Journal of Traditional Chinese Medicine最新文献

{"title":"Shengmai San preserves myocardial calcium homeostasis by inhibiting CaMKII activity before pathologic changes in diabetic mice","authors":"Runhao Ma, Jingheng Wei, Lihua Sun, Haifeng Cui, Shanfei Shang, J. A. Liu Yin, Xiaolu Shi","doi":"10.1097/gscm.0000000000000063","DOIUrl":"https://doi.org/10.1097/gscm.0000000000000063","url":null,"abstract":"Background: Diabetic cardiomyopathy (DCM) is a common heart problem in people with diabetes. It is a big public health problem that needs to be treated effectively. Shengmai San (SMS) can be used to treat diabetic cardiomyopathy, coronary heart disease, and heart damage, but it is unclear whether it can protect the calcium balance of diabetic cardiomyopathy in the early stages. Objective: To investigate the regulatory mechanism of SMS on sarcoplasmic reticulum calcium transport in diabetic mice. Methods: Eight-week-old db/db mouse models were randomly divided into a diabetic model group (model), SMS intervention group (SMS), and CaMKⅡ inhibitor group (KN-93). Age-matched db/m mice were used as a control group. After 8 weeks of treatment, cardiac function and morphology were assessed, and calcium transients in cardiomyocytes and sarcoplasmic reticulum calcium transport were detected. Western blot was used to detect the expression of CaMKⅡ and proteins related to myocardial calcium transport. Results: In 16-week-old db/db mice, there was no obvious abnormality in myocardial contractile function, the ventricular wall was not thickened, and the cross-sectional area of cardiomyocytes was not significantly enlarged. Compared with the model group, in the SMS group, the calcium transient amplitude was increased, the calcium content of the sarcoplasmic reticulum was upregulated, the calcium elimination time constant was decreased, calcium elimination was accelerated, and the proportion of calcium released from the sarcoplasmic reticulum during the calcium transient was increased. At the same time, SMS could reduce cytosolic free calcium in diabetic mice, and its possible mechanism was to reduce calcium leakage from the sarcoplasmic reticulum, and its effect was similar to that of the KN93 group. The expressions of CaMKII protein and p-CaMKII protein were significantly upregulated in the model group, while SMS could significantly downregulate the expressions of both. Conclusions: SMS can reduce sarcoplasmic reticulum calcium leak and protect the calcium homeostasis of diabetic myocardium. Its mechanism may be by reducing the expression of CaMKII protein and the phosphorylation level of CaMKII protein.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 2","pages":"187-197"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"AS-SABR\" OZIQ-OVQAT QO‘SHIMCHASI TARKIBIDAGI VITAMINLAR ANALIZI VA ULARNING ASAB KASALLIKLARNI OLDINI OLISHDAGI AHAMIYATI","authors":"Shoxsanam Akromjon qizi Obidova, Ibrohimjon Rahmonovich Asqarov, Madinaxon Maxmudovna Atabayeva","doi":"10.55475/jcgtm/vol3.iss6.2024.395","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss6.2024.395","url":null,"abstract":"As-sabr oziq-ovqat qo‘shimchasi tarkibidagi vitaminlar miqdorini yuqori samarali suyuqlik xromatografiyasi (YSSX) usuli yordamida aniqlash natijalari tahlil qilingan. Tadqiqot natijalari mazkur qo‘shimchaning biologik faol birikmalarining miqdoriy va sifat jihatlarini tavsiflashga yo‘naltirilgan. Olingan ma’lumotlarga asoslanib, ushbu biologik faol moddalar markaziy asab tizimi kasalliklarini oldini olish va ularni korreksiyalash maqsadida qo‘llash imkoniyati ko‘rib chiqilgan. Oziq-ovqat sanoati va tibbiyotda qo‘llanilishi bo‘yicha amaliy tavsiyalar keltirilgan.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 6","pages":"154-171"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.jcgtm.org/index.php/home/article/download/395/573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITTIKANAK O’SIMLIGI TARKIBIDAGI SUVDA ERUVCHAN VITAMINLAR MIQDORINI YUSSX USULIDA ANIQLASH","authors":"Aslbek Baxtiyorbekovich Yo'lchiyev, Zarnigor Abduqodirova","doi":"10.55475/jcgtm/vol3.iss6.2024.388","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss6.2024.388","url":null,"abstract":"Tabiat ne’matlaridan olinadigan dori-darmonlar kimyoviy-sun’iy ravishda olinadigan preparatlarga nisbatan afzaldir. Chunki tabiat ehsoni hisoblangan o’simliklardan tarkib topgan dorilar deyarli asoratsiz hisoblanadi. Mazkur ittikanak o’simligi tarkibidagi vitaminlarni yuqori samarali suyuqlik xromatografiyada miqdori aniqlandi. Tahlil natijalari asosida o’simlik xomashyosi tarkibidagi vitaminlar miqdori keltirildi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 6","pages":"136-153"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.jcgtm.org/index.php/home/article/download/388/569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"АНАЛИЗ ВОДОРАСТВОРИМЫХ ВИТАМИНОВ В ЭКСТРАКТЕ ЛИСТЬЕВ АЙВЫ (CYDONIA OBLONGA MILL.)","authors":"Кобилджон Кахрамонович Отахонов, Диёрахон Исомиддин кизи Тойчиева","doi":"10.55475/jcgtm/vol3.iss6.2024.428","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss6.2024.428","url":null,"abstract":"Данная статья посвящена определению содержания водорастворимых витаминов в экстракте листьев айвы (Cydonia oblonga Mill.) методом высокоэффективной жидкостной хроматографии (ВЭЖХ). Листья айвы издавна широко использовались в народной медицине, и в их составе были выявлены различные биологически активные химические соединения. В ходе исследования методом ВЭЖХ были количественно определены витамины B1, B2, B3, B6, B9, PP, B12 и C, а также проанализировано их виологическое значение. Полученные результаты научно подтверждают лечебные свойства листьев айвы и открывают перспективы их применения в медицине и фармацевтической промышленности.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 6","pages":"308-331"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/428/617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GULXAYRI (ALTHAÉA OFFICINÁLIS) O’SIMLIGI TARKIBIDAGI SUVDA ERUVCHAN VITAMINLAR MIQDORINI ANIQLASH","authors":"Ibrohimjon Rahmonovich Asqarov, Mirjalol Muqimjon o'g'li Mo'minjonov, Zulxumor Isroil qizi Xusanova","doi":"10.55475/jcgtm/vol3.iss5.2024.389","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss5.2024.389","url":null,"abstract":"Ushbu maqolada dorivor gulxayri (Althaéa officinális) o‘simligining vegatativ organlari – barg hamda poyasi tarkibidagi suvdan eruvchan vitaminlar, B gurux vitaminlari, vitamin PP, vitamin C miqdorini yuqori samarali suyuqlik xromatogrammasi yordamida aniqlash natijalari hamda ularning meyorlari diogramma va jadvallarda keltirilgan. Bu o’simlikning organizimga kerakli vitaminlarga boyligi va ijobiy ta’sirlari izohlangan.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 5","pages":"173-193"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/389/533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147904721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZUBTURUM VA DALACHOY O’SIMLIKLARINING ANTIOKSIDANTLIK XUSUSIYATINI O’RGANISH","authors":"Xabibullo No'manjon o'g'li Qodirov, Ibrohimjon Rahmonovich Asqarov","doi":"10.55475/jcgtm/vol3.iss5.2024.354","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss5.2024.354","url":null,"abstract":"Hozirgi kunga kelib, o‘simliklardan tayyorlangan tabiiy-dori vositalariga qiziqish va ehtiyoj ortib boryapti. Butun dunyoda bemorlarni davolashda o‘simliklardan tayyorlangan tabiiy-dori vositalar va oziq-ovqat qo‘shilmalaridan foydalanish Yevropa davlatlarida yuqori ko‘rsatkichlarni tashkil etadi. Ayniqsa Italiyada davolashda o‘simliklardan foydalanish organizmga sintetik dori vositalaridan ko‘ra foydaliroq ta’sirga ega ekanligini allaqachon tushunib yetishgan. Osiyoda joylashgan yirik rivojlangan davlatlar Koreya, Yaponiya va Xitoyning tibbiyotda o‘simliklardan keng foydalanishi hech kimga sir emas. Shuning uchun biz zubturum va dalachoydan oziq-ovqat qo‘shilmasi yaratish maqsadida, Antioksidant aniqlanishi zubturum va dalachoyni oshqazon ichak epidermis qavatini regeneratsiyasi bo’lishi oshqozon ichak yara kasalliklardida ijobiy ta’siri borligidan dalolatdir.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 5","pages":"213-232"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/354/541","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VALERIANA (VALERIÁNA OFFICINÁLIS) O’SIMLIGINING SHIFOBAXSHLIK XUSUSIYATLARI VA UNING TARKIBIDAGI AYRIM VITAMINLAR MIQDORINI ANIQLASH","authors":"Ibrohimjon Rahmonovich Asqarov, Farhod Sultonahmadovich Abdugapparov, Irodaxon Maxmudovna Raximova","doi":"10.55475/jcgtm/vol3.iss5.2024.358","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss5.2024.358","url":null,"abstract":"Hozirgi zamondagi dolzarb muammolarni hisobga olgan holda, dorivor asorun o‘simligi asosida asab kasalligini samarali davolash xususiyatiga ega ekanligi aniqlangan. Ushbu maqolada dorivor asorun tabiiy dorivor o’simligi tarkibidagi vitaminlar miqdorini aniqlash bo’yicha olib borilgan tadqiqot natijalari keltirilgan. O’simlik tarkibidagi suvda eruvchan vitaminlar miqdorini Yaponiyaning Shimadzu kompaniyasida ishlab chiqarilgan LC-40 Nexera Lite yuqori samarali suyuqlik xromatografida amalga oshirildi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 5","pages":"287-301"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/358/557","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TUKLI ERVA (Aerva lanata Juss.) O’SIMLIGI TARKIBIDAGI VITAMINLAR MIQDORINI YUSSX USULIDA ANIQLASH","authors":"Ibrohimjon Rahmonovich Asqarov, Obidjon Shaxabidinovich Abdulloyev, Xilolaxon G’olibjon qizi Maxmudova","doi":"10.55475/jcgtm/vol3.iss5.2024.372","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss5.2024.372","url":null,"abstract":"Maqolada tukli erva (Aerva lanata Juss.) o’simligining kimyoviy tarkibi, uning inson salomatligi uchun ahamiyati haqida ma’lumotlar keltirilgan. O’simlikning suvli ekstrakti tarkibidagi suvda eruvchan vitaminlar miqdorini C<B9<B1 tartibida ortib borishi yuqori samarali suyuqlik xromatogafiyasi usulida aniqlangan.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 5","pages":"233-253"},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/372/545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147881691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive effects of curcumin and glucosamine on knee function, cartilage protection, and subchondral bone preservation in a posttraumatic osteoarthritis rat model","authors":"Jiming Li, Shaofeng Huo, Cuishan Huang, Wenxiang Cheng, Shan Liang, Wenrong Chen, Suqiong Fang, Ling Qin, Peng Chen, Ligen Lin, Xinluan Wang","doi":"10.1097/gscm.0000000000000053","DOIUrl":"https://doi.org/10.1097/gscm.0000000000000053","url":null,"abstract":"Objective: Investigate the combined effects of curcumin and glucosamine on knee function, subchondral bone preservation, and cartilage protection in posttraumatic osteoarthritis (OA) rats. Background: OA increasingly become a global public health concern. Curcumin and glucosamine, both widely used as dietary supplements for OA, have shown distinct therapeutic effects. However, curcumin’s low bioavailability and the debated efficacy of glucosamine limit their broader clinical use. Methods: Posttraumatic OA was induced in Lewis rats through medial meniscus transection surgery. Rats were treated for 8 weeks with curcumin phospholipid liposome (C, 120 mg/kg/d), glucosamine (G, 190 mg/kg/d), or a combination of both (CG, C: G = 1:3, 63/190 mg/kg/d). Knee width was measured weekly, and weight-bearing was assessed twice weekly. Subchondral bone and cartilage changes were analyzed using micro-CT, toluidine blue staining, and the Osteoarthritis Research Society International (OARSI) score. Collagen II expression in cartilage was evaluated by immunohistochemistry. Results: Curcumin phospholipid liposomes significantly reduced joint swelling by up to 4.1% ( P < 0.001) and improved weight-bearing force by 24.2% at week 2 ( P < 0.01) and 14.9% at week 8 ( P < 0.05) in comparison with the medial meniscus transection group. Analysis of micro-CT indicated an increase in bone volume (BV; 11.6%) and bone mineral content (BMC; 13.0%) ( P < 0.05). Histologic analysis showed a 28.8% reduction in OARSI scores ( P < 0.01) and a 53.1% increase in collagen II expression ( P < 0.005). Glucosamine treatment reduced joint swelling by up to 5.7% ( P < 0.0001), improved weight-bearing by 31.6% ( P < 0.001) at week 2, and significantly increased BV (30.4%) and BMC (29.9%; P < 0.05). The combined treatment further reduced swelling by up to 6.6% ( P < 0.0001) and improved the R/L weight-bearing ratio by 24.7% ( P < 0.0001) at week 8. It also enhanced BV (28.6%), BMC (29.7%), and anisotropy degree (59.3%; P < 0.05). In addition, the combination therapy decreased OARSI scores by 27.1% ( P < 0.01) and enhanced the expression of collagen II by 54.2% ( P < 0.005), indicating enhanced cartilage and subchondral bone protection. Conclusion: Curcumin showed superior protection for cartilage, while glucosamine mainly benefited subchondral bone. Combined treatment demonstrated additive effects, improving both knee structure and physical function in OA, offering enhanced pain relief, anti-inflammatory action, and joint preservation.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 1","pages":"69-80"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LIMONO’T (MELISSA OFICINALIS L) O’SIMLIGI TARKIBIDAGI SUVDA ERUVCHAN VITAMINLARNI YUSSX USULDA ANIQLASH","authors":"Ibrohimjon Rahmonovich Asqarov, Baxtiyor Yormaxamatovich Abdug'aniyev, S.A. Rustamov, Oydinoy Alisher qizi Isaqova","doi":"10.55475/jcgtm/vol3.iss4.2024.316","DOIUrl":"https://doi.org/10.55475/jcgtm/vol3.iss4.2024.316","url":null,"abstract":"Ushbu maqola mamlakatimizda o’suvchi limono’t (Melissa officinalis L) o’simligiga asab kasalliklarini davolashda ishlatiladigan sintetik dori vositalari o’rnini bosish xususiyatlarini beruvchi vitaminlar miqdorini analiz qilishga qaratilgan. Limono’tining xlorid kislotaning 0,1 N suvli eritmasidagi ekstrakti tarkibidagi vitaminlar miqdorini yuqori samaralik suyuqlik xromotografiyasi usulida aniqlanganda vitaminlar miqdori quyidagicha tartibda: B1 - 22.348, B9-16.3, B6- 1.778, C-1.778, B3-1.778, B2 - 0.950, PP -0.091 mg/g da bo’lishi o’z tasdig’ini topdi. Bu esa ushbu o’simlikni asab kasalliklarini oldini olish va davolashda samarali vositalar ishlab chiqarishda istiqbolli dorivor o’simliklar qatoriga kiritish imkonini beradi.","PeriodicalId":17513,"journal":{"name":"Journal of Traditional Chinese Medicine","volume":"3 4","pages":"165-181"},"PeriodicalIF":0.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://www.jcgtm.org/index.php/home/article/download/316/441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}