Vanessa de Souza, Marlon da Palma Cruz, Caroline Chaves Bittencourt, Ana Paula Ligeiro de Oliveira, José Antônio Silva Júnior, Stella Regina Zamuner, Nivaldo Antonio Parizotto, Richard Eloin Liebano, Rodrigo Álvaro Brandão Lopes Martins, Rodrigo Labat Marcos
{"title":"光生物调节在糖尿病神经病变中的剂量参数和临床结果：简要综述。","authors":"Vanessa de Souza, Marlon da Palma Cruz, Caroline Chaves Bittencourt, Ana Paula Ligeiro de Oliveira, José Antônio Silva Júnior, Stella Regina Zamuner, Nivaldo Antonio Parizotto, Richard Eloin Liebano, Rodrigo Álvaro Brandão Lopes Martins, Rodrigo Labat Marcos","doi":"10.1007/s10103-025-04701-7","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and systemic inflammation. Diabetic neuropathy (DN) is a prevalent and debilitating complication of type 2 diabetes mellitus (T2D), associated with sensory impairment, persistent pain, and increased risk of lower limb amputations. Photobiomodulation (PBM) has been investigated as an adjunctive treatment due to its effects on cellular repair mechanisms, pain modulation, and wound healing.This review aims to synthesize evidence from clinical and preclinical studies published between 2015 and 2025, focusing on dosimetric parameters used in PBM for DN and their association with clinical outcomes.The search was conducted in the LILACS, SciELO, EMBASE, MEDLINE, PubMed e Cochrane Library, covering publications from 2015 to 2025. A total of 23 studies met the inclusion criteria. This review provides comprehensive evidence supporting PBM as a promising, safe and effective adjunctive therapy for diabetic neuropathy. The most consistent therapeutic effects were observed with wavelengths ((630-670 nm/808-904 nm), fluences of 3-10 J/cm², output power between 45 and 100 mW, and treatment protocols comprising at least 12 sessions. Despite the favorable therapeutic outcomes, the absence of standardized dosimetry among the studies remains a major challenge. Therefore, further research is needed to define optimized and reproducible therapeutic protocols.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"40 1","pages":"436"},"PeriodicalIF":2.4000,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dosimetric parameters and clinical outcomes of photobiomodulation in diabetic neuropathy: a concise review.\",\"authors\":\"Vanessa de Souza, Marlon da Palma Cruz, Caroline Chaves Bittencourt, Ana Paula Ligeiro de Oliveira, José Antônio Silva Júnior, Stella Regina Zamuner, Nivaldo Antonio Parizotto, Richard Eloin Liebano, Rodrigo Álvaro Brandão Lopes Martins, Rodrigo Labat Marcos\",\"doi\":\"10.1007/s10103-025-04701-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and systemic inflammation. Diabetic neuropathy (DN) is a prevalent and debilitating complication of type 2 diabetes mellitus (T2D), associated with sensory impairment, persistent pain, and increased risk of lower limb amputations. Photobiomodulation (PBM) has been investigated as an adjunctive treatment due to its effects on cellular repair mechanisms, pain modulation, and wound healing.This review aims to synthesize evidence from clinical and preclinical studies published between 2015 and 2025, focusing on dosimetric parameters used in PBM for DN and their association with clinical outcomes.The search was conducted in the LILACS, SciELO, EMBASE, MEDLINE, PubMed e Cochrane Library, covering publications from 2015 to 2025. A total of 23 studies met the inclusion criteria. This review provides comprehensive evidence supporting PBM as a promising, safe and effective adjunctive therapy for diabetic neuropathy. The most consistent therapeutic effects were observed with wavelengths ((630-670 nm/808-904 nm), fluences of 3-10 J/cm², output power between 45 and 100 mW, and treatment protocols comprising at least 12 sessions. Despite the favorable therapeutic outcomes, the absence of standardized dosimetry among the studies remains a major challenge. 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Dosimetric parameters and clinical outcomes of photobiomodulation in diabetic neuropathy: a concise review.
Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and systemic inflammation. Diabetic neuropathy (DN) is a prevalent and debilitating complication of type 2 diabetes mellitus (T2D), associated with sensory impairment, persistent pain, and increased risk of lower limb amputations. Photobiomodulation (PBM) has been investigated as an adjunctive treatment due to its effects on cellular repair mechanisms, pain modulation, and wound healing.This review aims to synthesize evidence from clinical and preclinical studies published between 2015 and 2025, focusing on dosimetric parameters used in PBM for DN and their association with clinical outcomes.The search was conducted in the LILACS, SciELO, EMBASE, MEDLINE, PubMed e Cochrane Library, covering publications from 2015 to 2025. A total of 23 studies met the inclusion criteria. This review provides comprehensive evidence supporting PBM as a promising, safe and effective adjunctive therapy for diabetic neuropathy. The most consistent therapeutic effects were observed with wavelengths ((630-670 nm/808-904 nm), fluences of 3-10 J/cm², output power between 45 and 100 mW, and treatment protocols comprising at least 12 sessions. Despite the favorable therapeutic outcomes, the absence of standardized dosimetry among the studies remains a major challenge. Therefore, further research is needed to define optimized and reproducible therapeutic protocols.
期刊介绍：
Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics.
The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.
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