Lasers in Medical Science最新文献

{"title":"Thulium laser-assisted delivery of growth factors for treating androgenetic alopecia - a randomized, controlled, clinical study.","authors":"Lynhda Nguyen, Stefan W Schneider, Katharina Herberger","doi":"10.1007/s10103-026-05066-1","DOIUrl":"10.1007/s10103-026-05066-1","url":null,"abstract":"<p><p>Androgenetic alopecia (AGA) is the most common form of hair loss and can significantly impact quality of life. Emerging non-invasive treatments include laser-assisted delivery of biomimetic growth factor-based serums. The aim of the study was to evaluate the safety and efficacy of non-ablative fractional laser (NAFL)-assisted delivery, with or without adjunct red light therapy, in patients with AGA. In this pilot study, patients were randomly assigned to: (I) NAFL-assisted serum delivery plus red light therapy (triple), (II) NAFL-assisted serum delivery alone (dual), or (III) NAFL plus red light therapy without serum (EBD-only). Primary outcomes were hair density and thickness. Secondary outcomes included patient satisfaction, tolerability, and adverse events. Hair density increased in all groups, with greater improvement in the triple (25.6 ± 7.0 %) and dual (22.7 ± 3.4 %) groups compared to EBD-only (4.9 ± 9.2 %). Hair thickness improved in both serum groups but not in the EBD-only group. Clinical outcomes were similar between triple and dual treatments, though satisfaction was higher with triple therapy. No severe adverse events occurred. Preliminary evidence suggests that NAFL-assisted delivery of biomimetic growth factors is a safe and effective non-invasive treatment for AGA.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of bleaching-remineralization sequence on enamel microhardness and surface properties during laser-assisted bleaching.","authors":"Aybuke Uslu Tekce, Kemal Işıklı, Ece Meral, Filiz Yalcin Cakir","doi":"10.1007/s10103-026-04983-5","DOIUrl":"10.1007/s10103-026-04983-5","url":null,"abstract":"<p><p>This in vitro study evaluated whether the sequence of bleaching and remineralization procedures and the type of remineralizing agent influence enamel microhardness, surface roughness, and color change following diode laser-assisted bleaching. One hundred twenty human enamel specimens were randomly assigned to two treatment sequences: Bleach-First (BF) and Remineralize-First (RF), each further subdivided into four groups (n = 15) representing different remineralization mechanisms (CPP-ACP-based, calcium-phosphate-magnesium, hydroxyapatite-based, and fluoride varnish). Bleaching was performed using a 35% hydrogen peroxide gel (Whiteness HP, FGM) activated with a 940-nm diode laser (Epic X, Biolase; 7 W, continuous-wave mode; total irradiation time: 120 s). Surface microhardness (VHN; 200 g load for 15 s), surface roughness (Ra), and color (ΔE00) were measured at baseline and after each procedural stage. Data were statistically analyzed using repeated-measures and two-way ANOVA (α = 0.05). A significant difference between treatment sequences was observed at the initial stage (p < 0.001), with bleaching reducing and remineralization increasing microhardness. A significant time × sequence interaction (p < 0.001) indicated that these changes depended on the order of application, while no significant main effect of remineralizing agent or sequence × agent interaction was detected (p > 0.05). Surface roughness values showed no significant differences between sequences or agents, except for a transient increase in the fluoride varnish group in the RF sequence. Similarly, all groups exhibited clinically acceptable color change, with no significant differences between sequences or agents. SEM/EDS analyses further revealed sequence-dependent surface alterations, supporting the microhardness findings. The sequence of bleaching and remineralization procedures was identified as the primary factor influencing enamel microhardness, whereas the type of remineralizing agent had no significant effect. Remineralization applied after bleaching appears more effective for restoring enamel microhardness, without affecting surface roughness or color outcomes. Within the limitations of this in vitro study, post-bleaching remineralization demonstrated favorable effects on enamel microhardness without compromising bleaching efficacy.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of subjective and objective visual quality after LASEK, FS-LASIK, and TransPRK.","authors":"Wei Zhao, Rong Shi, Lijuan Sun, Zehong Dong, Jie Feng, Xueting Chen","doi":"10.1007/s10103-026-05043-8","DOIUrl":"10.1007/s10103-026-05043-8","url":null,"abstract":"<p><p>The objective of this study was to compare subjective and objective visual quality after three types of corneal refractive surgery (LASEK, FS-LASIK, and TransPRK). 150 patients (300 eyes) who underwent corneal refractive surgery were divided into three groups comprised of 45 patients (90 eyes) in the LASEK group, 55 patients (110 eyes) in the FS-LASIK group, and 50 patients (100 eyes) in the TransPRK group. Subjective evaluation included uncorrected distance visual acuity (UDVA), recorded in decimal notation, and the Quality-of-Life Impact of Refractive Correction (QIRC) questionnaire. Objective optical quality was measured with the OQAS II double-pass analyzer (Visiometrics, Spain) in 50 eyes per group. All three surgical procedures-LASEK, FS-LASIK, and TransPRK-significantly improved overall UDVA from baseline. At 6 months postoperatively, UDVA after LASEK and FS-LASIK was significantly higher than at 1 month, and UDVA at 1 month was significantly better than preoperative levels (P < 0.05). At 1 month, UDVA was significantly better after TransPRK than after LASEK or FS-LASIK, but this difference was no longer present at 6 months. At 6 months, QIRC scores were significantly higher than preoperative values after FS-LASIK (P = 0.004) and TransPRK (P = 0.016), whereas the increase after LASEK was not significant (P = 0.157). All procedures were associated with improvements in subjective and objective visual quality measures; however, no statistically significant differences were observed among the three surgical techniques at six months. Objective optical quality indices were within the normal range in all three groups at 6 months and did not differ significantly between techniques. All procedures (LASEK, FS-LASIK, and TransPRK) were associated with improvements in subjective and objective visual quality and quality of life; however, no statistically significant differences were observed among the three surgical techniques at six months postoperatively.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of surgical laser interventions and adjunctive photobiomodulation in osseous crown lengthening: A systematic review.","authors":"Kiarash Fereidouni, Omeed Mosleh-Shirazi, Pouya Nikdast, Farin Kiany","doi":"10.1007/s10103-026-05061-6","DOIUrl":"10.1007/s10103-026-05061-6","url":null,"abstract":"<p><p>To synthesize the available clinical evidence on laser-based interventions in osseous crown-lengthening procedures, considering surgical laser techniques and adjunctive photobiomodulation separately. A systematic search of PubMed/MEDLINE, Scopus, ScienceDirect, and Web of Science was conducted from database inception to June 2025. We included clinical studies involving adults undergoing osseous crown lengthening with laser-assisted surgery or postoperative photobiomodulation. Three reviewers independently screened titles and abstracts, assessed potentially eligible full-text articles, and extracted data. Risk of bias was assessed at the outcome level using RoB 2 for randomized studies and ROBINS-I for the nonrandomized comparative study. Because of substantial clinical and methodological heterogeneity, we evaluated findings using a structured narrative synthesis rather than meta-analysis. We included five clinical studies published between 2021 and 2024. Three evaluated lasers used during the surgical procedure, while two evaluated adjunctive photobiomodulation following conventional surgery. Some studies reported reduced intraoperative bleeding and improved surgical visibility with surgical laser techniques, although they did not consistently assess these outcomes using standardized quantitative measures. Periodontal and gingival-margin outcomes were generally comparable with conventional procedures. Findings regarding postoperative pain were inconsistent, with benefits reported in some but not all studies. Across two small studies using different irradiation protocols, adjunctive photobiomodulation was associated with reduced early postoperative pain at selected assessment times; only one study reported lower analgesic consumption. Among the four randomized studies, one assessed result was judged to have a high overall risk of bias and three raised some concerns; none was judged to have a low overall risk of bias. The nonrandomized comparative study was judged to have a serious risk of bias. Some studies descriptively reported potential intraoperative advantages with surgical laser techniques, while adjunctive photobiomodulation may reduce early postoperative pain at selected assessment times. Given the small and heterogeneous evidence base and its methodological limitations, current evidence remains insufficient to establish superiority over conventional osseous crown-lengthening surgery or to identify an optimal laser protocol.Clinical trial number: not applicable.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermographic outcomes of auricular laser acupuncture and auricular seed acupressure in older adults with chronic shoulder pain: an exploratory nonrandomized, nonconcurrent comparison.","authors":"Gerson Quadros, Emilia Angela Lo Schiavo Arisawa, Luís Eduardo Soares","doi":"10.1007/s10103-026-05078-x","DOIUrl":"10.1007/s10103-026-05078-x","url":null,"abstract":"<p><strong>Purpose: </strong>Compare pain, quality of life, and cutaneous temperature changes within predefined anterior, lateral, and posterior shoulder regions of interest between auricular laser acupuncture and seed acupressure in older adults with chronic shoulder pain.</p><p><strong>Methods: </strong>This exploratory, nonrandomized, open-label study enrolled 20 adults aged 60-90 years, allocated by order of entry to consecutive, nonconcurrent cohorts of auricular laser acupuncture (n = 10) or seed acupressure (n = 10), treated twice weekly for five weeks. VAS, McGill, SF-36, and thermography were assessed before the first (A1) and fifth sessions (A2) and after the tenth (A3) and analyzed using linear mixed-effects models.</p><p><strong>Results: </strong>From A1 to A3, VAS decreased by - 2.70 points in Laser (95% CI - 4.37 to - 1.03) and - 2.50 in Seed (95% CI - 4.17 to - 0.83); the between-group difference was - 0.20 points (Laser - Seed; 95% CI - 2.54 to 2.14). Selected McGill and SF-36 outcomes changed; McGill affective A1-to-A2 change differed between groups (Laser - Seed: -2.70; 95% CI - 4.86 to - 0.55; p = 0.017). Anterior thermal range (ΔT) showed a TIME × GROUP interaction (p = 0.007); the A1-to-A3 between-group difference was - 1.941 °C (Seed - Laser; 95% CI - 3.097 to - 0.785), although Seed ΔT was higher at baseline (+ 1.496 °C; 95% CI 0.607 to 2.385). Lateral ΔT showed a TIME effect (p = 0.033); posterior ΔT showed none.</p><p><strong>Conclusion: </strong>Clinical outcomes improved over time without evidence of differential changes between interventions. Thermography identified region-specific ΔT trajectories, warranting further investigation as a complementary method.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov NCT07010627.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of pyogenic granuloma with a 577-nm diode laser in dark-skinned patients: A prospective case series.","authors":"Essamelden Mohamed","doi":"10.1007/s10103-026-05053-6","DOIUrl":"10.1007/s10103-026-05053-6","url":null,"abstract":"<p><strong>Introduction: </strong>Pyogenic granulomas are common benign vascular lesions found on exposed skin in children. Treatment in darker skin types can be challenging because of increased epidermal melanin absorption and the associated risk of collateral thermal injury.</p><p><strong>Objectives: </strong>To evaluate the efficacy and safety of a 577-nm diode laser for the treatment of pyogenic granuloma in patients with dark skin types.</p><p><strong>Patients and methods: </strong>Nine patients with pyogenic granuloma and skin types IV-V were enrolled in this prospective case series. They were treated every two weeks with a 577 nm diode laser using a 1 mm spot size, with fluence ranging from 19-23 J/cm2 depending on lesion size until bleeding stopped. Sessions were repeated every two weeks until complete clearance. Patients were followed clinically and photographically every two weeks, and then one month after the final session.</p><p><strong>Results: </strong>This prospective case series included 9 patients clinically diagnosed with pyogenic granuloma. The mean age was 18.0 ± 14.6 years (range, 6-40 years), and the mean duration of pyogenic granuloma was 9.1 ± 3.94 months. Lesions were present on the lips of 4 patients (44.4%), the cheeks in 2 patients (22.2%), hands (2 patients, 22.2%), and neck (1 patient, 11.1%). All patients were treated with a 577 nm diode laser session every 2 weeks until complete clearance. Complete clearance was achieved in 3 patients after the first session, 4 patients after the second session, 1 patient after third session, and only one patient required four treatment sessions. Atrophic scarring was the only reported side effect, occurring in one case.</p><p><strong>Conclusion: </strong>Treatment with a 577-nm diode laser appears to be a safe and effective option for pyogenic granuloma in patients with darker skin types.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13683522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting corneal changes after PRK: Integrating biomechanics with tomographic remodeling.","authors":"Murat Kaşıkcı, Göksu Alaçamlı, Konuralp Yakar","doi":"10.1007/s10103-026-05074-1","DOIUrl":"10.1007/s10103-026-05074-1","url":null,"abstract":"<p><p>Photorefractive keratectomy (PRK) alters corneal biomechanical and tomographic measurements, but postoperative change, an abnormal index classification, and progressive ectasia are distinct. Saif et al. reported biomechanical changes at 6 months; a separate Pentacam cohort showed tomographic changes at 1 month. Clinically and topographically normal eyes assessed approximately 25 years after PRK also had frequent abnormal classifications. These different cohorts and observation periods cannot establish a common postoperative trajectory or show that an abnormal result is benign in an individual eye. Prospective paired Pentacam and Corvis ST measurements in the same eyes, followed by independent validation, are needed to develop postoperative references. Until then, serial clinical and tomographic findings should inform interpretation of isolated index abnormalities.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13677635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of hyaluronic acid spray and low-level laser therapy on wound healing following gingivectomy: a randomized controlled clinical trial.","authors":"Nezahat Arzu Kayar, Ipek Ozgu, Fatma Koksel Babun, Ayşenur Çohadar Kaya, Deniz Ozel, Esra Bolat Gümüs, Mükerrem Hatipoglu","doi":"10.1007/s10103-026-05069-y","DOIUrl":"10.1007/s10103-026-05069-y","url":null,"abstract":"<p><p>Gingivectomy wounds heal by secondary intention, prolonging recovery and postoperative discomfort; this randomized controlled trial compared low-level laser therapy and hyaluronic acid spray for early wound healing and postoperative pain after gingivectomy. Systemically healthy patients requiring gingivectomy were randomly allocated to receive either LLLT (940 nm diode laser, 3 W, 128.4 J/cm², applied on days 0, 3, 5, and 7) or 0.04% high-molecular-weight HA spray (applied twice daily for 7 days). Wound epithelialization was quantified through Mira-2-Ton plaque-disclosing staining combined with digital planimetric analysis (ImageJ) at baseline and on postoperative days 3, 7, and 14. Secondary outcomes included gingival index (GI), full-mouth bleeding score (FMBS), probing pocket depth (PPD), and visual analogue scale (VAS) pain scores. A total of 64 participants were enrolled and randomized (n = 32 per group). Both groups exhibited significant wound area reduction over time (p < 0.001). However, the HA spray group demonstrated significantly higher wound epithelialization percentages (percentage reduction from baseline in the non-epithelialized, disclosing-solution-stained wound surface area) than the LLLT group on days 3 (p < 0.001; Cohen's d = 1.39), 7 (p < 0.001; d = 1.12), and 14 (p = 0.044; d = 0.73). The HA spray group also reported significantly lower VAS pain scores on days 1 and 3 (p < 0.05). Periodontal parameters improved significantly from baseline to week 6 in both groups (all p < 0.001), with no significant between-group differences at week 6 for GI (p = 0.999), FMBS (p = 0.843), or PPD (p = 0.718). HA spray yielded significantly accelerated re-epithelialization and superior early pain reduction compared to LLLT following gingivectomy, suggesting it may serve as a practical, patient-friendly adjunctive alternative to laser biostimulation in postoperative wound management. Trial registration: ClinicalTrials.gov Number: NCT07034625.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13675292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbrella review of low-level light therapy: evidence across clinical conditions.","authors":"Eunhye Song, Lin Ang, Mi Hong Yim, Sunmi Choi, Jihye Kim","doi":"10.1007/s10103-026-05064-3","DOIUrl":"10.1007/s10103-026-05064-3","url":null,"abstract":"<p><p>Low-level light therapy (LLLT) and photobiomodulation (PBM) have been studied in diverse clinical fields. Although numerous systematic reviews have been published, their findings are fragmented and inconsistent. This umbrella review of systematic reviews aimed to synthesize the evidence on the effectiveness and safety of LLLT across various clinical conditions. PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception to February 24, 2026. Eligible studies were systematic reviews or meta-analyses of LLLT in humans. Data on clinical conditions, intervention characteristics, overall direction of conclusions, and adverse events were extracted. Methodological quality was assessed using AMSTAR 2. A total of 100 systematic reviews were included, representing 1,164 primary-study occurrences and 790 unique eligible primary studies. Oral and dental conditions accounted for the largest evidence base (53 reviews), followed by musculoskeletal disorders (22 reviews), oncology-related complications (8 reviews), and wound and lymphatic conditions (8 reviews). Overall, 62 reviews reached conclusions favoring the evaluated intervention, 34 reported neutral or mixed conclusions, and 4 had unclear conclusions. The highest proportion of favorable conclusions was observed for oncology-related complications. Of the 100 reviews, 11 reported one or more adverse events or side effects, 32 explicitly reported no adverse events, and 57 did not provide adverse-event information. Most reviews received low (30.0%) or critically low (60.0%) overall confidence ratings using AMSTAR 2. The review literature suggests potential clinical benefit of LLLT in selected indications, particularly oncology-related complications such as oral mucositis. However, these descriptive patterns do not establish treatment efficacy or the certainty of the underlying evidence. Heterogeneity in treatment parameters, generally low methodological confidence, and incomplete adverse-event reporting limit interpretation and preclude firm conclusions about safety.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Fissurectomy Combined with Limited Lateral Internal Sphincterotomy for Chronic Anal Fissure: A Minimally Invasive Technique.","authors":"Nitish Jhawar, Monika Joshi","doi":"10.1007/s10103-026-05025-w","DOIUrl":"10.1007/s10103-026-05025-w","url":null,"abstract":"<p><p>Chronic anal fissure (CAF) is a common benign anorectal condition characterised by severe pain and internal anal sphincter (IAS) hypertonia. Although lateral internal sphincterotomy (LIS) remains the surgical gold standard, the risk of postoperative faecal incontinence remains a clinically significant concern. We describe a minimally invasive hybrid technique combining 1470-nm diode laser fissurectomy with a limited closed LIS. The laser ablates the chronic ulcer triad whilst a tailored sphincterotomy confined to the distal one-third of the IAS addresses the underlying hypertonia. Based on published series of comparable sphincterotomy techniques, this approach is designed to target healing rates of 93-97 %, comparable to traditional LIS, with significantly reduced postoperative pain and a substantially lower risk of faecal incontinence through sphincter-sparing design. These figures represent literature-derived benchmarks that the technique is designed to achieve, rather than outcomes from a formal patient cohort reported in this article. Laser fissurectomy combined with limited closed LIS is a reproducible, day case technique conceptually designed to balance high healing rates with preservation of anorectal function, pending formal prospective validation. It is suitable for adoption in any coloproctological unit equipped with 1470-nm diode laser technology.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}