Risk assessment model for endpoints of ischemic stroke: A study protocol for a registry study

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE
Zhang Yin , Liu Yue , Wang Guiqian , Sun Shuailing , Gao Yang , Xie Yanming
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引用次数: 4

Abstract

OBJECTIVE

To evaluate the risk of ischemic stroke endpoints by establishing risk assessment models that combine Traditional Chinese Medicine (TCM) and modern medicine indicators.

METHODS/DESIGN

The proposed study is a registry-based participant survey conducted in seven hospitals nationwide in China. After obtaining informed consent, 3000 patients diagnosed with ischemic stroke will be recruited. One-year follow-ups will be performed on-site in hospitals and by telephone to track endpoint events. Comparative analysis of the prevalence of endpoint events and other TCM or modern medicine features in different groups will be conducted using frequency analysis and χ2 tests, and the results will be expressed as composition ratios. Comparative analysis of quantitative scores and related patterns or symptoms will be conducted using a rank-sum test. Correlation analysis of endpoint events and TCM or modern medicine factors will be performed using a multivariate Cox proportional hazard model.

DISCUSSION

Previous reports have described modern medicine indicator-based risk assessment models for ischemic stroke endpoint events, but no such studies have included TCM features. Our new risk assessment model combines TCM and modern medicine indicators and thus has the potential to facilitate early warning, early intervention, and early control of ischemic stroke endpoint events.

缺血性卒中终点的风险评估模型:一项注册研究的研究方案
目的建立中医指标与现代医学指标相结合的缺血性脑卒中终点风险评估模型,评价缺血性脑卒中终点风险。方法/设计本研究是一项基于登记的参与者调查,在中国7家医院进行。在获得知情同意后,将招募3000名诊断为缺血性卒中的患者。将在医院现场进行为期一年的随访,并通过电话跟踪终点事件。采用频率分析和χ2检验对不同组的终点事件发生率及其他中医或现代医学特征进行比较分析,结果以构成比表示。将使用秩和检验对定量分数和相关模式或症状进行比较分析。终点事件与中医或现代医学因素的相关性分析将使用多变量Cox比例风险模型进行。先前的报告描述了基于现代医学指标的缺血性卒中终点事件风险评估模型,但没有此类研究包括中医特征。我们的新风险评估模型结合了中医和现代医学指标,具有促进缺血性脑卒中终点事件早期预警、早期干预和早期控制的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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