Journal of Veterinary Diagnostic Investigation最新文献

Diseases of the nervous system of equids in Brazil: a review. 巴西马科动物神经系统疾病综述。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-30 DOI: 10.1177/10406387251325881

Kesia S Carvalho, Claudio S L de Barros, Fabio S Mendonça, Mizael Machado, Franklin Riet-Correa

{"title":"Diseases of the nervous system of equids in Brazil: a review.","authors":"Kesia S Carvalho, Claudio S L de Barros, Fabio S Mendonça, Mizael Machado, Franklin Riet-Correa","doi":"10.1177/10406387251325881","DOIUrl":"10.1177/10406387251325881","url":null,"abstract":"In Brazil, CNS diseases in equids were little known until the 1980s. Since then, several diagnostic laboratories have been operating in different universities, initially in the South and Southeast regions and, later, in the Central-West, Northeast and North regions. However, the knowledge accumulated from the diagnoses of nervous system diseases of equids made at these institutions over the years has not been reviewed comprehensively, and many papers are published in Portuguese. Here, we review 18 diseases that occur in the nervous system of equids in Brazil, including some critical infectious diseases (rabies, equine encephalomyelitides, equine herpesviral myeloencephalopathy, protozoan myeloencephalitis), and diseases caused by toxic plants and mycotoxins. Our review provides reference data to assist pathologists and clinicians in diagnosing neurologic diseases in equids. We also hope it will serve as a reference for professionals in this field abroad, allowing them to compare data in the epidemiology and pathology of the nervous system diseases of equids in different regions of the world.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251325881"},"PeriodicalIF":1.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perirenal hemorrhage associated with feline infectious peritonitis: a novel presentation of a classic disease. 与猫感染性腹膜炎相关的肾周出血：一种经典疾病的新表现。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-29 DOI: 10.1177/10406387251341239

Madeleine I Gauthier, Carolyn Legge, Dayna A Goldsmith, Maria Bravo Araya, Jennifer L Davies

{"title":"Perirenal hemorrhage associated with feline infectious peritonitis: a novel presentation of a classic disease.","authors":"Madeleine I Gauthier, Carolyn Legge, Dayna A Goldsmith, Maria Bravo Araya, Jennifer L Davies","doi":"10.1177/10406387251341239","DOIUrl":"10.1177/10406387251341239","url":null,"abstract":"Feline infectious peritonitis (FIP), caused by a mutated biotype of feline coronavirus (FCoV; Coronaviridae, Alphacoronavirus), is a significant disease of felids. We investigated perirenal hemorrhage, an unreported lesion in FIP, through a retrospective analysis of 51 immunohistochemistry-confirmed FIP cases submitted to the Diagnostic Services Unit (DSU; University of Calgary, Calgary, Alberta, Canada) between 2010 June 30 and 2024 June 30. Five cats had perirenal hemorrhage in the right retroperitoneal space; 4 had concurrent subcapsular renal hemorrhage; and 1 had sublumbar muscle hemorrhage and hemoabdomen. One case had additional hemorrhages in the brain and cervical spinal cord. Concurrent gross lesions typical of FIP included pyogranulomatous inflammation in various organs and protein-rich cavitary effusions. Histologic lesions typical of FIP (vasculitis and pyogranulomatous inflammation) were present in the kidneys and retroperitoneal fat of 4 cases, and in 3 cases, FCoV antigen was demonstrated in the regions of hemorrhage. The exact mechanism of this hemorrhage is unknown, but we speculate that vasculitis caused by FIP is the cause. Despite the relatively low prevalence of perirenal hemorrhage in this cohort, this lesion represents a unique, previously unreported manifestation of FIP that clinicians and pathologists should be aware of and consider in the differential diagnosis for fluid accumulation or space-occupying lesions in the retroperitoneum of cats.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251341239"},"PeriodicalIF":1.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of amyloid deposits in exocrine pancreatic tumors in cats. 猫外分泌胰腺肿瘤中淀粉样蛋白沉积的特征。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251343842

Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Noboru Machida, Tomoaki Murakami

{"title":"Characterization of amyloid deposits in exocrine pancreatic tumors in cats.","authors":"Niki Sedghi Masoud, Susumu Iwaide, Yoshiyuki Itoh, Miki Hisada, Tomoyuki Harada, Noboru Machida, Tomoaki Murakami","doi":"10.1177/10406387251343842","DOIUrl":"10.1177/10406387251343842","url":null,"abstract":"Some types of amyloidosis are observed as localized conditions associated with tumors, such as plasmacytoma and C-cell carcinoma. Although pancreatic endocrine tumors have been linked to amyloid deposition, the potential for amyloid formation in exocrine pancreatic tumors has remained unexplored in both animals and humans. We examined amyloid deposits in 24 feline cases of exocrine pancreatic tumors. Histologic analysis identified amyloid deposits in 8 cases, appearing as Congo red-positive amorphous material in the luminal corpora amylacea. Microdissection and mass spectrometry analysis of amyloid deposits from 5 cases identified lithostathine as the major component in 3 of the cases. Immunohistochemistry confirmed the presence of lithostathine in these deposits, identifying lithostathine-derived amyloid. Conversely, other cases had no consistent lithostathine positivity, indicating that multiple amyloidogenic proteins, not just lithostathine, may be involved in exocrine pancreatic tumor-associated amyloidosis.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251343842"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemorrhagic septicemia in the United States: molecular characterization of isolates and comparison to a global collection. 美国出血性败血症：分离株的分子特征和与全球收集的比较。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251342528

Kelli J Maddock, Brianna L S Stenger, Heidi L Pecoraro, Jill C Roberts, John Dustin Loy, Brett T Webb

{"title":"Hemorrhagic septicemia in the United States: molecular characterization of isolates and comparison to a global collection.","authors":"Kelli J Maddock, Brianna L S Stenger, Heidi L Pecoraro, Jill C Roberts, John Dustin Loy, Brett T Webb","doi":"10.1177/10406387251342528","DOIUrl":"10.1177/10406387251342528","url":null,"abstract":"Hemorrhagic septicemia-causing strains of Pasteurella multocida are endemic in Asia and Africa, but naturally occurring hemorrhagic septicemia has not been described in livestock in the United States since 1993. There are 5 capsular types of P. multocida: A, B, D, E, and F. Two capsular types (B, E) cause hemorrhagic septicemia, whereas capsular types A and, to a lesser extent, D are associated with enzootic bovine pneumonia. Here we describe 2 naturally occurring cases of hemorrhagic septicemia caused by P. multocida capsular type B:3,4 in the United States, including molecular characterization of these strains, with a comparison to available reference strains and publicly available genomes of P. multocida capsular type B. Genomic analyses demonstrated that our case strains are similar to a strain isolated from New Jersey cattle in 1968 and to contemporaneous strains from New Zealand and Canada. These strains are different from those circulating globally, as demonstrated by the need to assign new sequence types for our isolates. Hemorrhagic septicemia appears to be re-emerging globally in countries that have not seen outbreaks in decades and may be poised for re-emergence in the United States given the identification of these novel strains.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251342528"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anogenital papillomatosis associated with a novel papillomavirus in a grey-headed flying fox. 灰头狐的肛门生殖器乳头状瘤病与一种新型乳头状瘤病毒有关。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-24 DOI: 10.1177/10406387251341935

John S Munday, Susan E Brown, Emily E Kay, Ludovica D Valenza

{"title":"Anogenital papillomatosis associated with a novel papillomavirus in a grey-headed flying fox.","authors":"John S Munday, Susan E Brown, Emily E Kay, Ludovica D Valenza","doi":"10.1177/10406387251341935","DOIUrl":"10.1177/10406387251341935","url":null,"abstract":"A 0.5-cm nodular thickening of the vagina was observed in a flying fox (Pteropus poliocephalus) that had been rescued after becoming entangled in fruit netting. Over the following 6 mo, the thickening progressed to diffuse multinodular mucosal thickening of both the vagina and anus. The proliferative lesions were removed surgically. Histologically, the thickened mucosa was arranged in numerous small exophytic papillomas. Cells within the basilar layers were crowded and basophilic. Rarely, enlarged cells that contained increased quantities of pale, smudged eosinophilic cytoplasm [consistent with papillomavirus (PV)-induced cellular changes] were visible. PCR amplified a PV DNA sequence from a sample of affected vaginal mucosa; the sequence was ~90% similar to a PV DNA sequence previously detected as a subclinical infection in an African species of fruit bat. The lesion had not recurred within 6 mo of surgical excision. This is the second report of PV-associated disease in bats; to our knowledge, PV infection has not been reported previously in association with anogenital lesions in bats. Additionally, to our knowledge, a PV has not been identified previously in an Australian bat species.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251341935"},"PeriodicalIF":1.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of serologic evidence of orthoflavivirus infection in dogs with meningoencephalitis of unknown origin and steroid-responsive meningitis-arteritis in the Netherlands. 荷兰不明原因脑膜脑炎和类固醇反应性脑膜炎动脉炎犬中正黄病毒感染的血清学证据缺乏。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-21 DOI: 10.1177/10406387251340619

Koen M Santifort, Kiki Streng, Niklas Bergknut, Iris Van Soens, Marta Plonek, Wim H M van der Poel

{"title":"Lack of serologic evidence of orthoflavivirus infection in dogs with meningoencephalitis of unknown origin and steroid-responsive meningitis-arteritis in the Netherlands.","authors":"Koen M Santifort, Kiki Streng, Niklas Bergknut, Iris Van Soens, Marta Plonek, Wim H M van der Poel","doi":"10.1177/10406387251340619","DOIUrl":"10.1177/10406387251340619","url":null,"abstract":"The pathogenesis of meningoencephalomyelitis of unknown origin (MUO) and steroid-responsive meningitis-arteritis (SRMA) in dogs remains enigmatic. Numerous studies have attempted and failed to identify (viral) pathogens in samples from MUO- or SRMA-diagnosed dogs. Orthoflavivirus-associated meningoencephalitis or meningoencephalomyelitis has been diagnosed in dogs in several European countries. We investigated serologic evidence for orthoflavivirus infection in dogs with clinical diagnoses of MUO or SRMA in the Netherlands. Twelve dogs with a clinical diagnosis of MUO based on signalment, neurologic examination, MRI studies, CSF analysis, and response to treatment were included in the study (age range: 1-11 y; 4 females, 8 males; weight range: 8-44 kg). Serum samples from all 12 dogs tested negative in a commercial competitive ELISA and virus neutralization tests for West Nile virus, Usutu virus, and tick-borne encephalitis virus. We did not find serologic evidence of orthoflavivirus infection in dogs with MUO or SRMA in the Netherlands.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251340619"},"PeriodicalIF":1.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina. 草酸盐肾病在牛与阿根廷大鳄消费有关。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-19 DOI: 10.1177/10406387251336265

Agustín Avellaneda-Cáceres, Stephen T Lee, Álvaro Ruiz, Gabriela V Sandoval, Luis A Colque-Caro, Daniel Cook, Laura S Aguirre, Francisco A Uzal, Juan F Micheloud

{"title":"Oxalate nephropathy in cattle associated with the consumption of Megathyrsus maximus in Argentina.","authors":"Agustín Avellaneda-Cáceres, Stephen T Lee, Álvaro Ruiz, Gabriela V Sandoval, Luis A Colque-Caro, Daniel Cook, Laura S Aguirre, Francisco A Uzal, Juan F Micheloud","doi":"10.1177/10406387251336265","DOIUrl":"10.1177/10406387251336265","url":null,"abstract":"Over a 2-wk period, 20 cows that were grazing a Megathyrsus maximus (Guinea grass) pasture died after developing depression, respiratory difficulty, and recumbency. Affected animals had increased serum urea, phosphorus, and creatinine concentrations, and below-normal calcium concentrations. Autopsy revealed moderate ascites; mildly enlarged, pale, mottled kidneys; and perirenal edema. Microscopically, there was hyperplasia of mesangial cells in the renal glomeruli, renal tubular epithelial necrosis, and hyaline casts and refractive crystals in cortical and medullary renal tubular lumens. Samples of M. maximus from the affected pasture contained elevated concentrations of soluble oxalate (3.71%). Our findings suggest that oxalate produced by M. maximus caused acute tubular injury. Our case highlights the critical need for monitoring oxalate levels in pastures and managing grazing practices, particularly under drought conditions, to prevent similar outbreaks in the future.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251336265"},"PeriodicalIF":1.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro evaluation of porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 sequences in samples containing PRRSV modified-live vaccine and wild-type strains. 猪繁殖与呼吸综合征病毒（PRRSV）修饰活疫苗和野生型毒株ORF5序列的体外评价

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-15 DOI: 10.1177/10406387251340342

Joaquín Alvarez-Norambuena, Albert Rovira, Cesar A Corzo, Mariana Kikuti

{"title":"In vitro evaluation of porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 sequences in samples containing PRRSV modified-live vaccine and wild-type strains.","authors":"Joaquín Alvarez-Norambuena, Albert Rovira, Cesar A Corzo, Mariana Kikuti","doi":"10.1177/10406387251340342","DOIUrl":"10.1177/10406387251340342","url":null,"abstract":"Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses and is a major challenge to the swine industry. The PRRS virus (PRRSV) has high rates of mutation and evolution. We examined the influence on ORF5 Sanger sequencing outcomes of various concentrations of a wild-type (WT) PRRSV (lineage 1A RFLP 1-7-4) and a modified-live vaccine (MLV) virus (lineage 5 RFLP 2-5-2) in the same sample. Vaccine-like sequences were detected more frequently than the WT virus when the MLV virus was present at equal or higher concentrations than the WT virus. This result suggests that ORF5 Sanger sequencing may preferentially detect the dominant virus in samples containing more than one virus, potentially masking WT viral infections in vaccinated herds. Although our findings highlight a limitation in identifying co-circulation of strains, Sanger sequencing is still widely used as an accessible tool to characterize PRRSVs. Advanced sequencing techniques, such as NGS or CLAMP-based approaches, would complement Sanger sequencing results and allow improved detection of co-circulating variants by minimizing consensus sequence bias and selectively blocking vaccine-like sequences.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251340342"},"PeriodicalIF":1.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the determination of cortisol in canine saliva by chemiluminescence immunoassay and liquid chromatography-tandem mass spectrometry. 化学发光免疫分析法与液相色谱-串联质谱法测定犬唾液中皮质醇的比较。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-14 DOI: 10.1177/10406387251327413

Maike Schroers, Yuri Zablotski, Andrea Meyer-Lindenberg

{"title":"Comparison of the determination of cortisol in canine saliva by chemiluminescence immunoassay and liquid chromatography-tandem mass spectrometry.","authors":"Maike Schroers, Yuri Zablotski, Andrea Meyer-Lindenberg","doi":"10.1177/10406387251327413","DOIUrl":"10.1177/10406387251327413","url":null,"abstract":"We determined saliva cortisol concentrations (SCCs) in samples from 36 dogs using a chemiluminescence immunoassay (CLIA) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) before and after a 10-min veterinary visit. The median cortisol concentration of the 77 samples analyzed with CLIA was 1.34 nmol/L, and the concentration of samples analyzed with LC-MS/MS was 1.30 nmol/L. With an intercept (a) of -0.06 (95% CI: -0.16 to 0.02) and a slope (b) of 0.97 (95% CI: 0.90-0.97) the Passing-Bablok regression revealed that there were no significant systematic and proportional differences between the 2 methods. In the Bland-Altman analysis, the bias was 0.08 nmol/L (95% CI: -0.38 to 0.54 nmol/L) between the 2 methods. Comparing the hormone levels in the saliva of 36 dogs before and after a veterinary visit, the CLIA method had a mean difference of 0.03 nmol/L (95% CI: -1.72 to 4.75 nmol/L; p = 0.35) and the LC-MS/MS method a mean difference of 0.12 nmol/L (95% CI 95%: -2.43 to 4.40 nmol/L; p = 0.62). Comparison of cortisol changes before (p = 0.86) and after (p = 0.79) the veterinary visit revealed no differences in using either the CLIA or LC-MS/MS methods. There was also no difference in the assessment of hormone increase or decrease between CLIA (p = 0.72) and LC-MS/MS (p = 0.17). Overall, the measurement of SCC in dogs by either CLIA or LC-MS/MS provided comparable results.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251327413"},"PeriodicalIF":1.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T- and B-cell lymphomas in 2 captive green tree pythons. 2条圈养绿树蟒的T细胞和b细胞淋巴瘤。

IF 1.2 3区农林科学

Journal of Veterinary Diagnostic Investigation Pub Date : 2025-05-13 DOI: 10.1177/10406387251337369

Sara Pagliarani, Luke Haydock, Leonardo Susta, Pauline Delnatte, Cédric B Larouche, Mauricio Seguel

{"title":"T- and B-cell lymphomas in 2 captive green tree pythons.","authors":"Sara Pagliarani, Luke Haydock, Leonardo Susta, Pauline Delnatte, Cédric B Larouche, Mauricio Seguel","doi":"10.1177/10406387251337369","DOIUrl":"10.1177/10406387251337369","url":null,"abstract":"Two captive 19-y-old green tree pythons (Morelia viridis), a male and a female, were diagnosed with lymphoma. At autopsy, the female was in poor body condition and had an extensive subcutaneous soft tissue mass along the ribs. The mass was composed of numerous neoplastic round cells that were also present in the liver and spleen and within blood vessels. Neoplastic cells had marked, diffuse membranous-to-cytoplasmic immunolabeling for CD3, consistent with disseminated leukemic T-cell lymphoma. The male had a history of chronic spinal deformities and was in poor body condition. All examined organs contained variable numbers of neoplastic round cells with moderate-to-marked nuclear-to-cytoplasmic immunolabeling for PAX5, consistent with B-cell lymphoma. Here we describe 2 distinct immunophenotypes of lymphomas, including a B-cell neoplasm that has not been reported previously in snakes, to our knowledge. Our 2 cases highlight the potential value of CD3 and PAX5 immunohistochemical markers in ophidians and expand the spectrum of neoplastic diseases documented in reptiles. Understanding the clinical significance of lymphoma in snakes, including its potential impact on prognosis and challenges in management, is critical to refining therapeutic approaches in captive reptile care.","PeriodicalId":17579,"journal":{"name":"Journal of Veterinary Diagnostic Investigation","volume":" ","pages":"10406387251337369"},"PeriodicalIF":1.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0