Journal of Veterinary Diagnostic Investigation最新文献_第8页

Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia. 脂褐素在慢性马自主神经功能障碍的神经节神经元中积聚。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-07 DOI: 10.1177/10406387241265715

Lydia Tan Yi Shean, Elspeth M Milne, Darren J Shaw, Scott Maxwell, Jorge Del-Pozo

{"title":"Lipofuscin accumulates in ganglionic neurons in chronic equine dysautonomia.","authors":"Lydia Tan Yi Shean, Elspeth M Milne, Darren J Shaw, Scott Maxwell, Jorge Del-Pozo","doi":"10.1177/10406387241265715","DOIUrl":"10.1177/10406387241265715","url":null,"abstract":"Lipofuscin is a complex mixture of highly oxidized, cross-linked macromolecules that accumulates in neurons with age and some neurodegenerative diseases. Equine dysautonomia (ED) is a polyneuropathy that mainly affects autonomic and enteric nervous systems, resulting in alimentary tract dysfunction. Our main aim was to determine whether neuronal lipofuscin increased with increasing duration of ED. We investigated the prevalence of lipofuscin in cranial cervical ganglia of horses with acute (AED), subacute (SED), and chronic ED (CED), young controls (of similar age to ED cases), and aged controls (n = 8 per group). We used Schmorl stain for histologic detection of lipofuscin and assessed its accumulation in neurons using image analysis software. The percentage of neurons positive for lipofuscin increased with age in individual groups and all groups combined (p < 0.001). There were fewer positive neurons in AED and SED compared to aged controls (p < 0.001) and more in CED than AED cases (p = 0.042) and young controls (p = 0.012). We found a strong positive correlation between percentage positive neurons and percentage positive area of the neuron containing lipofuscin for combined groups (p < 0.001). Although neuronal lipofuscin increased in cranial cervical ganglion in CED cases, it remains to be determined whether this is a cause or consequence of neuronal degeneration.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"864-869"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular detection of Chlamydia abortus in endometrial biopsies of mares from western Canada. 加拿大西部母马子宫内膜活检中流产衣原体的分子检测。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-17 DOI: 10.1177/10406387241267864

R Madison Ricard, Bruce Wobeser

引用次数: 0

Rosette-forming multicentric B-cell lymphoma in a giant panda. 大熊猫身上的玫瑰花状多中心 B 细胞淋巴瘤。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1177/10406387241267887

Anne C N Tse, Christopher J Brackman, Carlton P M Yuen, Christopher M Perkins, Paolo Martelli, May P Y Tse

引用次数: 0

Synovial myxoma with cyst formation in the hip joint of a central bearded dragon. 中央胡须龙髋关节滑膜肌瘤伴囊肿形成。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.1177/10406387241277230

Melina Rasper-Hössinger, Patricia Edith Kunze, David Schmid, Eva Dervas

{"title":"Synovial myxoma with cyst formation in the hip joint of a central bearded dragon.","authors":"Melina Rasper-Hössinger, Patricia Edith Kunze, David Schmid, Eva Dervas","doi":"10.1177/10406387241277230","DOIUrl":"10.1177/10406387241277230","url":null,"abstract":"Degenerative bone lesions are rarely described in reptiles and belong mainly to the broad spectrum of metabolic bone diseases. Here we describe a 7-y-old female central bearded dragon (Pogona vitticeps) with a complex unilateral neoplastic lesion in the hip joint. The animal was presented because of severe progressive swelling of the left hindlimb, apathy, and weight loss. The swelling was soft and surrounded the left femur. Full-body radiographs were performed in 2 orthogonal projections. The main radiologic findings were severe soft tissue swelling centered on the proximal third of the left femur and an absent left femoral head. The caretaker elected euthanasia, and a postmortem examination was performed, followed by subsequent histologic examination. The swelling consisted of variably sized myxomatous proliferations and cysts that invaded the femoral bone. Furthermore, several long bones had lesions consistent with metabolic bone and degenerative joint diseases. Synovial myxomas are rare lesions of the joints that have, to our knowledge, not been described previously in reptiles.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"891-895"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genotyping of infectious bronchitis virus in Canada. 加拿大传染性支气管炎病毒基因分型。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI: 10.1177/10406387241265955

Davor Ojkic, Leonardo Susta, Emily Martin

引用次数: 0

Dermal melanoma with plasmacytoid differentiation in a dog. 一只狗患有浆细胞分化的皮肤黑色素瘤。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-20 DOI: 10.1177/10406387241273907

Ricardo E Mendes, Ronald H Tolbert, Catherine E Thorn, Daniel R Rissi

{"title":"Dermal melanoma with plasmacytoid differentiation in a dog.","authors":"Ricardo E Mendes, Ronald H Tolbert, Catherine E Thorn, Daniel R Rissi","doi":"10.1177/10406387241273907","DOIUrl":"10.1177/10406387241273907","url":null,"abstract":"A 10-y-old spayed female Staffordshire Terrier dog was evaluated because of a cutaneous left ear base mass. Cytology revealed sheets of cells with anisocytosis and anisokaryosis, round-to-oval or plasmacytoid cytoplasm, and round, central, or eccentric nuclei; binucleate cells were present. Cytologic findings were consistent with a round cell tumor (plasmacytoma or agranular mast cell tumor), amelanotic melanoma, or anaplastic carcinoma. Histologically, neoplastic cells were polygonal to elongate, with round-to-oval nuclei and prominent nucleoli and arranged in sheets and nests on a fibrovascular stroma. Neoplastic cells with plasmacytoid morphology (round, glassy, eosinophilic cytoplasm with eccentric nuclei) were present in ~30% of the neoplasm. There were 18 mitoses in 2.37 mm2 (10 FN22/40× fields). Neoplastic cells had cytoplasmic immunolabeling for melan A and PNL2 and no immunolabeling for AE3/1 and MUM1, consistent with a dermal melanoma with plasmacytoid differentiation. The patient was re-evaluated ~1 mo after the first biopsy because of local recurrence of the original mass and new masses on the interscapular area and right elbow; these neoplasms were histologically identical to the original submission, plus scattered neoplastic cells in the new masses contained brown cytoplasmic pigment. The dog was euthanized because of swelling and hemorrhage of the tumors and right pelvic limb lameness. Our findings were consistent with a dermal melanoma with plasmacytoid features that were similar to human plasmacytoid melanoma, a rare variant of human melanoma that is diagnostically challenging as it may mimic a plasmacytoma.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"941-944"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI changes observed in a case of atypical scrapie in a 7-year-old Herdwick ewe. 在一例 7 岁牧羊母羊非典型瘙痒症病例中观察到的核磁共振成像变化。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1177/10406387241267849

Sander Prins, Kim Hamer, Ana Cloquell, John Spiropoulos, Neil Sargison, Piet Vellema

{"title":"MRI changes observed in a case of atypical scrapie in a 7-year-old Herdwick ewe.","authors":"Sander Prins, Kim Hamer, Ana Cloquell, John Spiropoulos, Neil Sargison, Piet Vellema","doi":"10.1177/10406387241267849","DOIUrl":"10.1177/10406387241267849","url":null,"abstract":"Atypical scrapie is a transmissible spongiform encephalopathy that is rarely diagnosed in living animals. In March 2022, a 7-y-old Herdwick ewe was referred to the Scottish Centre for Production Animal Health and Food Safety because of circling behavior and ill thrift. The ewe had a low body condition score, was obtunded, with a wide-based stance of the pelvic limbs, and was circling to the left. Hematologic, biochemical, and CSF analyses were unremarkable, but postmortem magnetic resonance imaging (MRI) findings were consistent with diffuse, bilateral, and symmetrical atrophy of the forebrain and ventriculomegaly. The clinical signs, the involvement of an individual older ewe, and the MRI results led to the clinical diagnosis of scrapie. Immunohistochemistry on the fixed brain, performed by the U.K. Animal and Plant Health Agency, revealed deposits of PrPSc, which is a specific disease marker of transmissible spongiform encephalopathies, mainly in the cerebellum and at lower concentrations in the cerebrum and obex, consistent with the diagnosis of atypical scrapie. MRI findings in a sheep with atypical scrapie have not been described previously, to our knowledge. Scrapie should be included in the list of clinical differential diagnoses when veterinarians are presented with sheep with progressive neurologic signs of several weeks' duration.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"842-846"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes of mortality in farmed white-tailed deer in the midwestern United States, 2004-2023. 2004-2023 年美国中西部养殖白尾鹿的死亡原因。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.1177/10406387241271416

Amanda C Smith, Keiichi Kuroki, Rosalie A Ierardi, Lauren E Delaney, Tamara B Gull, Anthony J Ogunbadewa, Loren G Schultz

{"title":"Causes of mortality in farmed white-tailed deer in the midwestern United States, 2004-2023.","authors":"Amanda C Smith, Keiichi Kuroki, Rosalie A Ierardi, Lauren E Delaney, Tamara B Gull, Anthony J Ogunbadewa, Loren G Schultz","doi":"10.1177/10406387241271416","DOIUrl":"10.1177/10406387241271416","url":null,"abstract":"Farmed cervids are of growing economic importance in the midwestern United States. Although diseases of wild and captive cervids have been examined in more northerly climates, little information exists on the health challenges of deer in the Midwest. We characterized and summarized the causes of mortality in farmed white-tailed deer (Odocoileus virginianus) submitted to the University of Missouri Veterinary Medical Diagnostic Laboratory (Columbia, MO, USA) over a 19-y period (2004-2023). Of 388 cases examined, 253 (65%) were carcasses submitted for autopsy, and 135 (35%) cases were tissue samples harvested by field veterinarians. Infectious disease was the most common cause of mortality (n = 335; 86.3%). Of infectious causes, primary pneumonia was most common (n = 140; 41.7%), followed by septicemia (n = 68; 20.1%), and primary enteritis (n = 64; 19.1%). Viruses were detected in 18% of pneumonia cases. The most common non-infectious diagnoses were emaciation and trauma (both 4 each; 1%). Thirteen animals (3.4%) died of unknown causes. Forty-nine percent of cases were juvenile deer <1-y-old. Most cases were received in the summer (212; 54.6%). Infectious diseases, particularly bacteria and viruses, pose a significant health challenge to farmed deer in the midwestern United States.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"809-815"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute myeloid leukemia-M1 in a horse with neurologic signs and necrotizing enterocolitis. 一匹马患急性髓性白血病-M1，伴有神经症状和坏死性小肠结肠炎。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1177/10406387241268322

Jeongha Lee, Sydney Mordoh, Mustajab Mirza, Mariano Carossino, Fabio Del Piero

{"title":"Acute myeloid leukemia-M1 in a horse with neurologic signs and necrotizing enterocolitis.","authors":"Jeongha Lee, Sydney Mordoh, Mustajab Mirza, Mariano Carossino, Fabio Del Piero","doi":"10.1177/10406387241268322","DOIUrl":"10.1177/10406387241268322","url":null,"abstract":"An 18-y-old American Saddlebred mare was admitted with fever and acute onset of neurologic signs including grade 3 of 5 ataxia, difficulty in prehension, and dull mentation. Because of financial restraints, desired testing could not be performed; the horse's condition declined despite supportive treatment, and euthanasia was elected. Postmortem examination revealed petechiae and ecchymoses in the meninges and neuroparenchyma of the encephalon. Blast-like neoplastic round cells were identified within the vasculature and areas of hemorrhage in the neuroparenchyma, the intestinal submucosa, and other organs, including the liver, kidney, lung, and mesenteric lymph node. Necrotizing enterocolitis and acute fibrinonecrotizing bacterial pneumonia were also noted. Of the atypical round cells in the encephalon, >70% expressed ionized calcium-binding adapter molecule 1 (Iba1), 10-20% expressed myeloperoxidase (MPO), and <10% expressed PAX5, CD3, CD20, CD79a, or MUM1. The bone marrow was diffusely effaced by neoplastic round cells expressing Iba1, and ~70% of these cells expressed MPO with no expression of CD3 or CD20. CD172a also immunolabeled a portion of the neoplastic cells. These findings were consistent with the diagnosis of acute myeloid leukemia-M1 with an unusual neurologic presentation.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"836-841"},"PeriodicalIF":1.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11512458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Follicular thyroid carcinoma in an inbred family of mongrel dogs in Trinidad & Tobago. 特立尼达和多巴哥一个近亲繁殖杂种狗家族中的甲状腺滤泡癌。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1177/10406387241268203

Rod Suepaul, Stacy Rajh, Patricia Pow-Brown, Indira Pargass, Alissa Bally, Lana Gyan, Karelma Frontera-Acevedo

引用次数: 0