Journal of Veterinary Science最新文献

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Six-year surveillance of African Swine Fever in pigs and wild boars in an outbreak-origin region of Romania. 罗马尼亚一个非洲猪瘟发病地区猪和野猪中非洲猪瘟的六年监测。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-09-01 DOI: 10.4142/jvs.24272
Larisa Anghel Cireasa, Corneliu Ovidiu Vrancianu, Valentin Adrian Bâlteanu, Maria-Virginia Tanasa Acretei, Natalia Rosoiu
{"title":"Six-year surveillance of African Swine Fever in pigs and wild boars in an outbreak-origin region of Romania.","authors":"Larisa Anghel Cireasa, Corneliu Ovidiu Vrancianu, Valentin Adrian Bâlteanu, Maria-Virginia Tanasa Acretei, Natalia Rosoiu","doi":"10.4142/jvs.24272","DOIUrl":"https://doi.org/10.4142/jvs.24272","url":null,"abstract":"<p><strong>Importance: </strong>African Swine Fever (ASF) is a highly contagious and fatal disease severely affecting Romania's pig industry and wild boar populations. This study provides insights into the prevalence of ASF in Constanța County, where wetlands like the Danube Delta and Danube River, home to dense wild boar populations, facilitate the spread of the virus to domestic pigs.</p><p><strong>Objective: </strong>The study examined the incidence of ASF in pig and wild boar populations over six years (2018-2023) in Constanța County, Romania's second outbreak origin in 2018.</p><p><strong>Methods: </strong>The real-time polymerase chain reaction data from 3,187 samples (2,204 pigs and 983 wild boars) collected between 2018 and 2023 were analyzed. A 251 bp fragment of the African Swine Fever virus (ASFV) B646L gene (positions 105,320-105,570; GenBank MN194591.1), encoding the capsid protein p72, was amplified using a TaqMan assay, sequenced in 10 ASFV-positive samples, and subjected to phylogenetic analysis against ASFV GenBank references.</p><p><strong>Results: </strong>Analysis revealed a decline in ASF outbreaks in Constanța County, from 93 in 2018 to only two in 2022. Despite this, 2023 saw a resurgence, with 38 cases and 21 outbreaks in pigs from nearby private households, likely due to poor biosecurity. Phylogenetic analysis of 10 ASFV isolates and GenBank sequences from Europe, Asia, and Africa confirmed 100% similarity to strain II. ELISA testing identified ASFV antibodies in 23 of 144 pigs (15.9%) and 28 of 559 wild boars (5.0%), indicating that some animals survived ASFV infection.</p><p><strong>Conclusions and relevance: </strong>The results revealed a steady decline in ASF outbreaks and cases in Constanța County, attributed to eradication measures. The detection of ASFV antibodies in 51 animals highlights post-infection survival in both domestic pigs and wild boars, offering valuable insight for future research on the genetic basis of acquired immunity.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 5","pages":"e50"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of locking screw fixation into 3D-printed patient-specific porous titanium implants enhances osseointegration: an in vivo study in a rabbit bone defect model. 将锁定螺钉固定整合到3d打印患者特异性多孔钛植入物中,增强骨整合:一项兔骨缺损模型的体内研究。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-09-01 DOI: 10.4142/jvs.25179
Kyu-Won Kang, Sook Yang, Sun Young Kim, Jihye Choi, Byung-Jae Kang
{"title":"Integration of locking screw fixation into 3D-printed patient-specific porous titanium implants enhances osseointegration: an <i>in vivo</i> study in a rabbit bone defect model.","authors":"Kyu-Won Kang, Sook Yang, Sun Young Kim, Jihye Choi, Byung-Jae Kang","doi":"10.4142/jvs.25179","DOIUrl":"https://doi.org/10.4142/jvs.25179","url":null,"abstract":"<p><strong>Importance: </strong>Three-dimensional (3D) printing enables fabrication of patient-specific implants (PSIs) tailored to complex bone defects. Although locking screw fixation offers mechanical advantages in conventional plating, its integration into 3D-PSIs is technically challenging and has not been evaluated for biological outcomes.</p><p><strong>Objective: </strong>This study aimed to assess whether locking screw fixation enhances osseointegration compared to nonlocking fixation when directly integrated into 3D-printed porous titanium implants.</p><p><strong>Methods: </strong>Segmental femoral defects (20 mm) were created in ten adult rabbits, and customized porous Ti6Al4V implants were designed based on preoperative computed tomography (CT) scans. The implants incorporated threaded holes replicating the ARIX locking system and were fabricated via selective laser melting. Animals were randomly assigned to locking (n = 5) or nonlocking (n = 5) screw fixation groups. After 12 weeks, implant osseointegration was evaluated using radiography, micro-CT, and histological analyses.</p><p><strong>Results: </strong>All implants remained stable without failure. Micro-CT revealed significantly higher bone volume fraction in the locking group (27.8% ± 3.7%) than the nonlocking group (23.8% ± 1.7%; <i>p</i> < 0.05). Histology showed more extensive and homogeneous bone ingrowth in the locking group, whereas fibrous tissue formation was observed in some nonlocking cases. The bone area percentage was significantly greater in the locking group (24.4% ± 9.9%) than in the nonlocking group (12.2% ± 7.1%; <i>p</i> < 0.05).</p><p><strong>Conclusions and relevance: </strong>This study demonstrates that integrating locking screw fixation into 3D-printed porous titanium PSIs enhances osseointegration by improving primary stability. These findings suggest that locking fixation in PSI designs may improve outcomes for load-bearing bone defect reconstructions in veterinary and potentially human applications.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 5","pages":"e62"},"PeriodicalIF":1.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of tick-borne pathogens using next-generation sequencing in ticks from wild animals in the Republic of Korea. 利用韩国野生动物蜱的下一代测序分析蜱传病原体。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.24351
Hye-Ryung Byun, Mi-Sun Rieu, Seong-Ryeong Ji, Hyun-Young Nam, Seulgi Seo, Chang-Yong Choi, Ki-Jeong Na, Jong-Taek Kim, Soyeon Cho, Bo-Yeon Hwang, Joon-Seok Chae
{"title":"Analysis of tick-borne pathogens using next-generation sequencing in ticks from wild animals in the Republic of Korea.","authors":"Hye-Ryung Byun, Mi-Sun Rieu, Seong-Ryeong Ji, Hyun-Young Nam, Seulgi Seo, Chang-Yong Choi, Ki-Jeong Na, Jong-Taek Kim, Soyeon Cho, Bo-Yeon Hwang, Joon-Seok Chae","doi":"10.4142/jvs.24351","DOIUrl":"10.4142/jvs.24351","url":null,"abstract":"<p><strong>Importance: </strong>Climate and anthropogenic changes have resulted in the growth of tick populations and tick-borne pathogens worldwide. Standardized surveillance systems are essential for novel tick-borne pathogens in the Republic of Korea (ROK). Analysis of blood-fed ticks suggests that zoonotic pathogens have the potential to circulate between ticks and wild animals in natural environments.</p><p><strong>Objective: </strong>This study aimed to analyze blood-fed ticks from wild animals in the ROK and detect novel tick-borne pathogens in the ROK to develop effective surveillance systems and preventive strategies.</p><p><strong>Methods: </strong>Next-generation sequencing (NGS) identified 217 ticks with eight pooled samples collected from five wild mammals and 22 birds in five wildlife rescue centers and three bird banding stations in the ROK from February 2022 to May 2023.</p><p><strong>Results: </strong>After NGS, clean reads of 17,017,249-32,372,003 viruses, 116,996-289,716 bacteria, and 164,462-352,826 protozoa were obtained in each region. Several pathogens, including those in families such as <i>Phenuiviridae</i>, cause zoonotic diseases. This study identified 39 species, including 30 viruses, eight bacteria, and one protozoan, in 217 blood-feeding ticks from five wild mammals and 22 wild birds.</p><p><strong>Conclusions and relevance: </strong>This study suggests that tick-borne zoonotic pathogens can circulate in ticks and animals and have potential transmission effects in humans. Hence, wild animals, including mammals and birds, may serve as reservoirs of zoonotic infection carriers.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e46"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization and immunogenic evaluation of feline calicivirus epidemic strains. 猫杯状病毒流行株的鉴定及免疫原性评价。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.24331
Xiu Xue, Guangrong Zhao, Chenli Fang, Yajie Pan, Shuye Zhen, Hongwei Zhu, Jiayu Yu, Linlin Jiang, Jianlong Zhang, Kexue Han, Yinuo Han, Yang Liu, Xin Yu, Xingxiao Zhang
{"title":"Characterization and immunogenic evaluation of feline calicivirus epidemic strains.","authors":"Xiu Xue, Guangrong Zhao, Chenli Fang, Yajie Pan, Shuye Zhen, Hongwei Zhu, Jiayu Yu, Linlin Jiang, Jianlong Zhang, Kexue Han, Yinuo Han, Yang Liu, Xin Yu, Xingxiao Zhang","doi":"10.4142/jvs.24331","DOIUrl":"10.4142/jvs.24331","url":null,"abstract":"<p><strong>Importance: </strong>The feline calicivirus (FCV) is globally prevalent with regional specificity in its distribution, but the significant differences among strains limit the efficacy of vaccines. Therefore, understanding the prevalence and biological characteristics of FCV holds immense significance in facilitating the development of novel vaccines and targeted pharmaceuticals.</p><p><strong>Objective: </strong>This study aimed to understand the epidemiological status of the FCV in the Shandong region and identify candidate strains for vaccine development.</p><p><strong>Methods: </strong>In this study, 41 FCV strains were obtained from Shandong province in China. Phylogenetic analysis was conducted based on the VP1. The FCV023 strain was selected for pathogenicity and immunogenicity analysis.</p><p><strong>Results: </strong>Forty-one FCV strains were isolated from cats with a suspected FCV infection in Shandong province. The phylogenetic tree showed that the FCV isolates could be divided into three gene Clusters: Clusters I-III. Clusters I and II have a higher prevalence in Shandong province than Cluster III. The challenge experimental results showed that FCV023 could cause typical upper respiratory infections in cats. The <i>in vitro</i> neutralization assay showed that FCV023 positive serum could produce a neutralizing titer against FCV isolates distributed in different branches of phylogenetic trees.</p><p><strong>Conclusions and relevance: </strong>The FCV detection rate in Shandong Province was 70.69%, significantly higher than in other regions. Phylogenetic analysis suggested that FCV strains exhibit characteristic regional prevalence in Shandong Province. As a representative strain, FCV023 infections can cause typical upper respiratory symptoms in cats. The preliminarily screened FCV023 immune serum showed good neutralizing activity and can be considered a candidate strain for vaccine development.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e38"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PCR-based detection of hereditary mutations in SLC2A9, BTBD17, and NECAP1 among native Korean dog breeds. 韩国本土犬种SLC2A9、BTBD17和NECAP1基因遗传突变的pcr检测
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.25047
Mingue Kang, Byeongyong Ahn, Jaeyeol Shin, Chankyu Park
{"title":"PCR-based detection of hereditary mutations in <i>SLC2A9</i>, <i>BTBD17</i>, and <i>NECAP1</i> among native Korean dog breeds.","authors":"Mingue Kang, Byeongyong Ahn, Jaeyeol Shin, Chankyu Park","doi":"10.4142/jvs.25047","DOIUrl":"10.4142/jvs.25047","url":null,"abstract":"<p><strong>Importance: </strong>Understanding the susceptibility of native Korean dogs to genetic diseases is important for animal welfare and breeding. However, little is known regarding the segregation of genetic variations associated with genetic diseases among native Korean dog breeds, highlighting the need for further research in this area.</p><p><strong>Objective: </strong>A genome-wide analysis was conducted using the available whole genome sequencing (WGS) results of DongGyeongi, Sapsaree, and Jindo dogs to evaluate the presence of disease-associated mutations and develop polymerase chain reaction (PCR)-based typing methods.</p><p><strong>Methods: </strong>Using WGS data from 32 individuals of DongGyeongi, Sapsaree, and Jindo dogs, variant calling was used to identify variants associated with canine genetic diseases in Online Mendelian Inheritance in Animals. Additionally, allele-specific PCR-based typing methods for the identified mutations were developed.</p><p><strong>Results: </strong>Four different variants were identified: NC_006583.3:g.54192143C>G in the <i>T</i> gene associated with the bobtail phenotype, NC_006585.3:g.69456869G>T in <i>SLC2A9</i> associated with urolithiasis, NC_006591.3:g.6048201_6048202insG in <i>BTBD17</i> associated with abortion, and NC_006607.3:g.48121642G>A in <i>MLPH</i> associated with coat color dilution. The <i>BTBD17</i> mutant allele was present in all breeds (frequency = 0.33), whereas the <i>MLPH</i> mutant allele was found only in DongGyeongi (0.18) and Sapsaree breeds (0.20). The <i>T</i> and <i>SLC2A9</i> mutant alleles were specific to DongGyeongi (0.20 and 0.18, respectively).</p><p><strong>Conclusions and relevance: </strong>Genome-wide analysis was conducted to identify the causative mutations of genetic diseases in native Korean dogs. The observed frequencies of the identified variants differed among native Korean dog breeds. The typing methods used to detect variant alleles in this study will contribute to improving the genetic robustness of native Korean dog breeds.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e48"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection and genetic evolution analysis of porcine reproductive and respiratory syndrome virus in Chengdu from January 2021 to December 2022. 2021年1月- 2022年12月成都市猪繁殖与呼吸综合征病毒检测及遗传进化分析
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 Epub Date: 2025-05-08 DOI: 10.4142/jvs.24277
Hongyu Zhong, Kerong Li, Min Li, Kun Zhang, Yi Zhang, Luqi Liang, Haifeng Liu, Zhijun Zhong, Guangneng Peng, Xiaoxiao Zhou, Ziyao Zhou
{"title":"Detection and genetic evolution analysis of porcine reproductive and respiratory syndrome virus in Chengdu from January 2021 to December 2022.","authors":"Hongyu Zhong, Kerong Li, Min Li, Kun Zhang, Yi Zhang, Luqi Liang, Haifeng Liu, Zhijun Zhong, Guangneng Peng, Xiaoxiao Zhou, Ziyao Zhou","doi":"10.4142/jvs.24277","DOIUrl":"10.4142/jvs.24277","url":null,"abstract":"<p><strong>Importance: </strong>Pandemics involving the porcine reproductive and respiratory syndrome virus (PRRSV) impact swine health and productivity, causing economic devastation, especially in large-scale feeding areas.</p><p><strong>Objective: </strong>This study examined the prevalence and genetic variations of PRRSV in Chengdu, China, a vital transportation hub and the main area of pig breeding in southwest China, between January 2021 and December 2022.</p><p><strong>Methods: </strong>The samples were collected from 13 key pig-feeding areas in Chengdu. The positive PRRSV samples were detected using a real-time quantitative polymerase chain reaction. The genetic variations of the PRRSV were analyzed by amplifying the open reading frame 5 (ORF5) gene and comparing it with relevant reference sequences.</p><p><strong>Results: </strong>The PRRSV positive rate in Chengdu was 11.42% (276/2,416), including sublines 8.7, 5.1, 3.0, and 1.8. The ORF5 gene sequences in the samples had no insertion or deletion of amino acids but widespread variations, including the 13th and 151st positions, which were associated with viral virulence.</p><p><strong>Conclusions and relevance: </strong>The PRRSV pandemic in Chengdu was relevant, and recombination between vaccine strains and field strains can contribute to vaccine immune failure.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e36"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood pressure agreement between ideal and loose-fitting cuffs in anesthetized dogs. 在麻醉狗的理想和宽松袖口之间的血压一致。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.25081
Jennifer Pelchat, Anthony Carr, Shannon G Beazley
{"title":"Blood pressure agreement between ideal and loose-fitting cuffs in anesthetized dogs.","authors":"Jennifer Pelchat, Anthony Carr, Shannon G Beazley","doi":"10.4142/jvs.25081","DOIUrl":"10.4142/jvs.25081","url":null,"abstract":"<p><strong>Importance: </strong>Indirect blood pressure monitoring is used frequently in veterinary medicine. Blood pressure cuff looseness has not been investigated as a cause of erroneous measurements.</p><p><strong>Objective: </strong>To determine if cuff looseness affects blood pressure measurements in healthy anesthetized dogs.</p><p><strong>Methods: </strong>Between December 2020 and May 2022 at an institutional practice, 62 anesthetized healthy dogs were separated into two groups: ≤ 20 kg and > 20 kg. Tail base circumference of each dog was measured, and baseline was defined as ideal (0% looseness factor). The cuff was manually loosened sequentially from 0% to 2%, 5%, 8%, 10% and 15% looseness factors. High definition oscillometry was used to measure systolic (SAP), mean (MAP) and diastolic (DAP) arterial blood pressures. Bland and Altman for repeated measures was used to analyze SAP, MAP and DAP measurements of baseline and each looseness factor. Acceptable bias and limits of agreement (LoA) were set using American College of Veterinary Internal Medicine guidelines.</p><p><strong>Results: </strong>All biases were acceptable. In dogs ≤ 20 kg, LoA for all SAP looseness factors and MAP looseness factors of 10% and 15% did not fall within the guidelines. In dogs > 20 kg, LoA for all measurements except SAP 5%, 8% and 10% looseness factors fell within the guidelines.</p><p><strong>Conclusions and relevance: </strong>Loosening a cuff up to 15% did not result in significant changes to blood pressure measurements of healthy anesthetized dogs using high definition oscillometry.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e51"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia. 别嘌呤醇和苯溴马隆在高尿酸血症鹌鹑模型中的药动学和药效学比较。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.24313
ShaoJun Zheng, YaQin Bu, Sheng Li, NaiDong Chen
{"title":"Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia.","authors":"ShaoJun Zheng, YaQin Bu, Sheng Li, NaiDong Chen","doi":"10.4142/jvs.24313","DOIUrl":"10.4142/jvs.24313","url":null,"abstract":"<p><strong>Importance: </strong>Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodynamics (PD) and pharmacokinetics (PK) of uric acid-lowering drugs is essential for improving the treatment strategies in poultry.</p><p><strong>Objective: </strong>This study examined the PD and PK characteristics of allopurinol and benzbromarone, two uric acid-lowering drugs, in a quail model of HUA.</p><p><strong>Methods: </strong>A hyperuricemic quail model was established using a high-purine diet. Allopurinol and benzbromarone were administered orally. Blood samples were taken and analyzed for the drug concentrations using high-performance liquid chromatography. Pathological examinations were conducted to assess kidney damage.</p><p><strong>Results: </strong>Both drugs lowered the serum uric acid levels. On the other hand, the allopurinol treatment exhibited lower urea and creatinine levels than benzbromarone, indicating potential advantages in reducing kidney damage. Consistent with these findings, the pathological examinations revealed more pronounced kidney damage in the benzbromarone-treated group than in the allopurinol group. PK analysis showed that allopurinol exhibited faster absorption and elimination kinetics than benzbromarone. Both drugs showed a wide distribution in various tissues, with allopurinol and its active metabolite displaying higher excretion levels.</p><p><strong>Conclusions and relevance: </strong>This paper reports the absorption, distribution, metabolism, and excretion processes of allopurinol and benzbromarone in a quail model of HUA. These findings help better understand the PK characteristics of these drugs and promote the use of high uric acid therapy in poultry. In addition, this quail model is a valuable tool for future research on HUA and drug interventions.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e34"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical utility of two-dimensional shear wave elastography in two dogs with presumptive toxic hepatopathy. 二维横波弹性成像在两只假定中毒性肝病犬中的临床应用。
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.25083
Junyoung Kim, Dai Jung Chung, Soyoung Lee, Jihye Choi, Junghee Yoon
{"title":"Clinical utility of two-dimensional shear wave elastography in two dogs with presumptive toxic hepatopathy.","authors":"Junyoung Kim, Dai Jung Chung, Soyoung Lee, Jihye Choi, Junghee Yoon","doi":"10.4142/jvs.25083","DOIUrl":"10.4142/jvs.25083","url":null,"abstract":"<p><strong>Importance: </strong>Shear wave elastography (SWE) is a non-invasive ultrasound technique for assessing tissue stiffness. This study examined the clinical utility of two-dimensional SWE (2D-SWE) in two dogs diagnosed with presumptive toxic hepatopathy.</p><p><strong>Case presentation: </strong>The first case involved a 9-year-old Pompitz that presented with anorexia, vomiting, and diarrhea following garlic and onion ingestion. Laboratory tests revealed anemia, elevated liver enzyme levels, and diabetic ketoacidosis. Ultrasonography demonstrated increased hepatic echogenicity and elevated SWE values. Despite intensive treatment, the dog's condition deteriorated, with progressive increases in liver enzyme levels and SWE values, resulting in euthanasia. The second case involved a 1-year-old Maltipoo that presented vomiting, depression, and abdominal pain, with no reported history. Laboratory findings indicated elevated liver enzyme and bile acid levels. Ultrasonography revealed increased hepatic echogenicity and SWE values. Following treatment for acute toxic hepatopathy, the dog exhibited significant improvement within 3 days, with normalization of hepatic echogenicity, SWE values, and liver enzyme levels.</p><p><strong>Conclusions and relevance: </strong>These cases demonstrate the clinical relevance of 2D-SWE in assessing hepatic damage, tracking therapeutic response, and informing prognosis in presumptive toxic hepatopathy.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e45"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial Cluster Analysis and Key Influencing Factors of African Swine Fever in China (2018-2021). 2018-2021年中国非洲猪瘟疫情空间聚类分析及关键影响因素
IF 1.5 3区 农林科学
Journal of Veterinary Science Pub Date : 2025-07-01 DOI: 10.4142/jvs.24307
Liyuan Wang, Latiffah Binti Hassan, Ooi Peck Toung, Xia Li
{"title":"Spatial Cluster Analysis and Key Influencing Factors of African Swine Fever in China (2018-2021).","authors":"Liyuan Wang, Latiffah Binti Hassan, Ooi Peck Toung, Xia Li","doi":"10.4142/jvs.24307","DOIUrl":"10.4142/jvs.24307","url":null,"abstract":"<p><strong>Importance: </strong>African swine fever (ASF) is a significant transboundary disease with profound global economic impacts. ASF, caused by the <i>Asfarviridae</i> virus, is highly resilient and has caused substantial economic losses in affected regions, with no available vaccination or treatment. We conducted a comprehensive analysis of the spatial clusters and potential factors contributing to the ASF epidemic in China from August 2018 to April 2021.</p><p><strong>Objective: </strong>The study aimed to trace ASF transmission, map the spatial distribution and spread dynamics, and model the spread to evaluate the potential control strategies.</p><p><strong>Methods: </strong>Standardized deviational ellipse analysis was used to identify the directionality and distribution of ASF outbreaks. Ordinary least squares regression and geographically weighted regression were applied to account for spatial heterogeneity and explore the localized relationships within the data set.</p><p><strong>Results: </strong>The ASF transmission in China was delineated across three phases, characterized by an initial rapid spread, a subsequent westward expansion, and a final plateau phase with a southwestward trend. The key factors influencing ASF transmission included the pig population density, wind speeds, altitude, and the presence of high-risk roads, with seasonality also playing a significant role in the disease incidence.</p><p><strong>Conclusions and relevance: </strong>This research highlights the significant impact of small-scale farming practices and the live pig transportation network on ASF spread. In addition, it identifies key epidemiological factors, including the pig density and seasonal variations, which are crucial for developing effective disease control strategies.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"26 4","pages":"e44"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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