Simulated dose-dependent effects of 660 nm laser photostimulation on human sperm motility and acrosome integrity using MATLAB modeling.

IF 2.4 4区医学 Q3 ENGINEERING, BIOMEDICAL

Lasers in Medical Science Pub Date : 2025-10-10 DOI:10.1007/s10103-025-04677-4

Zahra Al Timimi

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引用次数: 0

Abstract

Low-level laser therapy (LLLT) has been demonstrated to have the potential for enhancing sperm function by means of photobiomodulation. Therapeutic dosing parameters to maximize the effect, though, remain undefined. To simulate dose-dependent effects of 660 nm laser irradiation on human sperm motility and acrosome integrity using MATLAB-based modeling. A simulation was established on the computer to assess reactions of sperm over a fluence range of 0.15-2.4 J/cm², which was produced from varying power densities (5-20 mW/cm²) and durations (30-120 s). Logistic and Gaussian functions with biologically natural noise were used in modeling motility and acrosome integrity in order to mimic experimental variation. Motility increased in sigmoidal manner, peaking at around 1.2 J/cm², while acrosome integrity peaked at around 0.6 J/cm² in the form of a bell curve. Optimal fluence range (0.6-0.9 J/cm²) balanced both improving motility and maintaining acrosomes intact. 660 nm laser stimulation of sperm motility and acrosome integrity is enhanced within a narrow fluence window. This in silico process offers a predictive, reproducible method for the determination of optimal PBM parameters in reproductive application.

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利用MATLAB建模模拟660 nm激光刺激对人类精子活力和顶体完整性的剂量依赖性影响。

低水平激光治疗（LLLT）已被证明具有通过光生物调节手段增强精子功能的潜力。然而，使效果最大化的治疗剂量参数仍未确定。利用matlab模拟660nm激光照射对人类精子活力和顶体完整性的剂量依赖性影响。在计算机上建立了一个模拟，以评估精子在0.15-2.4 J/cm²的影响范围内的反应，该影响范围是由不同的功率密度（5-20 mW/cm²）和持续时间（30-120 s）产生的。采用生物自然噪声的Logistic和高斯函数来模拟运动和顶体完整性，以模拟实验变化。运动性以s型曲线的方式增加，在1.2 J/cm²左右达到峰值，而顶体完整性以钟形曲线的形式在0.6 J/cm²左右达到峰值。最佳通量范围（0.6-0.9 J/cm²）平衡了改善运动和保持顶体完整的两方面。660nm激光刺激精子活力和顶体完整性增强在一个狭窄的影响窗口。该过程为再生应用中确定最佳PBM参数提供了一种可预测、可重复的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Medical Science 医学-工程：生物医学

CiteScore

4.50

自引率

4.80%

发文量

192

审稿时长

3-8 weeks

期刊介绍： Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.