after irradiation (P < 0.05). No significant difference was detected in the physicochemical indexes of platelet (platelet counts, MPV, PDW, MA, PF) between the control group and the treated group (after irradiation) (P > 0.05). Our platelet metabolomics analysis revealed alterations in 34 out of 981 quantified metabolites (3.5%). Additionally, we identified a total of 3726 proteins, and through comparative screening between two groups, we identified 71 differentially expressed proteins (1.9%), comprising 43 upregulated and 28 downregulated proteins. These findings suggest that a minimal number of proteins and metabolites exhibited changes in expression in the light-treated platelets compared to the untreated controls. The 450 nm blue light of a certain intensity irradiation could sufficiently kill S. aureus, but had no significant effect on the quality of apheresis platelets. This research has provided further evidence supporting the potential for 450 nm blue light to be developed as a pathogen reduction tool for stored platelets.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"426"},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A variable-pulse copper vapor laser at 578 nm application for the treatment of facial resistant Port wine stains: case report. 578 nm可变脉冲铜蒸气激光治疗面部顽抗波特酒斑1例。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-11 DOI: 10.1007/s10103-025-04651-0

Igor Ponomarev, Sergey Topchiy, Alexandra Pushkareva

{"title":"A variable-pulse copper vapor laser at 578 nm application for the treatment of facial resistant Port wine stains: case report.","authors":"Igor Ponomarev, Sergey Topchiy, Alexandra Pushkareva","doi":"10.1007/s10103-025-04651-0","DOIUrl":"https://doi.org/10.1007/s10103-025-04651-0","url":null,"abstract":"Port wine stain (PWS) is presented as a vascular anomaly, light pink to purple in color with various grades of hypertrophy. Facial unilateral upper eyelid and hypertrophic PWS have been reported to be most resistant to pulsed dye laser treatment due to larger vessel diameter and vessel depth.Therefore, it highlights the need for testing new laser modalities for the management of resistant PWS.56-years-old adult II Fitzpatrick phototype female patient, presented with a resistant hypertrophic PWS on the forehead and upper eyelid on the left is presented. Patient was treated with dual-wavelength copper vapor laser (CVL) radiation at 578 nm wavelength. The average power was 0.7-0.8 W with an exposure time of 0.08 -0.2 s.The spot size was1 mm.Patient showed about 75 % lightning of PWS after 2 copper vapor laser treatments. No recurrences were observed during the follow-up period up to 7 years.The variable-pulse copper vapor laser radiation at 578 nm proved to be a minimally invasive, safe and effective treatment for resistant and hypertrophic PWS with a good cosmetic outcome, without side effects (erythema, scarring, depigmentation).","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"428"},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergetic effect of lauric acid and tea tree oil-loaded solid lipid nanoparticles and photobiomodulation in diabetic wound healing. 月桂酸和茶树油负载固体脂质纳米颗粒的协同作用和光生物调节在糖尿病伤口愈合中的作用。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-11 DOI: 10.1007/s10103-025-04673-8

Fezile Motsoene, Heidi Abrahamse, Sathish Sundar Dhilip Kumar

{"title":"Synergetic effect of lauric acid and tea tree oil-loaded solid lipid nanoparticles and photobiomodulation in diabetic wound healing.","authors":"Fezile Motsoene, Heidi Abrahamse, Sathish Sundar Dhilip Kumar","doi":"10.1007/s10103-025-04673-8","DOIUrl":"10.1007/s10103-025-04673-8","url":null,"abstract":"The management of diabetic wounds requires more than traditional care due to the challenges faced by diabetic patients, including poor circulation, neuropathy, impaired immune response, chronic inflammation, elevated blood glucose levels, and a higher risk of infection. While conventional methods often have limitations, recent studies have shown that solid lipid nanoparticles (SLNs) in combination with Photobiomodulation (PBM) are effective in promoting wound healing. This study investigates the combined effect of lauric acid and tea tree oil-loaded SLNs (LT-SLNs) with PBM at 830 nm on fibroblast cell regeneration in an in vitro diabetic wound model. Diabetic WS1 fibroblast cells were subjected to a standardised in vitro scratch assay, followed by a comprehensive evaluation of cellular responses, which included morphological alterations, wound closure dynamics, ATP production, and apoptosis at 24- and 48-hours post-irradiation. These assessments provided a critical insight into the therapeutic efficacy and cellular behaviour under experimental conditions relevant to diabetic wound healing. The results demonstrated that LT-SLNs combined with PBM exhibited no cytotoxicity at a concentration of 12.5 mg/mL. While untreated cells displayed limited wound healing capacity, treatment with LT-SLNs, particularly when combined with photobiomodulation, significantly enhanced wound closure and promoted fibroblast migration, indicating a synergistic therapeutic effect. Our study significantly enhanced wound closure, ATP production, and migratory activity, indicating a synergistic effect of both LT-SLNs and PBM. The study highlights the promising potential of LT-SLNs combined with PBM for diabetic wound healing.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"427"},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intense pulsed Light, Light-Emitting Diode, and hydroxychloroquine in the treatment of rosacea: A clinical observation. 强脉冲光、发光二极管和羟氯喹治疗酒渣鼻的临床观察。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-11 DOI: 10.1007/s10103-025-04696-1

Chengyu Zhang, LiXin Song

{"title":"Intense pulsed Light, Light-Emitting Diode, and hydroxychloroquine in the treatment of rosacea: A clinical observation.","authors":"Chengyu Zhang, LiXin Song","doi":"10.1007/s10103-025-04696-1","DOIUrl":"10.1007/s10103-025-04696-1","url":null,"abstract":"Background: Rosacea is a common, chronic inflammatory skin condition lacking specific treatment. This study investigates the efficacy of various photoelectric therapies in treating rosacea. 90 rosacea patients who visited the dermatology outpatient clinic of the hospital from August 2022 to November 2023 were analyzed (retrospective registration 20240425). The patients were categorized into three groups based on different treatment methods: the control group received oral hydroxychloroquine sulfate and topical recombinant bovine basic fibroblast growth factor; observation group 1 underwent intense pulsed light therapy in addition to the control group's treatment; observation group 2 received light-emitting diode therapy on top of the control group's regimen. The therapeutic effect was evaluated by physicians' subjective evaluation and patients' pruritus symptoms. The effective rates of observation group 1, observation group 2, and the control group were 73.3%, 66.7%, and 40%, respectively, with statistical significance (P < 0.05). There was no significant difference between observation group 1 and observation group 2 (P < 0.05). Additionally, there were no significant adverse reactions in any of the three groups. The comparison between observation group 1 and observation group 2 revealed that the two combined treatment methods achieved similar and positive therapeutic effects across various clinical manifestations. The effectiveness of both observation groups was found to be superior to that of drug therapy alone.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"425"},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop Energy-based devices in dermatology: moving from static protocols to smart skin. 皮肤病学中基于能量的闭环设备：从静态协议到智能皮肤。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-11 DOI: 10.1007/s10103-025-04687-2

Diala Haykal

引用次数: 0

Simulated dose-dependent effects of 660 nm laser photostimulation on human sperm motility and acrosome integrity using MATLAB modeling. 利用MATLAB建模模拟660 nm激光刺激对人类精子活力和顶体完整性的剂量依赖性影响。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-10 DOI: 10.1007/s10103-025-04677-4

Zahra Al Timimi

{"title":"Simulated dose-dependent effects of 660 nm laser photostimulation on human sperm motility and acrosome integrity using MATLAB modeling.","authors":"Zahra Al Timimi","doi":"10.1007/s10103-025-04677-4","DOIUrl":"https://doi.org/10.1007/s10103-025-04677-4","url":null,"abstract":"Low-level laser therapy (LLLT) has been demonstrated to have the potential for enhancing sperm function by means of photobiomodulation. Therapeutic dosing parameters to maximize the effect, though, remain undefined. To simulate dose-dependent effects of 660 nm laser irradiation on human sperm motility and acrosome integrity using MATLAB-based modeling. A simulation was established on the computer to assess reactions of sperm over a fluence range of 0.15-2.4 J/cm², which was produced from varying power densities (5-20 mW/cm²) and durations (30-120 s). Logistic and Gaussian functions with biologically natural noise were used in modeling motility and acrosome integrity in order to mimic experimental variation. Motility increased in sigmoidal manner, peaking at around 1.2 J/cm², while acrosome integrity peaked at around 0.6 J/cm² in the form of a bell curve. Optimal fluence range (0.6-0.9 J/cm²) balanced both improving motility and maintaining acrosomes intact. 660 nm laser stimulation of sperm motility and acrosome integrity is enhanced within a narrow fluence window. This in silico process offers a predictive, reproducible method for the determination of optimal PBM parameters in reproductive application.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"418"},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of low-level laser as an adjunctive therapy in root canal treatment and retreatment: an umbrella review. 低水平激光在根管治疗和再治疗中的辅助治疗效果综述。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-10 DOI: 10.1007/s10103-025-04661-y

Beatriz Santos Pereira, Walbert A Vieira, Vinycius do Nascimento Santana, Arian Braido, Maria Amália Gonzaga Ribeiro

{"title":"Efficacy of low-level laser as an adjunctive therapy in root canal treatment and retreatment: an umbrella review.","authors":"Beatriz Santos Pereira, Walbert A Vieira, Vinycius do Nascimento Santana, Arian Braido, Maria Amália Gonzaga Ribeiro","doi":"10.1007/s10103-025-04661-y","DOIUrl":"https://doi.org/10.1007/s10103-025-04661-y","url":null,"abstract":"This study aimed to evaluate and synthesize evidence from systematic reviews investigating the efficacy of low-level laser therapy (LLLT) as an adjunct to endodontic treatment in reducing postoperative pain, microbial load, and promoting apical healing. A comprehensive search of electronic databases (PubMed, Embase, Web of Science, Cochrane Library, Google Scholar) was conducted from February 2024 to March 2025, to retrieve systematic reviews that evaluate the efficacy of LLLT as an adjunct to endodontic treatment in reducing postoperative pain, microbial load, and promoting apical healing. Two independent authors selected the studies, extracted relevant data, and assessed the individual risk of bias and methodological quality using the ROBIS and AMSTAR-2 tools, respectively. The electronic search identified 280 records, 18 of which met the eligibility criteria and were included in the qualitative synthesis. The studies were published between 2014 and 2024. Only six reviews demonstrated a low risk of bias, and two were classified as having high methodological quality. Most systematic reviews indicated that LLLT is effective in reducing the incidence and intensity of postoperative endodontic pain and the microbial load following instrumentation. The studies also highlighted the high heterogeneity, the lack of a standardized protocol for LLLT application, and the low certainty of evidence for the outcomes. LLLT is an important adjunctive therapy in endodontic treatment; however, robust evidence regarding its application protocol is still lacking.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"420"},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Network meta-analysis of different modalities of intense pulsed light therapy in the treatment of dry eye disease induced by meibomian gland dysfunction". 对“强脉冲光治疗睑板腺功能障碍引起的干眼病的不同方式的网络荟萃分析”的评论。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-10 DOI: 10.1007/s10103-025-04681-8

Koyel Roy, Yugdeepkaur Kaur

引用次数: 0

Non-Invasive blood quality parameter measurement system. 无创血液质量参数测量系统。

IF 2.4 4区医学

Lasers in Medical Science Pub Date : 2025-10-10 DOI: 10.1007/s10103-025-04690-7

Yaman Yazici

{"title":"Non-Invasive blood quality parameter measurement system.","authors":"Yaman Yazici","doi":"10.1007/s10103-025-04690-7","DOIUrl":"https://doi.org/10.1007/s10103-025-04690-7","url":null,"abstract":"Blood banking critically influences transfusion success and healthcare costs. To ensure the quality of stored red blood cell (RBC) products, current practice requires destructive sampling and laboratory testing of only a limited number of units. This work presents a device development framework; preliminary feasibility is demonstrated, while full validation is ongoing. Such methods (e.g., complete blood count, flow cytometry, or culture assays) depend on expendable reagents and skilled personnel, and they inevitably lead to the disposal of tested units (compromising bag integrity). Consequently, donated blood that could save a life may be lost during routine quality checks. This project proposes an innovative, optically based instrument to address these challenges. By employing Raman spectroscopy, the device will non-invasively assess critical blood quality parameters (hemoglobin, hematocrit, hemolysis ratio, leukocyte count, etc.) for every blood bag at all stages (collection, storage, and pre-transfusion) without any bag puncture or consumables, and will deliver results within minutes. A working prototype will be developed and calibrated against standard laboratory measurements. If successful, this system will increase transfusion safety, reduce waste and costs, and advance understanding of blood storage effects.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"423"},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0