Intense pulsed Light, Light-Emitting Diode, and hydroxychloroquine in the treatment of rosacea: A clinical observation.

IF 2.4 4区医学 Q3 ENGINEERING, BIOMEDICAL

Lasers in Medical Science Pub Date : 2025-10-11 DOI:10.1007/s10103-025-04696-1

Chengyu Zhang, LiXin Song

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Abstract

Background: Rosacea is a common, chronic inflammatory skin condition lacking specific treatment. This study investigates the efficacy of various photoelectric therapies in treating rosacea. 90 rosacea patients who visited the dermatology outpatient clinic of the hospital from August 2022 to November 2023 were analyzed (retrospective registration 20240425). The patients were categorized into three groups based on different treatment methods: the control group received oral hydroxychloroquine sulfate and topical recombinant bovine basic fibroblast growth factor; observation group 1 underwent intense pulsed light therapy in addition to the control group's treatment; observation group 2 received light-emitting diode therapy on top of the control group's regimen. The therapeutic effect was evaluated by physicians' subjective evaluation and patients' pruritus symptoms. The effective rates of observation group 1, observation group 2, and the control group were 73.3%, 66.7%, and 40%, respectively, with statistical significance (P < 0.05). There was no significant difference between observation group 1 and observation group 2 (P < 0.05). Additionally, there were no significant adverse reactions in any of the three groups. The comparison between observation group 1 and observation group 2 revealed that the two combined treatment methods achieved similar and positive therapeutic effects across various clinical manifestations. The effectiveness of both observation groups was found to be superior to that of drug therapy alone.

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强脉冲光、发光二极管和羟氯喹治疗酒渣鼻的临床观察。

背景：酒渣鼻是一种常见的慢性炎症性皮肤病，缺乏特异性治疗。本研究探讨各种光电疗法治疗酒渣鼻的疗效。对2022年8月至2023年11月在该院皮肤科门诊就诊的90例酒渣鼻患者进行分析（回顾性登记20240425例）。根据治疗方法的不同，将患者分为三组：对照组口服硫酸羟氯喹和外用重组牛碱性成纤维细胞生长因子；观察组1在对照组治疗的基础上进行强脉冲光治疗；观察2组患者在对照组治疗方案的基础上接受发光二极管治疗。采用医师主观评价和患者瘙痒症状评价治疗效果。观察组1、观察组2、对照组有效率分别为73.3%、66.7%、40%，差异均有统计学意义（P < 0.05）

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来源期刊

Lasers in Medical Science 医学-工程：生物医学

CiteScore

4.50

自引率

4.80%

发文量

192

审稿时长

3-8 weeks

期刊介绍： Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.