Lasers in Medical Science最新文献

{"title":"Re: The efficacy, satisfaction, and safety of carbon dioxide (CO2) fractional laser in combination with pulsed dye laser (PDL) versus each one alone in the treatment of hypertrophic burn scars: a single-blinded randomized controlled trial.","authors":"Yanran Yang, Zhanxue Sun","doi":"10.1007/s10103-026-05057-2","DOIUrl":"10.1007/s10103-026-05057-2","url":null,"abstract":"<p><p>This letter comments on the randomized trial by Karimi Kivi et al. comparing pulsed dye laser (PDL), ablative fractional carbon dioxide laser (AFCL), and their combination for hypertrophic burn scars. Several reporting and methodological issues warrant clarification, including the apparent inconsistency in the presentation of Vancouver Scar Scale data, the discrepancy between the reported total number of scars and the numbers shown in the original article, and the statistical handling of multiple scars from the same patient. Clarification of these issues would improve the transparency and interpretability of the study and facilitate its appropriate use in future evidence syntheses.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149195074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Laser-induced modulation of root dentin surface for growth factor release and enhanced stem cell response\".","authors":"Rodrigo Farias","doi":"10.1007/s10103-026-05068-z","DOIUrl":"10.1007/s10103-026-05068-z","url":null,"abstract":"<p><strong>Background: </strong>Laser conditioning of dentin has been investigated as a strategy to enhance growth factor release and cellular responses in regenerative endodontics. The recent study by Mokhtari et al. reported laser-induced modulation of root dentin, increased transforming growth factor-beta 1 (TGF-β1) release, and enhanced alkaline phosphatase (ALP) activity. However, several methodological aspects should be considered when interpreting these findings and their potential clinical translation.</p><p><strong>Main text: </strong>A critical analysis identifies important limitations in the experimental design. First, all laser-treated specimens were previously exposed to sodium hypochlorite, without a laser-only control, preventing the independent determination of the effect attributable to laser irradiation. Second, the concomitant increase in TGF-β1 release and ALP activity demonstrates an association but does not establish a causal mechanistic relationship, as no inhibition or neutralization experiments targeting TGF-β1 signaling were performed. Third, the use of mature dentin obtained from adult teeth limits direct extrapolation to immature permanent teeth, which are the clinical context emphasized in regenerative endodontics. In addition, the use of stem cells from human exfoliated deciduous teeth (SHED) does not fully represent endogenous cell populations involved in regenerative endodontics, and cellular migration or chemotaxis was not evaluated. Finally, differences in power and exposure time among wavelengths, together with the absence of calibrated power measurements and direct temperature monitoring, limit interpretation of dosimetry, dose-response relationships, and thermal safety.</p><p><strong>Conclusion: </strong>The findings provide preliminary evidence that laser irradiation may modify dentin and influence growth factor release and cellular responses. Nevertheless, laser-only controls, mechanistic assessment of TGF-β1 signaling, immature dentin models, evaluation of cellular migration, calibrated laser dosimetry, and temperature monitoring are necessary to strengthen the mechanistic and translational evidence supporting laser-assisted regenerative endodontic applications.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of low versus high intensity laser therapy in patients with subacute carpal tunnel syndrome: A randomized, single-blinded, controlled trial.","authors":"Arif Ali Rana, Ashfaq Ahmad, Siamak Bashardoust Tajali, Arooj Munawar, Maryam Shabbir","doi":"10.1007/s10103-026-05070-5","DOIUrl":"10.1007/s10103-026-05070-5","url":null,"abstract":"<p><p>A common entrapment of median nerve that causes pain, numbness, and functional impairment is called Carpal Tunnel Syndrome (CTS). Laser therapy is a noninvasive intervention for neural repair and pain modulation, but comparative evidence between Low-Level Laser Therapy (LLLT) and High-Intensity Laser Therapy (HILT) in subacute CTS is limited. The aims of this study were to compare the effects of LLLT and HILT on pain, functional status, electrophysiological, and ultrasonographic parameters in subacute CTS. A single-blinded randomized controlled trial (Reg. No. IRCT20241111063665N1) was conducted at the Department of Physiotherapy, The University of Lahore (UOL), Lahore, Pakistan, from August 2024 to March 2025. Sixty-nine participants with subacute CTS, confirmed by electromyography and nerve conduction studies, were randomly assigned to three groups (n = 23 each): Group A (HILT; 808 nm + physiotherapy), Group B (LLLT; 860 nm + physiotherapy), and Group C (physiotherapy + sham laser). Assessments were at baseline and week 6. Outcomes included pain (VAS), symptom severity and functional status (Boston Carpal Tunnel Questionnaire; BCTQ), grip strength, distal motor latency (DML), sensory nerve conduction velocity (SNCV), and median nerve cross-sectional area (CSA). ANCOVA with Bonferroni correction and effect size estimation was applied. At week 6, both HILT and LLLT showed significant improvements (p < 0.001). HILT achieved greater pain reduction (- 4.9) than LLLT (- 4.1) and control (- 2.2; p < 0.001), with greater improvement in BCTQ-SSS (- 2.2 points), BCTQ-FSS (- 1.9 points), grip strength (+ 9.9 kg), DML (- 1.2 ms), SNCV (+ 12.3 m/s), and CSA (- 3.7 mm²). Large effect sizes (Cohen's d > 0.8) were observed. Both LLLT and HILT are effective as adjuncts to physiotherapy in subacute CTS. HILT demonstrated greater improvements than LLLT within the parameters tested.Clinical Trial Number: IRCT20241111063665N1, Registration date: 17 March, 2025.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wavelength dependent effects of red and infrared photobiomodulation on neuropathic pain, skeletal muscle integrity, and mitochondrial respiration.","authors":"Maria Eduarda Rodrigues Santos, Manuel Alejandro Herrera Lopez, Luara Caniato Araujo, Danielle Paula Freitas Bataus Silva, Daniel Ferreira Carreira, Mauricio da Silva Baptista, Marucia Chacur","doi":"10.1007/s10103-026-05060-7","DOIUrl":"10.1007/s10103-026-05060-7","url":null,"abstract":"<p><p>Neuropathic pain is a chronic and difficult to treat condition affecting up to 10% of the population, significantly impairing quality of life and representing a public health concern. Photobiomodulation (PBMT) has emerged as a promising therapeutic approach, as photons can reach mitochondria and promote beneficial effects, including increased ATP production, reduced oxidative stress and inflammation, and improved mitochondrial metabolism and regeneration. However, gaps remain regarding its effects on mitochondrial dynamics in neuropathic pain. This study investigated the impact of PBMT at two wavelengths (660 nm, red and 904 nm, infrared) on nociceptive behavior (tactile allodynia, mechanical and thermal hyperalgesia), histological alterations, mitochondrial respiration, and protein expression by Western blotting in an experimental neuropathic pain model in male Wistar rats. PBMT reduced mechanical hyperalgesia and tactile allodynia, decreased inflammatory features, and promoted hyporadiance detected by infrared thermography. Chronic constriction of the sciatic nerve significantly reduced mitochondrial respiration in the gastrocnemius muscle. Although PBMT did not restore mitochondrial respiratory capacity, it induced relevant molecular alterations in mitochondrial proteins. Specifically, PBMT increased the expression of OPA1, a key regulator of mitochondrial dynamics, and modulated components of the electron transport chain and ATP synthase in a wavelength-dependent manner. Overall, PBMT modulated nociception and promoted mitochondrial molecular adaptations. These findings suggest that PBMT-induced analgesia may involve mechanisms independent of skeletal muscle mitochondrial bioenergetic restoration. Distinct wavelength-dependent responses further contribute to therapeutic parameter optimization and support future translational and clinical research. Clinical trial number: not applicable.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13668946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year follow-up of women with lichen sclerosus treated with laser therapy: A prospective observational study.","authors":"Volker Viereck, Marianne Gamper, Helena Bischofberger, Irena Zivanovic","doi":"10.1007/s10103-026-05062-5","DOIUrl":"10.1007/s10103-026-05062-5","url":null,"abstract":"<p><p>This prospective observational study evaluates the 2-year follow-up of a randomized controlled trial comparing a novel dual Nd:YAG/Er:YAG laser therapy with topical corticosteroid therapy for vulvar lichen sclerosus (LS). After the 6-month primary outcome assessment, observation continued with optional further treatment, including a free crossover laser therapy for the initial steroid group. At 24 months, participants were assessed for their subjective symptoms, treatment satisfaction, and maintenance therapy use. Sixty-five of 66 participants underwent four laser sessions during the 24-month follow-up period. The median interval between the final laser treatment and symptom recurrence requiring initiation of maintenance corticosteroid therapy was 7 months (interquartile range [IQR] 2.5-12.5 months). During follow-up, 40 women used maintenance corticosteroid therapy and five decided for an additional top-up laser treatment after a median interval of 18 months (IQR 16-20 months). Overall satisfaction with the treatment regimen was high, and most participants perceived laser therapy as effective. Subjective symptoms remained significantly improved compared with baseline throughout follow-up (p < 0.001). Among sexually active participants, the proportion without dyspareunia increased significantly from 4/31 at baseline to 14/31 at 24 months (p = 0.002). Dual Nd:YAG/Er:YAG laser therapy adjunct to maintenance corticosteroid therapy was well accepted and resulted in sustained symptomatic improvement in women with vulvar LS over 24 months. This combination therapy could represent a potential advance in the long-term management of LS.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the efficacy of antimicrobial photodynamic therapy (aPDT) with magnetic fields (MFs) stimulation in treating methicillin-resistant Staphylococcus aureus (MRSA) infected wounds in rats using 532 and 660 nm laser.","authors":"Nursakinah Suardi, Ali A Aldalawi, Mahdi A S Al-Farawn, Siti Khadijah Mohd Bakhori, Naser Mahmoud Ahmed, Mohd Hamzah Mohd Nasir, Hussein Jasim Shoaibeth, Faisal J Kadhim","doi":"10.1007/s10103-026-05065-2","DOIUrl":"10.1007/s10103-026-05065-2","url":null,"abstract":"<p><p>MRSA causes severe wound infections associated with tissue damage and increased apoptosis. This study evaluated the therapeutic efficacy of combining antimicrobial photodynamic therapy (aPDT) with external magnetic field (MF) stimulation in a MRSA infected rat wound model. One hundred male Wistar rats were allocated into five groups for two irradiation wavelengths, 532 nm and 660 nm: control (non-infected and MRSA infected untreated), laser alone, aPDT, laser combined with MF, and aPDT combined with MF. The aPDT protocol involved the topical application of a spinach-derived natural photosensitizer followed by laser irradiation, while a continuous external MF was applied locally over the wound site.Both wavelengths produced progressive reductions in bacterial load, with the magnitude of reduction depending on treatment and day. The aPDT-based treatments produced greater bacterial suppression than laser-only treatments, with aPDT + MF producing the lowest residual bacterial load at both wavelengths. At 532 nm, aPDT + MF produced a significantly lower bacterial load than aPDT alone on Day 4 (estimated mean difference = - 0.36 log₁₀ CFU/mL; adjusted p < 0.001). Histological analysis demonstrated reduced inflammatory cell infiltration and enhanced tissue regeneration in the combined group. These findings indicate that external MF stimulation enhances the antibacterial and tissue repair effects of aPDT in MRSA infected wounds.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of oral propranolol combined with pulsed dye laser versus monotherapy with oral propranolol in the treatment of mixed infantile hemangiomas.","authors":"Yang Gao, Hongliang Wang, Pan Li, Kai Lu, An Zhang, Yi Cheng","doi":"10.1007/s10103-026-05014-z","DOIUrl":"https://doi.org/10.1007/s10103-026-05014-z","url":null,"abstract":"<p><p>Oral propranolol is first-line for problematic infantile hemangiomas (IHs) but often leaves superficial residual lesions. This study assessed the efficacy and safety of adding pulsed dye laser (PDL) to propranolol versus propranolol alone for mixed IHs. This single-center retrospective cohort study included children with mixed IHs treated from January 2020 to September 2024, assigned to oral propranolol alone or with PDL. VESS (Vascular Density, Color Intensity, Texture Change) scores at 3 months, Achauer grade ≥ 4 at 1, 3, and 6 months, and regression metrics at 6 months were measured. Safety, parent-reported outcomes, treatment duration, and 12-month sequelae were also recorded. A total of 247 children were included (132 propranolol, 115 combination). The combination group had lower VESS scores at 3 months (all P < 0.010). Achauer grade ≥ 4 was more frequent at all time points (40.87% vs. 22.73% at 1 month, P = 0.002). Area reduction (75.66% vs. 70.75%, P < 0.001), thickness reduction (P = 0.024), and colorimetric ΔE (P = 0.003) were greater. Superficial erythema resolution improved (P = 0.002) with similar deep mass volume reduction. Satisfaction with color improvement (P < 0.001) and quality of life (P < 0.001), and shorter treatment duration (5.79 vs. 6.55 months, P = 0.007) favored the combined group. Recurrence (2.61% vs. 9.85%, P = 0.041) and residual telangiectasia (5.22% vs. 12.88%, P = 0.039) were lower. Transient purpura occurred only with PDL (22.61% vs. 0%, P < 0.001); other events were comparable. Adding PDL to oral propranolol significantly improves superficial clearance and aesthetic outcomes, accelerates global improvement, and reduces long-term recurrence and residual telangiectasia in mixed IHs.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface charge-dependent effects of BSA-curcumin nanoparticles combined with amikacin in antimicrobial photodynamic therapy: A pilot In Vivo study of multidrug-resistant Pseudomonas aeruginosa skin infection.","authors":"Isabelle Ribeiro Brambilla, Eloíse Gwyneth Lopes Oliveira, Mariany Fernandes da Silva Gravito de Carvalho, Isabelle Ferreira, Tassia Joi Martins, Jessica Aparecida Ribeiro Ambrósio, Andreza Ribeiro Simioni, Juliana Guerra Pinto, Juliana Ferreira-Strixino","doi":"10.1007/s10103-026-05054-5","DOIUrl":"10.1007/s10103-026-05054-5","url":null,"abstract":"<p><p>Skin infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa represent a significant therapeutic challenge because of high bacterial virulence and increasing antibiotic resistance. In this context, alternative strategies-such as nanotechnology and photodynamic therapy (PDT)-that can be combined with antibiotic therapy are being investigated as promising approaches for treating these infections. This study evaluated the therapeutic response of PDT mediated by anionic and cationic bovine serum albumin nanoparticles (NanoBSA) containing curcumin, in association with amikacin, in a murine model of cutaneous infection by MDR P. aeruginosa. The study was structured as a pilot trial involving 22 BALB/c mice infected and treated with free or nanoencapsulated curcumin and amikacin, followed by irradiation at 450 ± 10 nm. Blood and skin samples from the infected area were collected to analyze leukocyte profiles, serum inflammatory cytokines, and histopathological changes, and to measure changes in lesion area. The results demonstrated that the combination of PDT, NanoBSA, and amikacin promoted a greater reduction in lesion area, particularly with the anionic formulation. Leukocyte analysis indicated modulation of the inflammatory response, showing a more balanced profile in groups treated with amikacin, especially with the anionic formulation. Cytokine evaluation also showed modulation of the inflammatory response, most evident with the cationic formulation combined with amikacin. Histological findings showed improved tissue reorganization and structural preservation in groups undergoing combination therapy, with the anionic NanoBSA formulation standing out. Taken together, the results suggest that the combination of TFD, nanoencapsulated curcumin, and amikacin has therapeutic potential for treating cutaneous infections caused by MDR P. aeruginosa by promoting improved tissue repair and modulating the inflammatory response. Bacterial load was not quantified in the present study, which constitutes a limitation. Future studies should address this assay to confirm antimicrobial efficacy and help elucidate the underlying mechanisms.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Comparison of different cleaning techniques for the removal of root canal sealer from dentine surfaces: An SEM-EDX analysis.","authors":"Savas Sagmak","doi":"10.1007/s10103-026-05058-1","DOIUrl":"https://doi.org/10.1007/s10103-026-05058-1","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on laser-assisted veneer debonding.","authors":"Ioana Duncea, Cristina Muresan, Oana Almasan, Smaranda Buduru, Cecilia Bacali","doi":"10.1007/s10103-026-05052-7","DOIUrl":"https://doi.org/10.1007/s10103-026-05052-7","url":null,"abstract":"<p><p>This literature review examines the advancements in laser technology that have enhanced the veneer debonding process, offering insights into the proper implementation of these techniques in clinical practice with emphasis on laser parameters, debonding efficiency, thermal effects, and preservation of tooth structure. A systematic literature search was conducted on PubMed,Web of Science, Scopus and Cochrane Library. The review was structured according to the PICO framework. The search was performed independently by two reviewers on laser-assisted debonding of ceramic veneers using Er:YAG or Er,Cr:YSGG lasers.Based on a comprehensive evaluation of existing studies, the review presents different types of prosthetic restorations, materials, and laser parameters, and how they interact with each other. The benefits of laser precision, including improved control, workflow efficiency, fewer procedural steps, and reduced tissue impact, are emphasised to help dental practitioners enhance the standard of care in veneer debonding. Across the twenty nine studies that were obtained, laser debonding facilitated removal while pulpal temperature increases remained below commonly cited critical values. Both Er:YAG and Er,Cr:YSGG systems demonstrated effective veneer removal. Thinner veneers nedeed less irradiation time and lower energy. Limited enamel alterations occured when appropriate parameters were used. Current studies suggest that Er:YAG and Er, Cr: YSGG lasers offer clinical advantages in terms of efficiency, safety, and patient comfort. Studies demonstrate that optimized laser settings reduce debonding time and minimize the risk of thermal damage to underlying tooth structure and surrounding tissues. Debonding efficiency was influenced by veneer thickness, ceramic type, cement composition, laser power, pulse duration and cooling protocols Er:YAG and Er,Cr:YSGG lasers are promising tools for ceramic veneer debonding. However, results obtained in these studies cannot be directly associated to patient-centered issuses, further standardized clinical studies are required before definitive clinical recommendations can be made.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}