Lasers in Medical Science最新文献

{"title":"Midline frontal erythema responding favorably to pulsed dye laser: a persistant salmon patch or midline port wine stain?","authors":"Pingping Cai, Lei Zeng, Hualing Shi, Mengli Zhang, Lifang Guo, Yiping Ge","doi":"10.1007/s10103-025-04408-9","DOIUrl":"https://doi.org/10.1007/s10103-025-04408-9","url":null,"abstract":"<p><p>To characterize midfrontal erythema and evaluate the clinical efficacy of 595 nm pulsed dye laser treatment for this condition. A total of 85 patients presenting with vascular lesions in the midfrontal area were analyzed who received the pulsed dye laser treatment between 2018 and 2023. The efficacy and safety of the treatment was assessed. The total effective rate of pulsed dye laser treatment for midfrontal erythema was 96.4%, with a cure rate of 69.4%. No adverse event was observed. Patients' ages and color of the skin lesions affected the therapeutic outcomes. Younger patients had higher effective rates. And the patients with pink lesions show higher cure rates than those with purple-red lesions. Pulsed dye laser treatment was effective and safe for the treatment of midline frontal erythema, particularly when initiated early.So We propose the diagnosis of \"midfrontal erythema\" or \"persistent salmon patch\" for this condition. Clinical trial number: not applicable.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"152"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of photobiomodulation on adipocytic infiltration in sites of skin healing: in vivo experimental study.","authors":"Beatriz Paim de Figueiredo Braitenbach, Carla Barreto Silva de Cerqueira, Sarah Souza Lima, Isadora de Carvalho Hegouet, Bruna Carvalho Lopez Moreno, Alena Ribeiro Alves Peixoto Medrado","doi":"10.1007/s10103-025-04410-1","DOIUrl":"https://doi.org/10.1007/s10103-025-04410-1","url":null,"abstract":"<p><p>Adipocyte infiltration consists of a temporary increase in the number of adipocytes in the microenvironment of tissue injury. There is already evidence in the literature of adipocytes' participation in promoting the inflammatory response, and parallelly laser photobiomodulation can benefit the tissue repair process. This study aimed to chronologically analyze adipocytic infiltration in the repair of photobiomodulated skin wounds experimentally induced in rats through histomorphometric analysis. The sample consisted of 20 rats divided into 2 groups: control group and group subjected to laser photobiomodulation. The skin portions of the back of rats were processed and stained with Hematoxylin-Eosin in 4 μm thick sections including the surgical wound 5 and 10 days after the proposed treatments. Qualitative and quantitative analyses were performed by capturing images of tissue sections, describing the organizational pattern of adipocytes around the surgical wound and counting individual adipocytes in the connective tissue in formation. Adipocytic infiltration was observed in both experimental groups on the 5th day, with a decrease on the 10th day. The group treated with photobiomodulation presented a greater number of adipocytes compared to the control group, in both periods analyzed. The findings of the present study seem to corroborate the literature, which indicates that adipose cells might stimulate inflammation and repair, and photobiomodulation can enhance these effects, since it aids the process of adipocytic infiltration in the injured area. Clinical trial number: Not applicable.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"153"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-intensity laser therapy and photobiomodulation therapy on oral lichen planus-a systematic review and meta-analysis.","authors":"Panpan Liu, Qi Zhou, Jie Bao, Muni Chen, Mengting Xu, Jiamin Bian, Yueqiang Wen, Jiayu Yan","doi":"10.1007/s10103-025-04398-8","DOIUrl":"10.1007/s10103-025-04398-8","url":null,"abstract":"<p><p>This study evaluates the efficacy and safety of High-Intensity Laser Therapy (HILT) and Photobiomodulation (PBM) in treating Oral Lichen Planus (OLP), and explores optimal PBM parameter settings. A search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, and SinoMed was conducted for randomized controlled trials (RCTs) on laser therapy for OLP up to October 30, 2024. Study quality was assessed using the Cochrane risk of bias tool and the Jadad score. Eighteen studies were identified, with 16 involving 742 participants included in the meta-analysis. Eleven studies compared PBM with topical corticosteroids (TCS), and five compared HILT with TCS. HILT provided superior pain relief compared to TCS (SMD = -0.51, 95% CI [-0.79,-0.23]), while PBM showed comparable outcomes (SMD = -0.41, 95% CI [-0.87, 0.04]). PBM was more effective at pain relief with total energy density below 120 J/cm². Both HILT and PBM reduced recurrence rates (RR = 0.33,95%CI [0.15,0.73]; RR = 0.43, 95% CI [0.25, 0.74]) and improved cure rates (RR = 1.44, 95% CI [1.01, 2.06]; RR = 1.47, 95% CI [1.05, 2.05]). PBM had no adverse reactions, while HILT and TCS had associated adverse events. HILT and PBM may be considered effective alternatives to TCS. For PBM treatment of OLP, a total energy density below 120 J/cm² is advisable. Further large-scale studies are required to confirm these findings and refine laser parameters.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"151"},"PeriodicalIF":2.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of photodynamic therapy using gentamicin and imipenem-derived carbon dots on Pseudomonas aeruginosa isolates.","authors":"Somaye Shiralizadeh, Abbas Farmani, Leili Shokoohizadeh, Maryam Pourhajibagher, Mohammad Yousef Alikhani, Abbas Bahador","doi":"10.1007/s10103-025-04402-1","DOIUrl":"https://doi.org/10.1007/s10103-025-04402-1","url":null,"abstract":"<p><p>The increasing prevalence of antibiotic resistance poses a significant threat to the ability of healthcare systems to manage Pseudomonas aeruginosa infections, highlighting the need for innovative therapeutic strategies. The aim of this study was to evaluate the effects of photodynamic therapy (PDT) using carbon dots (CDs) derived from gentamicin and imipenem against P. aeruginosa isolates. A hydrothermal method was used to synthesise amine-functionalised CDs (CDsGEN-NH2, CDsIMP-NH2) from gentamicin and imipenem precursors, respectively. Conjugation of imipenem to CDsGEN-NH2 (CDsGEN-IMP) and gentamicin to CDsIMP-NH2 (CDsIMP-GEN) was achieved using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide. The synthesised CDs were analysed by HRTEM, zeta potential, UV-Vis, FTIR and fluorescence. The efficacy of photodynamic therapy (PDT) against P. aeruginosa ATCC27853 and two clinical P. aeruginosa isolates was evaluated using a combination of sub-minimum inhibitory concentrations (sub-MIC) and sub-lethal doses of UVA light (sDL) irradiation. The nanoscale size, electrical charge and photophysical properties of the synthesised CDs were confirmed by HRTEM, zeta potential, UV-Vis, FTIR and fluorescence techniques. Treatment with CDsGEN-NH2, CDsIMP-NH2 and CDsGEN-IMP at concentrations of 3 mg/mL (sub-MIC) and sDL irradiation for 10 s (3.12 J/cm²) resulted in significantly reduced viability in P. aeruginosa ATCC27853 compared to the control (P ≤ 0.05), achieving viable cell reductions of 3.44, 3.11 and 2.65 log, respectively. Treatment with CDsIMP-GEN at a concentration of 125 µg/mL (sub-MIC) and sDL irradiation for 10 s (3.12 J/cm²) also significantly reduced viability in P. aeruginosa ATCC27853 compared to the control (P ≤ 0.05), achieving a viable cell reduction of 3.75 log. These results demonstrate that CDs derived from imipenem and gentamicin can serve as effective antimicrobial agents in combination with UVA light irradiation for antimicrobial photodynamic therapy.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"150"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tattoo fading using Nd: YAG ns laser pulses by water cavitation bubbles and jet formation: (case study).","authors":"Muna B Mustafa, Walid K Hamoudi, Khawla S Khashan","doi":"10.1007/s10103-025-04405-y","DOIUrl":"https://doi.org/10.1007/s10103-025-04405-y","url":null,"abstract":"<p><p>Because it is difficult to totally remove ink particles trapped in the skin, tattoo removal-especially for deeply and densely pigmented types-remains a substantial issue. This frequently leads to scarring, persistent pigmentation, or an incomplete removal. Significant promise in resolving this problem since high-peak power pulsed Nd: YAG lasers can efficiently target ink particles even in deeper skin layers, they have shown. The purpose of this study is to assess how well the Nd: YAG laser uses tissue photodisruption to remove deeply embedded tattoo ink. High intensity Nd: YAG lasers provide a very efficient way to remove tattoos by dissolving ink particles with the least amount of harm to surrounding tissue. Two sessions of Q-switched Nd: YAG (1064 nm) laser treatment was performed on a 36-year-old woman who had a very deep black tattoo on her arm. When the tattooed area was treated with a laser beam with a 6-mm spot size and 5 J/cm² fluence. After two months, the process was repeated, and the last evaluation was carried out one month after the second therapy. For histologic research objectives, one local white rabbit was also included in this investigation. Under general anesthesia, the rabbit was injected with tattoos of black pigment and given a single session. Black ink significantly lightened without leaving any scars and a crust formed right after. The spectroscopic properties of black tattoo ink were examined. Following laser exposure, there was a noticeable decrease in the appearance of the ink without any indication of inflammation or cell growth. Within ten days, the skin's texture improved and the tattoo was 85% cleared after two laser sessions without blistering or changes in texture. Black ink granules were efficiently broken down by laser-induced cavitation, creating structures resembling bubbles. Ink fragments were phagocytized and distributed throughout the layers of the skin, whereas histological examination of treated black tattooed rabbit skin revealed a notable decrease in ink particle size without inflammatory reactions. albeit there was no injury to the epidermis, the 1064 nm Nd: YAG laser produced deep vacuoles and selective absorption by black ink, albeit localized inflammatory reactions were noted. The 1064 nm Q-switched Nd: YAG laser, operating at 6ns, demonstrated safety and effectiveness for deep tattoo removal. It achieved 85% clearance after two sessions, without inducing pigmentation changes.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"149"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of ultrasound and transfer energy capacitive and resistive (TECAR) therapy in patients with carpal tunnel syndrome.","authors":"Özge Tezen, Ayşe Merve Ata, Öznur Uzun, Furkan Çakır, Evren Yaşar","doi":"10.1007/s10103-025-04412-z","DOIUrl":"https://doi.org/10.1007/s10103-025-04412-z","url":null,"abstract":"<p><p>The aim of this study was to evaluate the effect of Transfer Energy Capacitive and Resistive (TECAR) therapy on pain, symptom severity and function in patients diagnosed with carpal tunnel syndrome (CTS) and to compare it with ultrasound (US) therapy. A total of 42 patients aged between 18 and 65 years, were divided into two groups; group 1 received US therapy, group 2 received TECAR therapy. Both groups received paraffin therapy and wrist orthosis. All Patients were evaluated using the Visual Analog Scale (VAS) for pain and paresthesia levels, the Boston Carpal Tunnel Questionnaire (BCTQ) for symptom severity and functional levels. Additionally, median nerve cross sectional area (CSA) was measured by ultrasound, at the baseline, post-treatment, first and third months. According to our results, VAS and BCTQ (symptom and function) scores significantly improved in both groups during follow-ups (all p < 0.01). However, there was no significant difference between the groups other than the VAS score at 3 months. At 3 months, Group 1 had a lower VAS score than Group 2 (p = 0.013). In Group 1, median nerve CSA decreased significantly after treatment (p < 0.001), and it was maintained during the first- and third-months follow-ups (p = 0.002 and p = 0.006, respectively). In Group 2, median nerve CSA decreased after treatment (p = 0.017) compared to before treatment and it returned to baseline levels in the third month (p = 0.770). While TECAR therapy may be beneficial in lowering pain and improving symptoms and functions in CTS patients, its effects were not as long-lasting as US. Clinical trial number: NCT06451094.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"147"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy and safety of home-used intense pulsed light with medical intense pulsed light for hair removal.","authors":"Yunling Yan, Sha Lu, Shan Wu, Kai Wang, Yunjing Xu, Kui Zhan, Ying Zeng, MaoQiang Man, Bin Yang, Zhenfeng Liu","doi":"10.1007/s10103-025-04414-x","DOIUrl":"https://doi.org/10.1007/s10103-025-04414-x","url":null,"abstract":"<p><p>Although many home-used intense pulsed light (IPL) are available for hair removal, whether these devices exhibit comparable efficacy and safety to those IPL used at hospitals is unknown. Therefore, we compared here the efficacy and safety of a home-used UI04 IPL freezing point hair removal device with a Broadband Light (BBL) intense pulsed light hair removal device for hair removal. A total of 84 participants were enrolled from our outpatient clinic. In each participant, the right and the left sides of the axilla, calf, or forearm were randomly assigned to either the observation side treated with a UI04 IPL hair removal device or control side treated with a BBL device for 3 months and were followed up for 3 months. Our results showed that 78 out of 84 (87.6%) patients completed the study. After 1-month treatment, the effective rate of hair removal was significantly higher on the observation side than on the control side (P = 0.001). After 3-month treatment, the effective rates on the observation and the control sides were comparable. The incidence of adverse reactions was similar between the two instruments. Thus, the UI04 IPL and BBL IPL hair removal device exhibit similar efficacy and safety for hair removal.This study confirms that the efficacy and safety of the UI04 IPL as an at-home hair removal device is similar to that of IPL devices, while they are inexpensive, easy to operate, portable, and can be used as an alternative treatment for hair removal. Trial registration 20210454.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"148"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic treatment with photobiomodulation decreases blood pressure and improves endothelial function in ovariectomized rats.","authors":"Nayara Formenton da Silva, Luis Henrique Oliveira de Moraes, Camila Pereira Sabadini, Rita Cristina Cotta Alcântara, Patricia Corrêa Dias, Gerson Jhonatan Rodrigues","doi":"10.1007/s10103-025-04404-z","DOIUrl":"https://doi.org/10.1007/s10103-025-04404-z","url":null,"abstract":"<p><p>Menopause is a natural phase, related to the aging reproductive female, characterized by decreased production of hormones steroids, mainly estrogen, involved in multiple physiological process, including cardiovascular function. This estrogen decline can lead to the development of hypertension, as well as other cardiovascular diseases. Strategies therapeutics complementary he comes winning emphasis as option for management women's insurance at menopause, such as photobiomodulation. Photobiomodulation (PBM) is the application of no invasive low light sources level, normally in the forms of low level lasers therapy (LLLT) or light emitting diodes (LEDs) that present potentials benefits therapeutics in the treatment of inflammation and stress oxidative, favoring angiogenesis, improving function cardiac and remodeling tissue. The objective of this work was to evaluate the in vivo effects of photobiomodularion on cardiovascular parameters in ovariectomy-induced menopause in female rats. Twenty-six 70-day-old female Wistar rats were randomly assigned to three experimental groups: sham (SH), ovariectomized (OVX), and ovariectomized treated with photobiomodulation (OVX + PBM). The ovaries of all animals in the OVX groups were surgically removed at 12 weeks of age. The OVX + PBM group received photobiomodulation treatment with 5.6 Joules per point at six points on the abdominal region, using a power of 100mW at a wavelength of 660 nm, applied twice a week for two weeks. Blood pressure was measured using tail plethysmography, and endothelial function was assessed through vascular reactivity tests. At the end of the treatment period, the mean blood pressure in the OVX + PBM group was significantly lower than in the untreated OVX group. PBM treatment also improved endothelium-dependent vasodilation in aortic rings of OVX rats compared to the untreated OVX group, with no significant difference between the OVX + PBM and Sham groups. In addition, PBM increased serum nitric oxide (NO) levels compared to the OVX group. These results suggest that PBM treatment effectively reduced blood pressure, increased serum NO levels, and reversed endothelial dysfunction in ovariectomized rats.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"144"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of the 1064 nm long-pulsed Nd: YAG laser for treating pyogenic granuloma children: a retrospective study of 30 patients.","authors":"Yuxin Lv, Li Liu, Xiaoyan Luo","doi":"10.1007/s10103-025-04401-2","DOIUrl":"https://doi.org/10.1007/s10103-025-04401-2","url":null,"abstract":"<p><p>Pyogenic Granuloma (PG) is a benign vascular tumor with multiple treatment; current therapies mainly focus on laser therapy but its' use in children was rarely been reported. This retrospective study aimed to analyze the effectiveness and safety of the 1064 nm long-pulsed Nd: YAG laser for treating PG among children attending our Dermatology Laser Clinic to take laser therapy. The researchers collected data of 30 Chinese pediatric PG patients treated with 1064 nm long-pulsed Nd: YAG laser with fluences of 85-130 J/cm² and pulse width of 10-40 and pulse of 1-4 at one-month intervals. Total treatment ranged from one to two sessions. A assessment of clinical efficacy was made by two physicians through measuring the long and short diameters of PG in standard photos to compute the changes in the PG volume. Based on the pretreatment and post-treatment photos, a 5-point grading scale was used for the evaluation of pigment clearance: 5 for complete (95-100%), 4 for excellent (75-94%), 3 for good (50-74%), 2 for fair (25-49%), and 1 for poor (0-24%). Adverse reactions such as bleeding, scar and pigmentation were recorded during the follow-up visit after treatment. Among these patients, 28 recovered after a single treatment, and 2 received two treatments. After the first laser treatment, there was a significant reduction in grading scores(p < 0.0001), accompanied by a notable improvement in physician visual evaluation. There was recurrence-free during 6 months of follow-up in all patients. Only 1 patient was observed with a scar. Post-inflammatory hyperpigmentation after treatment was observed in 2 patients which improved within 3 months. Hypopigmentation was not found after treatment. The 1064 nm long-pulsed Nd: YAG laser is an effective and safe approach for treating PG in children.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"146"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it beneficial to add laser ablation to curettage in the treatment of pilonidal sinus disease?","authors":"Mehmet Ali Demir, Tahsin Çolak, Cumhur Özcan, Hüseyin Oğuzhan İnan, Erkan Güler","doi":"10.1007/s10103-025-04409-8","DOIUrl":"10.1007/s10103-025-04409-8","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare laser application with sinus curettage against only sinus curettage in the treatment of pilonidal sinus disease (PSD) in terms of postoperative complications, wound healing, and recurrence. Additionally, we aimed to investigate factors associated with wound healing and recurrence after PSD surgery.</p><p><strong>Patients and methods: </strong>This study included patients diagnosed with PSD between February 2019, and September 2022. The patients were randomly assigned to either the laser + curettage (L/C; n = 40) group or the curettage-only (C; n = 40) group. The following data were collected: demographic and anthropometric information, smoking status, comorbidities, number of PSD-related orifices, complicated or uncomplicated disease, prior recurrence, postoperative findings, wound healing problems within 30 days postoperatively, and recurrence within 6 months postoperatively.</p><p><strong>Results: </strong>The L/C and C groups were similar in terms of age and sex distribution. The groups had similar results for postoperative pain, discharge, bleeding, wound healing problems at 30 days, and recurrence at 6 months. Multivariable logistic regression revealed that, high weight and higher orifice count were independently associated with wound healing problems. Additionally, high weight, higher orifice count and prior recurrence were independently associated with recurrence.</p><p><strong>Conclusion: </strong>Combined curettage and laser therapy showed non-significant but broad benefits over curettage alone, but statistical significance was not achieved in any of the adverse findings, as well as wound healing and recurrence. Higher body weight and higher orifice count were associated with both poor wound healing and recurrence, while prior recurrence was another factor associated with recurrence at 6 months.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"145"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}