Flavio H Alonso, Aria Phan, Kelly O'Connell, Demitria M Vasilatis
{"title":"犬胚胎特征的高级别少突胶质细胞瘤的细胞学和组织学研究。","authors":"Flavio H Alonso, Aria Phan, Kelly O'Connell, Demitria M Vasilatis","doi":"10.1177/10406387251331553","DOIUrl":null,"url":null,"abstract":"<p><p>A 10-y-old castrated male German Wirehaired Pointer dog was presented for referral evaluation of a brain mass and craniotomy. Pertinent history included acute onset of cluster seizures; the systemic physical examination was largely unremarkable. Thorough laboratory and imaging screening ruled out extracranial causes for the presenting clinical signs. MRI revealed a hemorrhagic and strongly contrast-enhancing mass in the left frontal lobe. Upon craniotomy, the lesion was abnormal cortical parenchyma with surrounding malacic tissue, which was excised and submitted for microscopic analyses. Cytologic examination of a squash preparation of the mass revealed a mildly inflamed and hemorrhagic neoplasm, with oligodendroglioma or an embryonal CNS neoplasm as primary differential diagnoses. Histopathology with immunohistochemistry confirmed a high-grade oligodendroglioma with embryonal morphology.</p>","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"712-715"},"PeriodicalIF":1.1000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003332/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cytology and histology of a high-grade oligodendroglioma with embryonal features in a dog.\",\"authors\":\"Flavio H Alonso, Aria Phan, Kelly O'Connell, Demitria M Vasilatis\",\"doi\":\"10.1177/10406387251331553\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A 10-y-old castrated male German Wirehaired Pointer dog was presented for referral evaluation of a brain mass and craniotomy. Pertinent history included acute onset of cluster seizures; the systemic physical examination was largely unremarkable. Thorough laboratory and imaging screening ruled out extracranial causes for the presenting clinical signs. MRI revealed a hemorrhagic and strongly contrast-enhancing mass in the left frontal lobe. Upon craniotomy, the lesion was abnormal cortical parenchyma with surrounding malacic tissue, which was excised and submitted for microscopic analyses. Cytologic examination of a squash preparation of the mass revealed a mildly inflamed and hemorrhagic neoplasm, with oligodendroglioma or an embryonal CNS neoplasm as primary differential diagnoses. Histopathology with immunohistochemistry confirmed a high-grade oligodendroglioma with embryonal morphology.</p>\",\"PeriodicalId\":17579,\"journal\":{\"name\":\"Journal of Veterinary Diagnostic Investigation\",\"volume\":\" \",\"pages\":\"712-715\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003332/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Veterinary Diagnostic Investigation\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1177/10406387251331553\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Diagnostic Investigation","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1177/10406387251331553","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Cytology and histology of a high-grade oligodendroglioma with embryonal features in a dog.
A 10-y-old castrated male German Wirehaired Pointer dog was presented for referral evaluation of a brain mass and craniotomy. Pertinent history included acute onset of cluster seizures; the systemic physical examination was largely unremarkable. Thorough laboratory and imaging screening ruled out extracranial causes for the presenting clinical signs. MRI revealed a hemorrhagic and strongly contrast-enhancing mass in the left frontal lobe. Upon craniotomy, the lesion was abnormal cortical parenchyma with surrounding malacic tissue, which was excised and submitted for microscopic analyses. Cytologic examination of a squash preparation of the mass revealed a mildly inflamed and hemorrhagic neoplasm, with oligodendroglioma or an embryonal CNS neoplasm as primary differential diagnoses. Histopathology with immunohistochemistry confirmed a high-grade oligodendroglioma with embryonal morphology.
期刊介绍:
The Journal of Veterinary Diagnostic Investigation (J Vet Diagn Invest) is an international peer-reviewed journal published bimonthly in English by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). JVDI is devoted to all aspects of veterinary laboratory diagnostic science including the major disciplines of anatomic pathology, bacteriology/mycology, clinical pathology, epidemiology, immunology, laboratory information management, molecular biology, parasitology, public health, toxicology, and virology.