Lasers in Medical Science最新文献

Evaluation of efficacy and safety for the energy delivery and skin tightness of monopolar radiofrequency device in Asian. 亚洲地区单极射频装置的能量输送和皮肤密封性的有效性和安全性评价。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-29 DOI: 10.1007/s10103-025-04475-y

Mi Soo Choi, Kyujin Yeom, Myung Hwa Kim, Byung Cheol Park

{"title":"Evaluation of efficacy and safety for the energy delivery and skin tightness of monopolar radiofrequency device in Asian.","authors":"Mi Soo Choi, Kyujin Yeom, Myung Hwa Kim, Byung Cheol Park","doi":"10.1007/s10103-025-04475-y","DOIUrl":"10.1007/s10103-025-04475-y","url":null,"abstract":"Monopolar radiofrequency(MRF) treatment is known to induce collagen contraction and remodeling in dermis. This study was conducted to evaluate safety of MRF in pre-clinical study first, and efficacy and safety in lifting and tightening of the face and upper neck in the clinical study. In pre-clinical setting, thermal imaging, and clinical and dermoscopic photography of after the procedure, and 7, 14, 30 days later were recorded. In clinical study, 23 subjects were enrolled and got 1 treatment. They were followed up at 4, 12, 24 weeks, and assessed using clinical photography. Changes in elasticity, pore number, wrinkle(%), and safety evaluation were also done. In the pre-clinical study, energy was safely delivered to the treatment area. In the clinical study, the clinical grades significantly decreased after 4, 12, and 24 weeks. Net and biological elasticity showed a significant increase at week 24. Pore count significantly decreased from week 12 and wrinkle started to decrease from week 4. Subjective satisfaction peaked in week 12. The average of pain score was 0.30 ± 0.63, and only mild adverse events were recorded. This study found that MRF deliver stable energy to the skin and have significant effect in skin laxity without complications.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"249"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial. 经颅光生物调节的剂量依赖性耐受性和安全性：一项随机对照试验。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-29 DOI: 10.1007/s10103-025-04501-z

David R A Coelho, Willians Fernando Vieira, Aura Maria Hurtado Puerto, Maia B Gersten, Katherine Anne Collins, Anna Peterson, Kari Siu, Ümit Tural, Dan Vlad Iosifescu, Paolo Cassano

{"title":"Dose-dependent tolerability and safety of transcranial photobiomodulation: a randomized controlled trial.","authors":"David R A Coelho, Willians Fernando Vieira, Aura Maria Hurtado Puerto, Maia B Gersten, Katherine Anne Collins, Anna Peterson, Kari Siu, Ümit Tural, Dan Vlad Iosifescu, Paolo Cassano","doi":"10.1007/s10103-025-04501-z","DOIUrl":"https://doi.org/10.1007/s10103-025-04501-z","url":null,"abstract":"Transcranial photobiomodulation (t-PBM) with near-infrared (NIR) light has emerged as a promising therapy for major depressive disorder (MDD). However, the dose-dependent tolerability of t-PBM has not been adequately explored. This secondary analysis of a sham-controlled clinical trial evaluated the safety and tolerability of t-PBM across varying doses in 31 subjects with MDD. Participants were randomly assigned to receive four sessions of NIR (808 nm) t-PBM (sham, low, medium, and high doses) approximately one week apart. The outcome was the emergence of side effects, assessed by the Systematic Assessment for Treatment-Emergent Effects-Specific Inquiry (SAFTEE-SI) scale. The frequency of side effects, compared to baseline or the prior week, was analyzed using Cochran's Q test. Additionally, body weight and systolic and diastolic blood pressures (SBP and DBP, respectively) were recorded and assessed with repeated measures ANOVA. The results showed no statistically significant changes in rates of any adverse events compared to baseline or prior week. The most notable rate increases were in \"delayed or absent orgasm\" for the medium dose compared to baseline among 10% of participants (Cochran's Q = 6.231; p = 0.101), and in \"ringing in ears or trouble hearing\" for the high dose compared to the prior week among 13% of participants (Cochran's Q = 6.231; p = 0.101). There were no significant changes in weight or SBP and DBP (F(4, 85) = 0.277, p = 0.892; F(4, 87.45) = 1.722, p = 0.152; F(4, 87.10) = 1.672, p = 0.164, respectively). In conclusion, this study did not find a significant association between the dose of t-PBM sessions and rates of adverse events or changes in vital signs. The side-effect profile of t-PBM appears benign, regardless of dosimetry.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"248"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could photobiomodulation be used for treatment of rosacea? 光生物调节可以用于治疗酒渣鼻吗？

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-29 DOI: 10.1007/s10103-025-04503-x

José Carlos Boaretto Netto, Ana Julia Cardoso Borges, Thayssa Gomes Farias, Adenilson de Souza da Fonseca

{"title":"Could photobiomodulation be used for treatment of rosacea?","authors":"José Carlos Boaretto Netto, Ana Julia Cardoso Borges, Thayssa Gomes Farias, Adenilson de Souza da Fonseca","doi":"10.1007/s10103-025-04503-x","DOIUrl":"https://doi.org/10.1007/s10103-025-04503-x","url":null,"abstract":"Rosacea is a chronic inflammatory disease characterized by facial skin lesions, including flushing, persistent erythema, papules, telangiectasia, and phymatous changes, affecting 5.5% of the world's population. Rosacea causes disfigurement and emotional ramifications and affects quality of life. The pathophysiology of this disease has yet to be understood, and new therapies are necessary. Photobiomodulation has been used to treat dermatological diseases and various conditions, such as inflammatory processes and pain relief. Thus, this study aimed to review studies on PBM for rosacea treatment, summarizing the radiation sources and subject features and reporting the main results. Scientific articles were accessed by PubMed, using keywords related to rosacea and photobiomodulation. Data on irradiation conditions, patient features, experimental models, and results obtained were assessed. The data analysis allowed to list the conditions for applying photobiomodulation that could lead to therapeutic effects, safety, and efficacy in treating the rosacea. Based on clinical and experimental studies accessed, photobiomodulation could decrease rosacea hallmarks and symptoms by decreasing of pro-inflammatory factor expression, inflammatory infiltration and immune cells, and promoting extracellular matrix remodeling. However, due to few studies available on the application of photobiomodulation in the treatment of rosacea, studies based on experimental and clinical models are necessary to better understand the mechanisms of action of this therapy, efficacy, and validation in the treatment of rosacea.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"250"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Sculpting perfection: advancements in hybrid laser therapy for scar management. 修正：雕刻完美：疤痕管理混合激光治疗的进步。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-28 DOI: 10.1007/s10103-025-04505-9

Fabiana Battaglia, Lucia Quattrocchi, Francesco Stagno d'Alcontres, Pietro Micieli, Giuseppe Trimarchi, Gabriele Delia

引用次数: 0

A comparative study of transurethral 450 nm DiLVP and 1470 nm DiLEP in the treatment of benign prostatic hyperplasia. 经尿道450 nm DiLVP与1470 nm DiLEP治疗良性前列腺增生的比较研究。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-28 DOI: 10.1007/s10103-025-04502-y

Zhichao Wang, Qingfei Xing, Xinghua Gao, Mengzhen Qiu, Longyang Zhang

{"title":"A comparative study of transurethral 450 nm DiLVP and 1470 nm DiLEP in the treatment of benign prostatic hyperplasia.","authors":"Zhichao Wang, Qingfei Xing, Xinghua Gao, Mengzhen Qiu, Longyang Zhang","doi":"10.1007/s10103-025-04502-y","DOIUrl":"https://doi.org/10.1007/s10103-025-04502-y","url":null,"abstract":"To compare the clinical effects of 450 nm diode laser vaporisation of the prostate (450 nm DiLVP) and 1470 nm diode laser enucleation of the prostate (1470 nm DiLEP) in the surgical treatment of benign prostate hyperplasia (BPH). BPH patients who were treated with 450 nm DiLVP or 1470 nm DiLEP in the Department of Urology of Jinan Central Hospital from November in 2021 to November in 2023 were selected for retrospective analysis. The assessment indexes included: (1) Preoperative general information; (2) Perioperative indicators; (3) Postoperative follow-up indicators(followed up at 1 and 3 months after surgery). A total of 128 BPH patients were included in the study, 63 in the experimental group with 450 nm DiLVP and 65 in the control group with 1470 nm DiLEP. There was no significant difference in the baseline information between the two groups (P > 0.05). Compared with the 1470 nm DiLEP group, the operation time, the laser energy consumption and bladder irrigation time were significantly reduced in the 450 nm DiLVP group (P < 0.001). At 3 months postoperatively, Qmax relief was significant in the 1470 nm DiLEP group (P = 0.023). (1) Perioperatively, compared with the 1470 nm DiLEP, 450 nm DiLVP has shorter operation time, irrigation time, and laser energy consumption; (2)Postoperative follow-up: 450 nm DiLVP and 1470 nm DiLEP have similar efficacy in improving BPH symptoms; 1470 nm DiLEP may have greater impact on max urinary flow rate in long-tem follow-up, which needs further verification.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"246"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of low-level laser therapy after rapid maxillary expansion: Micro-CT analysis. 上颌快速扩张术后低水平激光治疗的效果：显微ct分析。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-27 DOI: 10.1007/s10103-025-04497-6

Maria Bernadete Sasso Stuani, Andréa Sasso Stuani, Gabriela Leite Pedroso, Paôla Caroline da Silva Mira, Sara Gollino, Michel Dastra, Birte Melsen

{"title":"The effect of low-level laser therapy after rapid maxillary expansion: Micro-CT analysis.","authors":"Maria Bernadete Sasso Stuani, Andréa Sasso Stuani, Gabriela Leite Pedroso, Paôla Caroline da Silva Mira, Sara Gollino, Michel Dastra, Birte Melsen","doi":"10.1007/s10103-025-04497-6","DOIUrl":"https://doi.org/10.1007/s10103-025-04497-6","url":null,"abstract":"This study aimed to evaluate quantitatively the effects of low-level laser therapy (LLLT) on bone healing performed after rapid maxillary expansion (RME) in rats, using micro-computed tomography (micro-CT). Ninety rats were used, randomly distributed into three groups: control (n = 10) (young and adult rats - intact suture), experimental I (n = 40) (young and adult rats with RME without LLLT), and experimental II (n = 40) (young and adult rats with RME + LLLT). Five rats from the groups were euthanized on days 0, 7, 14, and 21 of the experiment and evaluated by microCT analysis. The laser increased the bone formation volume at 7 and 14 days (young rats) and 14 days (adult rats) were statistically significant (p < 0.05), but at the end of the healing (21 days), no statistically significant difference was observed between the laser and no-laser groups (p > 0.05). These findings suggest that LLLT improves bone mineralization during the early healing phases after RME, accelerating the process of bone mineralization during the initial experimental phase, which may have clinical implications in reducing orthodontic treatment duration and improving bone stability.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"245"},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICG/MnO₂-HFn-mPEG-DSPE-Lip enhances the anticancer activity of ICG phototherapy. ICG/MnO2-HFn-mPEG-DSPE-Lip增强ICG光疗的抗癌活性。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-24 DOI: 10.1007/s10103-025-04494-9

Dan Ma, Huixiang Lu, Hai Zhang, Anru Liao, Qianrong Peng, Min Yang

{"title":"ICG/MnO2-HFn-mPEG-DSPE-Lip enhances the anticancer activity of ICG phototherapy.","authors":"Dan Ma, Huixiang Lu, Hai Zhang, Anru Liao, Qianrong Peng, Min Yang","doi":"10.1007/s10103-025-04494-9","DOIUrl":"https://doi.org/10.1007/s10103-025-04494-9","url":null,"abstract":"Hypoxia poses a significant challenge to the efficacy of photodynamic therapy (PDT) for cancer treatment. This study aims to design and synthesize PEGylated liposomes encapsulating MnO₂, indocyanine green (ICG), and H-chain ferritin (HFn) to potentially address hypoxia and enhance the therapeutic outcomes of PDT. PEGylated liposomes (ICG/MnO₂-HFn-mPEG-DSPE-Lip) were constructed with a rod-like structure, incorporating MnO₂ as a hypoxia-modulating agent and ICG as a photosensitizer. The drug loading capacity, stability and safety of liposomes were characterized. Singlet oxygen quantum yield (ΦΔ) was measured under simulated tumor microenvironment conditions. In vitro phototoxicity was evaluated using A549 human lung adenocarcinoma cells. Liposomes have a high drug loading capacity, good biocompatibility and good long-term stability. Under tumor-simulated conditions, ΦΔ was significantly improved, increasing from 0.210 for free ICG to 0.507. The liposomes demonstrated remarkable phototoxic effects on A549 cells (90.5% cell death under combined PDT/PTT vs. 15% for free ICG). This nanoplatform proposes a novel strategy to overcome hypoxia-induced PDT resistance, and the enhanced efficacy may be attributed to the increased oxygen supply mediated by MnO2 carried by HFn. These findings provide important insights for the development of next-generation therapeutic systems targeting tumor hypoxia.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"243"},"PeriodicalIF":2.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laser ablation of bone for implant osteotomy preparation-modeling and an ex vivo validation study. 激光消融植体截骨预备模型及离体验证研究。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-24 DOI: 10.1007/s10103-025-04491-y

Kang-Jie Cheng, Xi-Xi Xu, Jia-Sheng Li, Wen-Quan Zhao, Russell Wang, Yun-Feng Liu

{"title":"Laser ablation of bone for implant osteotomy preparation-modeling and an ex vivo validation study.","authors":"Kang-Jie Cheng, Xi-Xi Xu, Jia-Sheng Li, Wen-Quan Zhao, Russell Wang, Yun-Feng Liu","doi":"10.1007/s10103-025-04491-y","DOIUrl":"https://doi.org/10.1007/s10103-025-04491-y","url":null,"abstract":"Mechanical drilling is currently a universal standard for implant osteotomy site preparation. Without proper cooling, high frictional heat can be generated inside the bone during drilling which may be detrimental for osteocyte survival. Mechanical fracture of bone near a drill bit surface can also impede the osseointegration process. Our new concept is to use a rapid laser ablation model for dental implant osteotomy preparation to minimize adverse effects on the bone from mechanical and thermal damages. A mathematical model was developed to detail the temperature and energy distribution within bone under laser irradiation. Thermal and energy transfer in bone was predicted during laser interaction using finite element simulations. Various parameters of laser irradiation settings were analyzed. The best designed laser irradiation condition was derived from our theoretic modeling in terms of thermal and mechanical characteristics for osteotomy. We also validated our theoretical prediction with an ex vivo animal bone study. We conclude that a smooth and clean surface was successfully formed with laser power of 10 W, scanning speed of 600 mm/s, and scanning interval of 20 μm. We also achieved the highest removal rate of 0.63 mm3/s. Our finite element model demonstrated that it could effectively predict the temperature and energy distribution during an osteotomy drilling. Our validated model can potentially offer a remarkable approach for a non-contact dental implant site preparation with minimal mechanical and thermal damages to the adjacent bone tissue which likely can augment bone repair and regeneration during an osseointegration process.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"244"},"PeriodicalIF":2.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors and prevalence of paradoxical hypertrichosis in alexandrite laser-based facial hair removal: results from a prospective clinical study. 预测因素和患病率的矛盾多毛在亚历山大变石激光面部毛发去除：结果从前瞻性临床研究。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-23 DOI: 10.1007/s10103-025-04498-5

Hanadi Qeyam, Ameera Elrafi, Sohaib Alomari, Mohammad Jaradat

{"title":"Predictors and prevalence of paradoxical hypertrichosis in alexandrite laser-based facial hair removal: results from a prospective clinical study.","authors":"Hanadi Qeyam, Ameera Elrafi, Sohaib Alomari, Mohammad Jaradat","doi":"10.1007/s10103-025-04498-5","DOIUrl":"https://doi.org/10.1007/s10103-025-04498-5","url":null,"abstract":"Objective: To investigate the prevalence and identify potential contributing factors of facial paradoxical hypertrichosis (PH) following long-pulse Alexandrite LHR among Jordanian women.Methodology: This observational, prospective study included female patients aged sixteen and above undergoing long-pulse Alexandrite laser treatment for facial hair at the Dermatology Department of King Abdullah University Hospital, Irbid, Jordan, from March 2023 to December 2024. Data on patient demographics, treatment sessions, and contributing factors such as hormonal conditions, family history, and sunblock use were collected through patient questionnaires and medical records.Results: The study revealed a prevalence of facial PH of 16.2%, significant associations were found with irregular menstrual cycles (33.3% vs. 12.6%, P = 0.001), family history of hirsutism (27.8% vs. 13.8%, P = 0.001), and Fitzpatrick skin types III and IV (27.1% and 21.9% respectively, P = 0.001). Multiple laser sessions (6-10) increased PH risk (30.9% vs. 6.8%, P = 0.001), as did PCOS (33.3% vs. 14.1%, P < 0.001). Regular sunblock use demonstrated a protective effect (12.1% vs. 36.1%, P = 0.001). OCP use showed no significant association with PH (13.8% vs. 17.6%, P = 0.19).Conclusion: Our findings highlight a higher-than-reported prevalence of PH following Alexandrite laser hair removal, key risk factors include PCOS, menstrual irregularities, darker skin types, and lack of sun protection. Understanding these associations can help clinicians take preventive measures, optimize patient selection, and provide better counseling to reduce the risk of paradoxical hypertrichosis and improve treatment outcomes.Clinical trial registration: Not applicable.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"240"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-soluble porphyrin-mediated enhanced photodynamic and chemotherapy employing doxorubicin for breast cancer. 水溶性卟啉介导的增强光动力学和使用阿霉素治疗乳腺癌的化疗。

IF 2.1 4区医学

Lasers in Medical Science Pub Date : 2025-05-23 DOI: 10.1007/s10103-025-04466-z

Aya Mokhtar, Tarek Mohamed, Ahmed O Eigza, Mohamed E El-Khouly

{"title":"Water-soluble porphyrin-mediated enhanced photodynamic and chemotherapy employing doxorubicin for breast cancer.","authors":"Aya Mokhtar, Tarek Mohamed, Ahmed O Eigza, Mohamed E El-Khouly","doi":"10.1007/s10103-025-04466-z","DOIUrl":"10.1007/s10103-025-04466-z","url":null,"abstract":"Breast cancer is the second most common cancer globally and the leading cause of cancer-related deaths in women. Current treatments, such as chemotherapy and surgery, often have side effects and can lead to drug resistance. Developing new treatments that specifically target cancer cells while minimizing side effects is essential. Combining traditional cancer treatments with photodynamic therapy (PDT) is a promising approach. This study evaluated the effectiveness of femtosecond laser-driven PDT using Doxorubicin (DOX) and tetrakis (1-methylpyridinium-4-yl) porphyrin (TMPyP), both individually and in combination, on MDA-MB-231 and T47D breast cancer cells. TMPyP-PDT and DOX monotherapy both exhibited dose-dependent cytotoxicity. However, combination therapy was more effective at lower DOX concentrations, potentially reducing side effects. This combination also increased reactive oxygen species (ROS) levels, inhibited angiogenesis by reducing TGF-β and VEGFA expression, and induced apoptosis by decreasing BCL-2 and increasing BAX levels compared to individual treatments. These findings suggest that combining TMPyP-mediated PDT with Doxorubicin could effectively inhibit breast cancer cell growth.","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"241"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0